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Visit our open access funding page or contact openaccess@nature.com to learn more about APC funding. | | | | Latest Correspondence | | | | | | | | | Latest Articles | View all Articles | | | Aviation effects on already-existing cirrus clouds OPEN | | Matthias Tesche, Peggy Achtert, Paul Glantz and Kevin J. Noone | | The extent to which air traffic affects the optical thickness of existing cirrus clouds in the upper atmosphere remains unknown. Here, the authors compare cirrus cloud properties inside and outside of real flight tracks and show that optical thickness is significantly increased within the flight path. | | 21 June 2016 | doi: 10.1038/ncomms12016 | | Earth Sciences Atmospheric science Climate science | Early role of vascular dysregulation on late-onset Alzheimer’s disease based on multifactorial data-driven analysis OPEN | | Y. Iturria-Medina, R. C. Sotero, P. J. Toussaint, J. M. Mateos-Pérez, A. C. Evans, null null, Michael W. Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John Morris, Leslie M. Shaw, Zaven Khachaturian, Greg Sorensen et al. | | Late-onset Alzheimer's disease (LOAD) is a complex multi-factorial disorder. Here, the authors perform a data-driven analysis of LOAD progression, including multimodal brain imaging, plasma and CSF biomarkers, and find vascular dysfunction is among the earliest and strongest altered events. | | 21 June 2016 | doi: 10.1038/ncomms11934 | | Biological Sciences Medical research Neuroscience | Counteracting H3K4 methylation modulators Set1 and Jhd2 co-regulate chromatin dynamics and gene transcription OPEN | | Saravanan Ramakrishnan, Srijana Pokhrel, Sowmiya Palani, Christian Pflueger, Timothy J. Parnell, Bradley R. Cairns, Srividya Bhaskara and Mahesh B. Chandrasekharan | | Histone H3K4 methylation affects gene transcription from yeast to humans. Here, the authors show that Set1 and Jhd2, the only H3K4 methyltransferase and H3K4 demethylase, respectively, in budding yeast, co-regulate both positive and negative transcription mediated by nucleosomal turnover and occupancy. | | 21 June 2016 | doi: 10.1038/ncomms11949 | | Biological Sciences Cell biology Molecular biology | Discovery of earth-abundant nitride semiconductors by computational screening and high-pressure synthesis OPEN | | Yoyo Hinuma, Taisuke Hatakeyama, Yu Kumagai, Lee A. Burton, Hikaru Sato, Yoshinori Muraba, Soshi Iimura, Hidenori Hiramatsu, Isao Tanaka, Hideo Hosono and Fumiyasu Oba | | Nitride semiconductors are attractive for various applications. Here a computational screening study identifies a number of possible ternary nitrides as promising candidates, including a phase that the authors synthesize for the first time via a high-pressure route. | | 21 June 2016 | doi: 10.1038/ncomms11962 | | Physical Sciences Condensed matter Materials science | Unassisted photoelectrochemical water splitting exceeding 7% solar-to-hydrogen conversion efficiency using photon recycling OPEN | | Xinjian Shi, Hokyeong Jeong, Seung Jae Oh, Ming Ma, Kan Zhang, Jeong Kwon, In Taek Choi, Il Yong Choi, Hwan Kyu Kim, Jong Kyu Kim and Jong Hyeok Park | | Unassisted water splitting by tandem photoelectrochemical and photovoltaic devices requires optimization of the absorbance and transmittance properties of the front photoelectrode. Here, Shi et al. use a conductive distributed Brag reflector to harvest photons of different wavelengths in the two subcells. | | 21 June 2016 | doi: 10.1038/ncomms11943 | | Physical Sciences Catalysis Materials science Physical chemistry | Activation of STING requires palmitoylation at the Golgi OPEN | | Kojiro Mukai, Hiroyasu Konno, Tatsuya Akiba, Takefumi Uemura, Satoshi Waguri, Toshihide Kobayashi, Glen N. Barber, Hiroyuki Arai and Tomohiko Taguchi | | STING is essential for the type I interferon immune response to foreign DNA. Here, the authors show that palmitoylation of STING at the Golgi is required for activating downstream signalling, and increased Golgi localization of certain STING variants may cause autoimmune disease in some cases. | | 21 June 2016 | doi: 10.1038/ncomms11932 | | Biological Sciences