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2016/09/20

Scientific Reports Table of Contents e-alert: 20 September 2016

  20 September 2016   
 
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Potential pitfalls of mass spectrometry to uncover mutations in childhood soft tissue sarcoma: A report from the Children’s Oncology Group

 
 

Lin Xu, Raphael A. Wilson, Theodore W. Laetsch et al.

 
 

Mass spectrometry-based methods have been widely applied – often as the sole method – to detect mutations in human cancer specimens. We applied this approach to 52 childhood soft …

 
 
 
 
 
 

Olive and grape seed extract prevents post-traumatic osteoarthritis damages and exhibits in vitro anti IL-1β activities before and after oral consumption

 
 

Elsa Mével, Christophe Merceron, Claire Vinatier et al.

 
 

Polyphenols exert a large range of beneficial effects in the prevention of age-related diseases. We sought to determine whether an extract of olive and grape seed standardized …

 
 
 
 
 
 

Synchrotron microbeam irradiation induces neutrophil infiltration, thrombocyte attachment and selective vascular damage in vivo

 
 

Daniel Brönnimann, Audrey Bouchet, Christoph Schneider et al.

 
 

Our goal was the visualizing the vascular damage and acute inflammatory response to micro- and minibeam irradiation in vivo. Microbeam (MRT) and minibeam radiation therapies …

 
 
 
 
 
 

β-Hairpin of Islet Amyloid Polypeptide Bound to an Aggregation Inhibitor

 
 

Ewa A. Mirecka, Sophie Feuerstein, Lothar Gremer et al.

 
 

In type 2 diabetes, the formation of islet amyloid consisting of islet amyloid polypeptide (IAPP) is associated with reduction in β-cell mass and contributes to the failure of …

 
 
 
 
 
 

Lactobacillus plantarum attenuates anxiety-related behavior and protects against stress-induced dysbiosis in adult zebrafish

 
 

Daniel J. Davis, Holly M. Doerr, Agata K. Grzelak et al.

 
 

The consumption of probiotics has become increasingly popular as a means to try to improve health and well-being. Not only are probiotics considered beneficial to digestive …

 
 
 
 
 
 

Full-length model of the human galectin-4 and insights into dynamics of inter-domain communication

 
 

Joane K. Rustiguel, Ricardo O. S. Soares, Steve P. Meisburger et al.

 
 

Galectins are proteins involved in diverse cellular contexts due to their capacity to decipher and respond to the information encoded by β-galactoside sugars. In particular, …

 
 
 
 
 
 

Thermal stress depletes energy reserves in Drosophila

 
 

Peter Klepsatel, Martina Gáliková, Yanjun Xu et al.

 
 

Understanding how environmental temperature affects metabolic and physiological functions is of crucial importance to assess the impacts of climate change on organisms. Here, we …

 
 
 
 
 
 

A Direct Comparison of Two Densely Sampled HIV Epidemics: The UK and Switzerland

 
 

Manon L. Ragonnet-Cronin, Mohaned Shilaih, Huldrych F. Günthard et al.

 
 

Phylogenetic clustering approaches can elucidate HIV transmission dynamics. Comparisons across countries are essential for evaluating public health policies. Here, we used a …

 
 
 
 
 
 

Complement component 3 deficiency prolongs MHC-II disparate skin allograft survival by increasing the CD4+ CD25+ regulatory T cells population

 
 

Quan-you Zheng, Shen-ju Liang, Gui-qing Li et al.

 
 

Recent reports suggest that complement system contributes to allograft rejection. However, its underlying mechanism is poorly understood. Herein, we investigate the role of …

 
 
 
 
 
 

SCOP/PHLPP1β in the basolateral amygdala regulates circadian expression of mouse anxiety-like behavior

 
 

Jun J. Nakano, Kimiko Shimizu, Shigeki Shimba et al.

 
 

While disruption of the circadian clock triggers a spectrum of affective abnormalities, how the clock regulates mammalian emotionality remains unclear. Here, we characterized the …

 
 
 
 
 
 

Nuclear localization of tricellulin promotes the oncogenic property of pancreatic cancer

 
 

Akira Takasawa, Masaki Murata, Kumi Takasawa et al.

 
 

Accumulating evidence has shown that dysregulation of tight junctions (TJs) is involved in tumor development and progression. In this study, we investigated the expression and …

 
 
 
 
 
 

Real-time and label-free monitoring of nanoparticle cellular uptake using capacitance-based assays

 
 

Rimi Lee, Dong hyun Jo, Sang J. Chung et al.

 
 

Nanoparticles have shown great potential as vehicles for the delivery of drugs, nucleic acids, and therapeutic proteins; an efficient, high-throughput screening method to analyze …

 
 
 
 
 
 

Size-Exclusion Chromatography-based isolation minimally alters Extracellular Vesicles’ characteristics compared to precipitating agents

 
 

Ana Gámez-Valero, Marta Monguió-Tortajada, Laura Carreras-Planella et al.

 
 

Extracellular vesicles (EVs) have become an attractive field among the scientific community. Yet, a major challenge is to define a consensus method for EVs isolation. Ul…

 
 
 
 
 
 

Turning the fate of reprogramming cells from retinal disorder to regeneration by Pax6 in newts

 
 

Martin Miguel Casco-Robles, Md Rafiqul Islam, Wataru Inami et al.

 
 

The newt, a urodele amphibian, has an outstanding ability– even as an adult –to regenerate a functional retina through reprogramming and proliferation of the retinal pigment …

 
 
 
 
 
 

A simple and cost-saving phenotypic drug susceptibility testing of HIV-1

 
 

Yunceng Weng, Ling Zhang, Jianfeng Huang et al.

 
 

It is essential to monitor the occurrence of drug-resistant strains and to provide guidance for clinically adapted antiviral treatment of HIV/AIDS. In this study, an individual …

 
 
 
 
 
 

Ultra-sensitive detection of brain-derived neurotrophic factor (BDNF) in the brain of freely moving mice using an interdigitated microelectrode (IME) biosensor

 
 

Yong Kyoung Yoo, Jaekwang Lee, Jinsik Kim et al.

 
 

Brain-derived neurotrophic factor (BDNF) plays a critical role in cognitive processes including learning and memory. However, it has been difficult to detect BDNF in the brains …

 
 
 
 
 
 

Macrophages facilitate the excystation and differentiation of Toxoplasma gondii sporozoites into tachyzoites following oocyst internalisation

 
 

Wesley Freppel, Pierre-Henri Puech, David J. P. Ferguson et al.

 
 

Toxoplasma gondii is a common parasite of humans and animals, which is transmitted via oocysts in cat faeces or tissue cysts in contaminated meat. The robust oocyst and sporocyst …

 
 
 
 
 
 

Suture pattern formation in ammonites and the unknown rear mantle structure

 
 

Shinya Inoue, Shigeru Kondo

 
 

Ammonite shells have complex patterns of suture lines that vary across species. The lines are formed at the intersection of the outer shell wall and the septa. The wavy septa can …

 
 
 
 
 
 

Improving methane production in cow dung and corn straw co-fermentation systems via enhanced degradation of cellulose by cabbage addition

 
 

Wenyang Wu, Yong Chen, Shah Faisal et al.

 
 

The effects of cabbage waste (CW) addition on methane production in cow dung and corn straw co-fermentation systems were investigated. Four experimental groups, each containing …

 
 
 
 
 
 

Automatic Bayesian single molecule identification for localization microscopy

 
 

Yunqing Tang, Johnny Hendriks, Thomas Gensch et al.

 
 

Single molecule localization microscopy (SMLM) is on its way to become a mainstream imaging technique in the life sciences. However, analysis of SMLM data is biased by user …

 
 
 
 
 
 

iRSpot-DACC: a computational predictor for recombination hot/cold spots identification based on dinucleotide-based auto-cross covariance

 
 

Bingquan Liu, Yumeng Liu, Xiaopeng Jin et al.

 
 

Meiotic recombination presents an uneven distribution across the genome. Genomic regions that exhibit at relatively high frequencies of recombination are called hotspots, whereas …

 
 
 
 
 
 

Reactive oxygen species do not contribute to ObgE*-mediated programmed cell death

 
 

Liselot Dewachter, Pauline Herpels, Natalie Verstraeten et al.

 
 

Programmed cell death (PCD) in bacteria is considered an important target for developing novel antimicrobials. Development of PCD-specific therapies requires a deeper …

 
 
 
 
 
 

Interoceptive Ability Predicts Survival on a London Trading Floor

 
 

Narayanan Kandasamy, Sarah N. Garfinkel, Lionel Page et al.

 
 

Interoception is the sensing of physiological signals originating inside the body, such as hunger, pain and heart rate. People with greater sensitivity to interoceptive signals, …

 
 
 
 
 
 

Dopaminergic neurons differentiating from LRRK2 G2019S induced pluripotent stem cells show early neuritic branching defects

 
 

Laurence Borgs, Elise Peyre, Philippe Alix et al.

 
 

Some mutations of the LRRK2 gene underlie autosomal dominant form of Parkinson’s disease (PD). The G2019S is a common mutation that accounts for about 2% of PD cases. To …

 
 
 
 
 
 

BMS-708163 and Nilotinib restore synaptic dysfunction in human embryonic stem cell-derived Alzheimer’s disease models

 
 

Hisae Nishioka, Norie Tooi, Takehisa Isobe et al.

 
 

Alzheimer’s disease (AD) is the most common form of dementia. Cellular AD models derived from human pluripotent stem cells are promising tools in AD research. We recently …

 
 
 
 
 
 

In Situ Anabolic Activity of Periodontal Pathogens Porphyromonas gingivalis and Filifactor alocis in Chronic Periodontitis

 
 

Ralee Spooner, Kris M. Weigel, Peter L. Harrison et al.

 
 

Porphyromonas gingivalis and Filifactor alocis are fastidious anaerobic bacteria strongly associated with chronic forms of periodontitis. Our understanding of the growth …

 
 
 
 
 
 

Mutation analysis of circulating plasma DNA to determine response to EGFR tyrosine kinase inhibitor therapy of lung adenocarcinoma patients

 
 

Anja Lisa Riediger, Steffen Dietz, Uwe Schirmer et al.

 
 

Long-lasting success in lung cancer therapy using tyrosine kinase inhibitors (TKIs) is rare since the tumors develop resistance due to the occurrence of molecularly altered …

 
 
 
 
 
 

The miR-33 gene is identified in a marine teleost: a potential role in regulation of LC-PUFA biosynthesis in Siganus canaliculatus

 
 

Qinghao Zhang, Cuihong You, Shuqi Wang et al.

 
 

As the first marine teleost demonstrated to have the ability to biosynthesize long-chain polyunsaturated fatty acids (LC-PUFA) from C18 PUFA precursors, rabbitfish Siganus …

 
 
 
 
 
 

Drought response transcriptomes are altered in poplar with reduced tonoplast sucrose transporter expression

 
 

Liang-Jiao Xue, Christopher J. Frost, Chung-Jui Tsai et al.

 
 

Transgenic Populus tremula x alba (717-1B4) plants with reduced expression of a tonoplast sucrose efflux transporter, PtaSUT4, exhibit reduced shoot growth compared to wild type …

 
 
 
 
 
 

Assimilation of virtual legs and perception of floor texture by complete paraplegic patients receiving artificial tactile feedback

 
 

Solaiman Shokur, Simone Gallo, Renan C. Moioli et al.

 
 

Spinal cord injuries disrupt bidirectional communication between the patient’s brain and body. Here, we demonstrate a new approach for reproducing lower limb somatosensory …

 
 
 
 
 
 

Quantitative and combinatory determination of in situ phosphorylation of tau and its FTDP-17 mutants

 
 

Taeko Kimura, Tomohisa Hosokawa, Masato Taoka et al.

 
 

Tau is hyperphosphorylated in the brains of patients with tauopathies, such as Alzheimer’s disease and frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17). …

 
 
 
 
 
 

N-Glycosylation of integrin α5 acts as a switch for EGFR-mediated complex formation of integrin α5β1 to α6β4

 
 

Qinglei Hang, Tomoya Isaji, Sicong Hou et al.

 
 

N-Glycosylation of integrin α5β1 is involved in multiple cell behaviors. We previously reported that the N-glycosylations of the calf domain on integrin α5 (S3–5,10–14) are …

 
 
 
 
 
 

Genome-directed analysis of prophage excision, host defence systems, and central fermentative metabolism in Clostridium pasteurianum

 
 

Michael E. Pyne, Xuejia Liu, Murray Moo-Young et al.

 
 

Clostridium pasteurianum is emerging as a prospective host for the production of biofuels and chemicals, and has recently been shown to directly consume electric current. Despite …

 
 
 
 
 
 

Inhibition promotes long-term potentiation at cerebellar excitatory synapses

 
 

F. Binda, K. Dorgans, S. Reibel et al.

 
 

The ability of the cerebellar cortex to learn from experience ensures the accuracy of movements and reflex adaptation, processes which require long-term plasticity at granule …

 
 
 
 
 
 

ATP from synaptic terminals and astrocytes regulates NMDA receptors and synaptic plasticity through PSD-95 multi-protein complex

 
 

U. Lalo, O. Palygin, A. Verkhratsky et al.

 
 

Recent studies highlighted the importance of astrocyte-secreted molecules, such as ATP, for the slow modulation of synaptic transmission in central neurones. Biophysical …

 
 
 
 
 
 

Uncovering the lipidic basis for the preparation of functional nicotinic acetylcholine receptor detergent complexes for structural studies

 
 

Orestes Quesada, Carol González -Freire, María Carla Ferrer et al.

 
 

This study compares the lipid composition, including individual phospholipid molecular species of solubilized nAChR detergent complexes (nAChR-DCs) with those of the bulk lipids …

 
 
 
 
 
 

DNA barcoding reveal patterns of species diversity among northwestern Pacific molluscs

 
 

Shao’e Sun, Qi Li, Lingfeng Kong et al.

 
 

This study represents the first comprehensive molecular assessment of northwestern Pacific molluscs. In total, 2801 DNA barcodes belonging to 569 species from China, Japan and …

 
 
 
 
 
 

Papain gel containing methylene blue for simultaneous caries removal and antimicrobial photoinactivation against Streptococcus mutans biofilms

 
 

Zenildo Santos Silva Jr., Ying-Ying Huang, Lucas Freitas de Freitas et al.

 
 

This study intended to evaluate the effects of a papain-gel with a red-light absorbing pigment (methylene blue – MB) to mediate photodynamic therapy (PDT) against Streptococcus …

 
 
 
 
 
 

Soil surface temperatures reveal moderation of the urban heat island effect by trees and shrubs

 
 

J. L. Edmondson, I. Stott, Z. G. Davies et al.

 
 

Urban areas are major contributors to air pollution and climate change, causing impacts on human health that are amplified by the microclimatological effects of buildings and …

 
 
 
 
 
 

Characterization of the mechanism of prolonged adaptation to osmotic stress of Jeotgalibacillus malaysiensis via genome and transcriptome sequencing analyses

 
 

Amira Suriaty Yaakop, Kok-Gan Chan, Robson Ee et al.

 
 

Jeotgalibacillus malaysiensis, a moderate halophilic bacterium isolated from a pelagic area, can endure higher concentrations of sodium chloride (NaCl) than other Jeotgalibacillus

 
 
 
 
 
 

Förster resonance energy transfer and protein-induced fluorescence enhancement as synergetic multi-scale molecular rulers

 
 

Evelyn Ploetz, Eitan Lerner, Florence Husada et al.

 
 

Advanced microscopy methods allow obtaining information on (dynamic) conformational changes in biomolecules via measuring a single molecular distance in the structure. It is, …

 
 
 
 
 
 

Flexible Neural Electrode Array Based-on Porous Graphene for Cortical Microstimulation and Sensing

 
 

Yichen Lu, Hongming Lyu, Andrew G. Richardson et al.

 
 

Neural sensing and stimulation have been the backbone of neuroscience research, brain-machine interfaces and clinical neuromodulation therapies for decades. To-date, most of the …

 
 
 
 
 
 

Structural Analysis of the Hg(II)-Regulatory Protein Tn501 MerR from Pseudomonas aeruginosa

 
 

Dan Wang, Shanqing Huang, Pingying Liu et al.

 
 

The metalloprotein MerR is a mercury(II)-dependent transcriptional repressor-activator that responds to mercury(II) with extraordinary sensitivity and selectivity. It’s widely …

 
 
 
 
 
 

Dissemination of IMP-4-encoding pIMP-HZ1-related plasmids among Klebsiella pneumoniae and Pseudomonas aeruginosa in a Chinese teaching hospital

 
 

Wei Feng, Dongsheng Zhou, Qian Wang et al.

 
 

A total of 26 blaIMP-4-carrying strains of Pseudomonas aeruginosa and Klebsiella pneumoniae were isolated from 2009 to 2013 in a Chinese teaching hospital, and these strains can …

 
 
 
 
 
 

Circulation of multiple serotypes of highly divergent enterovirus C in the Xinjiang Uighur Autonomous Region of China

 
 

Yong Zhang, Qiang Sun, Hui Cui et al.

 
 

Poliomyelitis associated with circulating vaccine-derived polioviruses (cVDPVs) is a serious public health issue in the post-eradication era, and the occurrence of recombinant …

 
 
 
 
 
 

Lack of adrenomedullin in mouse endothelial cells results in defective angiogenesis, enhanced vascular permeability, less metastasis, and more brain damage

 
 

Laura Ochoa-Callejero, Andrea Pozo-Rodrigálvarez, Ricardo Martínez-Murillo et al.

 
 

Adrenomedullin (AM) is a vasodilating peptide involved in the regulation of circulatory homeostasis and in the pathophysiology of certain cardiovascular diseases. AM plays …

 
 
 
 
 
 

Hybrid bright-field and hologram imaging of cell dynamics

 
 

Hyeokjun Byeon, Jaehyun Lee, Junsang Doh et al.

 
 

Volumetric observation is essential for understanding the details of complex biological phenomena. In this study, a bright-field microscope, which provides information on a …

 
 
 
 
 
 

Circulating tumor DNA detection in lung cancer patients before and after surgery

 
 

Nannan Guo, Feng Lou, Yongfu Ma et al.

 
 

Circulating tumor DNA (ctDNA) in peripheral blood is a “liquid biopsy” that contains representative tumor information including gene mutations. Additionally, repeated ctDNA …

 
 
 
 
 
 

Efficient delivery of DNA into bovine preimplantation embryos by multiwall carbon nanotubes

 
 

Michele Munk, Luiz O. Ladeira, Bruno C. Carvalho et al.

 
 

The pellucid zone (PZ) is a protective embryonic cells barrier against chemical, physical or biological substances. This put, usual transfection methods are not efficient for …

 
 
 
 
 
 

Global analysis of transcription in castration-resistant prostate cancer cells uncovers active enhancers and direct androgen receptor targets

 
 

Sari Toropainen, Einari A. Niskanen, Marjo Malinen et al.

 
 

Androgen receptor (AR) is a male sex steroid-activated transcription factor (TF) that plays a critical role in prostate cancers, including castration-resistant prostate cancers …

 
 
 
 
 
 

TSPO ligands stimulate ZnPPIX transport and ROS accumulation leading to the inhibition of P. falciparum growth in human blood

 
 

I. Marginedas-Freixa, C. Hattab, G. Bouyer et al.

 
 

After invading red blood cells (RBCs), Plasmodium falciparum (Pf) can export its own proteins to the host membrane and activate endogenous channels that are present in the …

 
 
 
 
 
 

Exploring the transcriptome of Staphylococcus aureus in its natural niche

 
 

Diego Chaves-Moreno, Melissa L. Wos-Oxley, Ruy Jáuregui et al.

 
 

Staphylococcus aureus is an important human pathogen and commensal, where the human nose is the predominant reservoir. To better understand its behavior in this environmental …

 
 
 
 
 
 

Single-Molecule Imaging Reveals the Activation Dynamics of Intracellular Protein Smad3 on Cell Membrane

 
 

Nan Li, Yong Yang, Kangmin He et al.

 
 

Smad3 is an intracellular protein that plays a key role in propagating transforming growth factor β (TGF-β) signals from cell membrane to nucleus. However whether the transient …

 
 
 
 
 
 

IL-6, IL-10 and TNFα do not improve early detection of post-endoscopic retrograde cholangiopancreatography acute pancreatitis: a prospective cohort study

 
 

Mar Concepción-Martín, Cristina Gómez-Oliva, Ana Juanes et al.

 
 

The most reliable indicators for post-ERCP acute pancreatitis are elevated amylase levels and abdominal pain 24 hours after ERCP. As ERCP is often performed on an outpatient …

 
 
 
 
 
 

Angiogenic microspheres promote neural regeneration and motor function recovery after spinal cord injury in rats

 
 

Shukui Yu, Shenglian Yao, Yujun Wen et al.

 
 

This study examined sustained co-delivery of vascular endothelial growth factor (VEGF), angiopoietin-1 and basic fibroblast growth factor (bFGF) encapsulated in angiogenic …

 
 
 
 
 
 

Functional Recovery of AQP2 Recessive Mutations Through Hetero-Oligomerization with Wild-Type Counterpart

 
 

Abdulah El Tarazi, Yoann Lussier, Sandra Da Cal et al.

 
 

Aquaporin-2 (AQP2) is a homotetrameric water channel responsible for the final water reuptake in the kidney. Mutations in the protein induce nephrogenic diabetes insipidus (NDI), …

 
 
 
 
 
 

Linked color imaging application for improving the endoscopic diagnosis accuracy: a pilot study

 
 

Xiaotian Sun, Tenghui Dong, Yiliang Bi et al.

 
 

Endoscopy has been widely used in diagnosing gastrointestinal mucosal lesions. However, there are still lack of objective endoscopic criteria. Linked color imaging (LCI) is newly …

 
 
 
 
 
 

Evaluation of Glutathione Peroxidase 4 role in Preeclampsia

 
 

Xinguo Peng, Yan Lin, Jinling Li et al.

 
 

Preeclampsia (PE) is a pregnancy-specific syndrome that may be lifethreatening to pregnancies and fetus. Glutathione Peroxidase 4 (GPx4) is a powerful antioxidant enzyme that can …

 
 
 
 
 
 

Transient receptor potential channel 1/4 reduces subarachnoid hemorrhage-induced early brain injury in rats via calcineurin-mediated NMDAR and NFAT dephosphorylation

 
 

Zhong Wang, Yibin Wang, Xiaodi Tian et al.

 
 

Transient receptor potential channel 1/4 (TRPC1/4) are considered to be related to subarachnoid hemorrhage (SAH)-induced cerebral vasospasm. In this study, a SAH rat model was …

 
 
 
 
 
 

Combining Exosomes Derived from Immature DCs with Donor Antigen-Specific Treg Cells Induces Tolerance in a Rat Liver Allograft Model

 
 

Ben Ma, Jing-Yue Yang, Wen-jie Song et al.

 
 

Allograft tolerance is the ultimate goal in the field of transplantation immunology. Immature dendritic cells (imDCs) play an important role in establishing tolerance but have …

 
 
 
 
 
 

Nox2 contributes to the arterial endothelial specification of mouse induced pluripotent stem cells by upregulating Notch signaling

 
 

Xueling Kang, Xiangxiang Wei, Xinhong Wang et al.

 
 

Reactive oxygen species (ROS) have a crucial role in stem-cell differentiation; however, the mechanisms by which ROS regulate the differentiation of stem cells into endothelial …

 
 
 
 
 
 

A combination hepatoma-targeted therapy based on nanotechnology: pHRE-Egr1-HSV-TK/131I-antiAFPMcAb-GCV/MFH

 
 

Mei Lin, Junxing Huang, Xingmao Jiang et al.

 
 

Combination targeted therapy is a promising cancer therapeutic strategy. Here, using PEI-Mn0.5Zn0.5Fe2O4 nanoparticles (PEI-MZF-NPs) as magnetic media for MFH (magnetic fluid …

 
 
 
 
 
 

Human CB1 Receptor Isoforms, present in Hepatocytes and β-cells, are Involved in Regulating Metabolism

 
 

Isabel González-Mariscal, Susan M. Krzysik-Walker, Máire E. Doyle et al.

 
 

Therapeutics aimed at blocking the cannabinoid 1 (CB1) receptor for treatment of obesity resulted in significant improvements in liver function, glucose uptake and pancreatic …

 
 
 
 
 
 

The N-terminal domain plays a crucial role in the structure of a full-length human mitochondrial Lon protease

 
 

Sami Kereïche, Lubomír Kováčik, Jan Bednár et al.

 
 

Lon is an essential, multitasking AAA+ protease regulating many cellular processes in species across all kingdoms of life. Altered expression levels of the human mitochondrial …

 
 
 
 
 
 

Orange protein has a role in phytoene synthase stabilization in sweetpotato

 
 

Seyeon Park, Ho Soo Kim, Young Jun Jung et al.

 
 

Carotenoids have essential roles in light-harvesting processes and protecting the photosynthetic machinery from photo-oxidative damage. Phytoene synthase (PSY) and Orange (Or) …

 
 
 
 
 
 

Identification of Doxorubicin as an Inhibitor of the IRE1α-XBP1 Axis of the Unfolded Protein Response

 
 

Dadi Jiang, Connor Lynch, Bruno C. Medeiros et al.

 
 

Activation of the IRE1α-XBP1 branch of the unfolded protein response (UPR) has been implicated in multiple types of human cancers, including multiple myeloma (MM). Through an in …

 
 
 
 
 
 

Modification of Susceptible and Toxic Herbs on Grassland Disease

 
 

Xiang Yao, Yubing Fan, Qing Chai et al.

 
 

Recent research shows that continuous overgrazing not only causes grassland biodiversity to decline, but also causes light fungal disease. Achnatherum inebrians is susceptible to …

 
 
 
 
 
 

Maternal Genetic Ancestry and Legacy of 10th Century AD Hungarians

 
 

Aranka Csősz, Anna Szécsényi-Nagy, Veronika Csákyová et al.

 
 

The ancient Hungarians originated from the Ural region in today’s central Russia and migrated across the Eastern European steppe, according to historical sources. The Hungarians …

 
 
 
 
 
 

The Tara Oceans voyage reveals global diversity and distribution patterns of marine planktonic ciliates

 
 

Anna Gimmler, Ralf Korn, Colomban de Vargas et al.

 
 

Illumina reads of the SSU-rDNA-V9 region obtained from the circumglobal Tara Oceans expedition allow the investigation of protistan plankton diversity patterns on a global scale. …

 
 
 
 
 
 

ZikaVR: An Integrated Zika Virus Resource for Genomics, Proteomics, Phylogenetic and Therapeutic Analysis

 
 

Amit Kumar Gupta, Karambir Kaur, Akanksha Rajput et al.

 
 

Current Zika virus (ZIKV) outbreaks that spread in several areas of Africa, Southeast Asia, and in pacific islands is declared as a global health emergency by World Health …

 
 
 
 
 
 

Micro-optical coherence tomography of the mammalian cochlea

 
 

Janani S. Iyer, Shelley A. Batts, Kengyeh K. Chu et al.

 
 

The mammalian cochlea has historically resisted attempts at high-resolution, non-invasive imaging due to its small size, complex three-dimensional structure, and embedded …

 
 
 
 
 
 

Enhanced mechanical performance of biocompatible hemicelluloses-based hydrogel via chain extension

 
 

Xian-Ming Qi, Ge-Gu Chen, Xiao-Dong Gong et al.

 
 

Hemicelluloses are widely used to prepare gel materials because of their renewability, biodegradability, and biocompatibility. Here, molecular chain extension of hemicelluloses …

 
 
 
 
 
 

USP16 Downregulation by Carboxyl-terminal Truncated HBx Promotes the Growth of Hepatocellular Carcinoma Cells

 
 

Yu Qian, Boshi Wang, Aihui Ma et al.

 
 

Hepatitis B virus (HBV) infection is a major factor that contributes to the development of hepatocellular carcinoma (HCC). HBV X protein (HBx) has been shown to accelerate HCC …

 
 
 
 
 
 

A highly efficient sorbitol dehydrogenase from Gluconobacter oxydans G624 and improvement of its stability through immobilization

 
 

Tae-Su Kim, Sanjay K. S. Patel, Chandrabose Selvaraj et al.

