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2016/06/22

Nature Communications - 22 June 2016

 
Nature Communications

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  Latest Correspondence  
 
Correspondence: On the enzymology and significance of HSPA1 lysine methylation OPEN
20 June 2016 | doi: 10.1038/ncomms11464
 
 
  Latest Articles View all Articles  
 
Aviation effects on already-existing cirrus clouds OPEN
Matthias Tesche, Peggy Achtert, Paul Glantz and Kevin J. Noone
The extent to which air traffic affects the optical thickness of existing cirrus clouds in the upper atmosphere remains unknown. Here, the authors compare cirrus cloud properties inside and outside of real flight tracks and show that optical thickness is significantly increased within the flight path.
21 June 2016 | doi: 10.1038/ncomms12016
Earth Sciences  Atmospheric science  Climate science 

Auditory experience-dependent cortical circuit shaping for memory formation in bird song learning OPEN
Shin Yanagihara and Yoko Yazaki-Sugiyama
Juvenile zebra finches learn to sing by memorizing and imitating their tutor's song, yet neural correlates of the tutor song have not been shown. Here the authors show a small subset of higher-level auditory cortex neurons are sharply tuned to the tutor's song and modulated by inhibition and arousal state.
21 June 2016 | doi: 10.1038/ncomms11946
Biological Sciences  Neuroscience 

Activated desorption at heterogeneous interfaces and long-time kinetics of hydrocarbon recovery from nanoporous media OPEN
Thomas Lee, Lydéric Bocquet and Benoit Coasne
Hydrocarbon recovery from gas shale challenges existing frameworks for fluid transport due to the nanoporous nature of the shale. Here, the authors use molecular simulation and statistical models to show that gas recovery is thermally activated due to interfacial effects at the nanoporous surface.
21 June 2016 | doi: 10.1038/ncomms11890
Chemical Sciences  Materials science  Physical chemistry 

Early role of vascular dysregulation on late-onset Alzheimer’s disease based on multifactorial data-driven analysis OPEN
Y. Iturria-Medina, R. C. Sotero, P. J. Toussaint, J. M. Mateos-Pérez, A. C. Evans, null null, Michael W. Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John Morris, Leslie M. Shaw, Zaven Khachaturian, Greg Sorensen et al.
Late-onset Alzheimer's disease (LOAD) is a complex multi-factorial disorder. Here, the authors perform a data-driven analysis of LOAD progression, including multimodal brain imaging, plasma and CSF biomarkers, and find vascular dysfunction is among the earliest and strongest altered events.
21 June 2016 | doi: 10.1038/ncomms11934
Biological Sciences  Medical research  Neuroscience 

Redox-freezing and nucleation of diamond via magnetite formation in the Earth’s mantle OPEN
Dorrit E. Jacob, Sandra Piazolo, Anja Schreiber and Patrick Trimby
Diamonds provide a window into deep Earth processes and can be used to understand the deep carbon cycle. Here, Jacob et al. show that diamond precipitation can be triggered by the oxidation of pyrrhotite to magnetite at the base of a cratonic lithosphere, providing insight into diamond formation.
21 June 2016 | doi: 10.1038/ncomms11891
Earth Sciences  Geology and geophysics 

Two-dimensional shape memory graphene oxide OPEN
Zhenyue Chang, Junkai Deng, Ganaka G. Chandrakumara, Wenyi Yan and Jefferson Zhe Liu
When reducing the size of shape memory materials to the nanoscale regime, the memory effect tends to diminish. Here, the authors report a theoretical proposal of a shape memory graphene oxide with ordered epoxy groups retaining excellent programmability and actuation capabilities.
21 June 2016 | doi: 10.1038/ncomms11972
Physical Sciences  Applied physics  Materials science  Nanotechnology 

Ultrasensitive photodetectors exploiting electrostatic trapping and percolation transport OPEN
Yingjie Zhang, Daniel J. Hellebusch, Noah D. Bronstein, Changhyun Ko, D. Frank Ogletree, Miquel Salmeron and A. Paul Alivisatos
Photodetector sensitivity is limited by charge carrier recombination. Here, Zhang et al. use nanocrystal ligand engineering and sintering to provide separate pathways for electron and holes, and to fabricate photodetectors with a high detectivity, especially promising for applications in low-light imaging.
21 June 2016 | doi: 10.1038/ncomms11924
Physical Sciences  Materials science  Nanotechnology 

Uncertainty in soil data can outweigh climate impact signals in global crop yield simulations OPEN
Christian Folberth, Rastislav Skalský, Elena Moltchanova, Juraj Balkovič, Ligia B. Azevedo, Michael Obersteiner and Marijn van der Velde
Global gridded crop models are increasingly used to assess climate change impacts on food production. Here, the authors assess crop yield uncertainty associated with soil data input, reporting that soil type strongly influences yield estimates, and may either buffer or amplify climate-related impacts.
21 June 2016 | doi: 10.1038/ncomms11872
Earth Sciences  Climate science  Ecology  Plant sciences 

Counteracting H3K4 methylation modulators Set1 and Jhd2 co-regulate chromatin dynamics and gene transcription OPEN
Saravanan Ramakrishnan, Srijana Pokhrel, Sowmiya Palani, Christian Pflueger, Timothy J. Parnell, Bradley R. Cairns, Srividya Bhaskara and Mahesh B. Chandrasekharan
Histone H3K4 methylation affects gene transcription from yeast to humans. Here, the authors show that Set1 and Jhd2, the only H3K4 methyltransferase and H3K4 demethylase, respectively, in budding yeast, co-regulate both positive and negative transcription mediated by nucleosomal turnover and occupancy.
21 June 2016 | doi: 10.1038/ncomms11949
Biological Sciences  Cell biology  Molecular biology 

Loss-tolerant state engineering for quantum-enhanced metrology via the reverse Hong–Ou–Mandel effect OPEN
Alexander E. Ulanov, Ilya A. Fedorov, Demid Sychev, Philippe Grangier and A. I. Lvovsky
N00N states are promising for quantum communications and metrology, but are vulnerable to losses. Here the authors develop a technique for preparing high-fidelity two-photon N00N states in a loss-free fashion, and demonstrate enhanced phase sensitivity without requiring recombination.
21 June 2016 | doi: 10.1038/ncomms11925
Physical Sciences  Applied physics  Optical physics  Theoretical physics 

Discovery of earth-abundant nitride semiconductors by computational screening and high-pressure synthesis OPEN
Yoyo Hinuma, Taisuke Hatakeyama, Yu Kumagai, Lee A. Burton, Hikaru Sato, Yoshinori Muraba, Soshi Iimura, Hidenori Hiramatsu, Isao Tanaka, Hideo Hosono and Fumiyasu Oba
Nitride semiconductors are attractive for various applications. Here a computational screening study identifies a number of possible ternary nitrides as promising candidates, including a phase that the authors synthesize for the first time via a high-pressure route.
21 June 2016 | doi: 10.1038/ncomms11962
Physical Sciences  Condensed matter  Materials science 

Unassisted photoelectrochemical water splitting exceeding 7% solar-to-hydrogen conversion efficiency using photon recycling OPEN
Xinjian Shi, Hokyeong Jeong, Seung Jae Oh, Ming Ma, Kan Zhang, Jeong Kwon, In Taek Choi, Il Yong Choi, Hwan Kyu Kim, Jong Kyu Kim and Jong Hyeok Park
Unassisted water splitting by tandem photoelectrochemical and photovoltaic devices requires optimization of the absorbance and transmittance properties of the front photoelectrode. Here, Shi et al. use a conductive distributed Brag reflector to harvest photons of different wavelengths in the two subcells.
21 June 2016 | doi: 10.1038/ncomms11943
Physical Sciences  Catalysis  Materials science  Physical chemistry 