Cell biology Immunology Molecular biology | Mnemonic convergence in the human hippocampus OPEN | | Alexander R. Backus, Sander E. Bosch, Matthias Ekman, Alejandro Vicente Grabovetsky and Christian F. Doeller | | The ability to form associations between events is the hallmark of episodic memory and is thought to involve the hippocampus. Here the authors use a combination of multivariate pattern and graph theoretical network analyses of functional imaging data in humans, and show conjunctive coding and hub-like network attributes in the hippocampus. | | 21 June 2016 | doi: 10.1038/ncomms11991 | | Biological Sciences Neuroscience | Faecal bile acids are natural ligands of the mouse accessory olfactory system OPEN | | Wayne I. Doyle, Jordan A. Dinser, Hillary L. Cansler, Xingjian Zhang, Daniel D. Dinh, Natasha S. Browder, Ian M. Riddington and Julian P. Meeks | | The accessory olfactory system (AOS) processes social chemosensory information and guides behaviors that are important for survival and reproduction in mammals. Here the authors report that mouse feces are a source of AOS neuronal activity and identify unconjugated bile acids in feces as a class of natural AOS ligands. | | 21 June 2016 | doi: 10.1038/ncomms11936 | | Biological Sciences Neuroscience | Tumour-initiating cell-specific miR-1246 and miR-1290 expression converge to promote non-small cell lung cancer progression OPEN | | Wen Cai Zhang, Tan Min Chin, Henry Yang, Min En Nga, Declan Patrick Lunny, Edwin Kok Hao Lim, Li Li Sun, Yin Huei Pang, Yi Ning Leow, Shanneen Rossellini Y Malusay, Priscilla Xin Hui Lim, Jeravan Zili Lee, Benedict Jian Wei Tan, Ng Shyh-Chang, Elaine Hsuen Lim, Wan Teck Lim, Daniel Shao Weng Tan, Eng Huat Tan, Bee Choo Tai, Ross Andrew Soo et al. | | miRNAs can function either as proto-oncogenes or tumour suppressors in several cancers; however their function in tumour initiating cells is unclear. Here, Zhang et al. show that tumour initiating cell-specific miR-1246 and miR-1290 promote lung cancer initiation and metastasis and could serve as prognostic markers. | | 21 June 2016 | doi: 10.1038/ncomms11702 | | Biological Sciences Cancer Molecular biology | The necroptosis-inducing kinase RIPK3 dampens adipose tissue inflammation and glucose intolerance OPEN | | Jérémie Gautheron, Mihael Vucur, Anne T. Schneider, Ilenia Severi, Christoph Roderburg, Sanchari Roy, Matthias Bartneck, Peter Schrammen, Mauricio Berriel Diaz, Josef Ehling, Felix Gremse, Felix Heymann, Christiane Koppe, Twan Lammers, Fabian Kiessling, Niels Van Best, Oliver Pabst, Gilles Courtois, Andreas Linkermann, Stefan Krautwald et al. | | The kinase RIPK3 initiates necroptosis, which has been reported to promote inflammation in various pathological conditions. Here, the authors show that genetic ablation of Ripk3 results in adipocyte apoptosis and white adipose tissue inflammation in obese mice, which promotes glucose intolerance. | | 21 June 2016 | doi: 10.1038/ncomms11869 | | Biological Sciences Medical research | Treg engage lymphotoxin beta receptor for afferent lymphatic transendothelial migration OPEN | | C. Colin Brinkman, Daiki Iwami, Molly K. Hritzo, Yanbao Xiong, Sarwat Ahmad, Thomas Simon, Keli L. Hippen, Bruce R. Blazar and Jonathan S. Bromberg | | Lymphotoxin regulates lymphoid organ architecture and adhesion molecules involved in lymphocyte trafficking. Here the authors show that lymphotoxin produced by regulatory T cells promotes their migration to the draining lymph nodes by engaging its cognate receptor on lymphatic endothelial cells. | | 21 June 2016 | doi: 10.1038/ncomms12021 | | Biological Sciences Immunology | Microfluidic single-cell transcriptional analysis rationally identifies novel surface marker profiles to enhance cell-based therapies OPEN | | Robert C. Rennert, Michael Januszyk, Michael Sorkin, Melanie Rodrigues, Zeshaan N. Maan, Dominik Duscher, Alexander J. Whittam, Revanth Kosaraju, Michael T. Chung, Kevin Paik, Alexander Y. Li, Michael Findlay, Jason P. Glotzbach, Atul J. Butte and Geoffrey C. Gurtner | | Unrecognized progenitor cell perturbations underlying a disease state may limit the efficacy of