 
 

A sorbitol dehydrogenase (GoSLDH) from Gluconobacter oxydans G624 (G. oxydans G624) was expressed in Escherichia coli BL21(DE3)-CodonPlus RIL. The complete 1455-bp …

 
 
 
 
 
 

Discovery and Optimization of N-Substituted 2-(4-pyridinyl)thiazole carboxamides against Tumor Growth through Regulating Angiogenesis Signaling Pathways

 
 

Wenbo Zhou, Wenshu Tang, Zhenliang Sun et al.

 
 

Inhibition of angiogenesis is considered as one of the desirable pathways for the treatment of tumor growth and metastasis. Herein we demonstrated that a series of …

 
 
 
 
 
 

Horizontal gene transfer drives adaptive colonization of apple trees by the fungal pathogen Valsa mali

 
 

Zhiyuan Yin, Baitao Zhu, Hao Feng et al.

 
 

Horizontal gene transfer (HGT) often has strong benefits for fungi. In a study of samples from apple canker in Shaanxi Province, China, diverse microbes, along with the …

 
 
 
 
 
 

Improved Transgenic Mouse Model for Studying HLA Class I Antigen Presentation

 
 

Man Huang, Wei Zhang, Jie Guo et al.

 
 

HLA class I (HLA-I) transgenic mice have proven to be useful models for studying human MHC-related immune responses over the last two decades. However, differences in the …

 
 
 
 
 
 

Determination by near infrared microscopy of the nitrogen and carbon content of tomato (Solanum lycopersicum L.) leaf powder

 
 

Gauthier Lequeue, Xavier Draye, Vincent Baeten

 
 

Near infrared microscopy (NIRM) has been developed as a rapid technique to predict the chemical composition of foods, reduce analytical costs and time and ease sample …

 
 
 
 
 
 

Corrigendum: Environmental chemicals impact dog semen quality in vitro and may be associated with a temporal decline in sperm motility and increased cryptorchidism

 
 

Richard G. Lea, Andrew S. Byers, Rebecca N. Sumner et al.

 
 

 
 
 
 
 
 

Rare variants in BRCA2 and CHEK2 are associated with the risk of urinary tract cancers

 
 

Yuqiu Ge, Yunyan Wang, Wei Shao et al.

 
 

Previous studies have shown that two rare variants, rs11571833 in BRCA2 and rs17879961 in CHEK2 were associated with lung cancer. However, the associations between these two …

 
 
 
 
 
 

THBS2 is a Potential Prognostic Biomarker in Colorectal Cancer

 
 

Xue Wang, Lei Zhang, Hui Li et al.

 
 

Colorectal cancer is one of the most common leading causes of death worldwide. Prognostic at an early stage is a useful way that decrease and avoid mortality. Although remarkable …

 
 
 
 
 
 

Extracellular cGMP Modulates Learning Biphasically by Modulating Glycine Receptors, CaMKII and Glutamate-Nitric Oxide-cGMP Pathway

 
 

Andrea Cabrera-Pastor, Michele Malaguarnera, Lucas Taoro-Gonzalez et al.

 
 

It has been proposed that extracellular cGMP modulates the ability to learn a Y maze task, but the underlying mechanisms remained unknown. Here we show that extracellular cGMP, …

 
 
 
 
 
 

Towards Biocontained Cell Factories: An Evolutionarily Adapted Escherichia coli Strain Produces a New-to-nature Bioactive Lantibiotic Containing Thienopyrrole-Alanine

 
 

Anja Kuthning, Patrick Durkin, Stefan Oehm et al.

 
 

Genetic code engineering that enables reassignment of genetic codons to non-canonical amino acids (ncAAs) is a powerful strategy for enhancing ribosomally synthesized peptides …

 
 
 
 
 
 

Chromatin remodeling during the in vivo glial differentiation in early Drosophila embryos

 
 

Youqiong Ye, Liang Gu, Xiaolong Chen et al.

 
 

Chromatin remodeling plays a critical role in gene regulation and impacts many biological processes. However, little is known about the relationship between chromatin remodeling …

 
 
 
 
 
 

Phenotypic, histological and proteomic analyses reveal multiple differences associated with chloroplast development in yellow and variegated variants from Camellia sinensis

 
 

Chengying Ma, Junxi Cao, Jianke Li et al.

 
 

Leaf colour variation is observed in several plants. We obtained two types of branches with yellow and variegated leaves from Camellia sinensis. To reveal the mechanisms that …

 
 
 
 
 
 

Integrated stress response of vertebrates is regulated by four eIF2α kinases

 
 

Shusuke Taniuchi, Masato Miyake, Kazue Tsugawa et al.

 
 

The integrated stress response (ISR) is a cytoprotective pathway initiated upon phosphorylation of the eukaryotic translation initiation factor 2 (eIF2α) residue designated …

 
 
 
 
 
 

Characterisation of a flavonoid ligand of the fungal protein Alt a 1

 
 

María Garrido-Arandia, Javier Silva-Navas, Carmen Ramírez-Castillejo et al.

 
 

Spores of pathogenic fungi are virtually ubiquitous and cause human disease and severe losses in crops. The endophytic fungi Alternaria species produce host-selective …

 
 
 
 
 
 

An integrative and comparative study of pan-cancer transcriptomes reveals distinct cancer common and specific signatures

 
 

Zhen Cao, Shihua Zhang

 
 

To investigate the commonalities and specificities across tumor lineages, we perform a systematic pan-cancer transcriptomic study across 6744 specimens. We find six pan-cancer …

 
 
 
 
 
 

Investigation of rare and low-frequency variants using high-throughput sequencing with pooled DNA samples

 
 

Jingwen Wang, Tiina Skoog, Elisabet Einarsdottir et al.

 
 

High-throughput sequencing using pooled DNA samples can facilitate genome-wide studies on rare and low-frequency variants in a large population. Some major questions concerning …

 
 
 
 
 
 

Regulation of osteoblast development by Bcl-2-associated athanogene-1 (BAG-1)

 
 

Joanna Greenhough, Emmanouil S. Papadakis, Ramsey I. Cutress et al.

 
 

BCL-2-associated athanogene-1 (BAG-1) is expressed by osteoblast-lineage cells; early embryonic lethality in Bag-1 null mice, however, has limited the investigation of BAG-1 …

 
 
 
 
 
 

Protein Folding Activity of the Ribosome is involved in Yeast Prion Propagation

 
 

Marc Blondel, Flavie Soubigou, Justine Evrard et al.

 
 

6AP and GA are potent inhibitors of yeast and mammalian prions and also specific inhibitors of PFAR, the protein-folding activity borne by domain V of the large rRNA of the large …

 
 
 
 
 
 

Nonlethal predator effects on the turn-over of wild bird flocks

 
 

Bernhard Voelkl, Josh A. Firth, Ben C. Sheldon

 
 

Nonlethal predator effects arise when individuals of a prey species adjust their behaviour due to the presence of predators. Non-lethal predator effects have been shown to affect …

 
 
 
 
 
 

Comparison of research methods for functional characterization of insect olfactory receptors

 
 

Bing Wang, Yang Liu, Kang He et al.

 
 

Insect olfactory receptors (ORs) in the peripheral olfactory system play an important role detecting elements of information from the environment. At present, various approaches …

 
 
 
 
 
 

Corrigendum: Polymorphisms in the Mannose-Binding Lectin Gene are Associated with Defective Mannose-Binding Lectin Functional Activity in Crohn’s Disease Patients

 
 

Laura Choteau, Francis Vasseur, Frederic Lepretre et al.

 
 

 
 
 
 
 
 

Protein aggregation activates erratic stress response in dietary restricted yeast cells

 
 

Ankan Kumar Bhadra, Eshita Das, Ipsita Roy

 
 

Chronic stress and prolonged activation of defence pathways have deleterious consequences for the cell. Dietary restriction is believed to be beneficial as it induces the …

 
 
 
 
 
 

TGF-β1 autocrine signalling and enamel matrix components

 
 

Saeko Kobayashi-Kinoshita, Yasuo Yamakoshi, Kazuo Onuma et al.

 
 

Transforming growth factor-β1 (TGF-β1) is present in porcine enamel extracts and is critical for proper mineralization of tooth enamel. Here, we show that the mRNA of latent …

 
 
 
 
 
 

Redox-dependent Regulation of Gluconeogenesis by a Novel Mechanism Mediated by a Peroxidatic Cysteine of Peroxiredoxin

 
 

Hayato Irokawa, Tsuyoshi Tachibana, Toshihiko Watanabe et al.

 
 

Peroxiredoxin is an abundant peroxidase, but its non-peroxidase function is also important. In this study, we discovered that Tsa1, a major peroxiredoxin of budding yeast cells, …

 
 
 
 
 
 

Autophagy-related proteins are functionally active in human spermatozoa and may be involved in the regulation of cell survival and motility

 
 

I. M. Aparicio, J. Espino, I. Bejarano et al.

 
 

Macroautophagy (hereafter autophagy) is an evolutionarily highly conserved cellular process that participates in the maintenance of intracellular homeostasis through the …

 
 
 
 
 
 

Dynamics of genome change among Legionella species

 
 

Sandeep J. Joseph, Daniel Cox, Bernard Wolff et al.

 
 

Legionella species inhabit freshwater and soil ecosystems where they parasitize protozoa. L. pneumonphila (LP) serogroup-1 (Lp1) is the major cause of Legionnaires’ Disease (LD), …

 
 
 
 
 
 

Application of RNA-seq for mitogenome reconstruction, and reconsideration of long-branch artifacts in Hemiptera phylogeny

 
 

Nan Song, Shiheng An, Xinming Yin et al.

 
 

Hemiptera make up the largest nonholometabolan insect assemblage. Despite previous efforts to elucidate phylogeny within this group, relationships among the major sub-lineages …

 
 
 
 
 
 

Entinostat up-regulates the CAMP gene encoding LL-37 via activation of STAT3 and HIF-1α transcription factors

 
 

Erica Miraglia, Frank Nylén, Katarina Johansson et al.

 
 

Bacterial resistance against classical antibiotics is a growing problem and the development of new antibiotics is limited. Thus, novel alternatives to antibiotics are warranted. …

 
 
 
 
 
 

Slowly dispersing neotenic beetles can speciate on a penny coin and generate space-limited diversity in the tropical mountains

 
 

Timothy C. Bray, Ladislav Bocak

 
 

We demonstrate the controversial origin of a biological species within an area of a few kilometres in the absence of physical barriers. We employed nuclear rRNA/mitochondrial and …

 
 
 
 
 
 

Chiral Antioxidant-based Gold Nanoclusters Reprogram DNA Epigenetic Patterns

 
 

Yue Ma, Hualin Fu, Chunlei Zhang et al.

 
 

Epigenetic modifications sit ‘on top of’ the genome and influence DNA transcription, which can force a significant impact on cellular behavior and phenotype and, consequently …

 
 
 
 
 
 

Biochemical and structural characterization of the interface mediating interaction between the influenza A virus non-structural protein-1 and a monoclonal antibody

 
 

Jianping Wu, Chee-Keng Mok, Vincent Tak Kwong Chow et al.

 
 

We have previously shown that a non-structural protein 1 (NS1)-binding monoclonal antibody, termed as 2H6, can significantly reduce influenza A virus (IAV) replication when …

 
 
 
 
 
 

Molecular basis of a novel renal amyloidosis due to N184K gelsolin variant

 
 

Francesco Bonì, Mario Milani, Riccardo Porcari et al.

 
 

Mutations in gelsolin are responsible for a systemic amyloidosis first described in 1969. Until recently, the disease was associated with two substitutions of the same residue, …

 
 
 
 
 
 

Mitigation of soil N2O emission by inoculation with a mixed culture of indigenous Bradyrhizobium diazoefficiens

 
 

Hiroko Akiyama, Yuko Takada Hoshino, Manabu Itakura et al.

 
 

Agricultural soil is the largest source of nitrous oxide (N2O), a greenhouse gas. Soybean is an important leguminous crop worldwide. Soybean hosts symbiotic nitrogen-fixing soil …

 
 
 
 
 
 

External cavity-quantum cascade laser infrared spectroscopy for secondary structure analysis of proteins at low concentrations

 
 

Andreas Schwaighofer, Mirta R. Alcaráz, Can Araman et al.

 
 

Fourier transform infrared (FTIR) and circular dichroism (CD) spectroscopy are analytical techniques employed for the analysis of protein secondary structure. The use of CD …

 
 
 
 
 
 

Reprofiled anthelmintics abate hypervirulent stationary-phase Clostridium difficile

 
 

Major Gooyit, Kim D. Janda

 
 

Prolonged use of broad-spectrum antibiotics disrupts the indigenous gut microbiota, which consequently enables toxigenic Clostridium difficile species to proliferate and cause …

 
 
 
 
 
 

Long-term exposure to microgravity impairs vestibulo-cardiovascular reflex

 
 

Hironobu Morita, Chikara Abe, Kunihiko Tanaka

 
 

The vestibular system is known to have an important role in controlling blood pressure upon posture transition (vestibulo-cardiovascular reflex, VCR). However, under a different …

 
 
 
 
 
 

Meta-analysis of associations between DLG5 R30Q and P1371Q polymorphisms and susceptibility to inflammatory bowel disease

 
 

Yunhai Li, Ping Chen, Jiazheng Sun et al.

 
 

Growing evidence from recent studies has demonstrated an association between inflammatory bowel disease (IBD) susceptibility and two polymorphisms of DLG5 R30Q (rs1248696) and …

 
 
 
 
 
 

Structural modulation of the gut microbiota and the relationship with body weight: compared evaluation of liraglutide and saxagliptin treatment

 
 

Lin Wang, Peicheng Li, Zhaosheng Tang et al.

 
 

The mechanisms underlying the weight-loss effect of GLP-1 receptor agonists need further elucidation. The present study was performed to explore the effects of liraglutide and …

 
 
 
 
 
 

Topical Simvastatin as Host-Directed Therapy against Severity of Cutaneous Leishmaniasis in Mice

 
 

Suraj P. Parihar, Mary-Anne Hartley, Ramona Hurdayal et al.

 
 

We recently demonstrated that statins mediate protection against intracellular pathogens, Mycobacterium tuberculosis and Listeria monocytogenes in mice. Here, we investigated the …

 
 
 
 
 
 

Pulsed Electromagnetic Field Assisted in vitro Electroporation: A Pilot Study

 
 

Vitalij Novickij, Audrius Grainys, Eglė Lastauskienė et al.

 
 

Electroporation is a phenomenon occurring due to exposure of cells to Pulsed Electric Fields (PEF) which leads to increase of membrane permeability. Electroporation is used in …

 
 
 
 
 
 

A Novel Assay for Screening Inhibitors Targeting HIV Integrase LEDGF/p75 Interaction Based on Ni2+ Coated Magnetic Agarose Beads

 
 

Zhang Dawei, He Hongqiu, Liu Mengmeng et al.

 
 

HIV-1 integrase (IN) plays an essential role in viral replication and thus serves as an important target for chemotherapeutic intervention against HIV-1 infection. However, the …

 
 
 
 
 
 

Copper(II) ions affect the gating dynamics of the 20S proteasome: a molecular and in cell study

 
 

Anna Maria Santoro, Irene Monaco, Francesco Attanasio et al.

 
 

Due to their altered metabolism cancer cells are more sensitive to proteasome inhibition or changes of copper levels than normal cells. Thus, the development of copper complexes …

 
 
 
 
 
 

Chronic Kappa opioid receptor activation modulates NR2B: Implication in treatment resistant depression

 
 

Shalini Dogra, Ajeet Kumar, Deepmala Umrao et al.

 
 

Psychotomimetic and prodepressive effect by kappa opioid receptor (KOR) activation in rodents and human is widely known. Significantly, recent clinical investigations …

 
 
 
 
 
 

Ursolic acid-mediated apoptosis of K562 cells involves Stat5/Akt pathway inhibition through the induction of Gfi-1

 
 

Ze Lin, Jikai Jiang, Xiao-Shan Liu

 
 

Ursolic acid (UA) is a promising natural compound for cancer prevention and therapy. We previously reported that UA induced apoptosis in CML-derived K562 cells. Here we show that …

 
 
 
 
 
 

Fibroblast growth factor (FGF) signaling regulates transforming growth factor beta (TGFβ)-dependent smooth muscle cell phenotype modulation

 
 

Pei-Yu Chen, Lingfeng Qin, Guangxin Li et al.

 
 

Smooth muscle cells (SMCs) in normal blood vessels exist in a highly differentiate state characterized by expression of SMC-specific contractile proteins (“contractile …

 
 
 
 
 
 

Potential of in vivo real-time gastric gas profiling: a pilot evaluation of heat-stress and modulating dietary cinnamon effect in an animal model

 
 

Jian Zhen Ou, Jeremy J. Cottrell, Nam Ha et al.

 
 

Gastroenterologists are still unable to differentiate between some of the most ordinary disorders of the gut and consequently patients are misdiagnosed. We have developed a …

 
 
 
 
 
 

Silencing of Histone Deacetylase 9 Expression in Podocytes Attenuates Kidney Injury in Diabetic Nephropathy

 
 

Feng Liu, Ming Zong, Xiaofei Wen et al.

 
 

Podocyte dysfunction is important in the onset and development of diabetic nephropathy (DN). Histone deacetylases (HDACs) have been recently proved to play critical roles in the …

 
 
 
 
 
 

A diverse virome in kidney transplant patients contains multiple viral subtypes with distinct polymorphisms

 
 

Asha Rani, Ravi Ranjan, Halvor S. McGee et al.

 
 

Recent studies have established that the human urine contains a complex microbiome, including a virome about which little is known. Following immunosuppression in kidney …

 
 
 
 
 
 

Reversible Brain Abnormalities in People Without Signs of Mountain Sickness During High-Altitude Exposure

 
 

Cunxiu Fan, Yuhua Zhao, Qian Yu et al.

 
 

A large proportion of lowlanders ascending to high-altitude (HA) show no signs of mountain sickness. Whether their brains have indeed suffered from HA environment and the …

 
 
 
 
 
 

Eukaryotic pathways targeted by the type III secretion system effector protein, BipC, involved in the intracellular lifecycle of Burkholderia pseudomallei

 
 

Wen-Tyng Kang, Kumutha Malar Vellasamy, Jamuna Vadivelu

 
 

Burkholderia pseudomallei, the etiological agent for melioidosis, is known to secrete a type III secretion system (TTSS) protein into the host’s internal milieu. One of the TTSS …

 
 
 
 
 
 

Methylcrotonoyl-CoA carboxylase 1 potentiates RLR-induced NF-κB signaling by targeting MAVS complex

 
 

Zhongying Cao, Zhangchuan Xia, Yaqin Zhou et al.

 
 

RNA virus infections are detected by the RIG-I family of receptors, which signal through the adaptor molecule mitochondrial antiviral signaling (MAVS). MAVS then recruits the …

 
 
 
 
 
 

Determinants of effective lentivirus-driven microRNA expression in vivo

 
 

Takuya Mishima, Elena Sadovsky, Margaret E. Gegick et al.

 
 

Manipulation of microRNA (miRNA) levels, including overexpression of mature species, has become an important biological tool, even motivating miRNA-based therapeutics. To assess …

 
 
 
 
 
 

Alterations in flowering strategies and sexual allocation of Caragana stenophylla along a climatic aridity gradient

 
 

Lina Xie, Hongyu Guo, Chengcang Ma

 
 

Plant can alter reproductive strategies for adaptation to different environments. However, alterations in flowering strategies and sexual allocation for the same species growing …

 
 
 
 
 
 

Effects of Propofol General Anesthesia on Olfactory Relearning

 
 

Li-Jie Jia, Pei Tang, Nicole R. Brandon et al.

 
 

How general anesthesia interferes with sensory processing to cause amnesia remains unclear. Here, we show that activation of a learning-associated immediate early gene in rat …

 
 
 
 
 
 

Genome-wide analysis of long intergenic non-coding RNAs in chickpea and their potential role in flower development

 
 

Niraj Khemka, Vikash Kumar Singh, Rohini Garg et al.

 
 

Non-coding RNAs constitute a major portion of the transcriptome in most of eukaryotes. Long non-coding transcripts originating from the DNA segment present between the protein …

 
 
 
 
 
 

The famous cultivated mushroom Bailinggu is a separate species of the Pleurotus eryngii species complex

 
 

Mengran Zhao, Jinxia Zhang, Qiang Chen et al.

 
 

The mushroom of the genus Pleurotus in western China, called Bailinggu, is a precious edible fungus with high economic value. However, its taxonomical position is unclear. Some …

 
 
 
 
 
 

CenH3 evolution reflects meiotic symmetry as predicted by the centromere drive model

 
 

František Zedek, Petr Bureš

 
 

The centromere drive model explaining rapid evolution of eukaryotic centromeres predicts higher frequency of positive selection acting on centromeric histone H3 (CenH3) in clades …

 
 
 
 
 
 

Extension of the classical classification of β-turns

 
 

Alexandre G. de Brevern

 
 

The functional properties of a protein primarily depend on its three-dimensional (3D) structure. These properties have classically been assigned, visualized and analysed on the …

 
 
 
 
 
 

Comparative DNA Methylation Profiling Reveals an Immunoepigenetic Signature of HIV-related Cognitive Impairment

 
 

Michael J. Corley, Christian Dye, Michelle L. D’Antoni et al.

 
 

Monocytes/macrophages contribute to the neuropathogenesis of HIV-related cognitive impairment (CI); however, considerable gaps in our understanding of the precise mechanisms …

 
 
 
 
 
 

In-hive Pesticide Exposome: Assessing risks to migratory honey bees from in-hive pesticide contamination in the Eastern United States

 
 

Kirsten S. Traynor, Jeffery S. Pettis, David R. Tarpy et al.

 
 

This study measured part of the in-hive pesticide exposome by analyzing residues from live in-hive bees, stored pollen, and wax in migratory colonies over time and compared …

 
 
 
 
 
 

Divergent Effects of Nitrogen Addition on Soil Respiration in a Semiarid Grassland

 
 

Cheng Zhu, Yiping Ma, Honghui Wu et al.

 
 

Nitrogen (N) deposition has been steadily increasing for decades, with consequences for soil respiration. However, we have a limited understanding of how soil respiration …

 
 
 
 
 
 

STYK1 promotes epithelial-mesenchymal transition and tumor metastasis in human hepatocellular carcinoma through MEK/ERK and PI3K/AKT signaling

 
 

Zhaowen Wang, Lei Qu, Biao Deng et al.

 
 

Serine/threonine/tyrosine kinase 1 (STYK1) is known to be involved in tumor progression. However, its molecular role and mechanism in hepatocellular carcinoma (HCC) remains …

 
 
 
 
 
 

Difference in leaf water use efficiency/photosynthetic nitrogen use efficiency of Bt-cotton and its conventional peer

 
 

Ruqing Guo, Shucun Sun, Biao Liu

 
 

This study is to test the effects of Bt gene introduction on the foliar water/nitrogen use efficiency in cotton. We measured leaf stomatal conductance, photosynthetic rate, and …

 
 
 
 
 
 

Tectonic and climatic impacts on the biota within the Red River Fault, evidence from phylogeography of Cycas dolichophylla (Cycadaceae)

 
 

Ying Zheng, Jian Liu, Xun Gong

 
 

Dramatic crustal deformation and river incision in Southwest China induced by the Indo-Asian collision have long been argued to contribute to the complicated landscapes, …

 
 
 
 
 
 

Synchronous vitellogenin expression and sexual maturation during migration are negatively correlated with juvenile hormone levels in Mythimna separata

 
 

Hai-Jun Xiao, Xiao-Wei Fu, Yong-Qiang Liu et al.

 
 

Annual migration of pests between different seasonal habitats can lead to serious crop damage. Reproductive immaturity is generally associated with the migratory process …

 
 
 
 
 
 

Double-Network Hydrogel with Tunable Mechanical Performance and Biocompatibility for the Fabrication of Stem Cells-Encapsulated Fibers and 3D Assemble

 
 

Zhe Liang, Chenguang Liu, Lili Li et al.

 
 

Fabrication of cell-encapsulated fibers could greatly contribute to tissue engineering and regenerative medicine. However, existing methods suffered from not only unavoidability …

 
 
 
 
 
 

Crystal structures of the bifunctional tRNA methyltransferase Trm5a

 
 

Caiyan Wang, Qian Jia, Ran Chen et al.

 
 

tRNA methyltransferase Trm5 catalyses the transfer of a methyl group from S-adenosyl-L-methionine to G37 in eukaryotes and archaea. The N1-methylated guanosine is the product of …

 
 
 
 
 
 

Effects of captivity and artificial breeding on microbiota in feces of the red-crowned crane (Grus japonensis)

 
 

Yuwei Xie, Pu Xia, Hui Wang et al.

 
 

Reintroduction of the threatened red-crowned crane has been unsuccessful. Although gut microbiota correlates with host health, there is little information on gut microbiota of …

 
 
 
 
 
 

Patterns of cooperation during collective emergencies in the help-or-escape social dilemma

 
 

Mehdi Moussaïd, Mareike Trauernicht

 
 

Although cooperation is central to the organisation of many social systems, relatively little is known about cooperation in situations of collective emergency. When groups of …

 
 
 
 
 
 

Identification of a novel sesquiterpene biosynthetic machinery involved in astellolide biosynthesis

 
 

Yasutomo Shinohara, Shunji Takahashi, Hiroyuki Osada et al.

 
 

Esterified drimane-type sesquiterpene lactones such as astellolides display various biological activities and are widely produced by plants and fungi. Given their low homology to …

 
 
 
 
 
 

Drug-loadable Mesoporous Bioactive Glass Nanospheres: Biodistribution, Clearance, BRL Cellular Location and Systemic Risk Assessment via 45Ca Labelling and Histological Analysis

 
 

Baiyan Sui, Gaoren Zhong, Jiao Sun

 
 

Mesoporous bioactive glass (MBG) nanospheres with excellent drug loading property have attracted significant attention in the field of nano-medicine. However, systemic metabolism …

 
 
 
 
 
 

Long-term adaptation of the influenza A virus by escaping cytotoxic T-cell recognition

 
 

Rutger G. Woolthuis, Christiaan H. van Dorp, Can Keşmir et al.

 
 

The evolutionary adaptation of the influenza A virus (IAV) to human antibodies is well characterised. Much less is known about the long-term evolution of cytotoxic T lymphocyte …

 
 
 
 
 
 

Identification of differentially expressed genes in Monochamus alternatus digested with azadirachtin

 
 

Tong Lin, Qisi Liu, Jingxiang Chen

 
 

The pine sawyer beetle Monochamus alternatus Hope, a major forest insect pest, is the primary vector of the destructive forest pest pine wood nematode, Bursaphelenchus xylophilus

 
 
 
 
 
 

Acoustic indices provide information on the status of coral reefs: an example from Moorea Island in the South Pacific

 
 

Frédéric Bertucci, Eric Parmentier, Gaël Lecellier et al.

 
 

Different marine habitats are characterised by different soundscapes. How or which differences may be representative of the habitat characteristics and/or community structure …

 
 
 
 
 
 

Catalytic Thr or Ser Residue Modulates Structural Switches in 2-Cys Peroxiredoxin by Distinct Mechanisms

 
 

Carlos A. Tairum, Melina Cardoso Santos, Carlos A. Breyer et al.

 
 

Typical 2-Cys Peroxiredoxins (2-Cys Prxs) reduce hydroperoxides with extraordinary rates due to an active site composed of a catalytic triad, containing a peroxidatic cysteine (CP

 
 
 
 
 
 

Morphological abnormalities and cell death in the Asian citrus psyllid (Diaphorina citri) midgut associated with Candidatus Liberibacter asiaticus

 
 

Murad Ghanim, Somayeh Fattah-Hosseini, Amit Levy et al.

 
 

Candidatus Liberibacter asiaticus (CLas) is a phloem-limited, gram-negative, fastidious bacterium that is associated with the development of citrus greening disease, also known …

 
 
 
 
 
 

Focused Ultrasound-Induced Blood-Brain Barrier Opening: Association with Mechanical Index and Cavitation Index Analyzed by Dynamic Contrast-Enhanced Magnetic-Resonance Imaging

 
 

Po-Chun Chu, Wen-Yen Chai, Chih-Hung Tsai et al.

 
 

Focused ultrasound (FUS) with microbubbles can temporally open the blood-brain barrier (BBB), and the cavitation activities of microbubbles play a key role in the BBB-opening …

 
 
 
 
 
 

Molecular Dynamics Simulations of the Permeation of Bisphenol A and Pore Formation in a Lipid Membrane

 
 

Liang Chen, Junlang Chen, Guoquan Zhou et al.