Activation of STING requires palmitoylation at the Golgi OPEN
Kojiro Mukai, Hiroyasu Konno, Tatsuya Akiba, Takefumi Uemura, Satoshi Waguri, Toshihide Kobayashi, Glen N. Barber, Hiroyuki Arai and Tomohiko Taguchi
STING is essential for the type I interferon immune response to foreign DNA. Here, the authors show that palmitoylation of STING at the Golgi is required for activating downstream signalling, and increased Golgi localization of certain STING variants may cause autoimmune disease in some cases.
21 June 2016 | doi: 10.1038/ncomms11932
Biological Sciences  Cell biology  Immunology  Molecular biology 

Structural basis for the recognition of guide RNA and target DNA heteroduplex by Argonaute OPEN
Tomohiro Miyoshi, Kosuke Ito, Ryo Murakami and Toshio Uchiumi
Argonaute proteins are important in the silencing machinery with some regulatory RNAs. Here, the authors solve the structure of an argonaute protein in complex with both the guide RNA and target DNA and propose a mechanism for their recognition.
21 June 2016 | doi: 10.1038/ncomms11846
Biological Sciences  Biochemistry  Molecular biology 

Slower carriers limit charge generation in organic semiconductor light-harvesting systems OPEN
Martin Stolterfoht, Ardalan Armin, Safa Shoaee, Ivan Kassal, Paul Burn and Paul Meredith
In organic solar cells, the photogeneration of free charge carriers is limited by the dissociation of interfacial charge transfer states. Here, the authors study the impact of charge carrier mobilities in operational devices and show that the slowest charge carriers limit the dissociation of charge transfer states.
21 June 2016 | doi: 10.1038/ncomms11944
Physical Sciences  Applied physics  Materials science  Nanotechnology 

Operating organic light-emitting diodes imaged by super-resolution spectroscopy OPEN
John T. King and Steve Granick
There is a need to characterize devices during operation in real-time and at nanoscopic length scales. Here, King et al. perform electroluminescence-STED imaging with a polymer based light-emitting diode, revealing nanoscopic defects that would be unresolvable with traditional optical microscopy.
21 June 2016 | doi: 10.1038/ncomms11691
Physical Sciences  Applied physics  Optical physics 

Thermoelectric materials by using two-dimensional materials with negative correlation between electrical and thermal conductivity OPEN
Myoung-Jae Lee, Ji-Hoon Ahn, Ji Ho Sung, Hoseok Heo, Seong Gi Jeon, Woo Lee, Jae Yong Song, Ki-Ha Hong, Byeongdae Choi, Sung-Hoon Lee and Moon-Ho Jo
The improvement of the thermoelectric figure of merit ZT has been hindered by the challenges associated with the independent control of the electrical and thermal conductivity. Here the authors show that SnS2 nanosheets can lead to an increased ZT via negative correlation between electrical and thermal conductivity.
21 June 2016 | doi: 10.1038/ncomms12011
Physical Sciences  Applied physics  Atomic and molecular physics  Nanotechnology 

Coupling of Higgs and Leggett modes in non-equilibrium superconductors OPEN
H. Krull, N. Bittner, G. S. Uhrig, D. Manske and A. P. Schnyder
Collective modes of amplitude and phase are decoupled in equilibrium systems, limiting the understanding of competing orders in correlated material. Here, Krull et al. report that a non-adiabatic pump pulse can induce an intricate coupling between Leggett and Higgs modes, providing a way to couple collective modes in non-equilibrium condition.
21 June 2016 | doi: 10.1038/ncomms11921
Physical Sciences  Condensed matter  Theoretical physics 

Mnemonic convergence in the human hippocampus OPEN
Alexander R. Backus, Sander E. Bosch, Matthias Ekman, Alejandro Vicente Grabovetsky and Christian F. Doeller
The ability to form associations between events is the hallmark of episodic memory and is thought to involve the hippocampus. Here the authors use a combination of multivariate pattern and graph theoretical network analyses of functional imaging data in humans, and show conjunctive coding and hub-like network attributes in the hippocampus.
21 June 2016 | doi: 10.1038/ncomms11991
Biological Sciences  Neuroscience 

Faecal bile acids are natural ligands of the mouse accessory olfactory system OPEN
Wayne I. Doyle, Jordan A. Dinser, Hillary L. Cansler, Xingjian Zhang, Daniel D. Dinh, Natasha S. Browder, Ian M. Riddington and Julian P. Meeks
The accessory olfactory system (AOS) processes social chemosensory information and guides behaviors that are important for survival and reproduction in mammals. Here the authors report that mouse feces are a source of AOS neuronal activity and identify unconjugated bile acids in feces as a class of natural AOS ligands.
21 June 2016 | doi: 10.1038/ncomms11936
Biological Sciences  Neuroscience 

Tumour-initiating cell-specific miR-1246 and miR-1290 expression converge to promote non-small cell lung cancer progression OPEN
Wen Cai Zhang, Tan Min Chin, Henry Yang, Min En Nga, Declan Patrick Lunny, Edwin Kok Hao Lim, Li Li Sun, Yin Huei Pang, Yi Ning Leow, Shanneen Rossellini Y Malusay, Priscilla Xin Hui Lim, Jeravan Zili Lee, Benedict Jian Wei Tan, Ng Shyh-Chang, Elaine Hsuen Lim, Wan Teck Lim, Daniel Shao Weng Tan, Eng Huat Tan, Bee Choo Tai, Ross Andrew Soo et al.
miRNAs can function either as proto-oncogenes or tumour suppressors in several cancers; however their function in tumour initiating cells is unclear. Here, Zhang et al. show that tumour initiating cell-specific miR-1246 and miR-1290 promote lung cancer initiation and metastasis and could serve as prognostic markers.
21 June 2016 | doi: 10.1038/ncomms11702
Biological Sciences  Cancer  Molecular biology 

The necroptosis-inducing kinase RIPK3 dampens adipose tissue inflammation and glucose intolerance OPEN
Jérémie Gautheron, Mihael Vucur, Anne T. Schneider, Ilenia Severi, Christoph Roderburg, Sanchari Roy, Matthias Bartneck, Peter Schrammen, Mauricio Berriel Diaz, Josef Ehling, Felix Gremse, Felix Heymann, Christiane Koppe, Twan Lammers, Fabian Kiessling, Niels Van Best, Oliver Pabst, Gilles Courtois, Andreas Linkermann, Stefan Krautwald et al.
The kinase RIPK3 initiates necroptosis, which has been reported to promote inflammation in various pathological conditions. Here, the authors show that genetic ablation of Ripk3 results in adipocyte apoptosis and white adipose tissue inflammation in obese mice, which promotes glucose intolerance.
21 June 2016 | doi: 10.1038/ncomms11869
Biological Sciences  Medical research 