cell therapies. Here, the authors use high-throughput, single-cell transcriptional analysis to identify disease-specific cellular alterations and prospectively isolate restorative cell subpopulations. | | 21 June 2016 | doi: 10.1038/ncomms11945 | | Biological Sciences Cell biology Molecular biology | On-chip coherent conversion of photonic quantum entanglement between different degrees of freedom OPEN | | Lan-Tian Feng, Ming Zhang, Zhi-Yuan Zhou, Ming Li, Xiao Xiong, Le Yu, Bao-Sen Shi, Guo-Ping Guo, Dao-Xin Dai, Xi-Feng Ren and Guang-Can Guo | | Harnessing multiple degrees of freedom of quantum states on chip could improve quantum information processing. Here, the authors demonstrate coherent conversion of quantum states between path, polarization and transverse waveguide-mode degrees of freedom in a quantum photonic integrated circuit. | | 20 June 2016 | doi: 10.1038/ncomms11985 | | Physical Sciences Optical physics | The power of a critical heat engine OPEN | | Michele Campisi and Rosario Fazio | | The second law of thermodynamics says that the efficiency of a heat engine is limited by the Carnot efficiency. Here, the authors use finite-size-scaling theory to investigate whether this ultimate limit can be achieved at finite power using quantum Otto engines. | | 20 June 2016 | doi: 10.1038/ncomms11895 | | Physical Sciences Theoretical physics | Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer OPEN | | Yujun Hao, Yardena Samuels, Qingling Li, Dawid Krokowski, Bo-Jhih Guan, Chao Wang, Zhicheng Jin, Bohan Dong, Bo Cao, Xiujing Feng, Min Xiang, Claire Xu, Stephen Fink, Neal J. Meropol, Yan Xu, Ronald A. Conlon, Sanford Markowitz, Kenneth W. Kinzler, Victor E. Velculescu, Henri Brunengraber et al. | | Cancer cells rely on glutamine to replenish the TCA cycle. Here, the authors show that oncogenic PIK3CA mutations drive this metabolic rewiring in colorectal cancer cells by up-regulating glutamate pyruvate transaminase expression, thus increasing sensitivity to glutamine starvation. | | 20 June 2016 | doi: 10.1038/ncomms11971 | | Biological Sciences Biochemistry Cancer Cell biology | Crystallization of spin superlattices with pressure and field in the layered magnet SrCu2(BO3)2 OPEN | | S. Haravifard, D. Graf, A. E. Feiguin, C. D. Batista, J. C. Lang, D. M. Silevitch, G. Srajer, B. D. Gaulin, H. A. Dabkowska and T. F. Rosenbaum | | Spin 1/2 dimer systems in an external magnetic field behave as a lattice gas of hard-core bosons, and can undergo condensation. Here the authors show in SrCu2(BO3)2 that new fractionally crystallized states are not only possible, but also tuneable with hydrostatic pressure. | | 20 June 2016 | doi: 10.1038/ncomms11956 | | Physical Sciences Condensed matter | Specific frontal neural dynamics contribute to decisions to check OPEN | | Frederic M. Stoll, Vincent Fontanier and Emmanuel Procyk | | Information seeking is thought to rely on the brain's frontal cortex but which regions specifically control this drive remains unknown. Here the authors show that monkeys deciding to seek information on the current state of the environment showed specific neural dynamics in the lateral prefrontal cortex and midcingulate cortex. | | 20 June 2016 | doi: 10.1038/ncomms11990 | | Biological Sciences Neuroscience | Development of background-free tame fluorescent probes for intracellular live cell imaging OPEN | | Samira Husen Alamudi, Rudrakanta Satapathy, Jihyo Kim, Dongdong Su, Haiyan Ren, Rajkumar Das, Lingna Hu, Enrique Alvarado-Martínez, Jung Yeol Lee, Christian Hoppmann, Eduardo Peña-Cabrera, Hyung-Ho Ha, Hee-Sung Park, Lei Wang and Young-Tae Chang | | The success of a fluorescent dye as a molecular probe to monitor the intracellular activity of biomolecules depends on its physicochemical characteristics. Here, the authors use a predictive model to identify key features that allow them to design cell permeable, background-free fluorescent probes. | | 20 June 2016 | doi: 10.1038/ncomms11964 | | Chemical Sciences Bioinformatics Chemical biology Organic chemistry | One-dimensional Magnus-type platinum double salts OPEN | | Christopher H. Hendon, Aron Walsh, Norinobu