 
 

Bisphenol A (BPA) is particularly considered as one of the most suspicious endocrine disruptors. Exposure to BPA may bring about possible human toxicities, such as cancerous …

 
 
 
 
 
 

α-Synuclein is a Novel Microtubule Dynamase

 
 

Daniele Cartelli, Alessandro Aliverti, Alberto Barbiroli et al.

 
 

α-Synuclein is a presynaptic protein associated to Parkinson’s disease, which is unstructured when free in the cytoplasm and adopts α helical conformation when bound to vesicles. …

 
 
 
 
 
 

Low genetic diversity and recent demographic expansion in the red starfish Echinaster sepositus (Retzius 1816)

 
 

Alex Garcia-Cisneros, Creu Palacín, Yousra Ben Khadra et al.

 
 

Understanding the phylogeography and genetic structure of populations and the processes responsible of patterns therein is crucial for evaluating the vulnerability of marine …

 
 
 
 
 
 

Primates’ behavioural responses to tourists: evidence for a trade-off between potential risks and benefits

 
 

Laëtitia Maréchal, Ann MacLarnon, Bonaventura Majolo et al.

 
 

The presence of, and interactions with tourists can be both risky and beneficial for wild animals. In wildlife tourism settings, animals often experience elevated rates of …

 
 
 
 
 
 

Investigating the Responses of Human Epithelial Cells to Predatory Bacteria

 
 

Ajay K. Monnappa, Wasimul Bari, Seong Yeol Choi et al.

 
 

One beguiling alternative to antibiotics for treating multi-drug resistant infections are Bdellovibrio-and-like-organisms (BALOs), predatory bacteria known to attack human …

 
 
 
 
 
 

DNA damage and Repair Modify DNA methylation and Chromatin Domain of the Targeted Locus: Mechanism of allele methylation polymorphism

 
 

Giusi Russo, Rosaria Landi, Antonio Pezone et al.

 
 

We characterize the changes in chromatin structure, DNA methylation and transcription during and after homologous DNA repair (HR). We find that HR modifies the DNA methylation …

 
 
 
 
 
 

siRNA capsulated brain-targeted nanoparticles specifically knock down OATP2B1 in mice: a mechanism for acute morphine tolerance suppression

 
 

Zi-Zhao Yang, Li Li, Lu Wang et al.

 
 

Regulating main brain-uptake transporter of morphine may restrict its tolerance generation, then modify its antinociception. In this study, more than 2 fold higher intracellular …

 
 
 
 
 
 

Adipokinetic hormones and their G protein-coupled receptors emerged in Lophotrochozoa

 
 

Shizhong Li, Frank Hauser, Signe K. Skadborg et al.

 
 

Most multicellular animals belong to two evolutionary lineages, the Proto– and Deuterostomia, which diverged 640–760 million years (MYR) ago. Neuropeptide signaling is abundant …

 
 
 
 
 
 

Unique roles of the unfolded protein response pathway in fungal development and differentiation

 
 

Kwang-Woo Jung, Yee-Seul So, Yong-Sun Bahn

 
 

Cryptococcus neoformans, a global fungal meningitis pathogen, employs the unfolded protein response pathway. This pathway, which consists of an evolutionarily conserved Ire1 …

 
 
 
 
 
 

Postsynaptic SDC2 induces transsynaptic signaling via FGF22 for bidirectional synaptic formation

 
 

Hsiao-Tang Hu, Hisashi Umemori, Yi-Ping Hsueh

 
 

Functional synapse formation requires tight coordination between pre- and post-synaptic termini. Previous studies have shown that postsynaptic expression of heparan sulfate …

 
 
 
 
 
 

The Tetraodon nigroviridis reference transcriptome: developmental transition, length retention and microsynteny of long non-coding RNAs in a compact vertebrate genome

 
 

Swaraj Basu, Yavor Hadzhiev, Giuseppe Petrosino et al.

 
 

Pufferfish such as fugu and tetraodon carry the smallest genomes among all vertebrates and are ideal for studying genome evolution. However, comparative genomics using these …

 
 
 
 
 
 

Fine-tuning of amino sugar homeostasis by EIIANtr in Salmonella Typhimurium

 
 

Woongjae Yoo, Hyunjin Yoon, Yeong-Jae Seok et al.

 
 

The nitrogen-metabolic phosphotransferase system, PTSNtr, consists of the enzymes INtr, NPr and IIANtr that are encoded by ptsP, ptsO, and ptsN, respectively. Due to the …

 
 
 
 
 
 

Amyloid structure exhibits polymorphism on multiple length scales in human brain tissue

 
 

Jiliang Liu, Isabel Costantino, Nagarajan Venugopalan et al.

 
 

Aggregation of Aβ amyloid fibrils into plaques in the brain is a universal hallmark of Alzheimer’s Disease (AD), but whether plaques in different individuals are equivalent is …

 
 
 
 
 
 

Global analysis of differential gene expression related to long-term sperm storage in oviduct of Chinese Soft-Shelled Turtle Pelodiscus sinensis

 
 

Tengfei Liu, Ping Yang, Hong Chen et al.

 
 

Important evolutionary and ecological consequences arise from the ability of female turtles to store viable spermatozoa for an extended period. Although previous morphological …

 
 
 
 
 
 

Distinct Roles for the N- and C-terminal Regions of M-Sec in Plasma Membrane Deformation during Tunneling Nanotube Formation

 
 

Shunsuke Kimura, Masami Yamashita, Megumi Yamakami-Kimura et al.

 
 

The tunneling nanotube (TNT) is a structure used for intercellular communication, and is a thin membrane protrusion mediating transport of various signaling molecules and …

 
 
 
 
 
 

SELMAP - SELEX affinity landscape MAPping of transcription factor binding sites using integrated microfluidics

 
 

Dana Chen, Yaron Orenstein, Rada Golodnitsky et al.

 
 

Transcription factors (TFs) alter gene expression in response to changes in the environment through sequence-specific interactions with the DNA. These interactions are best …

 
 
 
 
 
 

Prolonged California aridity linked to climate warming and Pacific sea surface temperature

 
 

Glen M. MacDonald, Katrina A. Moser, Amy M. Bloom et al.

 
 

California has experienced a dry 21st century capped by severe drought from 2012 through 2015 prompting questions about hydroclimatic sensitivity to anthropogenic climate change …

 
 
 
 
 
 

Y chromosome haplogroups based genome-wide association study pinpoints revelation for interactions on non-obstructive azoospermia

 
 

Chuncheng Lu, Yang Wen, Weiyue Hu et al.

 
 

The Y chromosome has high genetic variability with low rates of parallel and back mutations, which make up the most informative haplotyping system. To examine whether Y …

 
 
 
 
 
 

Anion channelrhodopsins for inhibitory cardiac optogenetics

 
 

Elena G. Govorunova, Shane R. Cunha, Oleg A. Sineshchekov et al.

 
 

Optical control of the heart muscle is a promising strategy for cardiology because it is more specific than traditional electrical stimulation, and allows a higher temporal …

 
 
 
 
 
 

Transient exposure to calcium ionophore enables in vitro fertilization in sterile mouse models

 
 

Felipe A. Navarrete, Antonio Alvau, Hoi Chang Lee et al.

 
 

Mammalian sperm acquire fertilizing capacity in the female tract in a process called capacitation. At the molecular level, capacitation requires protein kinase A activation, …

 
 
 
 
 
 

Tlr4-mutant mice are resistant to acute alcohol-induced sterol-regulatory element binding protein activation and hepatic lipid accumulation

 
 

Zhi-Hui Zhang, Xiao-Qian Liu, Cheng Zhang et al.

 
 

Previous studies demonstrated that acute alcohol intoxication caused hepatic lipid accumulation. The present study showed that acute alcohol intoxication caused hepatic lipid …

 
 
 
 
 
 

BG-4, a novel anticancer peptide from bitter gourd (Momordica charantia), promotes apoptosis in human colon cancer cells

 
 

Vermont P. Dia, Hari B. Krishnan

 
 

Momordica charantia is a perennial plant with reported health benefits. BG-4, a novel peptide from Momordica charantia, was isolated, purified and characterized. The trypsin …

 
 
 
 
 
 

The fungicide triadimefon affects beer flavor and composition by influencing Saccharomyces cerevisiae metabolism

 
 

Zhiqiang Kong, Minmin Li, Jingjing An et al.

 
 

Despite the fact that beer is produced on a large scale, the effects of pesticide residues on beer have been rarely investigated. In this study, we used micro-brewing settings to …

 
 
 
 
 
 

Telocytes in gastric lamina propria of the Chinese giant salamander, Andrias davidianus

 
 

Hui Zhang, Shengwei Zhong, Pengcheng Yu et al.

 
 

In this study, we attempt to identify gastric telocytes (TCs) of the Chinese giant salamander Andrias davidianus, by light microscopy, immunohistochemistry and transmission …

 
 
 
 
 
 

The coiled-coil domain of zebrafish TRPM7 regulates Mg·nucleotide sensitivity

 
 

Chad Jansen, Jaya Sahni, Sayuri Suzuki et al.

 
 

TRPM7 is a member of the Transient-Receptor-Potential Melastatin ion channel family. TRPM7 is a unique fusion protein of an ion channel and an α-kinase. Although mammalian TRPM7 …

 
 
 
 
 
 

The Impact of Cognitive Training on Cerebral White Matter in Community-Dwelling Elderly: One-Year Prospective Longitudinal Diffusion Tensor Imaging Study

 
 

Xinyi Cao, Ye Yao, Ting Li et al.

 
 

It has been shown that cognitive training (CogTr) is effective and recuperative for older adults, and can be used to fight against cognitive decline. In this study, we …

 
 
 
 
 
 

Analysis of long non-coding RNA expression profiles in pancreatic ductal adenocarcinoma

 
 

Xue-Liang Fu, De-Jun Liu, Ting-Ting Yan et al.

 
 

Pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive and lethal malignancies. Long non-coding RNAs (lncRNAs) are a novel class of non-protein-coding …

 
 
 
 
 
 

Diagnostic copper imaging of Menkes disease by synchrotron radiation-generated X-ray fluorescence analysis

 
 

Miyuki Kinebuchi, Akihiro Matsuura, Tohru Kiyono et al.

 
 

Copper (Cu) is an indispensable metal for normal development and function of humans, especially in central nervous system (CNS). However, its redox activity requires accurate Cu …

 
 
 
 
 
 

Oncogenic Mutations Differentially Affect Bax Monomer, Dimer, and Oligomeric Pore Formation in the Membrane

 
 

Mingzhen Zhang, Jie Zheng, Ruth Nussinov et al.

 
 

Dysfunction of Bax, a pro-apoptotic regulator of cellular metabolism is implicated in neurodegenerative diseases and cancer. We have constructed the first atomistic models of the …

 
 
 
 
 
 

MDM2 promoter SNP55 (rs2870820) affects risk of colon cancer but not breast-, lung-, or prostate cancer

 
 

Reham Helwa, Liv B. Gansmo, Pål Romundstad et al.

 
 

Two functional SNPs (SNP285G > C; rs117039649 and SNP309T > G; rs2279744) have previously been reported to modulate Sp1 transcription factor binding to the promoter of the …

 
 
 
 
 
 

Corrigendum: Genome-wide analysis of tomato long non-coding RNAs and identification as endogenous target mimic for microRNA in response to TYLCV infection

 
 

Jinyan Wang, Wengui Yu, Yuwen Yang et al.

 
 

 
 
 
 
 
 

Corrigendum: Identification of cancer-driver genes in focal genomic alterations from whole genome sequencing data

 
 

Ho Jang, Youngmi Hur, Hyunju Lee

 
 

 
 
 
 
 
 

Chemokine CXCL1 mediated neutrophil recruitment: Role of glycosaminoglycan interactions

 
 

Kirti V. Sawant, Krishna Mohan Poluri, Amit K. Dutta et al.

 
 

The chemokine CXCL1/MGSA plays a pivotal role in the host immune response by recruiting and activating neutrophils for microbial killing at the tissue site. CXCL1 exists …

 
 
 
 
 
 

Complement C5a induces PD-L1 expression and acts in synergy with LPS through Erk1/2 and JNK signaling pathways

 
 

Ling-Ling An, Jacob V. Gorman, Geoffrey Stephens et al.

 
 

Severe bacterial infection results in both uncontrolled inflammation and immune suppression in septic patients. Although there is ample evidence that complement activation …

 
 
 
 
 
 

Efficient Production of Fluorescent Transgenic Rats using the piggyBac Transposon

 
 

Tianda Li, Ling Shuai, Junjie Mao et al.

 
 

Rats with fluorescent markers are of great value for studies that trace lineage-specific development, particularly those assessing the differentiation potential of embryonic stem …

 
 
 
 
 
 

Panel-Based Population Next-Generation Sequencing for Inherited Retinal Degenerations

 
 

Matthew Carrigan, Emma Duignan, Conor P. G. Malone et al.

 
 

Inherited retinopathies affect approximately two and a half million people globally, yet the majority of affected patients lack clear genetic diagnoses given the diverse range of …

 
 
 
 
 
 

Integrin α6/Akt/Erk signaling is essential for human breast cancer resistance to radiotherapy

 
 

Ting Hu, Rui Zhou, Yanxia Zhao et al.

 
 

Integrin α6 (ITGA6), a transmembrane glycoprotein adhesion receptor protein, is widely upregulated in many types of tumors and promotes migration and invasion in cancer cells. …

 
 
 
 
 
 

Corrigendum: Knocking down of heat-shock protein 27 directs differentiation of functional glutamatergic neurons from placenta-derived multipotent cells

 
 

Yu-Che Cheng, Chi-Jung Huang, Yih-Jing Lee et al.

 
 

 
 
 
 
 
 

Refinement of the androgen response element based on ChIP-Seq in androgen-insensitive and androgen-responsive prostate cancer cell lines

 
 

Stephen Wilson, Jianfei Qi, Fabian V. Filipp

 
 

Sequence motifs are short, recurring patterns in DNA that can mediate sequence-specific binding for proteins such as transcription factors or DNA modifying enzymes. The androgen …

 
 
 
 
 
 

The Crystal Structure of Peroxiredoxin Asp f3 Provides Mechanistic Insight into Oxidative Stress Resistance and Virulence of Aspergillus fumigatus

 
 

Falk Hillmann, Karine Bagramyan, Maria Straßburger et al.

 
 

Invasive aspergillosis and other fungal infections occur in immunocompromised individuals, including patients who received blood-building stem cell transplants, patients with …

 
 
 
 
 
 

Mechanistic Modelling of DNA Repair and Cellular Survival Following Radiation-Induced DNA Damage

 
 

Stephen J. McMahon, Jan Schuemann, Harald Paganetti et al.

 
 

Characterising and predicting the effects of ionising radiation on cells remains challenging, with the lack of robust models of the underlying mechanism of radiation responses …

 
 
 
 
 
 

Thiol dependent intramolecular locking of Orai1 channels

 
 

Dalia Alansary, Barbara Schmidt, Kathrin Dörr et al.

 
 

Store-operated Ca2+ entry mediated by STIM1-gated Orai1 channels is essential to activate immune cells and its inhibition or gain-of-function can lead to immune dysfunction and …

 
 
 
 
 
 

Future climate stimulates population out-breaks by relaxing constraints on reproduction

 
 

Katherine A. Heldt, Sean D. Connell, Kathryn Anderson et al.

 
 

When conditions are stressful, reproduction and population growth are reduced, but when favourable, reproduction and population size can boom. Theory suggests climate change is …

 
 
 
 
 
 

Comparative analysis of linker histone H1, MeCP2, and HMGD1 on nucleosome stability and target site accessibility

 
 

Caitlyn Riedmann, Yvonne N. Fondufe-Mittendorf

 
 

Chromatin architectural proteins (CAPs) bind the entry/exit DNA of nucleosomes and linker DNA to form higher order chromatin structures with distinct transcriptional outcomes. …

 
 
 
 
 
 

An APOC3 3′UTR variant associated with plasma triglycerides levels and coronary heart disease by creating a functional miR-4271 binding site

 
 

Sen-Lin Hu, Guang-Lin Cui, Jin Huang et al.

 
 

Apolipoprotein C-III (APOC3) is a key regulator of plasma triglycerides levels. Increasing evidence has shown that loss-of-function mutations in APOC3 is associated with …

 
 
 
 
 
 

The enhanced atorvastatin hepatotoxicity in diabetic rats was partly attributed to the upregulated hepatic Cyp3a and SLCO1B1

 
 

Nan Shu, Mengyue Hu, Zhaoli Ling et al.

 
 

Liver injury is a common adverse effect of atorvastatin. This study aimed to investigate atorvastatin-induced hepatotoxicity in diabetic rats induced by high-fat diet combined …

 
 
 
 
 
 

Splenic CD11clowCD45RBhigh dendritic cells derived from endotoxin-tolerant mice attenuate experimental acute liver failure

 
 

Sai-Nan Zhang, Nai-Bin Yang, Shun-Lan Ni et al.

 
 

Endotoxin tolerance (ET) is suggested to attenuate the severity of acute liver failure (ALF) in mice, possibly through both innate and adaptive immunity. However, the involvement …

 
 
 
 
 
 

Subpathway-CorSP: Identification of metabolic subpathways via integrating expression correlations and topological features between metabolites and genes of interest within pathways

 
 

Chenchen Feng, Jian Zhang, Xuecang Li et al.

 
 

Metabolic pathway analysis is a popular strategy for comprehensively researching metabolites and genes of interest associated with specific diseases. However, the traditional …

 
 
 
 
 
 

Gene deleted live attenuated Leishmania vaccine candidates against visceral leishmaniasis elicit pro-inflammatory cytokines response in human PBMCs

 
 

Kumar Avishek, Himanshu Kaushal, Sreenivas Gannavaram et al.

 
 

Currently no effective vaccine is available for human visceral leishmaniasis(VL) caused by Leishmania donovani. Previously, we showed that centrin1 and p27gene deleted live …

 
 
 
 
 
 

Imaging the antimicrobial mechanism(s) of cathelicidin-2

 
 

Viktoria A. F. Schneider, Maarten Coorens, Soledad R. Ordonez et al.

 
 

Host defence peptides (HDPs) have the potential to become alternatives to conventional antibiotics in human and veterinary medicine. The HDP chicken cathelicidin-2 (CATH-2) has …

 
 
 
 
 
 

The Use of a Novel NanoLuc -Based Reporter Phage for the Detection of Escherichia coli O157:H7

 
 

Dandan Zhang, Claudia P. Coronel-Aguilera, Patricia L. Romero et al.

 
 

Rapid detection of the foodborne pathogen Escherichia coli O157:H7 is of vital importance for public health worldwide. Among detection methods, reporter phages represent unique …

 
 
 
 
 
 

Hook2, a microtubule-binding protein, interacts with Par6α and controls centrosome orientation during polarized cell migration

 
 

Emilie Pallesi-Pocachard, Elsa Bazellieres, Annelise Viallat-Lieutaud et al.

 
 

Polarity protein complexes function during polarized cell migration and a subset of these proteins localizes to the reoriented centrosome during this process. Despite these …

 
 
 
 
 
 

Allergy-specific Phenome-Wide Association Study for Immunogenes in Turkish Children

 
 

Sefayet Karaca, Ersoy Civelek, Mehmet Karaca et al.

 
 

To dissect the role of immunogenetics in allergy and asthma, we performed a phenome-wide association study in 974 Turkish children selected from a cross-sectional study conducted …

 
 
 
 
 
 

Deep brain stimulation of the subthalamic nucleus modulates sensitivity to decision outcome value in Parkinson’s disease

 
 

Ben Seymour, Michael Barbe, Peter Dayan et al.

 
 

Deep brain stimulation (DBS) of the subthalamic nucleus in Parkinson’s disease is known to cause a subtle but important adverse impact on behaviour, with impulsivity its most …

 
 
 
 
 
 

Virulence Differences among Melissococcus plutonius Strains with Different Genetic Backgrounds in Apis mellifera Larvae under an Improved Experimental Condition

 
 

Keiko Nakamura, Yuko Yamazaki, Akiyo Shiraishi et al.

 
 

European foulbrood (EFB) caused by Melissococcus plutonius is an important bacterial disease of honeybee larvae. M. plutonius strains can be grouped into three genetically …

 
 
 
 
 
 

Double-layered cell transfer technology for bone regeneration

 
 

Keiko Akazawa, Kengo Iwasaki, Mizuki Nagata et al.

 
 

For cell-based medicine, to mimic in vivo cellular localization, various tissue engineering approaches have been studied to obtain a desirable arrangement of cells on scaffold …

 
 
 
 
 
 

Characterization of human mitochondrial ferritin promoter: identification of transcription factors and evidences of epigenetic control

 
 

Michela Guaraldo, Paolo Santambrogio, Elisabetta Rovelli et al.

 
 

Mitochondrial ferritin (FtMt) is an iron storage protein belonging to the ferritin family but, unlike the cytosolic ferritin, it has an iron-unrelated restricted tissue …

 
 
 
 
 
 

Redox/methylation mediated abnormal DNA methylation as regulators of ambient fine particulate matter-induced neurodevelopment related impairment in human neuronal cells

 
 

Hongying Wei, Fan Liang, Ge Meng et al.

 
 

Fine particulate matter (PM2.5) has been implicated as a risk factor for neurodevelopmental disorders including autism in children. However, the underlying biological mechanism …

 
 
 
 
 
 

The PCP pathway regulates Baz planar distribution in epithelial cells

 
 

Benoit Aigouy, André Le Bivic

 
 

The localisation of apico-basal polarity proteins along the Z-axis of epithelial cells is well understood while their distribution in the plane of the epithelium is poorly …

 
 
 
 
 
 

Erratum: Advances in mapping malaria for elimination: fine resolution modelling of Plasmodium falciparum incidence

 
 

Victor A. Alegana, Peter M. Atkinson, Christopher Lourenço et al.

 
 

 
 
 
 
 
 

Fecal metabolome of the Hadza hunter-gatherers: a host-microbiome integrative view

 
 

Silvia Turroni, Jessica Fiori, Simone Rampelli et al.

 
 

The recent characterization of the gut microbiome of traditional rural and foraging societies allowed us to appreciate the essential co-adaptive role of the microbiome in …

 
 
 
 
 
 

Amyloidogenic amyloid-β-peptide variants induce microbial agglutination and exert antimicrobial activity

 
 

Philipp Spitzer, Mateja Condic, Martin Herrmann et al.

 
 

Amyloid-β (Aβ) peptides are the main components of the plaques found in the brains of patients with Alzheimer’s disease. However, Aβ peptides are also detectable in secretory …

 
 
 
 
 
 

Attention induced neural response trade-off in retinotopic cortex under load

 
 

Ana Torralbo, Todd A. Kelley, Geraint Rees et al.

 
 

The effects of perceptual load on visual cortex response to distractors are well established and various phenomena of ‘inattentional blindness’ associated with elimination of …

 
 
 
 
 
 

Simple and rapid detection of Tilletia horrida causing rice kernel smut in rice seeds

 
 

Yu Chen, Xue Yang, Jian Yao et al.

 
 

A simple and rapid method for the detection of Tilletia horrida, the causal agent of rice kernel smut, in rice seeds is developed based on specific polymerase chain reaction …

 
 
 
 
 
 

Visible-absorption spectroscopy as a biomarker to predict treatment response and prognosis of surgically resected esophageal cancer

 
 

Pei-Wen Yang, I-Jen Hsu, Chun-Wei Chang et al.

 
 

The application of optical absorption spectra in prognostic prediction has hardly been investigated. We developed and evaluated a novel two dimensional absorption spectrum …

 
 
 
 
 
 

Wild capuchin monkeys adjust stone tools according to changing nut properties

 
 

Lydia V. Luncz, Tiago Falótico, Alejandra Pascual-Garrido et al.

 
 

Animals foraging in their natural environments need to be proficient at recognizing and responding to changes in food targets that affect accessibility or pose a risk. Wild …

 
 
 
 
 
 

High-throughput sequencing-based analysis of endogenetic fungal communities inhabiting the Chinese Cordyceps reveals unexpectedly high fungal diversity

 
 

Fei Xia, Xin Chen, Meng-Yuan Guo et al.

 
 

Chinese Cordyceps, known in Chinese as “DongChong XiaCao”, is a parasitic complex of a fungus (Ophiocordyceps sinensis) and a caterpillar. The current study explored the …

 
 
 
 
 
 

Synthesis and mechanisms of action of novel harmine derivatives as potential antitumor agents

 
 

Xiao-Fei Zhang, Rong-qin Sun, Yi-fan Jia et al.

 
 

A series of novel harmine derivatives bearing a benzylindine substituent in position-1 of β-carboline ring were synthesized and evaluated as antitumor agents. The N2-benzylated …

 
 
 
 
 
 

A Rapid and Efficient Luminescence-based Method for Assaying Phosphoglycosyltransferase Enzymes

 
 

Debasis Das, Marthe. T. C. Walvoort, Vinita Lukose et al.

 
 

Phosphoglycosyltransferases (PGTs) are families of integral membrane proteins with intriguingly diverse architectures. These enzymes function to initiate many important …

 
 
 
 
 
 

Bexarotene targets autophagy and is protective against thromboembolic stroke in aged mice with tauopathy

 
 

Mikko T. Huuskonen, Sanna Loppi, Hiramani Dhungana et al.

 
 

Stroke is a highly debilitating, often fatal disorder for which current therapies are suitable for only a minor fraction of patients. Discovery of novel, effective therapies is …

 
 
 
 
 
 

An Intronless β-amyrin Synthase Gene is More Efficient in Oleanolic Acid Accumulation than its Paralog in Gentiana straminea

 
 

Yanling Liu, Zhongjuan Zhao, Zheyong Xue et al.

 
 

Paralogous members of the oxidosqualene cyclase (OSC) family encode a diversity of enzymes that are important in triterpenoid biosynthesis. This report describes the isolation of …

 
 
 
 
 
 

Rational engineering of a virulence gene from Mycobacterium tuberculosis facilitates proteomic analysis of a natural protein N-terminus

 
 

Cristal Reyna, Felix Mba Medie, Matthew M. Champion et al.

 
 

Mass spectrometry (MS) for the detection of proteins is an indispensable tool for evaluating the biological processes of the proteome. Proteomics frequently requires proteolysis …

 
 
 
 
 
 

Regulatory T cells control strain specific resistance to Experimental Autoimmune Prostatitis

 
 

Maria L. Breser, Andreia C. Lino, Ruben D. Motrich et al.

 
 

Susceptibility to autoimmune diseases results from the encounter of a complex and long evolved genetic context with a no less complex and changing environment. Major actors in …

 
 
 
 
 
 

Fungal Aflatoxins Reduce Respiratory Mucosal Ciliary Function

 
 

Robert J. Lee, Alan D. Workman, Ryan M. Carey et al.

 
 

Aflatoxins are mycotoxins secreted by Aspergillus flavus, which can colonize the respiratory tract and cause fungal rhinosinusitis or bronchopulmonary aspergillosis. A. flavus is …

 
 
 
 
 
 

P2X-mediated AMPA receptor internalization and synaptic depression is controlled by two CaMKII phosphorylation sites on GluA1 in hippocampal neurons

 
 

Johan-Till Pougnet, Benjamin Compans, Audrey Martinez et al.

 
 

Plasticity at excitatory synapses can be induced either by synaptic release of glutamate or the release of gliotransmitters such as ATP. Recently, we showed that postsynaptic …

 
 
 
 
 
 

QTL meta-analysis of root traits in Brassica napus under contrasting phosphorus supply in two growth systems

 
 

Ying Zhang, Catherine L. Thomas, Jinxia Xiang et al.

 
 

A high-density SNP-based genetic linkage map was constructed and integrated with a previous map in the Tapidor x Ningyou7 (TNDH) Brassica napus population, giving a new map with …

 
 
 
 
 
 

TRPM4-mediated control of FcεRI-evoked Ca2+ elevation comprises enhanced plasmalemmal trafficking of TRPM4 channels in connective tissue type mast cells

 
 

Torben Rixecker, Ilka Mathar, Rebekka Medert et al.