A dynamic pathway analysis approach reveals a limiting futile cycle in N-acetylglucosamine overproducing Bacillus subtilis OPEN
Yanfeng Liu, Hannes Link, Long Liu, Guocheng Du, Jian Chen and Uwe Sauer
Rate-limiting steps in synthetic metabolic pathways are difficult to identify. Here, the authors monitor metabolite dynamics and apply kinetic modelling during the start-up phase of the Bacillus subtilis GlcNAc pathway to discover a futile cycle, allowing them to identify a more productive strain.
21 June 2016 | doi: 10.1038/ncomms11933
Biological Sciences  Bioengineering  Microbiology  Systems biology 

Treg engage lymphotoxin beta receptor for afferent lymphatic transendothelial migration OPEN
C. Colin Brinkman, Daiki Iwami, Molly K. Hritzo, Yanbao Xiong, Sarwat Ahmad, Thomas Simon, Keli L. Hippen, Bruce R. Blazar and Jonathan S. Bromberg
Lymphotoxin regulates lymphoid organ architecture and adhesion molecules involved in lymphocyte trafficking. Here the authors show that lymphotoxin produced by regulatory T cells promotes their migration to the draining lymph nodes by engaging its cognate receptor on lymphatic endothelial cells.
21 June 2016 | doi: 10.1038/ncomms12021
Biological Sciences  Immunology 

Microfluidic single-cell transcriptional analysis rationally identifies novel surface marker profiles to enhance cell-based therapies OPEN
Robert C. Rennert, Michael Januszyk, Michael Sorkin, Melanie Rodrigues, Zeshaan N. Maan, Dominik Duscher, Alexander J. Whittam, Revanth Kosaraju, Michael T. Chung, Kevin Paik, Alexander Y. Li, Michael Findlay, Jason P. Glotzbach, Atul J. Butte and Geoffrey C. Gurtner
Unrecognized progenitor cell perturbations underlying a disease state may limit the efficacy of cell therapies. Here, the authors use high-throughput, single-cell transcriptional analysis to identify disease-specific cellular alterations and prospectively isolate restorative cell subpopulations.
21 June 2016 | doi: 10.1038/ncomms11945
Biological Sciences  Cell biology  Molecular biology 

On-chip coherent conversion of photonic quantum entanglement between different degrees of freedom OPEN
Lan-Tian Feng, Ming Zhang, Zhi-Yuan Zhou, Ming Li, Xiao Xiong, Le Yu, Bao-Sen Shi, Guo-Ping Guo, Dao-Xin Dai, Xi-Feng Ren and Guang-Can Guo
Harnessing multiple degrees of freedom of quantum states on chip could improve quantum information processing. Here, the authors demonstrate coherent conversion of quantum states between path, polarization and transverse waveguide-mode degrees of freedom in a quantum photonic integrated circuit.
20 June 2016 | doi: 10.1038/ncomms11985
Physical Sciences  Optical physics 

The power of a critical heat engine OPEN
Michele Campisi and Rosario Fazio
The second law of thermodynamics says that the efficiency of a heat engine is limited by the Carnot efficiency. Here, the authors use finite-size-scaling theory to investigate whether this ultimate limit can be achieved at finite power using quantum Otto engines.
20 June 2016 | doi: 10.1038/ncomms11895
Physical Sciences  Theoretical physics 

Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer OPEN
Yujun Hao, Yardena Samuels, Qingling Li, Dawid Krokowski, Bo-Jhih Guan, Chao Wang, Zhicheng Jin, Bohan Dong, Bo Cao, Xiujing Feng, Min Xiang, Claire Xu, Stephen Fink, Neal J. Meropol, Yan Xu, Ronald A. Conlon, Sanford Markowitz, Kenneth W. Kinzler, Victor E. Velculescu, Henri Brunengraber et al.
Cancer cells rely on glutamine to replenish the TCA cycle. Here, the authors show that oncogenic PIK3CA mutations drive this metabolic rewiring in colorectal cancer cells by up-regulating glutamate pyruvate transaminase expression, thus increasing sensitivity to glutamine starvation.
20 June 2016 | doi: 10.1038/ncomms11971
Biological Sciences  Biochemistry  Cancer  Cell biology 

Crystallization of spin superlattices with pressure and field in the layered magnet SrCu2(BO3)2 OPEN
S. Haravifard, D. Graf, A. E. Feiguin, C. D. Batista, J. C. Lang, D. M. Silevitch, G. Srajer, B. D. Gaulin, H. A. Dabkowska and T. F. Rosenbaum
Spin 1/2 dimer systems in an external magnetic field behave as a lattice gas of hard-core bosons, and can undergo condensation. Here the authors show in SrCu2(BO3)2 that new fractionally crystallized states are not only possible, but also tuneable with hydrostatic pressure.
20 June 2016 | doi: 10.1038/ncomms11956
Physical Sciences  Condensed matter 

Structural insights of ZIP4 extracellular domain critical for optimal zinc transport OPEN
Tuo Zhang, Dexin Sui and Jian Hu
Mutations in the extracellular domain of zinc transporter ZIP4 result in a lethal disorder. Here, the authors report the first crystal structure of ZIP4 extracellular domain, unveiling its unprecedented dimerization and two structural independent subdomains that have crucial roles in zinc transport.
20 June 2016 | doi: 10.1038/ncomms11979
Biological Sciences  Biochemistry  Biophysics 

Specific frontal neural dynamics contribute to decisions to check OPEN
Frederic M. Stoll, Vincent Fontanier and Emmanuel Procyk
Information seeking is thought to rely on the brain's frontal cortex but which regions specifically control this drive remains unknown. Here the authors show that monkeys deciding to seek information on the current state of the environment showed specific neural dynamics in the lateral prefrontal cortex and midcingulate cortex.
20 June 2016 | doi: 10.1038/ncomms11990
Biological Sciences  Neuroscience 

Development of background-free tame fluorescent probes for intracellular live cell imaging OPEN
Samira Husen Alamudi, Rudrakanta Satapathy, Jihyo Kim, Dongdong Su, Haiyan Ren, Rajkumar Das, Lingna Hu, Enrique Alvarado-Martínez, Jung Yeol Lee, Christian Hoppmann, Eduardo Peña-Cabrera, Hyung-Ho Ha, Hee-Sung Park, Lei Wang and Young-Tae Chang
The success of a fluorescent dye as a molecular probe to monitor the intracellular activity of biomolecules depends on its physicochemical characteristics. Here, the authors use a predictive model to identify key features that allow them to design cell permeable, background-free fluorescent probes.
20 June 2016 | doi: 10.1038/ncomms11964
Chemical Sciences  Bioinformatics  Chemical biology  Organic chemistry 

One-dimensional Magnus-type platinum double salts OPEN
Christopher H. Hendon, Aron Walsh, Norinobu Akiyama, Yosuke Konno, Takashi Kajiwara, Tasuku Ito, Hiroshi Kitagawa and Ken Sakai
Mixed-valent one-dimensional platinum chains are interesting inorganic compounds with potential applications in molecular electronics. Here, the authors report a series of platinum dimer-based chains with controllable oxidation state and conductivity behaviour.
20 June 2016 | doi: 10.1038/ncomms11950
Chemical Sciences  Inorganic chemistry 

Water-mediated cation intercalation of open-framework indium hexacyanoferrate with high voltage and fast kinetics OPEN
Liang Chen, Hezhu Shao, Xufeng Zhou, Guoqiang Liu, Jun Jiang and Zhaoping Liu
Rechargeable aqueous metal-ion batteries are promising for large-scale applications, but performance and stability issues still remain. Here the authors utilize open-framework indium hexacyanoferrate cathodes to improve performance, showing that water-mediated cation intercalation occurs at the cathode.
20 June 2016 | doi: 10.1038/ncomms11982
Chemical Sciences  Materials science  Physical chemistry 