Akiyama, Yosuke Konno, Takashi Kajiwara, Tasuku Ito, Hiroshi Kitagawa and Ken Sakai | | Mixed-valent one-dimensional platinum chains are interesting inorganic compounds with potential applications in molecular electronics. Here, the authors report a series of platinum dimer-based chains with controllable oxidation state and conductivity behaviour. | | 20 June 2016 | doi: 10.1038/ncomms11950 | | Chemical Sciences Inorganic chemistry | Nanoreporter PET predicts the efficacy of anti-cancer nanotherapy OPEN | | Carlos Pérez-Medina, Dalya Abdel-Atti, Jun Tang, Yiming Zhao, Zahi A. Fayad, Jason S. Lewis, Willem J. M. Mulder and Thomas Reiner | | Nanoparticle drug formulations are currently used as cancer treatment but the response in patients is highly variable. Here, the authors developed a Zirconium-89 nanoreporter able to predict using PET, therapeutic accumulation and efficacy of anti-cancer nanoparticle drug formulations when co-injected in a murine breast cancer model. | | 20 June 2016 | doi: 10.1038/ncomms11838 | | Biological Sciences Cell biology Medical research | Loss of the RNA-binding protein TACO1 causes late-onset mitochondrial dysfunction in mice OPEN | | Tara R. Richman, Henrik Spåhr, Judith A. Ermer, Stefan M. K. Davies, Helena M. Viola, Kristyn A. Bates, John Papadimitriou, Livia C. Hool, Jennifer Rodger, Nils-Göran Larsson, Oliver Rackham and Aleksandra Filipovska | | Mutations in the translational activator of cytochrome c oxidase subunit I (TACO1) causes cytochrome c oxidase deficiency and Leigh Syndrome in patients. Here, the authors characterize mice with a mutation that causes lack of TACO1 expression, identifying a mouse model that could be useful for preclinical trials. | | 20 June 2016 | doi: 10.1038/ncomms11884 | | Biological Sciences Biochemistry | Doping-enhanced radiative efficiency enables lasing in unpassivated GaAs nanowires OPEN | | Tim Burgess, Dhruv Saxena, Sudha Mokkapati, Zhe Li, Christopher R. Hall, Jeffrey A. Davis, Yuda Wang, Leigh M. Smith, Lan Fu, Philippe Caroff, Hark Hoe Tan and Chennupati Jagadish | | Until now, efforts to enhance the performance of nanolasers have focused on reducing the rate of non-radiative recombination. Here, Burgess et al. employ controlled impurity doping to increase the rate of radiative recombination. | | 17 June 2016 | doi: 10.1038/ncomms11927 | | Physical Sciences Materials science Nanotechnology Optical physics | Early synaptic deficits in the APP/PS1 mouse model of Alzheimer’s disease involve neuronal adenosine A2A receptors OPEN | | Silvia Viana da Silva, Matthias Georg Haberl, Pei Zhang, Philipp Bethge, Cristina Lemos, Nélio Gonçalves, Adam Gorlewicz, Meryl Malezieux, Francisco Q. Gonçalves, Noëlle Grosjean, Christophe Blanchet, Andreas Frick, U Valentin Nägerl, Rodrigo A. Cunha and Christophe Mulle | | Hippocampal synaptic dysfunctions are an early symptom of Alzheimer’s disease. Here, the authors find adenosine A2A receptors are up-regulated in APP/PS1 model mice and that deleting or blocking receptor activity helps alleviate plasticity and memory impairments. | | 17 June 2016 | doi: 10.1038/ncomms11915 | | Biological Sciences Neuroscience | Coherent manipulation of a solid-state artificial atom with few photons OPEN | | V. Giesz, N. Somaschi, G. Hornecker, T. Grange, B. Reznychenko, L. De Santis, J. Demory, C. Gomez, I. Sagnes, A. Lemaître, O. Krebs, N. D. Lanzillotti-Kimura, L. Lanco, A. Auffeves and P. Senellart | | Quantum information processing requires a system in which a single photon controls a single atom and vice versa. Here, the authors demonstrate such reciprocal operation and achieve coherent manipulation of a quantum dot by a few photons sent on an optical cavity. | | 17 June 2016 | doi: 10.1038/ncomms11986 | | Physical Sciences Optical physics | Floquet topological insulators for sound OPEN | | Romain Fleury, Alexander B Khanikaev and Andrea Alù | | One-way sound propagation has been recently proposed in the context of topological acoustics, but is challenged by introducing uniform media motion. Here, Fleury et al. present a practical scheme to achieve topological propagation by modulating in time the