 
 

TRPM4 proteins form Ca2+-activated non selective cation (CAN) channels that affect transmembrane Ca2+-influx by determining the membrane potential. Tight control of the …

 
 
 
 
 
 

Two-Dimensional Fluorescence Difference Spectroscopy to Characterize Nanoparticles and their Interactions

 
 

Miranda N. Hurst, Robert K. DeLong

 
 

Two dimensional fluorescence difference spectroscopy (2D FDS) detects nanoparticle interactions following surface functionalization and biomolecule loading by generating a …

 
 
 
 
 
 

Erratum: Genetic variability in a frozen batch of MCF-7 cells invisible in routine authentication affecting cell function

 
 

Andre Kleensang, Marguerite M. Vantangoli, Shelly Odwin-DaCosta et al.

 
 

 
 
 
 
 
 

Identification of Viruses in Cases of Pediatric Acute Encephalitis and Encephalopathy Using Next-Generation Sequencing

 
 

Jun-ichi Kawada, Yusuke Okuno, Yuka Torii et al.

 
 

Acute encephalitis/encephalopathy is a severe neurological syndrome that is occasionally associated with viral infection. Comprehensive virus detection assays are desirable …

 
 
 
 
 
 

Role of anterior piriform cortex in the acquisition of conditioned flavour preference

 
 

Cristina Mediavilla, Mar Martin-Signes, Severiano Risco

 
 

Flavour aversion learning (FAL) and conditioned flavour preference (CFP) facilitate animal survival and play a major role in food selection, but the neurobiological mechanisms …

 
 
 
 
 
 

A super gene expression system enhances the anti-glioma effects of adenovirus-mediated REIC/Dkk-3 gene therapy

 
 

Tetsuo Oka, Kazuhiko Kurozumi, Yosuke Shimazu et al.

 
 

Reduced expression in immortalized cells/Dickkopf-3 (REIC/Dkk-3) is a tumor suppressor and therapeutic gene in many human cancers. Recently, an adenovirus REIC vector with the …

 
 
 
 
 
 

Mitochondrial dysfunction is an important cause of neurological deficits in an inflammatory model of multiple sclerosis

 
 

Mona Sadeghian, Vincenzo Mastrolia, Ali Rezaei Haddad et al.

 
 

Neuroinflammation can cause major neurological dysfunction, without demyelination, in both multiple sclerosis (MS) and a mouse model of the disease (experimental autoimmune …

 
 
 
 
 
 

Contamination-controlled high-throughput whole genome sequencing for influenza A viruses using the MiSeq sequencer

 
 

Hong Kai Lee, Chun Kiat Lee, Julian Wei-Tze Tang et al.

 
 

Accurate full-length genomic sequences are important for viral phylogenetic studies. We developed a targeted high-throughput whole genome sequencing (HT-WGS) method for influenza …

 
 
 
 
 
 

Genetically Low Vitamin D Levels, Bone Mineral Density, and Bone Metabolism Markers: a Mendelian Randomisation Study

 
 

Shan-Shan Li, Li-Hong Gao, Xiao-Ya Zhang et al.

 
 

Low serum 25-hydroxyvitamin D (25OHD) is associated with osteoporosis and osteoporotic fracture, but it remains uncertain whether these associations are causal. We conducted a …

 
 
 
 
 
 

An integrative study identifies KCNC2 as a novel predisposing factor for childhood obesity and the risk of diabetes in the Korean population

 
 

Joo-Yeon Hwang, Hyo Jung Lee, Min Jin Go et al.

 
 

Obesity is a major risk factor for type 2 diabetes. To unravel the genetic determinants of obesity-associated diabetes, we performed a genome-wide study using the 1,000 …

 
 
 
 
 
 

Enteric neurons from Parkinson’s disease patients display ex vivo aberrations in mitochondrial structure

 
 

A. S. Baumuratov, P. M. A. Antony, M. Ostaszewski et al.

 
 

Based on autopsy material mitochondrial dysfunction has been proposed being part of the pathophysiological cascade of Parkinson’s disease (PD). However, in living patients, …

 
 
 
 
 
 

ASPP2 involvement in p53-mediated HIV-1 envelope glycoprotein gp120 neurotoxicity in mice cerebrocortical neurons

 
 

Zhiying Liu, Yunjin Zang, Luxin Qiao et al.

 
 

The mechanisms behind HIV-1-associated neurocognitive disorders are still unclear. Apoptosis-stimulating protein 2 of p53 (ASPP2) is a damage-inducible p53-binding protein that …

 
 
 
 
 
 

Acetazolamide Mitigates Astrocyte Cellular Edema Following Mild Traumatic Brain Injury

 
 

Nasya M. Sturdivant, Sean G. Smith, Syed F. Ali et al.

 
 

Non-penetrating or mild traumatic brain injury (mTBI) is commonly experienced in accidents, the battlefield and in full-contact sports. Astrocyte cellular edema is one of the …

 
 
 
 
 
 

GLITTER: a web-based application for gene link inspection through tissue-specific coexpression

 
 

Xiangtao Liu, Pengfei Yu, Chao Cheng et al.

 
 

Accumulating evidence supports the polygenic nature of most complex diseases, suggesting the involvement of many susceptibility genes with small effect sizes. Although hundreds …

 
 
 
 
 
 

Curcumin protects ANIT-induced cholestasis through signaling pathway of FXR-regulated bile acid and inflammation

 
 

Fan Yang, Xiaowen Tang, Lili Ding et al.

 
 

Cholestasis is a clinically significant symptom and widely associated with liver diseases, however, there are very few effective therapies for cholestasis. Danning tablet (DNT, a …

 
 
 
 
 
 

Skin scarification with Plasmodium falciparum peptide vaccine using synthetic TLR agonists as adjuvants elicits malaria sporozoite neutralizing immunity

 
 

Robert A. Mitchell, Rita Altszuler, Ute Frevert et al.

 
 

Malaria eradication will require a combination of vector control, chemotherapy and an easily administered vaccine. Sterile immunity can be elicited in humans by immunization with …

 
 
 
 
 
 

NOX2 amplifies acetaldehyde-mediated cardiomyocyte mitochondrial dysfunction in alcoholic cardiomyopathy

 
 

Moritz Brandt, Venkata Garlapati, Matthias Oelze et al.

 
 

Alcoholic cardiomyopathy (ACM) resulting from excess alcohol consumption is an important cause of heart failure (HF). Although it is assumed that the cardiotoxicity of the …

 
 
 
 
 
 

Persistent inflammatory state after photoreceptor loss in an animal model of retinal degeneration

 
 

Agustina Noailles, Victoria Maneu, Laura Campello et al.

 
 

Microglia act as the resident immune cells of the central nervous system, including the retina. In response to damaging stimuli microglia adopt an activated state, which can …

 
 
 
 
 
 

Residue Geometry Networks: A Rigidity-Based Approach to the Amino Acid Network and Evolutionary Rate Analysis

 
 

Alexander S. Fokas, Daniel J. Cole, Sebastian E. Ahnert et al.

 
 

Amino acid networks (AANs) abstract the protein structure by recording the amino acid contacts and can provide insight into protein function. Herein, we describe a novel AAN …

 
 
 
 
 
 

A HTML5 open source tool to conduct studies based on Libet’s clock paradigm

 
 

Pablo Garaizar, Carmelo P. Cubillas, Helena Matute

 
 

Libet’s clock is a well-known procedure in experiments in psychology and neuroscience. Examples of its use include experiments exploring the subjective sense of agency, …

 
 
 
 
 
 

Voluntary movement affects simultaneous perception of auditory and tactile stimuli presented to a non-moving body part

 
 

Qiao Hao, Hiroki Ora, Ken-ichiro Ogawa et al.

 
 

The simultaneous perception of multimodal sensory information has a crucial role for effective reactions to the external environment. Voluntary movements are known to …

 
 
 
 
 
 

Does cryptic microbiota mitigate pine resistance to an invasive beetle-fungus complex? Implications for invasion potential

 
 

Chihang Cheng, Letian Xu, Dandan Xu et al.

 
 

Microbial symbionts are known to assist exotic pests in their colonization of new host plants. However, there has been little evidence linking symbiotic invasion success to …

 
 
 
 
 
 

PPM1D controls nucleolar formation by up-regulating phosphorylation of nucleophosmin

 
 

Yuuki Kozakai, Rui Kamada, Junya Furuta et al.

 
 

An increase of nucleolar number and size has made nucleoli essential markers for cytology and tumour development. However, the underlying basis for their structural integrity and …

 
 
 
 
 
 

πSPIM: high NA high resolution isotropic light-sheet imaging in cell culture dishes

 
 

Patrick Theer, Denitsa Dragneva, Michael Knop

 
 

Light-sheet fluorescence microscopy (LSFM), also termed single plane illumination microscopy (SPIM), enables live cell fluorescence imaging with optical sectioning capabilities …

 
 
 
 
 
 

Probing the luminal microenvironment of reconstituted epithelial microtissues

 
 

Alec E. Cerchiari, Karen E. Samy, Michael E. Todhunter et al.

 
 

Polymeric microparticles can serve as carriers or sensors to instruct or characterize tissue biology. However, incorporating microparticles into tissues for in vitro assays …

 
 
 
 
 
 

Model suggests potential for Porites coral population recovery after removal of anthropogenic disturbance (Luhuitou, Hainan, South China Sea)

 
 

Meixia Zhao, Bernhard Riegl, Kefu Yu et al.

 
 

Population models are important for resource management and can inform about potential trajectories useful for planning purposes, even with incomplete monitoring data. From size …

 
 
 
 
 
 

Chronic Moderate Alcohol Intakes Accelerate SR-B1 Mediated Reverse Cholesterol Transport

 
 

Menghua Li, Yan Diao, Ying Liu et al.

 
 

Cholesterol is essential for all animal life. However, a high level of cholesterol in the body is strongly associated with the progression of various severe diseases. In our …

 
 
 
 
 
 

EGFP oligomers as natural fluorescence and hydrodynamic standards

 
 

György Vámosi, Norbert Mücke, Gabriele Müller et al.

 
 

EGFP oligomers are convenient standards for experiments on fluorescent protein-tagged biomolecules. In this study, we characterized their hydrodynamic and fluorescence …

 
 
 
 
 
 

Increased water salinity applied to tomato plants accelerates the development of the leaf miner Tuta absoluta through bottom-up effects

 
 

Peng Han, Zhi-jian Wang, Anne-Violette Lavoir et al.

 
 

Variation in resource inputs to plants may trigger bottom-up effects on herbivorous insects. We examined the effects of water input: optimal water vs. limited water; water …

 
 
 
 
 
 

Matrix metalloproteinase inhibitor, doxycycline and progression of calcific aortic valve disease in hyperlipidemic mice

 
 

Jae-Joon Jung, Mahmoud Razavian, Hye-Yeong Kim et al.

 
 

Calcific aortic valve disease (CAVD) is the most common cause of aortic stenosis. Currently, there is no non-invasive medical therapy for CAVD. Matrix metalloproteinases (MMPs) …

 
 
 
 
 
 

Development of a SNP array and its application to genetic mapping and diversity assessment in pepper (Capsicum spp.)

 
 

Jiaowen Cheng, Cheng Qin, Xin Tang et al.

 
 

The development and application of single nucleotide polymorphisms (SNPs) is in its infancy for pepper. Here, a set of 15,000 SNPs were chosen from the resequencing data to …

 
 
 
 
 
 

Improving the performance of the PLB index for ligand-binding site prediction using dihedral angles and the solvent-accessible surface area

 
 

Chen Cao, Shutan Xu

 
 

Protein ligand-binding site prediction is highly important for protein function determination and structure-based drug design. Over the past twenty years, dozens of computational …

 
 
 
 
 
 

Changes in intracellular copper concentration and copper-regulating gene expression after PC12 differentiation into neurons

 
 

Yasumitsu Ogra, Aya Tejima, Naohiro Hatakeyama et al.

 
 

It is suspected that some neurodegenerative diseases are a result of the disturbance of copper (Cu) homeostasis, although it remains unclear whether the disturbance of Cu …

 
 
 
 
 
 

Sterilization Effects of Adult-targeted Baits Containing Insect Growth Regulators on Delia antiqua

 
 

Fangyuan Zhou, Guodong Zhu, Haipeng Zhao et al.

 
 

The onion maggot, Delia antiqua, is a devastating pest of liliaceous crops and current control measures fail to avert pesticide residues, threats to agroecosystem, and costly …

 
 
 
 
 
 

The porin VDAC2 is the mitochondrial platform for Bax retrotranslocation

 
 

Joachim Lauterwasser, Franziska Todt, Ralf M. Zerbes et al.

 
 

The pro-apoptotic Bcl-2 protein Bax can permeabilize the outer mitochondrial membrane and therefore commit human cells to apoptosis. Bax is regulated by constant translocation to …

 
 
 
 
 
 

PI3 Kinase Pathway and MET Inhibition is Efficacious in Malignant Pleural Mesothelioma

 
 

Rajani Kanteti, Jacob J. Riehm, Immanuel Dhanasingh et al.

 
 

Malignant pleural mesothelioma (MPM) is an aggressive cancer that is commonly associated with prior asbestos exposure. Receptor tyrosine kinases (RTKs) such as MET and its …

 
 
 
 
 
 

Regulation of Mitoflash Biogenesis and Signaling by Mitochondrial Dynamics

 
 

Wenwen Li, Tao Sun, Beibei Liu et al.

 
 

Mitochondria are highly dynamic organelles undergoing constant network reorganization and exhibiting stochastic signaling events in the form of mitochondrial flashes …

 
 
 
 
 
 

Crocetin exploits p53-induced death domain (PIDD) and FAS-associated death domain (FADD) proteins to induce apoptosis in colorectal cancer

 
 

Pallab Ray, Deblina Guha, Juni Chakraborty et al.

 
 

Tumor suppressor p53 preserves the genomic integrity by restricting anomaly at the gene level. The hotspots for mutation in half of all colon cancers reside in p53. Hence, in a …

 
 
 
 
 
 

Altered Intranetwork and Internetwork Functional Connectivity in Type 2 Diabetes Mellitus With and Without Cognitive Impairment

 
 

Shi-Qi Yang, Zhi-Peng Xu, Ying Xiong et al.

 
 

Type 2 diabetes mellitus (T2DM) is associated with cognitive impairment. We investigated whether alterations of intranetwork and internetwork functional connectivity with T2DM …

 
 
 
 
 
 

De novo sequencing, assembly and analysis of eight different transcriptomes from the Malayan pangolin

 
 

Aini Mohamed Yusoff, Tze King Tan, Ranjeev Hari et al.

 
 

Pangolins are scale-covered mammals, containing eight endangered species. Maintaining pangolins in captivity is a significant challenge, in part because little is known about …

 
 
 
 
 
 

De novo Transcriptome Analysis Reveals Distinct Defense Mechanisms by Young and Mature Leaves of Hevea brasiliensis (Para Rubber Tree)

 
 

Yongjun Fang, Hailiang Mei, Binhui Zhou et al.

 
 

Along with changes in morphology in the course of maturation, leaves of Hevea brasiliensis become more resistant to leaf diseases, including the South American Leaf Blight …

 
 
 
 
 
 

Characterization of a knock-in mouse model of the homozygous p.V37I variant in Gjb2

 
 

Ying Chen, Lingxiang Hu, Xueling Wang et al.

 
 

The homozygous p.V37I variant in GJB2 is prevalent in East and Southeast Asians and may lead to mild-to-moderate hearing loss with reduced penetrance. To investigate the …

 
 
 
 
 
 

Deoxyinosine triphosphate induces MLH1/PMS2- and p53-dependent cell growth arrest and DNA instability in mammalian cells

 
 

Yasuto Yoneshima, Nona Abolhassani, Teruaki Iyama et al.

 
 

Deoxyinosine (dI) occurs in DNA either by oxidative deamination of a previously incorporated deoxyadenosine residue or by misincorporation of deoxyinosine triphosphate (dITP) …

 
 
 
 
 
 

Morphological change in cranial shape following the transition to agriculture across western Eurasia

 
 

Olivia Cheronet, John A. Finarelli, Ron Pinhasi

 
 

The Neolithic transition brought about fundamental social, dietary and behavioural changes in human populations, which, in turn, impacted skeletal morphology. Crania are shaped …

 
 
 
 
 
 

Altered brain ion gradients following compensation for elevated CO2 are linked to behavioural alterations in a coral reef fish

 
 

R. M. Heuer, M. J. Welch, J. L. Rummer et al.

 
 

Neurosensory and behavioural disruptions are some of the most consistently reported responses upon exposure to ocean acidification-relevant CO2 levels, especially in coral reef …

 
 
 
 
 
 

Crystal structures of archaeal 2-oxoacid:ferredoxin oxidoreductases from Sulfolobus tokodaii

 
 

Zhen Yan, Akane Maruyama, Takatoshi Arakawa et al.

 
 

As the first three-dimensional structure of the two-subunit type 2-oxoacid:ferredoxin oxidoreductases (OFOR) from archaea, we solved the crystal structures of STK_23000/STK_22980 …

 
 
 
 
 
 

The yeast Aft2 transcription factor determines selenite toxicity by controlling the low affinity phosphate transport system

 
 

María Pérez-Sampietro, Albert Serra-Cardona, David Canadell et al.

 
 

The yeast Saccharomyces cerevisiae is employed as a model to study the cellular mechanisms of toxicity and defense against selenite, the most frequent environmental selenium …

 
 
 
 
 
 

Patterns of contribution to citizen science biodiversity projects increase understanding of volunteers’ recording behaviour

 
 

Elizabeth H. Boakes, Gianfranco Gliozzo, Valentine Seymour et al.

 
 

The often opportunistic nature of biological recording via citizen science leads to taxonomic, spatial and temporal biases which add uncertainty to biodiversity estimates. …

 
 
 
 
 
 

A polymorphic (GA/CT)n- SSR influences promoter activity of Tryptophan decarboxylase gene in Catharanthus roseus L. Don

 
 

Santosh Kumar, Sabhyata Bhatia

 
 

Simple Sequence Repeats (SSRs) of polypurine-polypyrimidine type motifs occur very frequently in the 5′ flanks of genes in plants and have recently been implicated to have a role …

 
 
 
 
 
 

Discovery of a Metastatic Immune Escape Mechanism Initiated by the Loss of Expression of the Tumour Biomarker Interleukin-33

 
 

Iryna Saranchova, Jeffrey Han, Hui Huang et al.

 
 

A new paradigm for understanding immune-surveillance and immune escape in cancer is described here. Metastatic carcinomas express reduced levels of IL-33 and diminished levels of …

 
 
 
 
 
 

The analysis of heterotaxy patients reveals new loss-of-function variants of GRK5

 
 

Davor Lessel, Tariq Muhammad, Teresa Casar Tena et al.

 
 

G protein-coupled receptor kinase 5 (GRK5) is a regulator of cardiac performance and a potential therapeutic target in heart failure in the adult. Additionally, we have …

 
 
 
 
 
 

Concurrent micro-RNA mediated silencing of tick-borne flavivirus replication in tick vector and in the brain of vertebrate host

 
 

Konstantin A. Tsetsarkin, Guangping Liu, Heather Kenney et al.

 
 

Tick-borne viruses include medically important zoonotic pathogens that can cause life-threatening diseases. Unlike mosquito-borne viruses, whose impact can be restrained via …

 
 
 
 
 
 

Utility of the dual-specificity protein kinase TTK as a therapeutic target for intrahepatic spread of liver cancer

 
 

Ruoyu Miao, Yan Wu, Haohai Zhang et al.

 
 

Therapies for primary liver cancer, the third leading cause of cancer-related death worldwide, remain limited. Following multi-omics analysis (including whole genome and …

 
 
 
 
 
 

Pits, a protein interacting with Ttk69 and Sin3A, has links to histone deacetylation

 
 

Gwo-Jen Liaw

 
 

Histone deacetylation plays an important role in transcriptional repression. Previous results showed that the genetic interaction between ttk and rpd3, which encodes a class I …

 
 
 
 
 
 

Cell wall degradation is required for normal starch mobilisation in barley endosperm

 
 

Vasilios M. E. Andriotis, Martin Rejzek, Elaine Barclay et al.

 
 

Starch degradation in barley endosperm provides carbon for early seedling growth, but the control of this process is poorly understood. We investigated whether endosperm cell …

 
 
 
 
 
 

Vitamin B2 as a virulence factor in Pseudogymnoascus destructans skin infection

 
 

Miroslav Flieger, Hana Bandouchova, Jan Cerny et al.

 
 

Pathogenic and non-pathogenic related microorganisms differ in secondary metabolite production. Here we show that riboflavin overproduction by a fungal pathogen and its …

 
 
 
 
 
 

Functional metabolic interactions of human neuron-astrocyte 3D in vitro networks

 
 

Daniel Simão, Ana P. Terrasso, Ana P. Teixeira et al.

 
 

The generation of human neural tissue-like 3D structures holds great promise for disease modeling, drug discovery and regenerative medicine strategies. Promoting the …

 
 
 
 
 
 

Binding affinity of amyloid oligomers to cellular membranes is a generic indicator of cellular dysfunction in protein misfolding diseases

 
 

Elisa Evangelisti, Roberta Cascella, Matteo Becatti et al.

 
 

The conversion of peptides or proteins from their soluble native states into intractable amyloid deposits is associated with a wide range of human disorders. Misfolded protein …

 
 
 
 
 
 

The multifaceted RisA regulon of Bordetella pertussis

 
 

Loïc Coutte, Ludovic Huot, Rudy Antoine et al.

 
 

The whooping cough agent Bordetella pertussis regulates the production of its virulence factors by the BvgA/S system. Phosphorylated BvgA activates the virulence-activated genes (

 
 
 
 
 
 

Early-life sexual segregation: ontogeny of isotopic niche differentiation in the Antarctic fur seal

 
 

L. Kernaléguen, J. P. Y. Arnould, C. Guinet et al.

 
 

Investigating the ontogeny of niche differentiation enables to determine at which life-stages sexual segregation arises, providing insights into the main factors driving resource …

 
 
 
 
 
 

Inhibition of Drp1 mitochondrial translocation provides neural protection in dopaminergic system in a Parkinson’s disease model induced by MPTP

 
 

Emily Filichia, Barry Hoffer, Xin Qi et al.

 
 

Accumulating evidence suggest mitochondria-mediated pathways play an important role in dopaminergic neuronal cell death in Parkinson’s disease (PD). Drp1, a key regulator of …

 
 
 
 
 
 

Augmented 3D super-resolution of fluorescence-free nanoparticles using enhanced dark-field illumination based on wavelength-modulation and a least-cubic algorithm

 
 

Peng Zhang, Kyungsoo Kim, Seungah Lee et al.

 
 

Augmented three-dimensional (3D) subdiffraction-limited resolution of fluorescence-free single-nanoparticles was achieved with wavelength-dependent enhanced dark-field (EDF) …

 
 
 
 
 
 

Fluorescence imaging of chromosomal DNA using click chemistry

 
 

Takumi Ishizuka, Hong Shan Liu, Kenichiro Ito et al.

 
 

Chromosome visualization is essential for chromosome analysis and genetic diagnostics. Here, we developed a click chemistry approach for multicolor imaging of chromosomal DNA …

 
 
 
 
 
 

HSCCC-based strategy for preparative separation of in vivo metabolites after administration of an herbal medicine: Saussurea laniceps, a case study

 
 

Tao Yi, Lin Zhu, Guo-Yuan Zhu et al.

 
 

This paper reports a novel strategy based on high-speed counter-current chromatography (HSCCC) technique to separate in vivo metabolites from refined extract of urine after …

 
 
 
 
 
 

Metabolic engineering of cottonseed oil biosynthesis pathway via RNA interference

 
 

Zhongping Xu, Jingwen Li, Xiaoping Guo et al.

 
 

Cottonseed oil is recognized as an important oil in food industry for its unique characters: low flavor reversion and the high level of antioxidants (VitaminE) as well as …

 
 
 
 
 
 

Trp53 deficient mice predisposed to preterm birth display region-specific lipid alterations at the embryo implantation site

 
 

Ingela Lanekoff, Jeeyeon Cha, Jennifer E. Kyle et al.

 
 

Here we demonstrate that conditional deletion of mouse uterine Trp53 (p53d/d), molecularly linked to mTORC1 activation and causally linked to premature uterine senescence and …

 
 
 
 
 
 

Molecular organization, localization and orientation of antifungal antibiotic amphotericin B in a single lipid bilayer

 
 

Wojciech Grudzinski, Joanna Sagan, Renata Welc et al.

 
 

Amphotericin B is a popular antifungal antibiotic, a gold standard in treatment of systemic mycotic infections, due to its high effectiveness. On the other hand, applicability of …

 
 
 
 
 
 

Lipid membrane-mediated attraction between curvature inducing objects

 
 

Casper van der Wel, Afshin Vahid, Anđela Šarić et al.

 
 

The interplay of membrane proteins is vital for many biological processes, such as cellular transport, cell division, and signal transduction between nerve cells. Theoretical …

 
 
 
 
 
 

Real-time Functional Analysis of Inertial Microfluidic Devices via Spectral Domain Optical Coherence Tomography

 
 

Biqin Dong, Siyu Chen, Fan Zhou et al.

 
 

We report the application of spectral-domain optical coherence tomography (SD-OCT) technology that enables real-time functional analysis of sorting microparticles and cells in an …

 
 
 
 
 
 

Quadrant Field Pupillometry Detects Melanopsin Dysfunction in Glaucoma Suspects and Early Glaucoma

 
 

Prakash Adhikari, Andrew J. Zele, Ravi Thomas et al.

 
 

It is difficult to detect visual function deficits in patients at risk for glaucoma (glaucoma suspects) and at early disease stages with conventional ophthalmic tests such as …

 
 
 
 
 
 

Conformational Ensemble of hIAPP Dimer: Insight into the Molecular Mechanism by which a Green Tea Extract inhibits hIAPP Aggregation

 
 

Yuxiang Mo, Jiangtao Lei, Yunxiang Sun et al.

 
 

Small oligomers formed early along human islet amyloid polypeptide (hIAPP) aggregation is responsible for the cell death in Type II diabetes. The epigallocatechin gallate (EGCG), …

 
 
 
 
 
 

4-Hydroxy-2-nonenal induces apoptosis by activating ERK1/2 signaling and depleting intracellular glutathione in intestinal epithelial cells

 
 

Yun Ji, Zhaolai Dai, Guoyao Wu et al.

 
 

Excessive reactive oxygen species (ROS) induces oxidative damage to cellular constituents, ultimately leading to induction of apoptotic cell death and the pathogenesis of various …

 
 
 
 
 
 

Microwave ablation of hepatocellular carcinoma as first-line treatment: long term outcomes and prognostic factors in 221 patients

 
 

Tao Wang, Xiao-Jie Lu, Jia-Chang Chi et al.

 
 

This retrospective study aimed at evaluating the long-term outcomes and prognostic factors of microwave ablation (MWA) as a first-line treatment for hepatocellular carcinoma …

 
 
 
 
 
 

Protective effects of sirtuin 3 in a murine model of sepsis-induced acute kidney injury

 
 

Wen-Yu Zhao, Lei Zhang, Ming-Xing Sui et al.

 
 

Acute kidney injury (AKI) is a rapid loss of kidney function characterized by damage to renal tubular cells driven by mitochondrial dysregulation and oxidative stress. Here, we …

 
 
 
 
 
 

Targeting Motor End Plates for Delivery of Adenoviruses: An Approach to Maximize Uptake and Transduction of Spinal Cord Motor Neurons

 
 

Andrew Paul Tosolini, Renée Morris

 
 

Gene therapy can take advantage of the skeletal muscles/motor neurons anatomical relationship to restrict gene expression to the spinal cord ventral horn. Furthermore, …

 
 
 
 
 
 

An Auditory BCI System for Assisting CRS-R Behavioral Assessment in Patients with Disorders of Consciousness

 
 

Jun Xiao, Qiuyou Xie, Yanbin He et al.

 
 

The Coma Recovery Scale-Revised (CRS-R) is a consistent and sensitive behavioral assessment standard for disorders of consciousness (DOC) patients. However, the CRS-R has …

 
 
 
 
 
 

Cold tolerance is unaffected by oxygen availability despite changes in anaerobic metabolism

 
 

Leigh Boardman, Jesper G. Sørensen, Vladimír Koštál et al.