Translation control during prolonged mTORC1 inhibition mediated by 4E-BP3 OPEN
Yoshinori Tsukumo, Tommy Alain, Bruno D. Fonseca, Robert Nadon and Nahum Sonenberg
The eIF4E-binding proteins (4E-BPs) are critical repressors of cap-dependent translation via mTOR, a pathway frequently hyperactivated in cancer. Here the authors show that 4E-BP3 specifically mediates the cap-dependent translation repression and antiproliferative effects of prolonged pharmacological mTOR inhibition.
20 June 2016 | doi: 10.1038/ncomms11776
Biological Sciences  Biochemistry  Cancer  Cell biology 

CRF-like receptor SEB-3 in sex-common interneurons potentiates stress handling and reproductive drive in C. elegans OPEN
Changhoon Jee, Jimmy F. Goncalves, Brigitte LeBoeuf and L. Rene Garcia
Innate animal behaviours can be negatively regulated by environmental stressors. Jee et al. show that suppression of male C. elegans copulation behaviour by noxious light can be overcome by activation of SEB-3, a homologue of the stress-associated mammalian corticotropin-releasing factor receptor family.
20 June 2016 | doi: 10.1038/ncomms11957
Biological Sciences  Neuroscience 

Nanoreporter PET predicts the efficacy of anti-cancer nanotherapy OPEN
Carlos Pérez-Medina, Dalya Abdel-Atti, Jun Tang, Yiming Zhao, Zahi A. Fayad, Jason S. Lewis, Willem J. M. Mulder and Thomas Reiner
Nanoparticle drug formulations are currently used as cancer treatment but the response in patients is highly variable. Here, the authors developed a Zirconium-89 nanoreporter able to predict using PET, therapeutic accumulation and efficacy of anti-cancer nanoparticle drug formulations when co-injected in a murine breast cancer model.
20 June 2016 | doi: 10.1038/ncomms11838
Biological Sciences  Cell biology  Medical research 

KRT14 marks a subpopulation of bladder basal cells with pivotal role in regeneration and tumorigenesis OPEN
George Papafotiou, Varvara Paraskevopoulou, Eleni Vasilaki, Zoi Kanaki, Nikolaos Paschalidis and Apostolos Klinakis
It is unclear whether there is a progenitor/stem cell in the basal layer of the urothelium in the bladder. Here, the authors identify Keratin14 positive cells that can regenerate the bladder in both a natural and injury-induced manner, and following neoplastic transformation, can give rise to tumours.
20 June 2016 | doi: 10.1038/ncomms11914
Biological Sciences  Cell biology  Developmental biology 

Loss of the RNA-binding protein TACO1 causes late-onset mitochondrial dysfunction in mice OPEN
Tara R. Richman, Henrik Spåhr, Judith A. Ermer, Stefan M. K. Davies, Helena M. Viola, Kristyn A. Bates, John Papadimitriou, Livia C. Hool, Jennifer Rodger, Nils-Göran Larsson, Oliver Rackham and Aleksandra Filipovska
Mutations in the translational activator of cytochrome c oxidase subunit I (TACO1) causes cytochrome c oxidase deficiency and Leigh Syndrome in patients. Here, the authors characterize mice with a mutation that causes lack of TACO1 expression, identifying a mouse model that could be useful for preclinical trials.
20 June 2016 | doi: 10.1038/ncomms11884
Biological Sciences  Biochemistry 

Merging rhodium-catalysed C–H activation and hydroamination in a highly selective [4+2] imine/alkyne annulation OPEN
Rajith S. Manan and Pinjing Zhao
C–H activations and hydroaminations are useful synthetic procedures for building up complex, functional molecules. Here, the authors report a single catalyst capable of performing tandem C–H activation and hydroamination, giving access to N-heterocycles via the [4+2] annulation of aromatic imines and alkynes.
20 June 2016 | doi: 10.1038/ncomms11506
Chemical Sciences  Catalysis  Organic chemistry 

Doping-enhanced radiative efficiency enables lasing in unpassivated GaAs nanowires OPEN
Tim Burgess, Dhruv Saxena, Sudha Mokkapati, Zhe Li, Christopher R. Hall, Jeffrey A. Davis, Yuda Wang, Leigh M. Smith, Lan Fu, Philippe Caroff, Hark Hoe Tan and Chennupati Jagadish
Until now, efforts to enhance the performance of nanolasers have focused on reducing the rate of non-radiative recombination. Here, Burgess et al. employ controlled impurity doping to increase the rate of radiative recombination.
17 June 2016 | doi: 10.1038/ncomms11927
Physical Sciences  Materials science  Nanotechnology  Optical physics 

Molecular preservation of 1.88 Ga Gunflint organic microfossils as a function of temperature and mineralogy OPEN
Julien Alleon, Sylvain Bernard, Corentin Le Guillou, Johanna Marin-Carbonne, Sylvain Pont, Olivier Beyssac, Kevin D. McKeegan and François Robert
Thermal diagenesis is generally seen as detrimental to the preservation of organic biosignatures. Using synchrotron-based XANES data, Alleon et al. find preservation of the molecular signatures of organic microfossils from the 1.88 Ga Gunflint cherts.
17 June 2016 | doi: 10.1038/ncomms11977
Earth Sciences  Geology and geophysics  Palaeontology 

Microbial interactions lead to rapid micro-scale successions on model marine particles OPEN
Manoshi S. Datta, Elzbieta Sliwerska, Jeff Gore, Martin F. Polz and Otto X. Cordero
Particles of organic matter in the ocean harbour microbial communities that digest and recycle essential nutrients. Here, Datta et al. use model marine particles to show that the attached bacterial communities undergo rapid, reproducible successions driven by ecological interactions.
17 June 2016 | doi: 10.1038/ncomms11965
Biological Sciences  Ecology  Microbiology 

Interferometric measurements of many-body topological invariants using mobile impurities OPEN
F. Grusdt, N. Y. Yao, D. Abanin, M. Fleischhauer and E. Demler
Probing topological orders in many-body systems remains a major challenge, which requires bulk-edge correspondence. Here, Grusdt et al. present an approach to show that fractional charges can be directly probed in the bulk of fractional quantum Hall systems using mobile impurities through interferometric measurements.
17 June 2016 | doi: 10.1038/ncomms11994
Physical Sciences  Condensed matter 

Early synaptic deficits in the APP/PS1 mouse model of Alzheimer’s disease involve neuronal adenosine A2A receptors OPEN
Silvia Viana da Silva, Matthias Georg Haberl, Pei Zhang, Philipp Bethge, Cristina Lemos, Nélio Gonçalves, Adam Gorlewicz, Meryl Malezieux, Francisco Q. Gonçalves, Noëlle Grosjean, Christophe Blanchet, Andreas Frick, U Valentin Nägerl, Rodrigo A. Cunha and Christophe Mulle
Hippocampal synaptic dysfunctions are an early symptom of Alzheimer’s disease. Here, the authors find adenosine A2A receptors are up-regulated in APP/PS1 model mice and that deleting or blocking receptor activity helps alleviate plasticity and memory impairments.
17 June 2016 | doi: 10.1038/ncomms11915
Biological Sciences  Neuroscience 