acoustic properties of a lattice of resonators, resembling Floquet topological insulators in condensed matter. | | 17 June 2016 | doi: 10.1038/ncomms11744 | | Physical Sciences Applied physics Condensed matter | Pairing in a dry Fermi sea OPEN | | T. A Maier, P. Staar, V. Mishra, U. Chatterjee, J. C. Campuzano and D. J. Scalapino | | Pairing interaction appears at room temperature in traditional superconductors with a Cooper instability in the Fermi sea. Here, Maier et al. report that in the pseudogap phase of cuprate, where this instability is absent, superconductivity arises from an increase in the strength of the spin fluctuation pairing interaction as the temperature decreases. | | 17 June 2016 | doi: 10.1038/ncomms11875 | | Physical Sciences Condensed matter Materials science | A threshold level of NFATc1 activity facilitates thymocyte differentiation and opposes notch-driven leukaemia development OPEN | | Stefan Klein-Hessling, Ronald Rudolf, Khalid Muhammad, Klaus-Peter Knobeloch, Muhammad Ahmad Maqbool, Pierre Cauchy, Jean-Christophe Andrau, Andris Avots, Claudio Talora, Volker Ellenrieder, Isabella Screpanti, Edgar Serfling and Amiya Kumar Patra | | NFATc1 orchestrates thymocyte development. Here the authors show that NFATc1 expression is regulated by distinct promoters during thymocyte differentiation, and by conditional deletion of individual promoters in mice they define their specific roles in the control of T-cell development by NFATc1. | | 17 June 2016 | doi: 10.1038/ncomms11841 | | Biological Sciences Cancer Immunology | High-field plasma acceleration in a high-ionization-potential gas OPEN | | S. Corde, E. Adli, J. M. Allen, W. An, C. I. Clarke, B. Clausse, C. E. Clayton, J. P. Delahaye, J. Frederico, S. Gessner, S. Z. Green, M. J. Hogan, C. Joshi, M. Litos, W. Lu, K. A. Marsh, W. B. Mori, N. Vafaei-Najafabadi, D. Walz and V. Yakimenko et al. | | Plasma accelerators driven by particle beams are a promising technology, but the acceleration distance and energy gain are strongly limited by head erosion in a high-ionization-potential gas. Here the authors observe up to 130% energy boost in a self-focused electron beam, with limited head erosion. | | 17 June 2016 | doi: 10.1038/ncomms11898 | | Physical Sciences Fluids and plasma physics Particle physics | Contrasting emergence of Lyme disease across ecosystems OPEN | | Atle Mysterud, William Ryan Easterday, Vetle Malmer Stigum, Anders Bjørnsgaard Aas, Erling L. Meisingset and Hildegunn Viljugrein | | Environmental change is thought to have driven the recent emergence of Lyme disease in Europe. Using a decade of human disease incidence data across a large area in Norway, Mysterud et al. show that incidence correlates with deer population, but that deer population plays a limited role in recent disease emergence. | | 16 June 2016 | doi: 10.1038/ncomms11882 | | Biological Sciences Ecology | Sugary interfaces mitigate contact damage where stiff meets soft OPEN | | Hee Young Yoo, Mihaela Iordachescu, Jun Huang, Elise Hennebert, Sangsik Kim, Sangchul Rho, Mathias Foo, Patrick Flammang, Hongbo Zeng, Daehee Hwang, J. Herbert Waite and Dong Soo Hwang | | Robust attachment between living tissues and inert materials is challenging to achieve. Here, Hwang and co-workers look at the molecular level between tissue and embedded byssal threads of Atrina pectinata and how this affects tenacity, toughness, and robustness. | | 16 June 2016 | doi: 10.1038/ncomms11923 | | Chemical Sciences Chemical biology Materials science | Nickel–vanadium monolayer double hydroxide for efficient electrochemical water oxidation OPEN | | Ke Fan, Hong Chen, Yongfei Ji, Hui Huang, Per Martin Claesson, Quentin Daniel, Bertrand Philippe, Håkan Rensmo, Fusheng Li, Yi Luo and Licheng Sun | | Water oxidation is a key component of water splitting, but more effective catalysts for the process are still required. Here the authors synthesize a monolayer nickel-vanadium layered double hydroxide material showing high activity for water oxidation owing to enhanced conductivity and abundant active sites. | | 16 June 2016 | doi: 10.1038/ncomms11981 | | Chemical Sciences