 
 

Insect cold tolerance depends on their ability to withstand or repair perturbations in cellular homeostasis caused by low temperature stress. Decreased oxygen availability …

 
 
 
 
 
 
 
 
 
 
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Chemical Sciences top
 
 
 
 
 
 
 

Linear biocompatible glyco-polyamidoamines as dual action mode virus infection inhibitors with potential as broad-spectrum microbicides for sexually transmitted diseases

 
 

Nicolò Mauro, Paolo Ferruti, Elisabetta Ranucci et al.

 
 

The initial steps of viral infections are mediated by interactions between viral proteins and cellular receptors. Blocking the latter with high-affinity ligands may inhibit …

 
 
 
 
 
 

High Cycle-life Shape Memory Polymer at High Temperature

 
 

Deyan Kong, Xinli Xiao

 
 

High cycle-life is important for shape memory materials exposed to numerous cycles, and here we report shape memory polyimide that maintained both high shape fixity (Rf) and …

 
 
 
 
 
 

Structural Analysis of the Hg(II)-Regulatory Protein Tn501 MerR from Pseudomonas aeruginosa

 
 

Dan Wang, Shanqing Huang, Pingying Liu et al.

 
 

The metalloprotein MerR is a mercury(II)-dependent transcriptional repressor-activator that responds to mercury(II) with extraordinary sensitivity and selectivity. It’s widely …

 
 
 
 
 
 

A new insight into the immobilization mechanism of Zn on biochar: the role of anions dissolved from ash

 
 

Tingting Qian, Yujun Wang, Tingting Fan et al.

 
 

Biochar is considered to be a promising material for heavy metal immobilization in soil. However, the immobilization mechanisms of Zn2+ on biochars derived from many common waste …

 
 
 
 
 
 

In Situ Nanopressing: A General Approach to Robust Nanoparticles-Polymer Surface Structures

 
 

Xiaojie Zhang, Junhui He, Binbin Jin

 
 

We report a novel, facile and general approach, in situ nanopressing, to integrate nanoparticles and polymers in a thin film configuration, where both nanoparticles exposure and …

 
 
 
 
 
 

Single-Molecule Imaging Reveals the Activation Dynamics of Intracellular Protein Smad3 on Cell Membrane

 
 

Nan Li, Yong Yang, Kangmin He et al.

 
 

Smad3 is an intracellular protein that plays a key role in propagating transforming growth factor β (TGF-β) signals from cell membrane to nucleus. However whether the transient …

 
 
 
 
 
 

Amino-Fe3O4 Microspheres Directed Synthesis of a Series of Polyaniline Hierarchical Nanostructures with Different Wettability

 
 

Yong Ma, Yanhui Chen, Chunping Hou et al.

 
 

We demonstrated polyaniline (PANI) dimensional transformation by adding trace amino-Fe3O4 microspheres to aniline polymerization. Different PANI nanostructures (i.e., flowers, …

 
 
 
 
 
 

External cavity-quantum cascade laser infrared spectroscopy for secondary structure analysis of proteins at low concentrations

 
 

Andreas Schwaighofer, Mirta R. Alcaráz, Can Araman et al.

 
 

Fourier transform infrared (FTIR) and circular dichroism (CD) spectroscopy are analytical techniques employed for the analysis of protein secondary structure. The use of CD …

 
 
 
 
 
 

Highly efficient removal of lead and cadmium during wastewater irrigation using a polyethylenimine-grafted gelatin sponge

 
 

Bingbing Li, Feng Zhou, Kai Huang et al.

 
 

Wastewater irrigation is a very important resource for heavy metal pollution in soil and then accumulation in vegetable crops. In this study, a polyethylenimine (PEI)-grafted …

 
 
 
 
 
 

Nitroaromatic explosives detection using electrochemically exfoliated graphene

 
 

Ying Teng Yew, Adriano Ambrosi, Martin Pumera

 
 

Detection of nitroaromatic explosives is of paramount importance from security point of view. Graphene sheets obtained from the electrochemical anodic exfoliation of graphite …

 
 
 
 
 
 

Saddle point localization of molecular wavefunctions

 
 

Georg Ch. Mellau, Alexandra A. Kyuberis, Oleg L. Polyansky et al.

 
 

The quantum mechanical description of isomerization is based on bound eigenstates of the molecular potential energy surface. For the near-minimum regions there is a …

 
 
 
 
 
 

Time-dependent effects of ultraviolet and nonthermal atmospheric pressure plasma on the biological activity of titanium

 
 

Sung-Hwan Choi, Won-Seok Jeong, Jung-Yul Cha et al.

 
 

Here, we evaluated time-dependent changes in the effects of ultraviolet (UV) and nonthermal atmospheric pressure plasma (NTAPPJ) on the biological activity of titanium compared …

 
 
 
 
 
 

A novel insight into membrane fouling mechanism regarding gel layer filtration: Flory-Huggins based filtration mechanism

 
 

Qian Lei, Meijia Zhang, Liguo Shen et al.

 
 

This study linked the chemical potential change to high specific filtration resistance (SFR) of gel layer, and then proposed a novel membrane fouling mechanism regarding gel …

 
 
 
 
 
 

Incorporation of Eu(III) into Calcite under Recrystallization conditions

 
 

S. E. Hellebrandt, S. Hofmann, N. Jordan et al.

 
 

The interaction of calcite with trivalent europium under recrystallization conditions was studied on the molecular level using site-selective time-resolved laser fluorescence …

 
 
 
 
 
 

Synergistic effect of tartaric acid with 2,6-diaminopyridine on the corrosion inhibition of mild steel in 0.5 M HCl

 
 

Yujie Qiang, Lei Guo, Shengtao Zhang et al.

 
 

The inhibitive ability of 2,6-diaminopyridine, tartaric acid and their synergistic effect towards mild steel corrosion in 0.5 M HCl solution was evaluated at various …

 
 
 
 
 
 

Study of the effect of excited state concentration on photodegradation of the p3ht polymer

 
 

V. N. Peters, Rohan Alexander, D’Angelo A. Peters et al.

 
 

We have studied photoinduced reduction of absorption and emission in p3ht, a semiconducting polymer, and found that the rate of photodegradation (destruction of the constituent …

 
 
 
 
 
 

Palladium-catalyzed direct arylation and cyclization of o-iodobiaryls to a library of tetraphenylenes

 
 

Chendan Zhu, Yue Zhao, Di Wang et al.

 
 

Aryl–aryl bond formation constitutes one of the most important subjects in organic synthesis. The recent developments in direct arylation reactions forming aryl–aryl bond have …

 
 
 
 
 
 

Building better lithium-sulfur batteries: from LiNO3 to solid oxide catalyst

 
 

Ning Ding, Lan Zhou, Changwei Zhou et al.

 
 

Lithium nitrate (LiNO3) is known as an important electrolyte additive in lithium-sulfur (Li-S) batteries. The prevailing understanding is that LiNO3 reacts with metallic lithium …

 
 
 
 
 
 

The electron donating capacity of biochar is dramatically underestimated

 
 

Antonin Prévoteau, Frederik Ronsse, Inés Cid et al.

 
 

Biochars have gathered considerable interest for agronomic and engineering applications. In addition to their high sorption ability, biochars have been shown to accept or donate …

 
 
 
 
 
 

Oncogenic Mutations Differentially Affect Bax Monomer, Dimer, and Oligomeric Pore Formation in the Membrane

 
 

Mingzhen Zhang, Jie Zheng, Ruth Nussinov et al.

 
 

Dysfunction of Bax, a pro-apoptotic regulator of cellular metabolism is implicated in neurodegenerative diseases and cancer. We have constructed the first atomistic models of the …

 
 
 
 
 
 

Comprehensive approach for predicting toxicological effects of ionic liquids on several biological systems using unified descriptors

 
 

Chul-Woong Cho, Stefan Stolte, Yeoung-Sang Yun

 
 

The challenge and opportunity for design of environmentally-benign ionic liquids (ILs) would start from prediction of their toxicological effects on several endpoints solely …

 
 
 
 
 
 

Generation of self-clusters of galectin-1 in the farnesyl-bound form

 
 

Kazumi Yamaguchi, Yusuke Niwa, Takakazu Nakabayashi et al.

 
 

Ras protein is involved in a signal transduction cascade in cell growth, and cluster formation of H-Ras and human galectin-1 (Gal-1) complex is considered to be crucial to …

 
 
 
 
 
 

Trp53 deficient mice predisposed to preterm birth display region-specific lipid alterations at the embryo implantation site

 
 

Ingela Lanekoff, Jeeyeon Cha, Jennifer E. Kyle et al.

 
 

Here we demonstrate that conditional deletion of mouse uterine Trp53 (p53d/d), molecularly linked to mTORC1 activation and causally linked to premature uterine senescence and …

 
 
 
 
 
 

Facile synthesis of pristine graphene-palladium nanocomposites with extraordinary catalytic activities using swollen liquid crystals

 
 

T. Vats, S. Dutt, R. Kumar et al.

 
 

Amazing conductivity, perfect honeycomb sp2 arrangement and the high theoretical surface area make pristine graphene as one of the best materials suited for application as …

 
 
 
 
 
 

High-effective approach from amino acid esters to chiral amino alcohols over Cu/ZnO/Al2O3 catalyst and its catalytic reaction mechanism

 
 

Shuangshuang Zhang, Jun Yu, Huiying Li et al.

 
 

Developing the high-efficient and green synthetic method for chiral amino alcohols is an intriguing target. We have developed the Mg2+-doped Cu/ZnO/Al2O3 catalyst for …

 
 
 
 
 
 

Reproducible Ultrahigh SERS Enhancement in Single Deterministic Hotspots Using Nanosphere-Plane Antennas Under Radially Polarized Excitation

 
 

Jing Long, Hui Yi, Hongquan Li et al.

 
 

Surface enhanced Raman scattering (SERS) in a nanometer size hotspot has empowered the investigation of chemical structures and dynamic behaviors of one and a few molecules. …

 
 
 
 
 
 

Two-dimensional artificial light-harvesting antennae with predesigned high-order structure and robust photosensitising activity

 
 

Xiao Feng, Xuesong Ding, Long Chen et al.

 
 

Highly ordered discrete assemblies of chlorophylls that are found in natural light-harvesting antennae are key to photosynthesis, which converts light energy to chemical energy …

 
 
 
 
 
 

Light effect on Click reaction: Role of photonic quantum dot catalyst

 
 

Debkumar Nandi, Abu Taher, Rafique Ul Islam et al.

 
 

Due to the light excitation, the valence band electron of the copper (I) sulfide quantum dot transfer to the conduction band and act as a scavenger of the terminal proton of the …

 
 
 
 
 
 

Augmented 3D super-resolution of fluorescence-free nanoparticles using enhanced dark-field illumination based on wavelength-modulation and a least-cubic algorithm

 
 

Peng Zhang, Kyungsoo Kim, Seungah Lee et al.

 
 

Augmented three-dimensional (3D) subdiffraction-limited resolution of fluorescence-free single-nanoparticles was achieved with wavelength-dependent enhanced dark-field (EDF) …

 
 
 
 
 
 

Fluorescence imaging of chromosomal DNA using click chemistry

 
 

Takumi Ishizuka, Hong Shan Liu, Kenichiro Ito et al.

 
 

Chromosome visualization is essential for chromosome analysis and genetic diagnostics. Here, we developed a click chemistry approach for multicolor imaging of chromosomal DNA …

 
 
 
 
 
 
 
 
Physical Sciences top
 
 
 
 
 
 
 

Room-temperature exciton-polaritons with two-dimensional WS2

 
 

L. C. Flatten, Z. He, D. M. Coles et al.

 
 

Two-dimensional transition metal dichalcogenides exhibit strong optical transitions with significant potential for optoelectronic devices. In particular they are suited for …

 
 
 
 
 
 

High Cycle-life Shape Memory Polymer at High Temperature

 
 

Deyan Kong, Xinli Xiao

 
 

High cycle-life is important for shape memory materials exposed to numerous cycles, and here we report shape memory polyimide that maintained both high shape fixity (Rf) and …

 
 
 
 
 
 

Gain enhanced Fano resonance in a coupled photonic crystal cavity-waveguide structure

 
 

Yanhui Zhao, Chenjiang Qian, Kangsheng Qiu et al.

 
 

Systems with coupled cavities and waveguides have been demonstrated as optical switches and optical sensors. To optimize the functionalities of these optical devices, Fano …

 
 
 
 
 
 

Omnidirectional and broadband absorption enhancement from trapezoidal Mie resonators in semiconductor metasurfaces

 
 

Ragip A. Pala, Serkan Butun, Koray Aydin et al.

 
 

Light trapping in planar ultrathin-film solar cells is limited due to a small number of optical modes available in the thin-film slab. A nanostructured thin-film design could …

 
 
 
 
 
 

Controlling Directionality and Dimensionality of Radiation by Perturbing Separable Bound States in the Continuum

 
 

Nicholas Rivera, Chia Wei Hsu, Bo Zhen et al.

 
 

A bound state in the continuum (BIC) is an unusual localized state that is embedded in a continuum of extended states. Here, we present the general condition for BICs to arise …

 
 
 
 
 
 

X-ray-generated heralded macroscopical quantum entanglement of two nuclear ensembles

 
 

Wen-Te Liao, Christoph H. Keitel, Adriana Pálffy

 
 

Heralded entanglement between macroscopical samples is an important resource for present quantum technology protocols, allowing quantum communication over large distances. In …

 
 
 
 
 
 

Tin doped indium oxide anodes with artificially controlled nano-scale roughness using segregated Ag nanoparticles for organic solar cells

 
 

Hyo-Joong Kim, Eun-Hye Ko, Yong-Jin Noh et al.

 
 

Nano-scale surface roughness in transparent ITO films was artificially formed by sputtering a mixed Ag and ITO layer and wet etching of segregated Ag nanoparticles from the …

 
 
 
 
 
 

Linear biocompatible glyco-polyamidoamines as dual action mode virus infection inhibitors with potential as broad-spectrum microbicides for sexually transmitted diseases

 
 

Nicolò Mauro, Paolo Ferruti, Elisabetta Ranucci et al.

 
 

The initial steps of viral infections are mediated by interactions between viral proteins and cellular receptors. Blocking the latter with high-affinity ligands may inhibit …

 
 
 
 
 
 

Novel Solvent-free Perovskite Deposition in Fabrication of Normal and Inverted Architectures of Perovskite Solar Cells

 
 

Bahram Abdollahi Nejand, Saba Gharibzadeh, Vahid Ahmadi et al.

 
 

We introduced a new approach to deposit perovskite layer with no need for dissolving perovskite precursors. Deposition of Solution-free perovskite (SFP) layer is a key method for …

 
 
 
 
 
 

In Situ Nanopressing: A General Approach to Robust Nanoparticles-Polymer Surface Structures

 
 

Xiaojie Zhang, Junhui He, Binbin Jin

 
 

We report a novel, facile and general approach, in situ nanopressing, to integrate nanoparticles and polymers in a thin film configuration, where both nanoparticles exposure and …

 
 
 
 
 
 

Evidence for Bulk Ripplocations in Layered Solids

 
 

Jacob Gruber, Andrew C. Lang, Justin Griggs et al.

 
 

Plastically anisotropic/layered solids are ubiquitous in nature and understanding how they deform is crucial in geology, nuclear engineering, microelectronics, among other …

 
 
 
 
 
 

Creep to inertia dominated stick-slip behavior in sliding friction modulated by tilted non-uniform loading

 
 

Pengyi Tian, Dashuai Tao, Wei Yin et al.

 
 

Comprehension of stick-slip motion is very important for understanding tribological principles. The transition from creep-dominated to inertia-dominated stick-slip as the …

 
 
 
 
 
 

The Asymmetric Active Coupler: Stable Nonlinear Supermodes and Directed Transport

 
 

Yannis Kominis, Tassos Bountis, Sergej Flach

 
 

We consider the asymmetric active coupler (AAC) consisting of two coupled dissimilar waveguides with gain and loss. We show that under generic conditions, not restricted by …

 
 
 
 
 
 

Hybrid bright-field and hologram imaging of cell dynamics

 
 

Hyeokjun Byeon, Jaehyun Lee, Junsang Doh et al.

 
 

Volumetric observation is essential for understanding the details of complex biological phenomena. In this study, a bright-field microscope, which provides information on a …

 
 
 
 
 
 

Resolution criteria in double-slit microscopic imaging experiments

 
 

Shangting You, Cuifang Kuang, Baile Zhang

 
 

Double-slit imaging is widely used for verifying the resolution of high-resolution and super-resolution microscopies. However, due to the fabrication limits, the slit width is …

 
 
 
 
 
 

Flexible Neural Electrode Array Based-on Porous Graphene for Cortical Microstimulation and Sensing

 
 

Yichen Lu, Hongming Lyu, Andrew G. Richardson et al.

 
 

Neural sensing and stimulation have been the backbone of neuroscience research, brain-machine interfaces and clinical neuromodulation therapies for decades. To-date, most of the …

 
 
 
 
 
 

A mixed solution-processed gate dielectric for zinc-tin oxide thin-film transistor and its MIS capacitance

 
 

Hunho Kim, Young-Jin Kwack, Eui-Jung Yun et al.

 
 

Solution-processed gate dielectrics were fabricated with the combined ZrO2 and Al2O3 (ZAO) in the form of mixed and stacked types for oxide thin film transistors (TFTs). ZAO thin …

 
 
 
 
 
 

Enhanced Crystallization Behaviors of Silicon-Doped Sb2Te Films: Optical Evidences

 
 

Shuang Guo, Liping Xu, Jinzhong Zhang et al.

 
 

The optical properties and structural variations of silicon (Si) doped Sb2Te (SST) films as functions of temperature (210–620 K) and Si concentration (0–33%) have been …

 
 
 
 
 
 

Three-dimensional bulk electronic structure of the Kondo lattice CeIn3 revealed by photoemission

 
 

Yun Zhang, Haiyan Lu, Xiegang Zhu et al.

 
 

We show the three-dimensional electronic structure of the Kondo lattice CeIn3 using soft x-ray angle resolved photoemission spectroscopy in the paramagnetic state. For the first …

 
 
 
 
 
 

Hidden electronic rule in the “cluster-plus-glue-atom” model

 
 

Jinglian Du, Chuang Dong, Roderick Melnik et al.

 
 

Electrons and their interactions are intrinsic factors to affect the structure and properties of materials. Based on the “cluster-cluster-plus-glue-atom” model, an electron …

 
 
 
 
 
 

Extraordinary transmission of gigahertz surface acoustic waves

 
 

Sylvain Mezil, Kazuki Chonan, Paul H. Otsuka et al.

 
 

Extraordinary transmission of waves, i.e. a transmission superior to the amount predicted by geometrical considerations of the aperture alone, has to date only been studied in …

 
 
 
 
 
 

Effect of cation substitution on bridgmanite elasticity: A key to interpret seismic anomalies in the lower mantle

 
 

Hiroshi Fukui, Akira Yoneda, Akihiko Nakatsuka et al.

 
 

Seismological observations show that, in some regions of the lower mantle, an increase in bulk sound velocity, interestingly, occurs in the same volume where there is a decrease …

 
 
 
 
 
 

Structural Analysis of the Hg(II)-Regulatory Protein Tn501 MerR from Pseudomonas aeruginosa

 
 

Dan Wang, Shanqing Huang, Pingying Liu et al.

 
 

The metalloprotein MerR is a mercury(II)-dependent transcriptional repressor-activator that responds to mercury(II) with extraordinary sensitivity and selectivity. It’s widely …

 
 
 
 
 
 

A new insight into the immobilization mechanism of Zn on biochar: the role of anions dissolved from ash

 
 

Tingting Qian, Yujun Wang, Tingting Fan et al.

 
 

Biochar is considered to be a promising material for heavy metal immobilization in soil. However, the immobilization mechanisms of Zn2+ on biochars derived from many common waste …

 
 
 
 
 
 

Hierarchical nanoporosity enhanced reversible capacity of bicontinuous nanoporous metal based Li-O2 battery

 
 

Xianwei Guo, Jiuhui Han, Pan Liu et al.

 
 

High-energy-density rechargeable Li-O2 batteries are one of few candidates that can meet the demands of electric drive vehicles and other high-energy applications because of the …

 
 
 
 
 
 

Single-Molecule Imaging Reveals the Activation Dynamics of Intracellular Protein Smad3 on Cell Membrane

 
 

Nan Li, Yong Yang, Kangmin He et al.

 
 

Smad3 is an intracellular protein that plays a key role in propagating transforming growth factor β (TGF-β) signals from cell membrane to nucleus. However whether the transient …

 
 
 
 
 
 

Estimating the palliative effect of percutaneous endoscopic gastrostomy in an observational registry using principal stratification and generalized propensity scores

 
 

Pallavi S. Mishra-Kalyani, Brent A. Johnson, Jonathan D. Glass et al.

 
 

Clinical disease registries offer a rich collection of valuable patient information but also pose challenges that require special care and attention in statistical analyses. The …

 
 
 
 
 
 

Förster resonance energy transfer and protein-induced fluorescence enhancement as synergetic multi-scale molecular rulers

 
 

Evelyn Ploetz, Eitan Lerner, Florence Husada et al.

 
 

Advanced microscopy methods allow obtaining information on (dynamic) conformational changes in biomolecules via measuring a single molecular distance in the structure. It is, …

 
 
 
 
 
 

A combination hepatoma-targeted therapy based on nanotechnology: pHRE-Egr1-HSV-TK/131I-antiAFPMcAb-GCV/MFH

 
 

Mei Lin, Junxing Huang, Xingmao Jiang et al.

 
 

Combination targeted therapy is a promising cancer therapeutic strategy. Here, using PEI-Mn0.5Zn0.5Fe2O4 nanoparticles (PEI-MZF-NPs) as magnetic media for MFH (magnetic fluid …

 
 
 
 
 
 

Superfluidity enhanced by spin-flip tunnelling in the presence of a magnetic field

 
 

Jun-Hui Zheng, Daw-Wei Wang, Gediminas Juzeliūnas

 
 

It is well-known that when the magnetic field is stronger than a critical value, the spin imbalance can break the Cooper pairs of electrons and hence hinder the superconductivity …

 
 
 
 
 
 

Experimental Trapped-ion Quantum Simulation of the Kibble-Zurek dynamics in momentum space

 
 

Jin-Ming Cui, Yun-Feng Huang, Zhao Wang et al.

 
 

The Kibble-Zurek mechanism is the paradigm to account for the nonadiabatic dynamics of a system across a continuous phase transition. Its study in the quantum regime is hindered …

 
 
 
 
 
 

Viscoelastic properties and efficient acoustic damping in confined polymer nano-layers at GHz frequencies

 
 

Mike Hettich, Karl Jacob, Oliver Ristow et al.

 
 

We investigate the viscoelastic properties of confined molecular nano-layers by time resolved optical pump-probe measurements. Access to the elastic properties is provided by the …

 
 
 
 
 
 

Amino-Fe3O4 Microspheres Directed Synthesis of a Series of Polyaniline Hierarchical Nanostructures with Different Wettability

 
 

Yong Ma, Yanhui Chen, Chunping Hou et al.

 
 

We demonstrated polyaniline (PANI) dimensional transformation by adding trace amino-Fe3O4 microspheres to aniline polymerization. Different PANI nanostructures (i.e., flowers, …

 
 
 
 
 
 

Molecularly Engineered Organic-Inorganic Hybrid Perovskite with Multiple Quantum Well Structure for Multicolored Light-Emitting Diodes

 
 

Hongwei Hu, Teddy Salim, Bingbing Chen et al.

 
 

Organic-inorganic hybrid perovskites have the potential to be used as a new class of emitters with tunable emission, high color purity and good ease of fabrication. Recent …

 
 
 
 
 
 

External cavity-quantum cascade laser infrared spectroscopy for secondary structure analysis of proteins at low concentrations

 
 

Andreas Schwaighofer, Mirta R. Alcaráz, Can Araman et al.

 
 

Fourier transform infrared (FTIR) and circular dichroism (CD) spectroscopy are analytical techniques employed for the analysis of protein secondary structure. The use of CD …

 
 
 
 
 
 

Nitroaromatic explosives detection using electrochemically exfoliated graphene

 
 

Ying Teng Yew, Adriano Ambrosi, Martin Pumera

 
 

Detection of nitroaromatic explosives is of paramount importance from security point of view. Graphene sheets obtained from the electrochemical anodic exfoliation of graphite …

 
 
 
 
 
 

High speed e-beam writing for large area photonic nanostructures — a choice of parameters

 
 

Kezheng Li, Juntao Li, Christopher Reardon et al.

 
 

Photonic nanostructures are used for many optical systems and applications. However, some high-end applications require the use of electron-beam lithography (EBL) to generate …

 
 
 
 
 
 

Superconducting ferecrystals: turbostratically disordered atomic-scale layered (PbSe)1.14(NbSe2)n thin films

 
 

Corinna Grosse, Matti B. Alemayehu, Matthias Falmbigl et al.

 
 

Hybrid electronic heterostructure films of semi- and superconducting layers possess very different properties from their bulk counterparts. Here, we demonstrate superconductivity …

 
 
 
 
 
 

Mechanisms Responsible for the Large Piezoelectricity at the Tetragonal-Orthorhombic Phase Boundary of (1-x)BaZr0.2Ti0.8O3-xBa0.7Ca0.3TiO3 System

 
 

Tao Yang, Xiaoqin Ke, Yunzhi Wang

 
 

Recently it was found that in the lead-free (1-x)BaZr0.2Ti0.8O3-xBa0.7Ca0.3TiO3 (BZT-xBCT) system, the highest piezoelectric d33 coefficient appears at the tetragonal (T) – …

 
 
 
 
 
 

Memory-effect based deconvolution microscopy for super-resolution imaging through scattering media

 
 

Eitan Edrei, Giuliano Scarcelli

 
 

High-resolution imaging through turbid media is a fundamental challenge of optical sciences that has attracted a lot of attention in recent years for its wide range of potential …

 
 
 
 
 
 

Direct theoretical evidence for weaker correlations in electron-doped and Hg-based hole-doped cuprates

 
 

Seung Woo Jang, Hirofumi Sakakibara, Hiori Kino et al.

 
 

Many important questions for high-Tc cuprates are closely related to the insulating nature of parent compounds. While there has been intensive discussion on this issue, all …

 
 
 
 
 
 

Encoded diffractive optics for full-spectrum computational imaging

 
 

Felix Heide, Qiang Fu, Yifan Peng et al.

 
 

Diffractive optical elements can be realized as ultra-thin plates that offer significantly reduced footprint and weight compared to refractive elements. However, such elements …

 
 
 
 
 
 

Observation of re-entrant spin reorientation in TbFe1−xMnxO3

 
 

Yifei Fang, Ya Yang, Xinzhi Liu et al.

 
 

We report a spin reorientation from Γ4(Gx, Ay, Fz) to Γ1(Ax, Gy, Cz) magnetic configuration near room temperature and a re-entrant transition from Γ1(Ax, Gy, Cz) to Γ4(Gx, Ay, Fz

 
 
 
 
 
 

Lateral photovoltaic effect in flexible free-standing reduced graphene oxide film for self-powered position-sensitive detection

 
 

In Kyu Moon, Bugeun Ki, Seonno Yoon et al.

 
 

Lightweight, simple and flexible self-powered photodetectors are urgently required for the development and application of advanced optical systems for the future of wearable …

 
 
 
 
 
 

The hidden hyperbolic geometry of international trade: World Trade Atlas 1870–2013

 
 

Guillermo García-Pérez, Marián Boguñá, Antoine Allard et al.

 
 

Here, we present the World Trade Atlas 1870–2013, a collection of annual world trade maps in which distance combines economic size and the different dimensions that affect …

 
 
 
 
 
 

An Object-Independent ENZ Metamaterial-Based Wideband Electromagnetic Cloak

 
 

Sikder Sunbeam Islam, Mohammad Rashed Iqbal Faruque, Mohammad Tariqul Islam

 
 

A new, metamaterial-based electromagnetic cloaking operation is proposed in this study. The metamaterial exhibits a sharp transmittance in the C-band of the microwave spectrum …

 
 
 
 
 
 

Enhanced dielectric properties of poly(vinylidene fluoride) composites filled with nano iron oxide-deposited barium titanate hybrid particles

 
 

Changhai Zhang, Qingguo Chi, Jiufeng Dong et al.