Coherent manipulation of a solid-state artificial atom with few photons OPEN
V. Giesz, N. Somaschi, G. Hornecker, T. Grange, B. Reznychenko, L. De Santis, J. Demory, C. Gomez, I. Sagnes, A. Lemaître, O. Krebs, N. D. Lanzillotti-Kimura, L. Lanco, A. Auffeves and P. Senellart
Quantum information processing requires a system in which a single photon controls a single atom and vice versa. Here, the authors demonstrate such reciprocal operation and achieve coherent manipulation of a quantum dot by a few photons sent on an optical cavity.
17 June 2016 | doi: 10.1038/ncomms11986
Physical Sciences  Optical physics 

Floquet topological insulators for sound OPEN
Romain Fleury, Alexander B Khanikaev and Andrea Alù
One-way sound propagation has been recently proposed in the context of topological acoustics, but is challenged by introducing uniform media motion. Here, Fleury et al. present a practical scheme to achieve topological propagation by modulating in time the acoustic properties of a lattice of resonators, resembling Floquet topological insulators in condensed matter.
17 June 2016 | doi: 10.1038/ncomms11744
Physical Sciences  Applied physics  Condensed matter 

Operando NMR spectroscopic analysis of proton transfer in heterogeneous photocatalytic reactions OPEN
Xue Lu Wang, Wenqing Liu, Yan-Yan Yu, Yanhong Song, Wen Qi Fang, Daxiu Wei, Xue-Qing Gong, Ye-Feng Yao and Hua Gui Yang
Identifying proton transfer processes in catalytic reactions is a technically challenging task. Here, the authors employ operando nuclear magnetic resonance spectroscopy to study the reaction mechanism and intermediates of the photocatalytic hydrogen evolution, and to identify the proton sources.
17 June 2016 | doi: 10.1038/ncomms11918
Chemical Sciences  Analytical chemistry  Catalysis  Physical chemistry 

Pairing in a dry Fermi sea OPEN
T. A Maier, P. Staar, V. Mishra, U. Chatterjee, J. C. Campuzano and D. J. Scalapino
Pairing interaction appears at room temperature in traditional superconductors with a Cooper instability in the Fermi sea. Here, Maier et al. report that in the pseudogap phase of cuprate, where this instability is absent, superconductivity arises from an increase in the strength of the spin fluctuation pairing interaction as the temperature decreases.
17 June 2016 | doi: 10.1038/ncomms11875
Physical Sciences  Condensed matter  Materials science 

Integrating an electrically active colloidal quantum dot photodiode with a graphene phototransistor OPEN
Ivan Nikitskiy, Stijn Goossens, Dominik Kufer, Tania Lasanta, Gabriele Navickaite, Frank H. L. Koppens and Gerasimos Konstantatos
The combination of fast photo-response and high gain plays a pivotal role in photodetector devices. Here the authors combine a colloidal quantum dot photodiode with a graphene phototransistor to overcome the speed, quantum efficiency and linear dynamic range limitations of available phototransistors.
17 June 2016 | doi: 10.1038/ncomms11954
Physical Sciences  Applied physics  Materials science  Nanotechnology 

A threshold level of NFATc1 activity facilitates thymocyte differentiation and opposes notch-driven leukaemia development OPEN
Stefan Klein-Hessling, Ronald Rudolf, Khalid Muhammad, Klaus-Peter Knobeloch, Muhammad Ahmad Maqbool, Pierre Cauchy, Jean-Christophe Andrau, Andris Avots, Claudio Talora, Volker Ellenrieder, Isabella Screpanti, Edgar Serfling and Amiya Kumar Patra
NFATc1 orchestrates thymocyte development. Here the authors show that NFATc1 expression is regulated by distinct promoters during thymocyte differentiation, and by conditional deletion of individual promoters in mice they define their specific roles in the control of T-cell development by NFATc1.
17 June 2016 | doi: 10.1038/ncomms11841
Biological Sciences  Cancer  Immunology 

Direct imaging of topological edge states at a bilayer graphene domain wall OPEN
Long-Jing Yin, Hua Jiang, Jia-Bin Qiao and Lin He
Domain wall between gapped graphene bilayers is believed to host one-dimensional topological states, which is yet waiting for direct evidences. Here, Yin et al. report images of the AB-BA stacked bilayer graphene domain wall, providing direct evidence for topological edge states in such system.
17 June 2016 | doi: 10.1038/ncomms11760
Physical Sciences  Condensed matter  Materials science  Nanotechnology 

Mid Pleistocene foraminiferal mass extinction coupled with phytoplankton evolution OPEN
Sev Kender, Erin L. McClymont, Aurora C. Elmore, Dario Emanuele, Melanie J. Leng and Henry Elderfield
The cause of a 20% decline in sea floor calcareous foraminifera species during the Mid-Pleistocene remains enigmatic. Here, the authors present new geochemical evidence, from the Tasman Sea that supports a change in phytoplankton food source as the primary driver.
17 June 2016 | doi: 10.1038/ncomms11970
Earth Sciences  Climate science  Ecology  Oceanography 

High-field plasma acceleration in a high-ionization-potential gas OPEN
S. Corde, E. Adli, J. M. Allen, W. An, C. I. Clarke, B. Clausse, C. E. Clayton, J. P. Delahaye, J. Frederico, S. Gessner, S. Z. Green, M. J. Hogan, C. Joshi, M. Litos, W. Lu, K. A. Marsh, W. B. Mori, N. Vafaei-Najafabadi, D. Walz and V. Yakimenko et al.
Plasma accelerators driven by particle beams are a promising technology, but the acceleration distance and energy gain are strongly limited by head erosion in a high-ionization-potential gas. Here the authors observe up to 130% energy boost in a self-focused electron beam, with limited head erosion.
17 June 2016 | doi: 10.1038/ncomms11898
Physical Sciences  Fluids and plasma physics  Particle physics 

Tumour suppressor death-associated protein kinase targets cytoplasmic HIF-1α for Th17 suppression OPEN
Ting-Fang Chou, Ya-Ting Chuang, Wan-Chen Hsieh, Pei-Yun Chang, Hsin-Yu Liu, Shu-Ting Mo, Tzu-Sheng Hsu, Shi-Chuen Miaw, Ruey-Hwa Chen, Adi Kimchi and Ming-Zong Lai
HIF-1α is critical for Th17 differentiation. Here the authors show that DAPK (Death-Associated Protein Kinase) inhibits Th17 differentiation and immunopathology in a mouse model of multiple sclerosis by promoting HIF1-α binding to its negative regulator PHD2.
17 June 2016 | doi: 10.1038/ncomms11904
Biological Sciences  Immunology 

Structure and inference in annotated networks OPEN
M. E. J. Newman and Aaron Clauset
Analysis of network structure is usually based on knowledge of connections alone, ignoring additional information such as gender or age of individuals in social networks. Here the authors devise an approach that incorporates such metadata and uses it to improve the detection of network communities.
16 June 2016 | doi: 10.1038/ncomms11863
Biological Sciences  Systems biology  Theoretical physics 

Contrasting emergence of Lyme disease across ecosystems OPEN
Atle Mysterud, William Ryan Easterday, Vetle Malmer Stigum, Anders Bjørnsgaard Aas, Erling L. Meisingset and Hildegunn Viljugrein
Environmental change is thought to have driven the recent emergence of Lyme disease in Europe. Using a decade of human disease incidence data across a large area in Norway, Mysterud et al. show that incidence correlates with deer population, but that deer population plays a limited role in recent disease emergence.
16 June 2016 | doi: 10.1038/ncomms11882
Biological Sciences  Ecology 