Catalysis Materials science Physical chemistry | Hypothalamic CRH neurons orchestrate complex behaviours after stress OPEN | | Tamás Füzesi, Nuria Daviu, Jaclyn I. Wamsteeker Cusulin, Robert P. Bonin and Jaideep S. Bains | | Animals exhibit a number of complex behaviours following stressful events, although the underlying circuitry is undetermined. Here, the authors use optogenetic targeting to identify a role for corticotrophin releasing hormone cells in the paraventricular nucleus in regulating such behavioural responses to acute stress. | | 16 June 2016 | doi: 10.1038/ncomms11937 | | Biological Sciences Neuroscience | Molecular basis for CPAP-tubulin interaction in controlling centriolar and ciliary length OPEN | | Xiangdong Zheng, Anand Ramani, Komal Soni, Marco Gottardo, Shuangping Zheng, Li Ming Gooi, Wenjing Li, Shan Feng, Aruljothi Mariappan, Arpit Wason, Per Widlund, Andrei Pozniakovsky, Ina Poser, Haiteng Deng, Guangshuo Ou, Maria Riparbelli, Callaini Giuliano, Anthony A. Hyman, Michael Sattler, Jay Gopalakrishnan et al. | | Centrioles and cilia are microtubule-based structures of defined architecture, but what regulates this architecture is not clear. Here the authors discover that centrosomal-P4.1-associated-protein (CPAP) binds the α/β-tubulin dimer and licenses it for tubulin delivery contributing to centriolar/ciliary length and architecture control. | | 16 June 2016 | doi: 10.1038/ncomms11874 | | Biological Sciences Cell biology | Direct evidence of the molecular basis for biological silicon transport OPEN | | Michael J. Knight, Laura Senior, Bethany Nancolas, Sarah Ratcliffe and Paul Curnow | | Diatoms sheath themselves in a self-made casing of silica, which requires the function of silicic acid transporters. Here, the authors identify versions of these transporters that are experimentally tractable, and develop a fluorescence method to study silicic acid transport in vitro. | | 16 June 2016 | doi: 10.1038/ncomms11926 | | Biological Sciences Biochemistry | Three-dimensional spatiotemporal focusing of holographic patterns OPEN | | Oscar Hernandez, Eirini Papagiakoumou, Dimitrii Tanese, Kevin Fidelin, Claire Wyart and Valentina Emiliani | | Three-dimensional computer-generated holography cannot be implemented with temporal focusing. Here, Hernandez et al. use two spatial light modulators to control transverse- and axial-target light distribution, generating spatiotemporally focused patterns with uniform light distribution throughout the entire volume. | | 16 June 2016 | doi: 10.1038/ncomms11928 | | Physical Sciences Optical physics | Pliocene-Quaternary crustal melting in central and northern Tibet and insights into crustal flow OPEN | | Qiang Wang, Chris J. Hawkesworth, Derek Wyman, Sun-Lin Chung, Fu-Yuan Wu, Xian-Hua Li, Zheng-Xiang Li, Guo-Ning Gou, Xiu-Zheng Zhang, Gong-Jian Tang, Wei Dan, Lin Ma and Yan-Hui Dong | | The role of the low velocity-high conductivity zones (LV–HCZs) in developing the Tibetan Plateau has remained controversial. Here, Wang et al. present new geochemical and petrological data that show the LV–HCZs are sources of partial melt thus giving insight into the development of the Tibetan Plateau. | | 16 June 2016 | doi: 10.1038/ncomms11888 | | Earth Sciences Geology and geophysics | Diversity, structure and convergent evolution of the global sponge microbiome OPEN | | Torsten Thomas, Lucas Moitinho-Silva, Miguel Lurgi, Johannes R. Björk, Cole Easson, Carmen Astudillo-García, Julie B. Olson, Patrick M. Erwin, Susanna López-Legentil, Heidi Luter, Andia Chaves-Fonnegra, Rodrigo Costa, Peter J. Schupp, Laura Steindler, Dirk Erpenbeck, Jack Gilbert, Rob Knight, Gail Ackermann, Jose Victor Lopez, Michael W. Taylor et al. | | Sponges are early-diverging marine organisms that establish complex symbioses with microorganisms. Here, Thomas et al. analyse the microbial communities associated with 81 species of sponges from around the world, shedding light on the ecological and evolutionary drivers of these host-microbe associations. | | 16 June 2016 | doi: 10.1038/ncomms11870 | | Biological Sciences Ecology Evolution Microbiology | Observing the release of