 
 

We report enhancement of the dielectric permittivity of poly(vinylidene fluoride) (PVDF) generated by depositing magnetic iron oxide (Fe3O4) nanoparticles on the surface of …

 
 
 
 
 
 

Retraction: Development of Alendronate-conjugated Poly (lactic-co-glycolic acid)-Dextran Nanoparticles for Active Targeting of Cisplatin in Osteosarcoma

 
 

Ping Liu, Liang Sun, Dong-sheng Zhou et al.

 
 

 
 
 
 
 
 

Highly efficient removal of lead and cadmium during wastewater irrigation using a polyethylenimine-grafted gelatin sponge

 
 

Bingbing Li, Feng Zhou, Kai Huang et al.

 
 

Wastewater irrigation is a very important resource for heavy metal pollution in soil and then accumulation in vegetable crops. In this study, a polyethylenimine (PEI)-grafted …

 
 
 
 
 
 

Pulsed Electromagnetic Field Assisted in vitro Electroporation: A Pilot Study

 
 

Vitalij Novickij, Audrius Grainys, Eglė Lastauskienė et al.

 
 

Electroporation is a phenomenon occurring due to exposure of cells to Pulsed Electric Fields (PEF) which leads to increase of membrane permeability. Electroporation is used in …

 
 
 
 
 
 

Ultrasensitive and low-volume point-of-care diagnostics on flexible strips – a study with cardiac troponin biomarkers

 
 

Nandhinee Radha Shanmugam, Sriram Muthukumar, Shalini Prasad

 
 

We demonstrate a flexible, mechanically stable, and disposable electrochemical sensor platform for monitoring cardiac troponins through the detection and quantification of …

 
 
 
 
 
 

Potential of in vivo real-time gastric gas profiling: a pilot evaluation of heat-stress and modulating dietary cinnamon effect in an animal model

 
 

Jian Zhen Ou, Jeremy J. Cottrell, Nam Ha et al.

 
 

Gastroenterologists are still unable to differentiate between some of the most ordinary disorders of the gut and consequently patients are misdiagnosed. We have developed a …

 
 
 
 
 
 

Saddle point localization of molecular wavefunctions

 
 

Georg Ch. Mellau, Alexandra A. Kyuberis, Oleg L. Polyansky et al.

 
 

The quantum mechanical description of isomerization is based on bound eigenstates of the molecular potential energy surface. For the near-minimum regions there is a …

 
 
 
 
 
 

Time-dependent effects of ultraviolet and nonthermal atmospheric pressure plasma on the biological activity of titanium

 
 

Sung-Hwan Choi, Won-Seok Jeong, Jung-Yul Cha et al.

 
 

Here, we evaluated time-dependent changes in the effects of ultraviolet (UV) and nonthermal atmospheric pressure plasma (NTAPPJ) on the biological activity of titanium compared …

 
 
 
 
 
 

Study of the effect of excited state concentration on photodegradation of the p3ht polymer

 
 

V. N. Peters, Rohan Alexander, D’Angelo A. Peters et al.

 
 

We have studied photoinduced reduction of absorption and emission in p3ht, a semiconducting polymer, and found that the rate of photodegradation (destruction of the constituent …

 
 
 
 
 
 

Flat-Lens Focusing of Electron Beams in Graphene

 
 

Yang Tang, Xiyuan Cao, Ran Guo et al.

 
 

Coupling electron beams carrying information into electronic units is fundamental in microelectronics. This requires precision manipulation of electron beams through a coupler …

 
 
 
 
 
 

Methane storage in nanoporous material at supercritical temperature over a wide range of pressures

 
 

Keliu Wu, Zhangxin Chen, Xiangfang Li et al.

 
 

The methane storage behavior in nanoporous material is significantly different from that of a bulk phase, and has a fundamental role in methane extraction from shale and its …

 
 
 
 
 
 

Eddy, drift wave and zonal flow dynamics in a linear magnetized plasma

 
 

H. Arakawa, S. Inagaki, M. Sasaki et al.

 
 

Turbulence and its structure formation are universal in neutral fluids and in plasmas. Turbulence annihilates global structures but can organize flows and eddies. The …

 
 
 
 
 
 

Experimental Realization of Tunable Metamaterial Hyper-transmitter

 
 

Young Joon Yoo, Changhyun Yi, Ji Sub Hwang et al.

 
 

We realized the tunable metamaterial hyper-transmitter in the microwave range utilizing simple planar meta-structure. The single-layer metamaterial hyper-transmitter shows that …

 
 
 
 
 
 

Superconductor to Mott insulator transition in YBa2Cu3O7/LaCaMnO3 heterostructures

 
 

B. A. Gray, S. Middey, G. Conti et al.

 
 

The superconductor-to-insulator transition (SIT) induced by means such as external magnetic fields, disorder or spatial confinement is a vivid illustration of a quantum phase …

 
 
 
 
 
 

Decoupling the refractive index from the electrical properties of transparent conducting oxides via periodic superlattices

 
 

David Caffrey, Emma Norton, Cormac Ó Coileáin et al.

 
 

We demonstrate an alternative approach to tuning the refractive index of materials. Current methodologies for tuning the refractive index of a material often result in …

 
 
 
 
 
 

Efficient Radiation by Electrically Small Antennas made of Coupled Split-ring Resonators

 
 

Liang Peng, Peiwei Chen, Aiting Wu et al.

 
 

In this paper, coupled split-ring resonators (SRRs) are used to construct the electrically small antennas. We show that through strong magnetic coupling, the coupled SRRs …

 
 
 
 
 
 

Solar-rechargeable battery based on photoelectrochemical water oxidation: Solar water battery

 
 

Gonu Kim, Misol Oh, Yiseul Park

 
 

As an alternative to the photoelectrochemical water splitting for use in the fuel cells used to generate electrical power, this study set out to develop a solar energy …

 
 
 
 
 
 

Giant Two-photon Absorption in Circular Graphene Quantum Dots in Infrared Region

 
 

Xiaobo Feng, Zhisong Li, Xin Li et al.

 
 

We investigate theoretically the two-photon absorption (TPA) for circular graphene quantum dots (GQDs) with the edge of armchair and zigzag on the basis of electronic energy …

 
 
 
 
 
 

Near-Field and Far-Field Directional Conversion of Spoof Surface Plasmon Polaritons

 
 

Heng-He Tang, Yunhua Tan, Pu-Kun Liu

 
 

A compact metallic meta-structure is proposed to realize directional conversion between spoof surface plasmon polaritons (SSPPs) and propagating waves at millimeter wave and THz …

 
 
 
 
 
 

Micro-bubble emission boiling with the cavitation bubble blow pit

 
 

Shigeaki Inada, Kazuaki Shinagawa, Suhaimi Bin Illias et al.

 
 

The miniaturization boiling (micro-bubble emission boiling [MEB]) phenomenon, with a high heat removal capacity that contributes considerably to the cooling of the divertor of …

 
 
 
 
 
 

A novel insight into membrane fouling mechanism regarding gel layer filtration: Flory-Huggins based filtration mechanism

 
 

Qian Lei, Meijia Zhang, Liguo Shen et al.

 
 

This study linked the chemical potential change to high specific filtration resistance (SFR) of gel layer, and then proposed a novel membrane fouling mechanism regarding gel …

 
 
 
 
 
 

High steady-state column density of I(2P3/2) atoms from I2 photodissociation at 532 nm: Towards parity non-conservation measurements

 
 

G. E. Katsoprinakis, G. Chatzidrosos, J. A. Kypriotakis et al.

 
 

Steady-state column densities of 1017 cm−2 of I(2P3/2) atoms are produced from photodissociation of I2 vapour at 290.5 K using 5 W of 532 nm laser light. Recombination of the I(2P

 
 
 
 
 
 

Building better lithium-sulfur batteries: from LiNO3 to solid oxide catalyst

 
 

Ning Ding, Lan Zhou, Changwei Zhou et al.

 
 

Lithium nitrate (LiNO3) is known as an important electrolyte additive in lithium-sulfur (Li-S) batteries. The prevailing understanding is that LiNO3 reacts with metallic lithium …

 
 
 
 
 
 

Synergistic effect of tartaric acid with 2,6-diaminopyridine on the corrosion inhibition of mild steel in 0.5 M HCl

 
 

Yujie Qiang, Lei Guo, Shengtao Zhang et al.

 
 

The inhibitive ability of 2,6-diaminopyridine, tartaric acid and their synergistic effect towards mild steel corrosion in 0.5 M HCl solution was evaluated at various …

 
 
 
 
 
 

Palladium-catalyzed direct arylation and cyclization of o-iodobiaryls to a library of tetraphenylenes

 
 

Chendan Zhu, Yue Zhao, Di Wang et al.

 
 

Aryl–aryl bond formation constitutes one of the most important subjects in organic synthesis. The recent developments in direct arylation reactions forming aryl–aryl bond have …

 
 
 
 
 
 

Absence of localization in disordered two-dimensional electron gas at weak magnetic field and strong spin-orbit coupling

 
 

Ying Su, C. Wang, Y. Avishai et al.

 
 

The one-parameter scaling theory of localization predicts that all states in a disordered two-dimensional system with broken time reversal symmetry are localized even in the …

 
 
 
 
 
 

Dielectric relaxation and pinning phenomenon of (Sr,Pb)TiO3 ceramics for dielectric tunable device application

 
 

Xian-Xiong Huang, Tian-Fu Zhang, Xin-Gui Tang et al.

 
 

The behavior of ferroelectric domain under applied electric field is very sensitive to point defects, which can lead to high temperature dielectric relaxation behaviors. In this …

 
 
 
 
 
 

Atomic and electronic structure of trilayer graphene/SiC(0001): Evidence of Strong Dependence on Stacking Sequence and charge transfer

 
 

Debora Pierucci, Thomas Brumme, Jean-Christophe Girard et al.

 
 

The transport properties of few-layer graphene are the directly result of a peculiar band structure near the Dirac point. Here, for epitaxial graphene grown on SiC, we determine …

 
 
 
 
 
 

The Lattice Kinetic Monte Carlo Simulation of Atomic Diffusion and Structural Transition for Gold

 
 

Xiang He, Feng Cheng, Zhao-Xu Chen

 
 

For the kinetic simulation of metal nanoparticles, we developed a self-consistent coordination-averaged energies for Au atoms based on energy properties of gold bulk phases. The …

 
 
 
 
 
 

Diverse ruthenium nitrides stabilized under pressure: a theoretical prediction

 
 

Yunkun Zhang, Lailei Wu, Biao Wan et al.

 
 

First-principles calculations were performed to understand the structural stability, synthesis routes, mechanical and electronic properties of diverse ruthenium nitrides. RuN …

 
 
 
 
 
 

Blue-green tunable color of Ce3+/Tb3+ coactivated NaBa3La3Si6O20 phosphor via energy transfer

 
 

Zhen Jia, Mingjun Xia

 
 

A series of color tunable phosphors NaBa3La3Si6O20:Ce3+, Tb3+ were synthesized via the high-temperature solid-state method. NaBa3La3Si6O20 crystallizes in noncentrosymmetric …

 
 
 
 
 
 

Addition of P3HT-grafted Silica nanoparticles improves bulk-heterojunction morphology in P3HT-PCBM blends

 
 

Mohit Garg, Venkat Padmanabhan

 
 

We present molecular dynamics simulations of a ternary blend of P3HT, PCBM and P3HT-grafted silica nanoparticles (SiNP) for applications in polymer-based solar cells. Using …

 
 
 
 
 
 

Charge transport mechanism in lead oxide revealed by CELIV technique

 
 

O. Semeniuk, G. Juska, J.-O. Oelerich et al.

 
 

Although polycrystalline lead oxide (PbO) belongs to the most promising photoconductors for optoelectronic and large area detectors applications, the charge transport mechanism …

 
 
 
 
 
 

Controllable quantum dynamics of inhomogeneous nitrogen-vacancy center ensembles coupled to superconducting resonators

 
 

Wan-lu Song, Wan-li Yang, Zhang-qi Yin et al.

 
 

We explore controllable quantum dynamics of a hybrid system, which consists of an array of mutually coupled superconducting resonators (SRs) with each containing a …

 
 
 
 
 
 

Engineering optical mode ferromagnetic resonance in FeCoB films with ultrathin Ru insertion

 
 

Shandong Li, Cuiling Wang, Xian-Ming Chu et al.

 
 

Ferromagnetic resonance (FMR) in soft magnetic films (SMFs) to a large extent determines the maximum working frequency of magnetic devices. The FMR frequency (fr) in an optical …

 
 
 
 
 
 

Simulation Study of CO2-EOR in Tight Oil Reservoirs with Complex Fracture Geometries

 
 

Pavel Zuloaga-Molero, Wei Yu, Yifei Xu et al.

 
 

The recent development of tight oil reservoirs has led to an increase in oil production in the past several years due to the progress in horizontal drilling and hydraulic …

 
 
 
 
 
 

Multifunctional 3D printing of heterogeneous hydrogel structures

 
 

Ali Nadernezhad, Navid Khani, Gözde Akdeniz Skvortsov et al.

 
 

Multimaterial additive manufacturing or three-dimensional (3D) printing of hydrogel structures provides the opportunity to engineer geometrically dependent functionalities. …

 
 
 
 
 
 

Incorporation of Eu(III) into Calcite under Recrystallization conditions

 
 

S. E. Hellebrandt, S. Hofmann, N. Jordan et al.

 
 

The interaction of calcite with trivalent europium under recrystallization conditions was studied on the molecular level using site-selective time-resolved laser fluorescence …

 
 
 
 
 
 

Super flame-retardant lightweight rime-like carbon-phenolic nanofoam

 
 

Haiming Cheng, Changqing Hong, Xinghong Zhang et al.

 
 

The desire for lightweight nanoporous materials with high-performance thermal insulation and efficient anti-ablation resistance for energy conservation and thermal …

 
 
 
 
 
 

Oncogenic Mutations Differentially Affect Bax Monomer, Dimer, and Oligomeric Pore Formation in the Membrane

 
 

Mingzhen Zhang, Jie Zheng, Ruth Nussinov et al.

 
 

Dysfunction of Bax, a pro-apoptotic regulator of cellular metabolism is implicated in neurodegenerative diseases and cancer. We have constructed the first atomistic models of the …

 
 
 
 
 
 

The electron donating capacity of biochar is dramatically underestimated

 
 

Antonin Prévoteau, Frederik Ronsse, Inés Cid et al.

 
 

Biochars have gathered considerable interest for agronomic and engineering applications. In addition to their high sorption ability, biochars have been shown to accept or donate …

 
 
 
 
 
 

Focused Ultrasound-Induced Blood-Brain Barrier Opening: Association with Mechanical Index and Cavitation Index Analyzed by Dynamic Contrast-Enhanced Magnetic-Resonance Imaging

 
 

Po-Chun Chu, Wen-Yen Chai, Chih-Hung Tsai et al.

 
 

Focused ultrasound (FUS) with microbubbles can temporally open the blood-brain barrier (BBB), and the cavitation activities of microbubbles play a key role in the BBB-opening …

 
 
 
 
 
 

Comprehensive approach for predicting toxicological effects of ionic liquids on several biological systems using unified descriptors

 
 

Chul-Woong Cho, Stefan Stolte, Yeoung-Sang Yun

 
 

The challenge and opportunity for design of environmentally-benign ionic liquids (ILs) would start from prediction of their toxicological effects on several endpoints solely …

 
 
 
 
 
 

Light-tunable Fano resonance in metal-dielectric multilayer structures

 
 

S. Hayashi, D. V. Nesterenko, A. Rahmouni et al.

 
 

High-Q optical Fano resonances realized in a variety of plasmonic nanostructures and metamaterials are very much promising for the development of new potent photonic devices, …

 
 
 
 
 
 

Topological phase transition and quantum spin Hall edge states of antimony few layers

 
 

Sung Hwan Kim, Kyung-Hwan Jin, Joonbum Park et al.

 
 

While two-dimensional (2D) topological insulators (TI’s) initiated the field of topological materials, only very few materials were discovered to date and the direct access to …

 
 
 
 
 
 

Corrigendum: Ultra-low Thermal Conductivity in Si/Ge Hierarchical Superlattice Nanowire

 
 

Xin Mu, Lili Wang, Xueming Yang et al.

 
 

 
 
 
 
 
 

Flash (Ultra-Rapid) Spark-Plasma Sintering of Silicon Carbide

 
 

Eugene A. Olevsky, Stephen M. Rolfing, Andrey L. Maximenko

 
 

A new ultra-rapid process of flash spark plasma sintering is developed. The idea of flash spark plasma sintering (or flash hot pressing - FHP) stems from the conducted …

 
 
 
 
 
 

Mesoporous Non-stacked Graphene-receptor Sensor for Detecting Nerve Agents

 
 

Hee Min Hwang, Eunhee Hwang, Doyoung Kim et al.

 
 

A novel gas sensor consisting of porous, non-stacked reduced graphene oxide (NSrGO)-heaxfluorohydoroxypropanyl benzene (HFHPB) nanosheets was successfully fabricated, allowing …

 
 
 
 
 
 

Topological band-order transition and quantum spin Hall edge engineering in functionalized X-Bi(111) (X = Ga, In, and Tl) bilayer

 
 

Youngjae Kim, Won Seok Yun, J. D. Lee

 
 

Functionalized X-Bi bilayers (X = Ga, In, and Tl) with halogens bonded on their both sides have been recently claimed to be the giant topological insulators due to the strong …

 
 
 
 
 
 

Enhanced Amplification and Fan-Out Operation in an All-Magnetic Transistor

 
 

Saswati Barman, Susmita Saha, Sucheta Mondal et al.

 
 

Development of all-magnetic transistor with favorable properties is an important step towards a new paradigm of all-magnetic computation. Recently, we showed such possibility in …

 
 
 
 
 
 

Emergence of event cascades in inhomogeneous networks

 
 

Tomokatsu Onaga, Shigeru Shinomoto

 
 

There is a commonality among contagious diseases, tweets, and neuronal firings that past events facilitate the future occurrence of events. The spread of events has been …

 
 
 
 
 
 

Ultra-strong and damage tolerant metallic bulk materials: A lesson from nanostructured pearlitic steel wires

 
 

A. Hohenwarter, B. Völker, M. W. Kapp et al.

 
 

Structural materials used for safety critical applications require high strength and simultaneously high resistance against crack growth, referred to as damage tolerance. …

 
 
 
 
 
 

Optical thermometry based on level anticrossing in silicon carbide

 
 

A. N. Anisimov, D. Simin, V. A. Soltamov et al.

 
 

We report a giant thermal shift of 2.1 MHz/K related to the excited-state zero-field splitting in the silicon vacancy centers in 4H silicon carbide. It is obtained from the …

 
 
 
 
 
 

Folding to Curved Surfaces: A Generalized Design Method and Mechanics of Origami-based Cylindrical Structures

 
 

Fei Wang, Haoran Gong, Xi Chen et al.

 
 

Origami structures enrich the field of mechanical metamaterials with the ability to convert morphologically and systematically between two-dimensional (2D) thin sheets and …

 
 
 
 
 
 

Robust entanglement between a movable mirror and atomic ensemble and entanglement transfer in coupled optomechanical system

 
 

Cheng-Hua Bai, Dong-Yang Wang, Hong-Fu Wang et al.

 
 

We propose a scheme for the creation of robust entanglement between a movable mirror and atomic ensemble at the macroscopic level in coupled optomechanical system. We numerically …

 
 
 
 
 
 

Generation of self-clusters of galectin-1 in the farnesyl-bound form

 
 

Kazumi Yamaguchi, Yusuke Niwa, Takakazu Nakabayashi et al.

 
 

Ras protein is involved in a signal transduction cascade in cell growth, and cluster formation of H-Ras and human galectin-1 (Gal-1) complex is considered to be crucial to …

 
 
 
 
 
 

Two-Dimensional Fluorescence Difference Spectroscopy to Characterize Nanoparticles and their Interactions

 
 

Miranda N. Hurst, Robert K. DeLong

 
 

Two dimensional fluorescence difference spectroscopy (2D FDS) detects nanoparticle interactions following surface functionalization and biomolecule loading by generating a …

 
 
 
 
 
 

Isogyres – Manifestation of Spin-orbit interaction in uniaxial crystal: A closed-fringe Fourier analysis of conoscopic interference

 
 

C. T. Samlan, Dinesh N. Naik, Nirmal K. Viswanathan

 
 

Discovered in 1813, the conoscopic interference pattern observed due to light propagating through a crystal, kept between crossed polarizers, shows isochromates and isogyres, …

 
 
 
 
 
 

Multipolar, time-dynamical model for the loss compensation and lasing of a spherical plasmonic nanoparticle spaser immersed in an active gain medium

 
 

Alessandro Veltri, Arkadi Chipouline, Ashod Aradian

 
 

The plasmonic response of a metal nanoparticle in the presence of surrounding gain elements is studied, using a space and time-dependent model, which integrates a quantum …

 
 
 
 
 
 

Application of Species Distribution Modeling for Avian Influenza surveillance in the United States considering the North America Migratory Flyways

 
 

Jaber Belkhiria, Moh A. Alkhamis, Beatriz Martínez-López

 
 

Highly Pathogenic Avian Influenza (HPAI) has recently (2014–2015) re-emerged in the United States (US) causing the largest outbreak in US history with 232 outbreaks and an …

 
 
 
 
 
 

Doped Graphene for DNA Analysis: the Electrochemical Signal is Strongly Influenced by the Kind of Dopant and the Nucleobase Structure

 
 

Huidi Tian, Lu Wang, Zdenek Sofer et al.

 
 

Doping graphene with heteroatoms can alter the electronic and electrochemical properties of the starting material. Contrasting properties should be expected when the doping is …

 
 
 
 
 
 

Acetazolamide Mitigates Astrocyte Cellular Edema Following Mild Traumatic Brain Injury

 
 

Nasya M. Sturdivant, Sean G. Smith, Syed F. Ali et al.

 
 

Non-penetrating or mild traumatic brain injury (mTBI) is commonly experienced in accidents, the battlefield and in full-contact sports. Astrocyte cellular edema is one of the …

 
 
 
 
 
 

Residue Geometry Networks: A Rigidity-Based Approach to the Amino Acid Network and Evolutionary Rate Analysis

 
 

Alexander S. Fokas, Daniel J. Cole, Sebastian E. Ahnert et al.

 
 

Amino acid networks (AANs) abstract the protein structure by recording the amino acid contacts and can provide insight into protein function. Herein, we describe a novel AAN …

 
 
 
 
 
 

Mechanistic Modelling of DNA Repair and Cellular Survival Following Radiation-Induced DNA Damage

 
 

Stephen J. McMahon, Jan Schuemann, Harald Paganetti et al.

 
 

Characterising and predicting the effects of ionising radiation on cells remains challenging, with the lack of robust models of the underlying mechanism of radiation responses …

 
 
 
 
 
 

Creation of an anti-imaging system using binary optics

 
 

Haifeng Wang, Jian Lin, Dawei Zhang et al.

 
 

We present a concealing method in which an anti-point spread function (APSF) is generated using binary optics, which produces a large-scale dark area in the focal region that can …

 
 
 
 
 
 

Morphology and Electric Conductance Change Induced by Voltage Pulse Excitation in (GeTe)2/Sb2Te3 Superlattices

 
 

Leonid Bolotov, Yuta Saito, Tetsuya Tada et al.

 
 

Chalcogenide superlattice (SL) phase-change memory materials are leading candidates for non-volatile, energy-efficient electric memory where the electric conductance switching is …

 
 
 
 
 
 

Precise Characterisation of Molecular Orientation in a Single Crystal Field-Effect Transistor Using Polarised Raman Spectroscopy

 
 

Sebastian Wood, Grigorios-Panagiotis Rigas, Alina Zoladek-Lemanczyk et al.

 
 

Charge transport in organic semiconductors is strongly dependent on the molecular orientation and packing, such that manipulation of this molecular packing is a proven technique …

 
 
 
 
 
 

Aspect-ratio driven evolution of high-order resonant modes and near-field distributions in localized surface phonon polariton nanostructures

 
 

Chase T. Ellis, Joseph G. Tischler, Orest J. Glembocki et al.

 
 

Polar dielectrics have garnered much attention as an alternative to plasmonic metals in the mid- to long-wave infrared spectral regime due to their low optical losses. As such, …

 
 
 
 
 
 

Near-field focus steering along arbitrary trajectory via multi-lined distributed nanoslits

 
 

Gun-Yeal Lee, Seung-Yeol Lee, Hansik Yun et al.

 
 

The modulation of near-field signals has recently attracted considerable interest because of demands for the development of nano-scale optical devices that are capable of …

 
 
 
 
 
 

From Biological Cilia to Artificial Flow Sensors: Biomimetic Soft Polymer Nanosensors with High Sensing Performance

 
 

Mohsen Asadnia, Ajay Giri Prakash Kottapalli, K. Domenica Karavitaki et al.

 
 

We report the development of a new class of miniature all-polymer flow sensors that closely mimic the intricate morphology of the mechanosensory ciliary bundles in biological …

 
 
 
 
 
 

Reproducible Ultrahigh SERS Enhancement in Single Deterministic Hotspots Using Nanosphere-Plane Antennas Under Radially Polarized Excitation

 
 

Jing Long, Hui Yi, Hongquan Li et al.

 
 

Surface enhanced Raman scattering (SERS) in a nanometer size hotspot has empowered the investigation of chemical structures and dynamic behaviors of one and a few molecules. …

 
 
 
 
 
 

Facile synthesis of pristine graphene-palladium nanocomposites with extraordinary catalytic activities using swollen liquid crystals

 
 

T. Vats, S. Dutt, R. Kumar et al.

 
 

Amazing conductivity, perfect honeycomb sp2 arrangement and the high theoretical surface area make pristine graphene as one of the best materials suited for application as …

 
 
 
 
 
 

Emission wavelength tuning of fluorescence by fine structural control of optical metamaterials with Fano resonance

 
 

Y. Moritake, Y. Kanamori, K. Hane

 
 

We demonstrated fine emission wavelength tuning of quantum dot (QD) fluorescence by fine structural control of optical metamaterials with Fano resonance. An asymmetric-double-bar …

 
 
 
 
 
 

Trp53 deficient mice predisposed to preterm birth display region-specific lipid alterations at the embryo implantation site

 
 

Ingela Lanekoff, Jeeyeon Cha, Jennifer E. Kyle et al.

 
 

Here we demonstrate that conditional deletion of mouse uterine Trp53 (p53d/d), molecularly linked to mTORC1 activation and causally linked to premature uterine senescence and …

 
 
 
 
 
 

Two-dimensional artificial light-harvesting antennae with predesigned high-order structure and robust photosensitising activity

 
 

Xiao Feng, Xuesong Ding, Long Chen et al.

 
 

Highly ordered discrete assemblies of chlorophylls that are found in natural light-harvesting antennae are key to photosynthesis, which converts light energy to chemical energy …

 
 
 
 
 
 

Light effect on Click reaction: Role of photonic quantum dot catalyst

 
 

Debkumar Nandi, Abu Taher, Rafique Ul Islam et al.

 
 

Due to the light excitation, the valence band electron of the copper (I) sulfide quantum dot transfer to the conduction band and act as a scavenger of the terminal proton of the …

 
 
 
 
 
 

One-Step Synthesis of Pt/Graphene Composites from Pt Acid Dissolved Ethanol via Microwave Plasma Spray Pyrolysis

 
 

Eun Hee Jo, Hankwon Chang, Sun Kyung Kim et al.

 
 

Pt nanoparticles-laden graphene (Pt/GR) composites were synthesized in the gas phase from a mixture of ethanol and Pt precursor by microwave plasma spray pyrolysis. The …

 
 
 
 
 
 

Optimized holographic femtosecond laser patterning method towards rapid integration of high-quality functional devices in microchannels

 
 

Chenchu Zhang, Yanlei Hu, Wenqiang Du et al.

 
 

Rapid integration of high-quality functional devices in microchannels is in highly demand for miniature lab-on-a-chip applications. This paper demonstrates the embellishment of …

 
 
 
 
 
 

Augmented 3D super-resolution of fluorescence-free nanoparticles using enhanced dark-field illumination based on wavelength-modulation and a least-cubic algorithm

 
 

Peng Zhang, Kyungsoo Kim, Seungah Lee et al.