Sugary interfaces mitigate contact damage where stiff meets soft OPEN
Hee Young Yoo, Mihaela Iordachescu, Jun Huang, Elise Hennebert, Sangsik Kim, Sangchul Rho, Mathias Foo, Patrick Flammang, Hongbo Zeng, Daehee Hwang, J. Herbert Waite and Dong Soo Hwang
Robust attachment between living tissues and inert materials is challenging to achieve. Here, Hwang and co-workers look at the molecular level between tissue and embedded byssal threads of Atrina pectinata and how this affects tenacity, toughness, and robustness.
16 June 2016 | doi: 10.1038/ncomms11923
Chemical Sciences  Chemical biology  Materials science 

Nickel–vanadium monolayer double hydroxide for efficient electrochemical water oxidation OPEN
Ke Fan, Hong Chen, Yongfei Ji, Hui Huang, Per Martin Claesson, Quentin Daniel, Bertrand Philippe, Håkan Rensmo, Fusheng Li, Yi Luo and Licheng Sun
Water oxidation is a key component of water splitting, but more effective catalysts for the process are still required. Here the authors synthesize a monolayer nickel-vanadium layered double hydroxide material showing high activity for water oxidation owing to enhanced conductivity and abundant active sites.
16 June 2016 | doi: 10.1038/ncomms11981
Chemical Sciences  Catalysis  Materials science  Physical chemistry 

Interaction-induced hopping phase in driven-dissipative coupled photonic microcavities OPEN
S. R. K. Rodriguez, A. Amo, I. Sagnes, L. Le Gratiet, E. Galopin, A. Lemaître and J. Bloch
Coupled semiconductor microcavities constitute a model system where the hopping, interaction, and decay of exciton polaritons can be engineered. Here, Rodriguez et al. show how the phase acquired by polaritons hopping between cavities can be controlled through polariton-polariton interactions.
16 June 2016 | doi: 10.1038/ncomms11887
Physical Sciences  Optical physics 

Suspension survival mediated by PP2A-STAT3-Col XVII determines tumour initiation and metastasis in cancer stem cells OPEN
Chen-Chi Liu, Shih-Pei Lin, Han-Shui Hsu, Shung-Haur Yang, Chiu-Hua Lin, Muh-Hwa Yang, Mien-Chie Hung and Shih-Chieh Hung
Tumour initiating cells (TICs) are anoikis resistant in suspension culture and they are critical for initiating tumorigenesis in vivo. Here, the authors show that these features are promoted by hemidesmosome-like structures enriched in laminin V and collagen XVII 5 upregulated in TICs by phospho-STAT3 whose levels are increased through PP2A inactivation.
16 June 2016 | doi: 10.1038/ncomms11798
Biological Sciences  Cancer  Cell biology 

Hypothalamic CRH neurons orchestrate complex behaviours after stress OPEN
Tamás Füzesi, Nuria Daviu, Jaclyn I. Wamsteeker Cusulin, Robert P. Bonin and Jaideep S. Bains
Animals exhibit a number of complex behaviours following stressful events, although the underlying circuitry is undetermined. Here, the authors use optogenetic targeting to identify a role for corticotrophin releasing hormone cells in the paraventricular nucleus in regulating such behavioural responses to acute stress.
16 June 2016 | doi: 10.1038/ncomms11937
Biological Sciences  Neuroscience 

The hot pick-up technique for batch assembly of van der Waals heterostructures OPEN
Filippo Pizzocchero, Lene Gammelgaard, Bjarke S. Jessen, José M. Caridad, Lei Wang, James Hone, Peter Bøggild and Timothy J. Booth
The reliable assembly of two-dimensional materials into van der Waals heterostructures is a critical step towards nanoscale electronic integration. Here the authors present a technique for batch fabrication of graphene/boron nitride stacks with clean interfaces and high-yield.
16 June 2016 | doi: 10.1038/ncomms11894
Physical Sciences  Condensed matter  Materials science  Nanotechnology 

Molecular basis for CPAP-tubulin interaction in controlling centriolar and ciliary length OPEN
Xiangdong Zheng, Anand Ramani, Komal Soni, Marco Gottardo, Shuangping Zheng, Li Ming Gooi, Wenjing Li, Shan Feng, Aruljothi Mariappan, Arpit Wason, Per Widlund, Andrei Pozniakovsky, Ina Poser, Haiteng Deng, Guangshuo Ou, Maria Riparbelli, Callaini Giuliano, Anthony A. Hyman, Michael Sattler, Jay Gopalakrishnan et al.
Centrioles and cilia are microtubule-based structures of defined architecture, but what regulates this architecture is not clear. Here the authors discover that centrosomal-P4.1-associated-protein (CPAP) binds the α/β-tubulin dimer and licenses it for tubulin delivery contributing to centriolar/ciliary length and architecture control.
16 June 2016 | doi: 10.1038/ncomms11874
Biological Sciences  Cell biology 

Direct evidence of the molecular basis for biological silicon transport OPEN
Michael J. Knight, Laura Senior, Bethany Nancolas, Sarah Ratcliffe and Paul Curnow
Diatoms sheath themselves in a self-made casing of silica, which requires the function of silicic acid transporters. Here, the authors identify versions of these transporters that are experimentally tractable, and develop a fluorescence method to study silicic acid transport in vitro.
16 June 2016 | doi: 10.1038/ncomms11926
Biological Sciences  Biochemistry 

Three-dimensional spatiotemporal focusing of holographic patterns OPEN
Oscar Hernandez, Eirini Papagiakoumou, Dimitrii Tanese, Kevin Fidelin, Claire Wyart and Valentina Emiliani
Three-dimensional computer-generated holography cannot be implemented with temporal focusing. Here, Hernandez et al. use two spatial light modulators to control transverse- and axial-target light distribution, generating spatiotemporally focused patterns with uniform light distribution throughout the entire volume.
16 June 2016 | doi: 10.1038/ncomms11928
Physical Sciences  Optical physics 

Structure of the exportin Xpo4 in complex with RanGTP and the hypusine-containing translation factor eIF5A OPEN
Metin Aksu, Sergei Trakhanov and Dirk Görlich
Xpo4 imports Sox2 and other proteins into the cell nucleus, while exporting eIF5A or Smad3; how it recognizes these proteins has been unclear. Here, the authors solved the crystal structure of the RanGTP, Xpo4 and eIF5A complex and investigate how Xpo4 identifies its major export cargo.
16 June 2016 | doi: 10.1038/ncomms11952
Biological Sciences  Biochemistry 

Pliocene-Quaternary crustal melting in central and northern Tibet and insights into crustal flow OPEN
Qiang Wang, Chris J. Hawkesworth, Derek Wyman, Sun-Lin Chung, Fu-Yuan Wu, Xian-Hua Li, Zheng-Xiang Li, Guo-Ning Gou, Xiu-Zheng Zhang, Gong-Jian Tang, Wei Dan, Lin Ma and Yan-Hui Dong
The role of the low velocity-high conductivity zones (LV–HCZs) in developing the Tibetan Plateau has remained controversial. Here, Wang et al. present new geochemical and petrological data that show the LV–HCZs are sources of partial melt thus giving insight into the development of the Tibetan Plateau.
16 June 2016 | doi: 10.1038/ncomms11888
Earth Sciences  Geology and geophysics 