twist by magnetic reconnection in a solar filament eruption OPEN | | Zhike Xue, Xiaoli Yan, Xin Cheng, Liheng Yang, Yingna Su, Bernhard Kliem, Jun Zhang, Zhong Liu, Yi Bi, Yongyuan Xiang, Kai Yang and Li Zhao | | Magnetic reconnection is a fundamental process giving rise to topology change and energy release in plasmas, of particular relevance for the Sun. Here the authors report the observation of fast reconnection in a solar filament eruption, which occurs between a set of ambient fibrils and the filament itself. | | 16 June 2016 | doi: 10.1038/ncomms11837 | | Physical Sciences Astronomy Fluids and plasma physics | Spin and wavelength multiplexed nonlinear metasurface holography OPEN | | Weimin Ye, Franziska Zeuner, Xin Li, Bernhard Reineke, Shan He, Cheng-Wei Qiu, Juan Liu, Yongtian Wang, Shuang Zhang and Thomas Zentgraf | | Metasurfaces offer an approach for computer generated holograms with good efficiency and ease of fabrication. Here, Ye et al. report on spin and wavelength multiplexed nonlinear metasurface holography, showing construction of holographic images using fundamental and harmonic generation waves of different spins. | | 16 June 2016 | doi: 10.1038/ncomms11930 | | Physical Sciences Materials science Optical physics | A Myc-driven self-reinforcing regulatory network maintains mouse embryonic stem cell identity OPEN | | Luca Fagnocchi, Alessandro Cherubini, Hiroshi Hatsuda, Alessandra Fasciani, Stefania Mazzoleni, Vittoria Poli, Valeria Berno, Riccardo L. Rossi, Rolland Reinbold, Max Endele, Timm Schroeder, Marina Rocchigiani, Żaneta Szkarłat, Salvatore Oliviero, Stephen Dalton and Alessio Zippo | | The Myc transcription factor is a major regulator of stem cell (SC) self-renewal and pluripotency but how this integrates signals from other pathways is unclear. Here, the authors show that Myc activation triggers epigenetic memory in self renewing embryonic SCs via PRC2-mediated potentiation of the Wnt pathway. | | 15 June 2016 | doi: 10.1038/ncomms11903 | | Biological Sciences Cell biology Developmental biology | Room temperature molecular up conversion in solution OPEN | | Aline Nonat, Chi Fai Chan, Tao Liu, Carlos Platas-Iglesias, Zhenyu Liu, Wing-Tak Wong, Wai-Kwok Wong, Ka-Leung Wong and Loïc J. Charbonnière | | Up conversion is an Anti-Stokes luminescent process by which photons of low energy are piled up to generate light at a higher energy. Here, the authors report a supramolecular assembly of fluoride-bridged erbium complexes which exhibit this behaviour in D2O solution at room temperature. | | 15 June 2016 | doi: 10.1038/ncomms11978 | | Chemical Sciences Inorganic chemistry Physical chemistry | A broad analysis of resistance development in the malaria parasite OPEN | | Victoria C. Corey, Amanda K. Lukens, Eva S. Istvan, Marcus C. S. Lee, Virginia Franco, Pamela Magistrado, Olivia Coburn-Flynn, Tomoyo Sakata-Kato, Olivia Fuchs, Nina F. Gnädig, Greg Goldgof, Maria Linares, Maria G. Gomez-Lorenzo, Cristina De Cózar, Maria Jose Lafuente-Monasterio, Sara Prats, Stephan Meister, Olga Tanaseichuk, Melanie Wree, Yingyao Zhou et al. | | It is unclear whether new antimalarial compounds may rapidly lose effectiveness in the field because of parasite resistance. Here, Corey et al. investigate the acquisition of drug resistance and the extent to which common resistance mechanisms decrease susceptibility to a diverse set of 50 antimalarial compounds. | | 15 June 2016 | doi: 10.1038/ncomms11901 | | Biological Sciences Chemical biology Microbiology | The innate immune protein calprotectin promotes Pseudomonas aeruginosa and Staphylococcus aureus interaction OPEN | | Catherine A. Wakeman, Jessica L. Moore, Michael J. Noto, Yaofang Zhang, Marc D. Singleton, Boone M. Prentice, Benjamin A. Gilston, Ryan S. Doster, Jennifer A. Gaddy, Walter J. Chazin, Richard M. Caprioli and Eric P. Skaar | | Co-infections with Pseudomonas aeruginosa and Staphylococcus aureus are common in cystic fibrosis patients. Here, the authors show that metal depletion induced by a host protein, calprotectin, promotes co-existence of both pathogens by inhibiting production of anti-staphylococcal molecules by