 
 

Augmented three-dimensional (3D) subdiffraction-limited resolution of fluorescence-free single-nanoparticles was achieved with wavelength-dependent enhanced dark-field (EDF) …

 
 
 
 
 
 

Nanoscale Chemical and Electrical Stabilities of Graphene-covered Silver Nanowire Networks for Transparent Conducting Electrodes

 
 

Seong Heon Kim, Woon Ih Choi, Kwang Hee Kim et al.

 
 

The hybrid structure of Ag nanowires (AgNWs) covered with graphene (Gr) shows synergetic effects on the performance of transparent conducting electrodes (TCEs). However, these …

 
 
 
 
 
 

Discriminating Bio-aerosols from Non-Bio-aerosols in Real-Time by Pump-Probe Spectroscopy

 
 

Gustavo Sousa, Geoffrey Gaulier, Luigi Bonacina et al.

 
 

The optical identification of bioaerosols in the atmosphere and its discrimination against combustion related particles is a major issue for real-time, field compatible …

 
 
 
 
 
 

Failure mechanism of monolayer graphene under hypervelocity impact of spherical projectile

 
 

Kang Xia, Haifei Zhan, De’an Hu et al.

 
 

The excellent mechanical properties of graphene have enabled it as appealing candidate in the field of impact protection or protective shield. By considering a monolayer graphene …

 
 
 
 
 
 

Heptagraphene: Tunable Dirac Cones in a Graphitic Structure

 
 

Alejandro Lopez-Bezanilla, Ivar Martin, Peter B. Littlewood

 
 

We predict the existence and dynamical stability of heptagraphene, a new graphitic structure formed of rings of 10 carbon atoms bridged by carbene groups yielding seven-membered …

 
 
 
 
 
 

Magnetic field sensing subject to correlated noise with a ring spin chain

 
 

Li-Sha Guo, Bao-Ming Xu, Jian Zou et al.

 
 

In this paper, we focus on the magnetic field sensing subject to a correlated noise. We use a ring spin chain with only the nearest neighbor interactions as our probe to estimate …

 
 
 
 
 
 

Controllable two-scale network architecture and enhanced mechanical properties of (Ti5Si3+TiBw)/Ti6Al4V composites

 
 

Y. Jiao, L. J. Huang, T. B. Duan et al.

 
 

Novel Ti6Al4V alloy matrix composites with a controllable two-scale network architecture were successfully fabricated by reaction hot pressing (RHP). TiB whiskers (TiBw) were

 
 
 
 
 
 

Establishing nonlinearity thresholds with ultraintense X-ray pulses

 
 

Jakub Szlachetko, Joanna Hoszowska, Jean-Claude Dousse et al.

 
 

X-ray techniques have evolved over decades to become highly refined tools for a broad range of investigations. Importantly, these approaches rely on X-ray measurements that …

 
 
 
 
 
 

Maze learning by a hybrid brain-computer system

 
 

Zhaohui Wu, Nenggan Zheng, Shaowu Zhang et al.

 
 

The combination of biological and artificial intelligence is particularly driven by two major strands of research: one involves the control of mechanical, usually prosthetic, …

 
 
 
 
 
 

From Zirconium Nanograins to Zirconia Nanoneedles

 
 

E. Zalnezhad, A. M. S. Hamouda, J. Jaworski et al.

 
 

Combinations of three simple techniques were utilized to gradually form zirconia nanoneedles from zirconium nanograins. First, a physical vapor deposition magnetron sputtering …

 
 
 
 
 
 

Influence of curvature strain and Van der Waals force on the inter-layer vibration mode of WS2 nanotubes: A confocal micro-Raman spectroscopic study

 
 

Xiao Hu Wang, Chang Cheng Zheng, Ji Qiang Ning

 
 

Transition-metal dichalcogenides (TMDs) nanostructures including nanotubes and monolayers have attracted great interests in materials science, chemistry to condensed matter …

 
 
 
 
 
 

Magneto-Optical Study of Defect Induced Sharp Photoluminescence in LaAlO3 and SrTiO3

 
 

Soumya Sarkar, Surajit Saha, M. R. Motapothula et al.

 
 

Strongly correlated electronic systems such as Transition Metal Oxides often possess various mid-gap states originating from intrinsic defects in these materials. In this paper, …

 
 
 
 
 
 

High-effective approach from amino acid esters to chiral amino alcohols over Cu/ZnO/Al2O3 catalyst and its catalytic reaction mechanism

 
 

Shuangshuang Zhang, Jun Yu, Huiying Li et al.

 
 

Developing the high-efficient and green synthetic method for chiral amino alcohols is an intriguing target. We have developed the Mg2+-doped Cu/ZnO/Al2O3 catalyst for …

 
 
 
 
 
 

Dispersion of nonresonant third-order nonlinearities in GeSiSn ternary alloys

 
 

Francesco De Leonardis, Benedetto Troia, Richard A. Soref et al.

 
 

Silicon (Si), tin (Sn), and germanium (Ge) alloys have attracted research attention as direct band gap semiconductors with applications in electronics and optoelectronics. In …

 
 
 
 
 
 

Lipid membrane-mediated attraction between curvature inducing objects

 
 

Casper van der Wel, Afshin Vahid, Anđela Šarić et al.

 
 

The interplay of membrane proteins is vital for many biological processes, such as cellular transport, cell division, and signal transduction between nerve cells. Theoretical …

 
 
 
 
 
 

Annual and seasonal spatial models for nitrogen oxides in Tehran, Iran

 
 

Heresh Amini, Seyed-Mahmood Taghavi-Shahri, Sarah B. Henderson et al.

 
 

Very few land use regression (LUR) models have been developed for megacities in low- and middle-income countries, but such models are needed to facilitate epidemiologic research …

 
 
 
 
 
 

Fluorescence imaging of chromosomal DNA using click chemistry

 
 

Takumi Ishizuka, Hong Shan Liu, Kenichiro Ito et al.

 
 

Chromosome visualization is essential for chromosome analysis and genetic diagnostics. Here, we developed a click chemistry approach for multicolor imaging of chromosomal DNA …

 
 
 
 
 
 

Real-time Functional Analysis of Inertial Microfluidic Devices via Spectral Domain Optical Coherence Tomography

 
 

Biqin Dong, Siyu Chen, Fan Zhou et al.

 
 

We report the application of spectral-domain optical coherence tomography (SD-OCT) technology that enables real-time functional analysis of sorting microparticles and cells in an …

 
 
 
 
 
 

Conformational Ensemble of hIAPP Dimer: Insight into the Molecular Mechanism by which a Green Tea Extract inhibits hIAPP Aggregation

 
 

Yuxiang Mo, Jiangtao Lei, Yunxiang Sun et al.

 
 

Small oligomers formed early along human islet amyloid polypeptide (hIAPP) aggregation is responsible for the cell death in Type II diabetes. The epigallocatechin gallate (EGCG), …

 
 
 
 
 
 

An Auditory BCI System for Assisting CRS-R Behavioral Assessment in Patients with Disorders of Consciousness

 
 

Jun Xiao, Qiuyou Xie, Yanbin He et al.

 
 

The Coma Recovery Scale-Revised (CRS-R) is a consistent and sensitive behavioral assessment standard for disorders of consciousness (DOC) patients. However, the CRS-R has …

 
 
 
 
 
 
 
Earth & Environmental Sciences top
 
 
 
 
 
 
 

Satellite data lift the veil on offshore platforms in the South China Sea

 
 

Yongxue Liu, Chao Sun, Jiaqi Sun et al.

 
 

Oil and gas exploration in the South China Sea (SCS) has garnered global attention recently; however, uncertainty regarding the accurate number of offshore platforms in the SCS, …

 
 
 
 
 
 

Soil surface temperatures reveal moderation of the urban heat island effect by trees and shrubs

 
 

J. L. Edmondson, I. Stott, Z. G. Davies et al.

 
 

Urban areas are major contributors to air pollution and climate change, causing impacts on human health that are amplified by the microclimatological effects of buildings and …

 
 
 
 
 
 

A new insight into the immobilization mechanism of Zn on biochar: the role of anions dissolved from ash

 
 

Tingting Qian, Yujun Wang, Tingting Fan et al.

 
 

Biochar is considered to be a promising material for heavy metal immobilization in soil. However, the immobilization mechanisms of Zn2+ on biochars derived from many common waste …

 
 
 
 
 
 

Effect of cation substitution on bridgmanite elasticity: A key to interpret seismic anomalies in the lower mantle

 
 

Hiroshi Fukui, Akira Yoneda, Akihiko Nakatsuka et al.

 
 

Seismological observations show that, in some regions of the lower mantle, an increase in bulk sound velocity, interestingly, occurs in the same volume where there is a decrease …

 
 
 
 
 
 

Physicochemistry and cardiovascular toxicity of metal fume PM2.5: a study of human coronary artery endothelial cells and welding workers

 
 

Chane-Yu Lai, Ching-Huang Lai, Hsiao-Chi Chuang et al.

 
 

Occupational exposure to welding fumes causes a higher incidence of cardiovascular disease; however, the association remains unclear. To clarify the possible association, …

 
 
 
 
 
 

Corrigendum: Predictability of Precipitation Over the Conterminous U.S. Based on the CMIP5 Multi-Model Ensemble

 
 

Mingkai Jiang, Benjamin S. Felzer, Dork Sahagian

 
 

 
 
 
 
 
 

Temporal variations of black carbon during haze and non-haze days in Beijing

 
 

Qingyang Liu, Tangming Ma, Michael R Olson et al.

 
 

Black carbon (BC) aerosol has been identified as one of key factors responsible for air quality in Beijing. BC emissions abatement could help slow regional climate change while …

 
 
 
 
 
 

Slowly dispersing neotenic beetles can speciate on a penny coin and generate space-limited diversity in the tropical mountains

 
 

Timothy C. Bray, Ladislav Bocak

 
 

We demonstrate the controversial origin of a biological species within an area of a few kilometres in the absence of physical barriers. We employed nuclear rRNA/mitochondrial and …

 
 
 
 
 
 

PAH contamination in Beijing’s topsoil: A unique indicator of the megacity’s evolving energy consumption and overall environmental quality

 
 

Jinguo Li, Yi Zheng, Xiaolin Luo et al.

 
 

To improve its air quality, Beijing, the capital of China, has implemented high-cost pollution control measures mainly focused on shifting its energy mix. However, the …

 
 
 
 
 
 

Highly efficient removal of lead and cadmium during wastewater irrigation using a polyethylenimine-grafted gelatin sponge

 
 

Bingbing Li, Feng Zhou, Kai Huang et al.

 
 

Wastewater irrigation is a very important resource for heavy metal pollution in soil and then accumulation in vegetable crops. In this study, a polyethylenimine (PEI)-grafted …

 
 
 
 
 
 

Mitigation of soil N2O emission by inoculation with a mixed culture of indigenous Bradyrhizobium diazoefficiens

 
 

Hiroko Akiyama, Yuko Takada Hoshino, Manabu Itakura et al.

 
 

Agricultural soil is the largest source of nitrous oxide (N2O), a greenhouse gas. Soybean is an important leguminous crop worldwide. Soybean hosts symbiotic nitrogen-fixing soil …

 
 
 
 
 
 

Muon dynamic radiography of density changes induced by hydrothermal activity at the La Soufrière of Guadeloupe volcano

 
 

Kevin Jourde, Dominique Gibert, Jacques Marteau et al.

 
 

Imaging geological structures through cosmic muon radiography is a newly developed technique which shows a great potential in volcanology. Here we demonstrate that muon …

 
 
 
 
 
 

Island building in the South China Sea: detection of turbidity plumes and artificial islands using Landsat and MODIS data

 
 

Brian B. Barnes, Chuanmin Hu

 
 

The South China Sea is currently in a state of intense geopolitical conflict, with six countries claiming sovereignty over some or all of the area. Recently, several countries …

 
 
 
 
 
 

Incorporation of Eu(III) into Calcite under Recrystallization conditions

 
 

S. E. Hellebrandt, S. Hofmann, N. Jordan et al.

 
 

The interaction of calcite with trivalent europium under recrystallization conditions was studied on the molecular level using site-selective time-resolved laser fluorescence …

 
 
 
 
 
 

Chiral PCB 91 and 149 Toxicity Testing in Embryo and Larvae (Danio rerio): Application of Targeted Metabolomics via UPLC-MS/MS

 
 

Tingting Chai, Feng Cui, Zhiqiang Yin et al.

 
 

In this study, we aimed to investigate the dysfunction of zebrafish embryos and larvae induced by rac-/(+)-/(−)- PCB91 and rac-/(−)-/(+)- PCB149. UPLC-MS/MS (Ultra-performance …

 
 
 
 
 
 

The persistence of pesticides in atmospheric particulate phase: An emerging air quality issue

 
 

Joanna Socorro, Amandine Durand, Brice Temime-Roussel et al.

 
 

The persistent organic pollutants (POPs) due to their physicochemical properties can be widely spread all over the globe; as such they represent a serious threat to both humans …

 
 
 
 
 
 

Global Ionospheric Modelling using Multi-GNSS: BeiDou, Galileo, GLONASS and GPS

 
 

Xiaodong Ren, Xiaohong Zhang, Weiliang Xie et al.

 
 

The emergence of China’s Beidou, Europe’s Galileo and Russia’s GLONASS satellites has multiplied the number of ionospheric piercing points (IPP) offered by GPS alone. This …

 
 
 
 
 
 

The electron donating capacity of biochar is dramatically underestimated

 
 

Antonin Prévoteau, Frederik Ronsse, Inés Cid et al.

 
 

Biochars have gathered considerable interest for agronomic and engineering applications. In addition to their high sorption ability, biochars have been shown to accept or donate …

 
 
 
 
 
 

The fungicide triadimefon affects beer flavor and composition by influencing Saccharomyces cerevisiae metabolism

 
 

Zhiqiang Kong, Minmin Li, Jingjing An et al.

 
 

Despite the fact that beer is produced on a large scale, the effects of pesticide residues on beer have been rarely investigated. In this study, we used micro-brewing settings to …

 
 
 
 
 
 

Primates’ behavioural responses to tourists: evidence for a trade-off between potential risks and benefits

 
 

Laëtitia Maréchal, Ann MacLarnon, Bonaventura Majolo et al.

 
 

The presence of, and interactions with tourists can be both risky and beneficial for wild animals. In wildlife tourism settings, animals often experience elevated rates of …

 
 
 
 
 
 

Simulation Study of CO2-EOR in Tight Oil Reservoirs with Complex Fracture Geometries

 
 

Pavel Zuloaga-Molero, Wei Yu, Yifei Xu et al.

 
 

The recent development of tight oil reservoirs has led to an increase in oil production in the past several years due to the progress in horizontal drilling and hydraulic …

 
 
 
 
 
 

Super flame-retardant lightweight rime-like carbon-phenolic nanofoam

 
 

Haiming Cheng, Changqing Hong, Xinghong Zhang et al.

 
 

The desire for lightweight nanoporous materials with high-performance thermal insulation and efficient anti-ablation resistance for energy conservation and thermal …

 
 
 
 
 
 

Prolonged California aridity linked to climate warming and Pacific sea surface temperature

 
 

Glen M. MacDonald, Katrina A. Moser, Amy M. Bloom et al.

 
 

California has experienced a dry 21st century capped by severe drought from 2012 through 2015 prompting questions about hydroclimatic sensitivity to anthropogenic climate change …

 
 
 
 
 
 

In-hive Pesticide Exposome: Assessing risks to migratory honey bees from in-hive pesticide contamination in the Eastern United States

 
 

Kirsten S. Traynor, Jeffery S. Pettis, David R. Tarpy et al.

 
 

This study measured part of the in-hive pesticide exposome by analyzing residues from live in-hive bees, stored pollen, and wax in migratory colonies over time and compared …

 
 
 
 
 
 

Corrigendum: Crustal movements due to Iceland’s shrinking ice caps mimic magma inflow signal at Katla volcano

 
 

Karsten Spaans, Sigrún Hreinsdóttir, Andrew Hooper et al.

 
 

 
 
 
 
 
 

Species characteristics of lead in sea foods collected from coastal water of Fujian, Southeastern of China

 
 

Ye He, Zhiqiang Chen, Fan Mo et al.

 
 

Various sea foods including fish, shellfish and shrimp were collected from different coastal areas of Fujian in China, and their Pb species characteristics were investigated in …

 
 
 
 
 
 

Oscillation of mineral compositions in Core SG-1b, western Qaidam Basin, NE Tibetan Plateau

 
 

Xiaomin Fang, Minghui Li, Zhengrong Wang et al.

 
 

Uplift of the Tibetan Plateau since the Late Miocene has greatly affected the nature of sediments deposited in the Qaidam Basin. However, due to the scarcity of continuously …

 
 
 
 
 
 

Application of Species Distribution Modeling for Avian Influenza surveillance in the United States considering the North America Migratory Flyways

 
 

Jaber Belkhiria, Moh A. Alkhamis, Beatriz Martínez-López

 
 

Highly Pathogenic Avian Influenza (HPAI) has recently (2014–2015) re-emerged in the United States (US) causing the largest outbreak in US history with 232 outbreaks and an …

 
 
 
 
 
 

Redox/methylation mediated abnormal DNA methylation as regulators of ambient fine particulate matter-induced neurodevelopment related impairment in human neuronal cells

 
 

Hongying Wei, Fan Liang, Ge Meng et al.

 
 

Fine particulate matter (PM2.5) has been implicated as a risk factor for neurodevelopmental disorders including autism in children. However, the underlying biological mechanism …

 
 
 
 
 
 

Comprehensive approach for predicting toxicological effects of ionic liquids on several biological systems using unified descriptors

 
 

Chul-Woong Cho, Stefan Stolte, Yeoung-Sang Yun

 
 

The challenge and opportunity for design of environmentally-benign ionic liquids (ILs) would start from prediction of their toxicological effects on several endpoints solely …

 
 
 
 
 
 

A change in coral extension rates and stable isotopes after El Niño-induced coral bleaching and regional stress events

 
 

S. Hetzinger, M. Pfeiffer, W.-Chr. Dullo et al.

 
 

Coral reefs are biologically diverse ecosystems threatened with effective collapse under rapid climate change, in particular by recent increases in ocean temperatures. Coral …

 
 
 
 
 
 

Thermomechanical controls on magma supply and volcanic deformation: application to Aira caldera, Japan

 
 

James Hickey, Joachim Gottsmann, Haruhisa Nakamichi et al.

 
 

Ground deformation often precedes volcanic eruptions, and results from complex interactions between source processes and the thermomechanical behaviour of surrounding rocks. …

 
 
 
 
 
 

Annual and seasonal spatial models for nitrogen oxides in Tehran, Iran

 
 

Heresh Amini, Seyed-Mahmood Taghavi-Shahri, Sarah B. Henderson et al.

 
 

Very few land use regression (LUR) models have been developed for megacities in low- and middle-income countries, but such models are needed to facilitate epidemiologic research …

 
 
 
 
 
 

Linkages between atmospheric blocking, sea ice export through Fram Strait and the Atlantic Meridional Overturning Circulation

 
 

M. Ionita, P. Scholz, G. Lohmann et al.

 
 

As a key persistent component of the atmospheric dynamics, the North Atlantic blocking activity has been linked to extreme climatic phenomena in the European sector. It has also …

 
 
 
 
 
 

Early-life sexual segregation: ontogeny of isotopic niche differentiation in the Antarctic fur seal

 
 

L. Kernaléguen, J. P. Y. Arnould, C. Guinet et al.

 
 

Investigating the ontogeny of niche differentiation enables to determine at which life-stages sexual segregation arises, providing insights into the main factors driving resource …

 
 
 
 
 
 

Discriminating Bio-aerosols from Non-Bio-aerosols in Real-Time by Pump-Probe Spectroscopy

 
 

Gustavo Sousa, Geoffrey Gaulier, Luigi Bonacina et al.

 
 

The optical identification of bioaerosols in the atmosphere and its discrimination against combustion related particles is a major issue for real-time, field compatible …

 
 
 
 
 
 

Sub-CMC solubilization of dodecane by rhamnolipid in saturated porous media

 
 

Hua Zhong, Hui Zhang, Zhifeng Liu et al.

 
 

Experiments were conducted with a two-dimensional flow cell to examine the effect of monorhamnolipid surfactant at sub-CMC concentrations on solubilization of dodecane in porous …

 
 
 
 
 
 

Model suggests potential for Porites coral population recovery after removal of anthropogenic disturbance (Luhuitou, Hainan, South China Sea)

 
 

Meixia Zhao, Bernhard Riegl, Kefu Yu et al.

 
 

Population models are important for resource management and can inform about potential trajectories useful for planning purposes, even with incomplete monitoring data. From size …

 
 
 
 
 
 

Cold tolerance is unaffected by oxygen availability despite changes in anaerobic metabolism

 
 

Leigh Boardman, Jesper G. Sørensen, Vladimír Koštál et al.

 
 

Insect cold tolerance depends on their ability to withstand or repair perturbations in cellular homeostasis caused by low temperature stress. Decreased oxygen availability …

 
 
 
 
 
 
 
Health Sciences top
 
 
 
 
 
 
 

Ginsenoside Rd attenuates breast cancer metastasis implicating derepressing microRNA-18a-regulated Smad2 expression

 
 

Peiwei Wang, Xiaoye Du, Minqi Xiong et al.

 
 

Metastasis remains a major cause of mortality and poor prognosis in breast cancer patients. Anti-metastatic therapies are in great need to achieve optimal clinical outcome in …

 
 
 
 
 
 

Systematic Review with Network Meta-Analysis: Antidiabetic Medication and Risk of Hepatocellular Carcinoma

 
 

Yao-Yao Zhou, Gui-Qi Zhu, Tian Liu et al.

 
 

Antidiabetic medication may modify the incidence of hepatocellular carcinoma (HCC). We aimed to compare the use of different antidiabetic strategies and the incidence of HCC. …

 
 
 
 
 
 

Prognostic significance of fibroblast growth factor receptor 4 polymorphisms on biochemical recurrence after radical prostatectomy in a Chinese population

 
 

Luyao Chen, Zhengwei Lei, Xin Ma et al.

 
 

Fibroblast growth factor receptor 4 (FGFR4) is a transmembrane receptor with ligand-induced tyrosine kinase activity and is involved in various biological and pathological …

 
 
 
 
 
 

Comparison of the 7th and proposed 8th editions of the AJCC/UICC TNM staging system for non-small cell lung cancer undergoing radical surgery

 
 

Ying Jin, Ming Chen, Xinmin Yu

 
 

The present study aims to compare the 7th and the proposed 8th edition of the AJCC/UICC TNM staging system for NSCLC in a cohort of patients from a single institution. A total of …

 
 
 
 
 
 

High-Resolution Imaging by Adaptive Optics Scanning Laser Ophthalmoscopy Reveals Two Morphologically Distinct Types of Retinal Hard Exudates

 
 

Muneo Yamaguchi, Shintaro Nakao, Yoshihiro Kaizu et al.

 
 

Histological studies from autopsy specimens have characterized hard exudates as a composition of lipid-laden macrophages or noncellular materials including lipid and …

 
 
 
 
 
 

The use of cellular thermal shift assay (CETSA) to study Crizotinib resistance in ALK-expressing human cancers

 
 

Abdulraheem Alshareef, Hai-Feng Zhang, Yung-Hsing Huang et al.

 
 

Various forms of oncogenic ALK proteins have been identified in various types of human cancers. While Crizotinib, an ALK inhibitor, has been found to be therapeutically useful …

 
 
 
 
 
 

Ramipril attenuates left ventricular remodeling by regulating the expression of activin A-follistatin in a rat model of heart failure

 
 

Qun Wei, Haiyan Liu, Miao Liu et al.

 
 

Prior studies have shown that overexpression of ACT A can lead to ventricular remodeling in rat models of heart failure. Furthermore, recently work studying demonstrated that …

 
 
 
 
 
 

A contaminant-free assessment of Endogenous Retroviral RNA in human plasma

 
 

Timokratis Karamitros, Dimitrios Paraskevis, Angelos Hatzakis et al.

 
 

Endogenous retroviruses (ERVs) comprise 6–8% of the human genome. HERVs are silenced in most normal tissues, up-regulated in stem cells and in placenta but also in cancer and …

 
 
 
 
 
 

IL-6, IL-10 and TNFα do not improve early detection of post-endoscopic retrograde cholangiopancreatography acute pancreatitis: a prospective cohort study

 
 

Mar Concepción-Martín, Cristina Gómez-Oliva, Ana Juanes et al.

 
 

The most reliable indicators for post-ERCP acute pancreatitis are elevated amylase levels and abdominal pain 24 hours after ERCP. As ERCP is often performed on an outpatient …

 
 
 
 
 
 

Functional Recovery of AQP2 Recessive Mutations Through Hetero-Oligomerization with Wild-Type Counterpart

 
 

Abdulah El Tarazi, Yoann Lussier, Sandra Da Cal et al.

 
 

Aquaporin-2 (AQP2) is a homotetrameric water channel responsible for the final water reuptake in the kidney. Mutations in the protein induce nephrogenic diabetes insipidus (NDI), …

 
 
 
 
 
 

Turning the fate of reprogramming cells from retinal disorder to regeneration by Pax6 in newts

 
 

Martin Miguel Casco-Robles, Md Rafiqul Islam, Wataru Inami et al.

 
 

The newt, a urodele amphibian, has an outstanding ability– even as an adult –to regenerate a functional retina through reprogramming and proliferation of the retinal pigment …

 
 
 
 
 
 

Global analysis of transcription in castration-resistant prostate cancer cells uncovers active enhancers and direct androgen receptor targets

 
 

Sari Toropainen, Einari A. Niskanen, Marjo Malinen et al.

 
 

Androgen receptor (AR) is a male sex steroid-activated transcription factor (TF) that plays a critical role in prostate cancers, including castration-resistant prostate cancers …

 
 
 
 
 
 

Circulating tumor DNA detection in lung cancer patients before and after surgery

 
 

Nannan Guo, Feng Lou, Yongfu Ma et al.

 
 

Circulating tumor DNA (ctDNA) in peripheral blood is a “liquid biopsy” that contains representative tumor information including gene mutations. Additionally, repeated ctDNA …

 
 
 
 
 
 

Transient receptor potential channel 1/4 reduces subarachnoid hemorrhage-induced early brain injury in rats via calcineurin-mediated NMDAR and NFAT dephosphorylation

 
 

Zhong Wang, Yibin Wang, Xiaodi Tian et al.

 
 

Transient receptor potential channel 1/4 (TRPC1/4) are considered to be related to subarachnoid hemorrhage (SAH)-induced cerebral vasospasm. In this study, a SAH rat model was …

 
 
 
 
 
 

β-Hairpin of Islet Amyloid Polypeptide Bound to an Aggregation Inhibitor

 
 

Ewa A. Mirecka, Sophie Feuerstein, Lothar Gremer et al.

 
 

In type 2 diabetes, the formation of islet amyloid consisting of islet amyloid polypeptide (IAPP) is associated with reduction in β-cell mass and contributes to the failure of …

 
 
 
 
 
 

A Direct Comparison of Two Densely Sampled HIV Epidemics: The UK and Switzerland

 
 

Manon L. Ragonnet-Cronin, Mohaned Shilaih, Huldrych F. Günthard et al.

 
 

Phylogenetic clustering approaches can elucidate HIV transmission dynamics. Comparisons across countries are essential for evaluating public health policies. Here, we used a …

 
 
 
 
 
 

Linked color imaging application for improving the endoscopic diagnosis accuracy: a pilot study

 
 

Xiaotian Sun, Tenghui Dong, Yiliang Bi et al.

 
 

Endoscopy has been widely used in diagnosing gastrointestinal mucosal lesions. However, there are still lack of objective endoscopic criteria. Linked color imaging (LCI) is newly …

 
 
 
 
 
 

Circulation of multiple serotypes of highly divergent enterovirus C in the Xinjiang Uighur Autonomous Region of China

 
 

Yong Zhang, Qiang Sun, Hui Cui et al.

 
 

Poliomyelitis associated with circulating vaccine-derived polioviruses (cVDPVs) is a serious public health issue in the post-eradication era, and the occurrence of recombinant …

 
 
 
 
 
 

Estimating the palliative effect of percutaneous endoscopic gastrostomy in an observational registry using principal stratification and generalized propensity scores

 
 

Pallavi S. Mishra-Kalyani, Brent A. Johnson, Jonathan D. Glass et al.