Diversity, structure and convergent evolution of the global sponge microbiome OPEN
Torsten Thomas, Lucas Moitinho-Silva, Miguel Lurgi, Johannes R. Björk, Cole Easson, Carmen Astudillo-García, Julie B. Olson, Patrick M. Erwin, Susanna López-Legentil, Heidi Luter, Andia Chaves-Fonnegra, Rodrigo Costa, Peter J. Schupp, Laura Steindler, Dirk Erpenbeck, Jack Gilbert, Rob Knight, Gail Ackermann, Jose Victor Lopez, Michael W. Taylor et al.
Sponges are early-diverging marine organisms that establish complex symbioses with microorganisms. Here, Thomas et al. analyse the microbial communities associated with 81 species of sponges from around the world, shedding light on the ecological and evolutionary drivers of these host-microbe associations.
16 June 2016 | doi: 10.1038/ncomms11870
Biological Sciences  Ecology  Evolution  Microbiology 

Observing the release of twist by magnetic reconnection in a solar filament eruption OPEN
Zhike Xue, Xiaoli Yan, Xin Cheng, Liheng Yang, Yingna Su, Bernhard Kliem, Jun Zhang, Zhong Liu, Yi Bi, Yongyuan Xiang, Kai Yang and Li Zhao
Magnetic reconnection is a fundamental process giving rise to topology change and energy release in plasmas, of particular relevance for the Sun. Here the authors report the observation of fast reconnection in a solar filament eruption, which occurs between a set of ambient fibrils and the filament itself.
16 June 2016 | doi: 10.1038/ncomms11837
Physical Sciences  Astronomy  Fluids and plasma physics 

Spin and wavelength multiplexed nonlinear metasurface holography OPEN
Weimin Ye, Franziska Zeuner, Xin Li, Bernhard Reineke, Shan He, Cheng-Wei Qiu, Juan Liu, Yongtian Wang, Shuang Zhang and Thomas Zentgraf
Metasurfaces offer an approach for computer generated holograms with good efficiency and ease of fabrication. Here, Ye et al. report on spin and wavelength multiplexed nonlinear metasurface holography, showing construction of holographic images using fundamental and harmonic generation waves of different spins.
16 June 2016 | doi: 10.1038/ncomms11930
Physical Sciences  Materials science  Optical physics 

A Myc-driven self-reinforcing regulatory network maintains mouse embryonic stem cell identity OPEN
Luca Fagnocchi, Alessandro Cherubini, Hiroshi Hatsuda, Alessandra Fasciani, Stefania Mazzoleni, Vittoria Poli, Valeria Berno, Riccardo L. Rossi, Rolland Reinbold, Max Endele, Timm Schroeder, Marina Rocchigiani, Żaneta Szkarłat, Salvatore Oliviero, Stephen Dalton and Alessio Zippo
The Myc transcription factor is a major regulator of stem cell (SC) self-renewal and pluripotency but how this integrates signals from other pathways is unclear. Here, the authors show that Myc activation triggers epigenetic memory in self renewing embryonic SCs via PRC2-mediated potentiation of the Wnt pathway.
15 June 2016 | doi: 10.1038/ncomms11903
Biological Sciences  Cell biology  Developmental biology 

Genetically and functionally defined NTS to PBN brain circuits mediating anorexia OPEN
Carolyn W. Roman, Victor A. Derkach and Richard D. Palmiter
Neurons in the nucleus of the solitary tract (NTS) are known to receive visceral signals from the gut during feeding. Here, the authors identify two populations of CCK- and DBH-expressing NTS neurons that work to suppress food intake when activated via opto- or chemogenetic stimulation.
15 June 2016 | doi: 10.1038/ncomms11905
Biological Sciences  Neuroscience 

Faster embryonic segmentation through elevated Delta-Notch signalling OPEN
Bo-Kai Liao, David J. Jörg and Andrew C. Oates
Rhythmic patterning governs the formation of somites in vertebrates, but how the period of such rhythms can be changed is unclear. Here, the authors generate a genetic model in zebrafish to increase DeltaD expression, which increases the range of Delta-Notch signalling, causing faster segmentation.
15 June 2016 | doi: 10.1038/ncomms11861
Biological Sciences  Cell biology  Developmental biology 

Bio-based polycarbonate as synthetic toolbox OPEN
O. Hauenstein, S. Agarwal and A. Greiner
With growing concerns over the sustainability of petroleum-based polymers, poly(limonene carbonate) is offered as a renewable alternative. Here, Greiner and co-workers have managed to tune the properties of poly(limonene carbonate) by carrying out several different chemical modifications.
15 June 2016 | doi: 10.1038/ncomms11862
Chemical Sciences  Materials science  Organic chemistry 

Robust estimates of overall immune-repertoire diversity from high-throughput measurements on samples OPEN
Joseph Kaplinsky and Ramy Arnaout
Diversity of an organism’s B- and T-cell repertoires is clinically important, but difficult to estimate due to uncertainty in the number of clones in a sample, sampling bias and experimental noise. Here Kaplinsky and Arnaout present Recon, a method that reconstructs the distribution of the overall repertoire from sample measurements.
15 June 2016 | doi: 10.1038/ncomms11881
Biological Sciences  Bioinformatics  Immunology 

Room temperature molecular up conversion in solution OPEN
Aline Nonat, Chi Fai Chan, Tao Liu, Carlos Platas-Iglesias, Zhenyu Liu, Wing-Tak Wong, Wai-Kwok Wong, Ka-Leung Wong and Loïc J. Charbonnière
Up conversion is an Anti-Stokes luminescent process by which photons of low energy are piled up to generate light at a higher energy. Here, the authors report a supramolecular assembly of fluoride-bridged erbium complexes which exhibit this behaviour in D2O solution at room temperature.
15 June 2016 | doi: 10.1038/ncomms11978
Chemical Sciences  Inorganic chemistry  Physical chemistry 

A broad analysis of resistance development in the malaria parasite OPEN
Victoria C. Corey, Amanda K. Lukens, Eva S. Istvan, Marcus C. S. Lee, Virginia Franco, Pamela Magistrado, Olivia Coburn-Flynn, Tomoyo Sakata-Kato, Olivia Fuchs, Nina F. Gnädig, Greg Goldgof, Maria Linares, Maria G. Gomez-Lorenzo, Cristina De Cózar, Maria Jose Lafuente-Monasterio, Sara Prats, Stephan Meister, Olga Tanaseichuk, Melanie Wree, Yingyao Zhou et al.
It is unclear whether new antimalarial compounds may rapidly lose effectiveness in the field because of parasite resistance. Here, Corey et al. investigate the acquisition of drug resistance and the extent to which common resistance mechanisms decrease susceptibility to a diverse set of 50 antimalarial compounds.
15 June 2016 | doi: 10.1038/ncomms11901
Biological Sciences  Chemical biology  Microbiology 

Microvesicles provide a mechanism for intercellular communication by embryonic stem cells during embryo implantation OPEN
Laura M. Desrochers, François Bordeleau, Cynthia A. Reinhart-King, Richard A. Cerione and Marc A. Antonyak
It is unclear how embryonic stem cells (ESC) communicate with surrounding cells during implantation. Here, the authors show that microvesicles (MV) are shed from ESCs, activating integrin and JNK/FAK kinases in trophoblasts, stimulating migration in vitro, and injecting MVs enhances blastocyst implantation.
15 June 2016 | doi: 10.1038/ncomms11958
Biological Sciences  Cell biology  Developmental biology 