P. aeruginosa. | | 15 June 2016 | doi: 10.1038/ncomms11951 | | Biological Sciences Immunology Microbiology | A multigene mutation classification of 468 colorectal cancers reveals a prognostic role for APC OPEN | | Michael J. Schell, Mingli Yang, Jamie K. Teer, Fang Yin Lo, Anup Madan, Domenico Coppola, Alvaro N. A. Monteiro, Michael V. Nebozhyn, Binglin Yue, Andrey Loboda, Gabriel A. Bien-Willner, Danielle M. Greenawalt and Timothy J. Yeatman | | APC is a well-known tumour suppressor that is frequently inactivated in colorectal cancer. Here, the authors sequence more than 1000 cancer genes in 468 colorectal cancers and show that mutation signatures can be used to classify the tumours and that multiple mutations in APC are associated with a poor prognosis. | | 15 June 2016 | doi: 10.1038/ncomms11743 | | Biological Sciences Cancer Genetics | Printable enzyme-embedded materials for methane to methanol conversion OPEN | | Craig D. Blanchette, Jennifer M. Knipe, Joshuah K. Stolaroff, Joshua R. DeOtte, James S. Oakdale, Amitesh Maiti, Jeremy M. Lenhardt, Sarah Sirajuddin, Amy C. Rosenzweig and Sarah E. Baker | | There is a need for small-scale reactors that convert methane emissions to more valuable products to reduce climate impacts. Here, the authors show that printing 3D structures of the pMMO enzyme enables continuous methane conversion under ambient conditions and reduces mass transfer limitations. | | 15 June 2016 | doi: 10.1038/ncomms11900 | | Chemical Sciences Bioengineering Biotechnology Catalysis | A CD36 ectodomain mediates insect pheromone detection via a putative tunnelling mechanism OPEN | | Carolina Gomez-Diaz, Benoîte Bargeton, Liliane Abuin, Natalia Bukar, Jaime H. Reina, Tudor Bartoi, Marion Graf, Huy Ong, Maximilian H. Ulbrich, Jean-Francois Masson and Richard Benton | | The CD36-related Sensory Neuron Membrane Protein 1 (SNMP1) facilitates pheromone detection by insect odorant receptors. Here Gomez-Diaz et al. show that the SNMP1 ectodomain is essential for function and propose that it forms a tunnel that transports pheromones from the extracellular fluid to their cognate receptors. | | 15 June 2016 | doi: 10.1038/ncomms11866 | | Biological Sciences Cell biology Neuroscience | Strain-relief by single dislocation loops in calcite crystals grown on self-assembled monolayers OPEN | | Johannes Ihli, Jesse N. Clark, Alexander S. Côté, Yi-Yeoun Kim, Anna S. Schenk, Alexander N. Kulak, Timothy P. Comyn, Oliver Chammas, Ross J. Harder, Dorothy M. Duffy, Ian K. Robinson and Fiona C. Meldrum | | Epitaxial crystal growth attracts significant interest. Here, the authors use Bragg Coherent Diffraction Imaging to demonstrate calcite crystal precipitation on self-assembled monolayers exhibiting single dislocation loops with different geometries to those generated in conventional epitaxial thin films. | | 15 June 2016 | doi: 10.1038/ncomms11878 | | Chemical Sciences Inorganic chemistry Materials science Physical chemistry | Dual mechanisms regulate ecosystem stability under decade-long warming and hay harvest OPEN | | Zheng Shi, Xia Xu, Lara Souza, Kevin Wilcox, Lifen Jiang, Junyi Liang, Jianyang Xia, Pablo García-Palacios and Yiqi Luo | | Species diversity is thought to play an important role in maintaining production stability. Shi et al. demonstrate that the dominant C4 plant also makes a substantial contribution to temporal stability in a grassland ecosystem subject to 15 years of experimental warming and hay harvest. | | 15 June 2016 | doi: 10.1038/ncomms11973 | | Biological Sciences Ecology | | | | | | | | | Latest Corrigenda | | | |
| | | Corrigendum: Intensification of the meridional temperature gradient in the Great Barrier Reef following the Last Glacial Maximum OPEN | | Thomas Felis, Helen V. McGregor, Braddock K. Linsley, Alexander W. Tudhope, Michael K. Gagan, Atsushi Suzuki, Mayuri Inoue, Alexander L. Thomas, Tezer M. Esat, William G. Thompson, Manish Tiwari, Donald C. Potts, Manfred Mudelsee, Yusuke Yokoyama and Jody M. Webster | | 15 June 2016 | doi: 10.1038/ncomms12006 | | Earth Sciences Climate science Oceanography |
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