Genome editing in butterflies reveals that spalt promotes and Distal-less represses eyespot colour patterns OPEN
Linlin Zhang and Robert D. Reed
Transcription factors Distal-less(Dll) and spalt were co-opted during the evolution of butterfly eyespots. Here, Zhang and Reed use CRISPR/Cas9 genome editing to show that while spalt is a positive regulator of eyespots as predicted, Dll knockouts have positive effects on both eyespot size and number, thus suggesting that Dll is an eyespot repressor, not an activator as previously thought.
15 June 2016 | doi: 10.1038/ncomms11769
Biological Sciences  Developmental biology  Evolution  Genetics

The innate immune protein calprotectin promotes Pseudomonas aeruginosa and Staphylococcus aureus interaction OPEN
Catherine A. Wakeman, Jessica L. Moore, Michael J. Noto, Yaofang Zhang, Marc D. Singleton, Boone M. Prentice, Benjamin A. Gilston, Ryan S. Doster, Jennifer A. Gaddy, Walter J. Chazin, Richard M. Caprioli and Eric P. Skaar
Co-infections with Pseudomonas aeruginosa and Staphylococcus aureus are common in cystic fibrosis patients. Here, the authors show that metal depletion induced by a host protein, calprotectin, promotes co-existence of both pathogens by inhibiting production of anti-staphylococcal molecules by P. aeruginosa.
15 June 2016 | doi: 10.1038/ncomms11951
Biological Sciences  Immunology  Microbiology 

A multigene mutation classification of 468 colorectal cancers reveals a prognostic role for APC OPEN
Michael J. Schell, Mingli Yang, Jamie K. Teer, Fang Yin Lo, Anup Madan, Domenico Coppola, Alvaro N. A. Monteiro, Michael V. Nebozhyn, Binglin Yue, Andrey Loboda, Gabriel A. Bien-Willner, Danielle M. Greenawalt and Timothy J. Yeatman
APC is a well-known tumour suppressor that is frequently inactivated in colorectal cancer. Here, the authors sequence more than 1000 cancer genes in 468 colorectal cancers and show that mutation signatures can be used to classify the tumours and that multiple mutations in APC are associated with a poor prognosis.
15 June 2016 | doi: 10.1038/ncomms11743
Biological Sciences  Cancer  Genetics 

Printable enzyme-embedded materials for methane to methanol conversion OPEN
Craig D. Blanchette, Jennifer M. Knipe, Joshuah K. Stolaroff, Joshua R. DeOtte, James S. Oakdale, Amitesh Maiti, Jeremy M. Lenhardt, Sarah Sirajuddin, Amy C. Rosenzweig and Sarah E. Baker
There is a need for small-scale reactors that convert methane emissions to more valuable products to reduce climate impacts. Here, the authors show that printing 3D structures of the pMMO enzyme enables continuous methane conversion under ambient conditions and reduces mass transfer limitations.
15 June 2016 | doi: 10.1038/ncomms11900
Chemical Sciences  Bioengineering  Biotechnology  Catalysis 

A CD36 ectodomain mediates insect pheromone detection via a putative tunnelling mechanism OPEN
Carolina Gomez-Diaz, Benoîte Bargeton, Liliane Abuin, Natalia Bukar, Jaime H. Reina, Tudor Bartoi, Marion Graf, Huy Ong, Maximilian H. Ulbrich, Jean-Francois Masson and Richard Benton
The CD36-related Sensory Neuron Membrane Protein 1 (SNMP1) facilitates pheromone detection by insect odorant receptors. Here Gomez-Diaz et al. show that the SNMP1 ectodomain is essential for function and propose that it forms a tunnel that transports pheromones from the extracellular fluid to their cognate receptors.
15 June 2016 | doi: 10.1038/ncomms11866
Biological Sciences  Cell biology  Neuroscience 

Strain-relief by single dislocation loops in calcite crystals grown on self-assembled monolayers OPEN
Johannes Ihli, Jesse N. Clark, Alexander S. Côté, Yi-Yeoun Kim, Anna S. Schenk, Alexander N. Kulak, Timothy P. Comyn, Oliver Chammas, Ross J. Harder, Dorothy M. Duffy, Ian K. Robinson and Fiona C. Meldrum
Epitaxial crystal growth attracts significant interest. Here, the authors use Bragg Coherent Diffraction Imaging to demonstrate calcite crystal precipitation on self-assembled monolayers exhibiting single dislocation loops with different geometries to those generated in conventional epitaxial thin films.
15 June 2016 | doi: 10.1038/ncomms11878
Chemical Sciences  Inorganic chemistry  Materials science  Physical chemistry 

Dual mechanisms regulate ecosystem stability under decade-long warming and hay harvest OPEN
Zheng Shi, Xia Xu, Lara Souza, Kevin Wilcox, Lifen Jiang, Junyi Liang, Jianyang Xia, Pablo García-Palacios and Yiqi Luo
Species diversity is thought to play an important role in maintaining production stability. Shi et al. demonstrate that the dominant C4 plant also makes a substantial contribution to temporal stability in a grassland ecosystem subject to 15 years of experimental warming and hay harvest.
15 June 2016 | doi: 10.1038/ncomms11973
Biological Sciences  Ecology 
 
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  Latest Corrigenda  
 
Corrigendum: Turnover time of fluorescent dissolved organic matter in the dark global ocean
Teresa S. Catalá, Isabel Reche, Antonio Fuentes-Lema, Cristina Romera-Castillo, Mar Nieto-Cid, Eva Ortega-Retuerta, Eva Calvo, Marta Álvarez, Cèlia Marrasé, Colin A. Stedmon and X. Antón Álvarez-Salgado
15 June 2016 | doi: 10.1038/ncomms12005
Earth Sciences  Biogeochemistry  Oceanography 

 
 
Corrigendum: Intensification of the meridional temperature gradient in the Great Barrier Reef following the Last Glacial Maximum OPEN
Thomas Felis, Helen V. McGregor, Braddock K. Linsley, Alexander W. Tudhope, Michael K. Gagan, Atsushi Suzuki, Mayuri Inoue, Alexander L. Thomas, Tezer M. Esat, William G. Thompson, Manish Tiwari, Donald C. Potts, Manfred Mudelsee, Yusuke Yokoyama and Jody M. Webster
15 June 2016 | doi: 10.1038/ncomms12006
Earth Sciences  Climate science  Oceanography 

 
 
Corrigendum: The seasonal sea-ice zone in the glacial Southern Ocean as a carbon sink OPEN
Andrea Abelmann, Rainer Gersonde, Gregor Knorr, Xu Zhang, Bernhard Chapligin, Edith Maier, Oliver Esper, Hans Friedrichsen, Gerrit Lohmann, Hanno Meyer and Ralf Tiedemann
15 June 2016 | doi: 10.1038/ncomms12004
Earth Sciences  Biogeochemistry  Climate science  Oceanography 

 
 
Corrigendum: Both respiration and photosynthesis determine the scaling of plankton metabolism in the oligotrophic ocean OPEN
Pablo Serret, Carol Robinson, María Aranguren-Gassis, Enma Elena García-Martín, Niki Gist, Vassilis Kitidis, José Lozano, John Stephens, Carolyn Harris and Rob Thomas
15 June 2016 | doi: 10.1038/ncomms12007
Biological Sciences  Biogeochemistry  Ecology  Oceanography 
 
 
 
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