 
 

Clinical disease registries offer a rich collection of valuable patient information but also pose challenges that require special care and attention in statistical analyses. The …

 
 
 
 
 
 

Mutation analysis of circulating plasma DNA to determine response to EGFR tyrosine kinase inhibitor therapy of lung adenocarcinoma patients

 
 

Anja Lisa Riediger, Steffen Dietz, Uwe Schirmer et al.

 
 

Long-lasting success in lung cancer therapy using tyrosine kinase inhibitors (TKIs) is rare since the tumors develop resistance due to the occurrence of molecularly altered …

 
 
 
 
 
 

Physicochemistry and cardiovascular toxicity of metal fume PM2.5: a study of human coronary artery endothelial cells and welding workers

 
 

Chane-Yu Lai, Ching-Huang Lai, Hsiao-Chi Chuang et al.

 
 

Occupational exposure to welding fumes causes a higher incidence of cardiovascular disease; however, the association remains unclear. To clarify the possible association, …

 
 
 
 
 
 

Evaluation of Glutathione Peroxidase 4 role in Preeclampsia

 
 

Xinguo Peng, Yan Lin, Jinling Li et al.

 
 

Preeclampsia (PE) is a pregnancy-specific syndrome that may be lifethreatening to pregnancies and fetus. Glutathione Peroxidase 4 (GPx4) is a powerful antioxidant enzyme that can …

 
 
 
 
 
 

Human CB1 Receptor Isoforms, present in Hepatocytes and β-cells, are Involved in Regulating Metabolism

 
 

Isabel González-Mariscal, Susan M. Krzysik-Walker, Máire E. Doyle et al.

 
 

Therapeutics aimed at blocking the cannabinoid 1 (CB1) receptor for treatment of obesity resulted in significant improvements in liver function, glucose uptake and pancreatic …

 
 
 
 
 
 

A combination hepatoma-targeted therapy based on nanotechnology: pHRE-Egr1-HSV-TK/131I-antiAFPMcAb-GCV/MFH

 
 

Mei Lin, Junxing Huang, Xingmao Jiang et al.

 
 

Combination targeted therapy is a promising cancer therapeutic strategy. Here, using PEI-Mn0.5Zn0.5Fe2O4 nanoparticles (PEI-MZF-NPs) as magnetic media for MFH (magnetic fluid …

 
 
 
 
 
 

Nox2 contributes to the arterial endothelial specification of mouse induced pluripotent stem cells by upregulating Notch signaling

 
 

Xueling Kang, Xiangxiang Wei, Xinhong Wang et al.

 
 

Reactive oxygen species (ROS) have a crucial role in stem-cell differentiation; however, the mechanisms by which ROS regulate the differentiation of stem cells into endothelial …

 
 
 
 
 
 

Combining Exosomes Derived from Immature DCs with Donor Antigen-Specific Treg Cells Induces Tolerance in a Rat Liver Allograft Model

 
 

Ben Ma, Jing-Yue Yang, Wen-jie Song et al.

 
 

Allograft tolerance is the ultimate goal in the field of transplantation immunology. Immature dendritic cells (imDCs) play an important role in establishing tolerance but have …

 
 
 
 
 
 

Erratum: Comparison of Diagnostic Performance of Semi-Quantitative Knee Ultrasound and Knee Radiography with MRI: Oulu Knee Osteoarthritis Study

 
 

Jana Podlipská, Ali Guermazi, Petri Lehenkari et al.

 
 

 
 
 
 
 
 

Corrigendum: First Experience of Ultrasound-guided Percutaneous Ablation for Recurrent Hepatoblastoma after Liver Resection in Children

 
 

Baoxian Liu, Luyao Zhou, Guangliang Huang et al.

 
 

 
 
 
 
 
 

Long Sleep Duration and Risk of Ischemic Stroke and Hemorrhagic Stroke: the Kailuan Prospective Study

 
 

Qiaofeng Song, Xiaoxue Liu, Wenhua Zhou et al.

 
 

The objective of this study was to examine the relationship between sleep duration and ischemic and hemorrhagic stroke in a community-based cohort. The current analysis included …

 
 
 
 
 
 

Erratum: Histological response of soda-lime glass-ceramic bactericidal rods implanted in the jaws of beagle dogs

 
 

José S. Moya, Arturo Martínez, Roberto López-Píriz et al.

 
 

 
 
 
 
 
 

FXR agonist obeticholic acid reduces hepatic inflammation and fibrosis in a rat model of toxic cirrhosis

 
 

Len Verbeke, Inge Mannaerts, Robert Schierwagen et al.

 
 

Hepatic inflammation drives hepatic stellate cells (HSC), resulting in liver fibrosis. The Farnesoid-X receptor (FXR) antagonizes inflammation through NF-κB inhibition. We …

 
 
 
 
 
 

Association of non-alcoholic fatty liver disease with major adverse cardiovascular events: A systematic review and meta-analysis

 
 

Shunquan Wu, Fuquan Wu, Yingying Ding et al.

 
 

Increasing evidence connects non-alcoholic fatty liver disease (NAFLD) to cardiovascular disease (CVD). The aim of this study is to assess whether and to what extent the excess …

 
 
 
 
 
 

Developmental Patterns of Cognitive Function and Associated Factors among the Elderly in Taiwan

 
 

Ting-Yu Chen, Hsing-Yi Chang

 
 

Previous research has discussed the factors associated with cognitive impairment, but the patterns of its development have been little described. Our aim was to examine long-term …

 
 
 
 
 
 

Protein malnutrition potentiates the amplifying pathway of insulin secretion in adult obese mice

 
 

Nayara Carvalho Leite, Flávia de Paula, Patrícia Cristine Borck et al.

 
 

Pancreatic beta cell (β) dysfunction is an outcome of malnutrition. We assessed the role of the amplifying pathway (AMP PATH) in β cells in malnourished obese mice. C57Bl-6 mice …

 
 
 
 
 
 

Potential of in vivo real-time gastric gas profiling: a pilot evaluation of heat-stress and modulating dietary cinnamon effect in an animal model

 
 

Jian Zhen Ou, Jeremy J. Cottrell, Nam Ha et al.

 
 

Gastroenterologists are still unable to differentiate between some of the most ordinary disorders of the gut and consequently patients are misdiagnosed. We have developed a …

 
 
 
 
 
 

The diagnostic accuracy of pericardial and urinary lipoarabinomannan (LAM) assays in patients with suspected tuberculous pericarditis

 
 

Shaheen Pandie, Jonathan G. Peter, Zita S. Kerbelker et al.

 
 

We evaluated the diagnostic accuracy of urinary and pericardial fluid (PF) lipoarabinomannan (LAM) assays in tuberculous pericarditis (TBP). From October 2009 through September …

 
 
 
 
 
 

A comprehensive validation of HBV-related acute-on-chronic liver failure models to assist decision-making in targeted therapeutics

 
 

Yi Shen, Xulin Wang, Sheng Zhang et al.

 
 

This research utilized an external longitudinal dataset of hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) to compare and validate various predictive models …

 
 
 
 
 
 

Corrigendum: Polymorphisms in the Mannose-Binding Lectin Gene are Associated with Defective Mannose-Binding Lectin Functional Activity in Crohn’s Disease Patients

 
 

Laura Choteau, Francis Vasseur, Frederic Lepretre et al.

 
 

 
 
 
 
 
 

Retraction: Development of Alendronate-conjugated Poly (lactic-co-glycolic acid)-Dextran Nanoparticles for Active Targeting of Cisplatin in Osteosarcoma

 
 

Ping Liu, Liang Sun, Dong-sheng Zhou et al.

 
 

 
 
 
 
 
 

Genome-wide association analysis reveals variants on chromosome 19 that contribute to childhood risk of chronic otitis media with effusion

 
 

Elisabet Einarsdottir, Lena Hafrén, Eira Leinonen et al.

 
 

To identify genetic risk factors of childhood otitis media (OM), a genome-wide association study was performed on Finnish subjects, 829 affected children, and 2118 randomly …

 
 
 
 
 
 

Fibroblast growth factor (FGF) signaling regulates transforming growth factor beta (TGFβ)-dependent smooth muscle cell phenotype modulation

 
 

Pei-Yu Chen, Lingfeng Qin, Guangxin Li et al.

 
 

Smooth muscle cells (SMCs) in normal blood vessels exist in a highly differentiate state characterized by expression of SMC-specific contractile proteins (“contractile …

 
 
 
 
 
 

Ursolic acid-mediated apoptosis of K562 cells involves Stat5/Akt pathway inhibition through the induction of Gfi-1

 
 

Ze Lin, Jikai Jiang, Xiao-Shan Liu

 
 

Ursolic acid (UA) is a promising natural compound for cancer prevention and therapy. We previously reported that UA induced apoptosis in CML-derived K562 cells. Here we show that …

 
 
 
 
 
 

Progressive muscle proteome changes in a clinically relevant pig model of Duchenne muscular dystrophy

 
 

Thomas Fröhlich, Elisabeth Kemter, Florian Flenkenthaler et al.

 
 

Duchenne muscular dystrophy (DMD) is caused by genetic deficiency of dystrophin and characterized by massive structural and functional changes of skeletal muscle tissue, leading …

 
 
 
 
 
 

Topical Simvastatin as Host-Directed Therapy against Severity of Cutaneous Leishmaniasis in Mice

 
 

Suraj P. Parihar, Mary-Anne Hartley, Ramona Hurdayal et al.

 
 

We recently demonstrated that statins mediate protection against intracellular pathogens, Mycobacterium tuberculosis and Listeria monocytogenes in mice. Here, we investigated the …

 
 
 
 
 
 

Corrigendum: Environmental chemicals impact dog semen quality in vitro and may be associated with a temporal decline in sperm motility and increased cryptorchidism

 
 

Richard G. Lea, Andrew S. Byers, Rebecca N. Sumner et al.

 
 

 
 
 
 
 
 

Reprofiled anthelmintics abate hypervirulent stationary-phase Clostridium difficile

 
 

Major Gooyit, Kim D. Janda

 
 

Prolonged use of broad-spectrum antibiotics disrupts the indigenous gut microbiota, which consequently enables toxigenic Clostridium difficile species to proliferate and cause …

 
 
 
 
 
 

Chronic Kappa opioid receptor activation modulates NR2B: Implication in treatment resistant depression

 
 

Shalini Dogra, Ajeet Kumar, Deepmala Umrao et al.

 
 

Psychotomimetic and prodepressive effect by kappa opioid receptor (KOR) activation in rodents and human is widely known. Significantly, recent clinical investigations …

 
 
 
 
 
 

Copper(II) ions affect the gating dynamics of the 20S proteasome: a molecular and in cell study

 
 

Anna Maria Santoro, Irene Monaco, Francesco Attanasio et al.

 
 

Due to their altered metabolism cancer cells are more sensitive to proteasome inhibition or changes of copper levels than normal cells. Thus, the development of copper complexes …

 
 
 
 
 
 

Silencing of Histone Deacetylase 9 Expression in Podocytes Attenuates Kidney Injury in Diabetic Nephropathy

 
 

Feng Liu, Ming Zong, Xiaofei Wen et al.

 
 

Podocyte dysfunction is important in the onset and development of diabetic nephropathy (DN). Histone deacetylases (HDACs) have been recently proved to play critical roles in the …

 
 
 
 
 
 

Long-term exposure to microgravity impairs vestibulo-cardiovascular reflex

 
 

Hironobu Morita, Chikara Abe, Kunihiko Tanaka

 
 

The vestibular system is known to have an important role in controlling blood pressure upon posture transition (vestibulo-cardiovascular reflex, VCR). However, under a different …

 
 
 
 
 
 

Meta-analysis of associations between DLG5 R30Q and P1371Q polymorphisms and susceptibility to inflammatory bowel disease

 
 

Yunhai Li, Ping Chen, Jiazheng Sun et al.

 
 

Growing evidence from recent studies has demonstrated an association between inflammatory bowel disease (IBD) susceptibility and two polymorphisms of DLG5 R30Q (rs1248696) and …

 
 
 
 
 
 

Investigation of rare and low-frequency variants using high-throughput sequencing with pooled DNA samples

 
 

Jingwen Wang, Tiina Skoog, Elisabet Einarsdottir et al.

 
 

High-throughput sequencing using pooled DNA samples can facilitate genome-wide studies on rare and low-frequency variants in a large population. Some major questions concerning …

 
 
 
 
 
 

Chiral Antioxidant-based Gold Nanoclusters Reprogram DNA Epigenetic Patterns

 
 

Yue Ma, Hualin Fu, Chunlei Zhang et al.

 
 

Epigenetic modifications sit ‘on top of’ the genome and influence DNA transcription, which can force a significant impact on cellular behavior and phenotype and, consequently …

 
 
 
 
 
 

A Novel Assay for Screening Inhibitors Targeting HIV Integrase LEDGF/p75 Interaction Based on Ni2+ Coated Magnetic Agarose Beads

 
 

Zhang Dawei, He Hongqiu, Liu Mengmeng et al.

 
 

HIV-1 integrase (IN) plays an essential role in viral replication and thus serves as an important target for chemotherapeutic intervention against HIV-1 infection. However, the …

 
 
 
 
 
 

Ultrasensitive and low-volume point-of-care diagnostics on flexible strips – a study with cardiac troponin biomarkers

 
 

Nandhinee Radha Shanmugam, Sriram Muthukumar, Shalini Prasad

 
 

We demonstrate a flexible, mechanically stable, and disposable electrochemical sensor platform for monitoring cardiac troponins through the detection and quantification of …

 
 
 
 
 
 

Reversible Brain Abnormalities in People Without Signs of Mountain Sickness During High-Altitude Exposure

 
 

Cunxiu Fan, Yuhua Zhao, Qian Yu et al.

 
 

A large proportion of lowlanders ascending to high-altitude (HA) show no signs of mountain sickness. Whether their brains have indeed suffered from HA environment and the …

 
 
 
 
 
 

A diverse virome in kidney transplant patients contains multiple viral subtypes with distinct polymorphisms

 
 

Asha Rani, Ravi Ranjan, Halvor S. McGee et al.

 
 

Recent studies have established that the human urine contains a complex microbiome, including a virome about which little is known. Following immunosuppression in kidney …

 
 
 
 
 
 

Entinostat up-regulates the CAMP gene encoding LL-37 via activation of STAT3 and HIF-1α transcription factors

 
 

Erica Miraglia, Frank Nylén, Katarina Johansson et al.

 
 

Bacterial resistance against classical antibiotics is a growing problem and the development of new antibiotics is limited. Thus, novel alternatives to antibiotics are warranted. …

 
 
 
 
 
 

Eukaryotic pathways targeted by the type III secretion system effector protein, BipC, involved in the intracellular lifecycle of Burkholderia pseudomallei

 
 

Wen-Tyng Kang, Kumutha Malar Vellasamy, Jamuna Vadivelu

 
 

Burkholderia pseudomallei, the etiological agent for melioidosis, is known to secrete a type III secretion system (TTSS) protein into the host’s internal milieu. One of the TTSS …

 
 
 
 
 
 

Complex inheritance in Pulmonary Arterial Hypertension patients with several mutations

 
 

Guillermo Pousada, Adolfo Baloira, Diana Valverde

 
 

Pulmonary Arterial Hypertension (PAH) is a rare and progressive disease with low incidence and prevalence, and elevated mortality. PAH is characterized by increased mean …

 
 
 
 
 
 

A space network structure constructed by tetraneedlelike ZnO whiskers supporting boron nitride nanosheets to enhance comprehensive properties of poly(L-lacti acid) scaffolds

 
 

Pei Feng, Shuping Peng, Ping Wu et al.

 
 

In this study, the mechanical strength and modulus of poly(L-lacti acid) (PLLA) scaffolds were enhanced with the mechanical properties of boron nitride nanosheets (BNNSs) and …

 
 
 
 
 
 

Elevated hemoglobin A1c Is Associated with Carotid Plaque Vulnerability: Novel Findings from Magnetic Resonance Imaging Study in Hypertensive Stroke Patients

 
 

Beibei Sun, Huilin Zhao, Xiaosheng Liu et al.

 
 

The association between hemoglobin A1c (HbA1c) level and carotid plaque vulnerability has been rarely studied by magnetic resonance imaging (MRI). The present study of …

 
 
 
 
 
 

Analysis of long non-coding RNA expression profiles in pancreatic ductal adenocarcinoma

 
 

Xue-Liang Fu, De-Jun Liu, Ting-Ting Yan et al.

 
 

Pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive and lethal malignancies. Long non-coding RNAs (lncRNAs) are a novel class of non-protein-coding …

 
 
 
 
 
 

Evaluation of the neural function of nonhuman primates with spinal cord injury using an evoked potential-based scoring system

 
 

Jichao Ye, Mengjun Ma, Zhongyu Xie et al.

 
 

Nonhuman primate models of spinal cord injury (SCI) have been widely used in evaluation of the efficacy and safety of experimental restorative interventions before clinical …

 
 
 
 
 
 

Tlr4-mutant mice are resistant to acute alcohol-induced sterol-regulatory element binding protein activation and hepatic lipid accumulation

 
 

Zhi-Hui Zhang, Xiao-Qian Liu, Cheng Zhang et al.

 
 

Previous studies demonstrated that acute alcohol intoxication caused hepatic lipid accumulation. The present study showed that acute alcohol intoxication caused hepatic lipid …

 
 
 
 
 
 

BG-4, a novel anticancer peptide from bitter gourd (Momordica charantia), promotes apoptosis in human colon cancer cells

 
 

Vermont P. Dia, Hari B. Krishnan

 
 

Momordica charantia is a perennial plant with reported health benefits. BG-4, a novel peptide from Momordica charantia, was isolated, purified and characterized. The trypsin …

 
 
 
 
 
 

Y chromosome haplogroups based genome-wide association study pinpoints revelation for interactions on non-obstructive azoospermia

 
 

Chuncheng Lu, Yang Wen, Weiyue Hu et al.

 
 

The Y chromosome has high genetic variability with low rates of parallel and back mutations, which make up the most informative haplotyping system. To examine whether Y …

 
 
 
 
 
 

Transient exposure to calcium ionophore enables in vitro fertilization in sterile mouse models

 
 

Felipe A. Navarrete, Antonio Alvau, Hoi Chang Lee et al.

 
 

Mammalian sperm acquire fertilizing capacity in the female tract in a process called capacitation. At the molecular level, capacitation requires protein kinase A activation, …

 
 
 
 
 
 

Anion channelrhodopsins for inhibitory cardiac optogenetics

 
 

Elena G. Govorunova, Shane R. Cunha, Oleg A. Sineshchekov et al.

 
 

Optical control of the heart muscle is a promising strategy for cardiology because it is more specific than traditional electrical stimulation, and allows a higher temporal …

 
 
 
 
 
 

Telocytes in gastric lamina propria of the Chinese giant salamander, Andrias davidianus

 
 

Hui Zhang, Shengwei Zhong, Pengcheng Yu et al.

 
 

In this study, we attempt to identify gastric telocytes (TCs) of the Chinese giant salamander Andrias davidianus, by light microscopy, immunohistochemistry and transmission …

 
 
 
 
 
 

The Impact of Cognitive Training on Cerebral White Matter in Community-Dwelling Elderly: One-Year Prospective Longitudinal Diffusion Tensor Imaging Study

 
 

Xinyi Cao, Ye Yao, Ting Li et al.

 
 

It has been shown that cognitive training (CogTr) is effective and recuperative for older adults, and can be used to fight against cognitive decline. In this study, we …

 
 
 
 
 
 

Diagnostic copper imaging of Menkes disease by synchrotron radiation-generated X-ray fluorescence analysis

 
 

Miyuki Kinebuchi, Akihiro Matsuura, Tohru Kiyono et al.

 
 

Copper (Cu) is an indispensable metal for normal development and function of humans, especially in central nervous system (CNS). However, its redox activity requires accurate Cu …

 
 
 
 
 
 

Investigating the Responses of Human Epithelial Cells to Predatory Bacteria

 
 

Ajay K. Monnappa, Wasimul Bari, Seong Yeol Choi et al.

 
 

One beguiling alternative to antibiotics for treating multi-drug resistant infections are Bdellovibrio-and-like-organisms (BALOs), predatory bacteria known to attack human …

 
 
 
 
 
 

The coiled-coil domain of zebrafish TRPM7 regulates Mg·nucleotide sensitivity

 
 

Chad Jansen, Jaya Sahni, Sayuri Suzuki et al.

 
 

TRPM7 is a member of the Transient-Receptor-Potential Melastatin ion channel family. TRPM7 is a unique fusion protein of an ion channel and an α-kinase. Although mammalian TRPM7 …

 
 
 
 
 
 

Corrigendum: N-terminal pro b-type natriuretic peptide (NT-pro-BNP) –based score can predict in-hospital mortality in patients with heart failure

 
 

Ya-Ting Huang, Yuan-Teng Tseng, Tung-Wei Chu et al.

 
 

 
 
 
 
 
 

Six Versus Twelve Months Clopidogrel Therapy After Drug-Eluting Stenting in Patients With Acute Coronary Syndrome: An ISAR-SAFE Study Subgroup Analysis

 
 

Raphaela Lohaus, Jonathan Michel, Katharina Mayer et al.

 
 

In patients presenting with acute coronary syndrome (ACS) the optimal duration of dual-antiplatelet therapy after drug-eluting stent (DES) implantation remains unclear. At 6 …

 
 
 
 
 
 

Erratum: Advances in mapping malaria for elimination: fine resolution modelling of Plasmodium falciparum incidence

 
 

Victor A. Alegana, Peter M. Atkinson, Christopher Lourenço et al.

 
 

 
 
 
 
 
 

The impact of the HbA1c level of type 2 diabetics on the structure of haemoglobin

 
 

Shaoying Ye, Ping Ruan, Junguang Yong et al.

 
 

This study explores the impact of HbA1c levels on the structure of haemoglobin (Hb) in patients with type 2 diabetes. Seventy-four diabetic patients were classified into the …

 
 
 
 
 
 

Associations of the MCM6-rs3754686 proxy for milk intake in Mediterranean and American populations with cardiovascular biomarkers, disease and mortality: Mendelian randomization

 
 

Caren E. Smith, Oscar Coltell, Jose V. Sorlí et al.

 
 

Controversy persists on the association between dairy products, especially milk, and cardiovascular diseases (CVD). Genetic proxies may improve dairy intake estimations, and …

 
 
 
 
 
 

Neuroprotective effect of docosahexaenoic acid nanoemulsion on erectile function in a rat model of bilateral cavernous nerve injury

 
 

Chun-Hou Liao, Yi-No Wu, Bin-Huei Chen et al.

 
 

There is an unmet need for treatment of erectile dysfunction resulting from radical prostatectomy and cavernous nerve (CN) injury. Given the neuroprotective properties of …

 
 
 
 
 
 

Decreasing prevalence and time trend of gastroschisis in 14 cities of Liaoning Province: 2006–2015

 
 

Na Li, Yan-Ling Chen, Jing Li et al.

 
 

To identify trends in the prevalence of gastroschisis on the basis of a large population-based observation study with cases identified by the Liaoning Birth Defects Registry …

 
 
 
 
 
 

Evaluation of frozen tissue-derived prognostic gene expression signatures in FFPE colorectal cancer samples

 
 

Jing Zhu, Natasha G. Deane, Keeli B. Lewis et al.

 
 

Defining molecular features that can predict the recurrence of colorectal cancer (CRC) for stage II-III patients remains challenging in cancer research. Most available clinical …

 
 
 
 
 
 

Erratum: Genetic variability in a frozen batch of MCF-7 cells invisible in routine authentication affecting cell function

 
 

Andre Kleensang, Marguerite M. Vantangoli, Shelly Odwin-DaCosta et al.

 
 

 
 
 
 
 
 

Replicating Cardiovascular Condition-Birth Month Associations

 
 

Li Li, Mary Regina Boland, Riccardo Miotto et al.

 
 

Independent replication is vital for study findings drawn from Electronic Health Records (EHR). This replication study evaluates the relationship between seasonal effects at …

 
 
 
 
 
 

A Simple Adaptive Transfer Function for Deriving the Central Blood Pressure Waveform from a Radial Blood Pressure Waveform

 
 

Mingwu Gao, William C. Rose, Barry Fetics et al.

 
 

Generalized transfer functions (GTFs) are available to compute the more relevant central blood pressure (BP) waveform from a more easily measured radial BP waveform. However, …

 
 
 
 
 
 

Curcumin protects ANIT-induced cholestasis through signaling pathway of FXR-regulated bile acid and inflammation

 
 

Fan Yang, Xiaowen Tang, Lili Ding et al.

 
 

Cholestasis is a clinically significant symptom and widely associated with liver diseases, however, there are very few effective therapies for cholestasis. Danning tablet (DNT, a …

 
 
 
 
 
 

Panel-Based Population Next-Generation Sequencing for Inherited Retinal Degenerations

 
 

Matthew Carrigan, Emma Duignan, Conor P. G. Malone et al.

 
 

Inherited retinopathies affect approximately two and a half million people globally, yet the majority of affected patients lack clear genetic diagnoses given the diverse range of …

 
 
 
 
 
 

Genetically Low Vitamin D Levels, Bone Mineral Density, and Bone Metabolism Markers: a Mendelian Randomisation Study

 
 

Shan-Shan Li, Li-Hong Gao, Xiao-Ya Zhang et al.

 
 

Low serum 25-hydroxyvitamin D (25OHD) is associated with osteoporosis and osteoporotic fracture, but it remains uncertain whether these associations are causal. We conducted a …

 
 
 
 
 
 

Application of Species Distribution Modeling for Avian Influenza surveillance in the United States considering the North America Migratory Flyways

 
 

Jaber Belkhiria, Moh A. Alkhamis, Beatriz Martínez-López

 
 

Highly Pathogenic Avian Influenza (HPAI) has recently (2014–2015) re-emerged in the United States (US) causing the largest outbreak in US history with 232 outbreaks and an …

 
 
 
 
 
 

α-Mangostin-encapsulated PLGA nanoparticles inhibit pancreatic carcinogenesis by targeting cancer stem cells in human, and transgenic (KrasG12D, and KrasG12D/tp53R270H) mice

 
 

Raj Kumar Verma, Wei Yu, Anju Shrivastava et al.

 
 

Activation of sonic hedgehog (Shh) in cancer stem cell (CSC) has been demonstrated with aggressiveness of pancreatic cancer. In order to enhance the biological activity of …

 
 
 
 
 
 

A super gene expression system enhances the anti-glioma effects of adenovirus-mediated REIC/Dkk-3 gene therapy

 
 

Tetsuo Oka, Kazuhiko Kurozumi, Yosuke Shimazu et al.

 
 

Reduced expression in immortalized cells/Dickkopf-3 (REIC/Dkk-3) is a tumor suppressor and therapeutic gene in many human cancers. Recently, an adenovirus REIC vector with the …

 
 
 
 
 
 

Contamination-controlled high-throughput whole genome sequencing for influenza A viruses using the MiSeq sequencer

 
 

Hong Kai Lee, Chun Kiat Lee, Julian Wei-Tze Tang et al.

 
 

Accurate full-length genomic sequences are important for viral phylogenetic studies. We developed a targeted high-throughput whole genome sequencing (HT-WGS) method for influenza …

 
 
 
 
 
 

Amyloidogenic amyloid-β-peptide variants induce microbial agglutination and exert antimicrobial activity

 
 

Philipp Spitzer, Mateja Condic, Martin Herrmann et al.

 
 

Amyloid-β (Aβ) peptides are the main components of the plaques found in the brains of patients with Alzheimer’s disease. However, Aβ peptides are also detectable in secretory …

 
 
 
 
 
 

Integrin α6/Akt/Erk signaling is essential for human breast cancer resistance to radiotherapy

 
 

Ting Hu, Rui Zhou, Yanxia Zhao et al.

 
 

Integrin α6 (ITGA6), a transmembrane glycoprotein adhesion receptor protein, is widely upregulated in many types of tumors and promotes migration and invasion in cancer cells. …

 
 
 
 
 
 

Role of anterior piriform cortex in the acquisition of conditioned flavour preference

 
 

Cristina Mediavilla, Mar Martin-Signes, Severiano Risco

 
 

Flavour aversion learning (FAL) and conditioned flavour preference (CFP) facilitate animal survival and play a major role in food selection, but the neurobiological mechanisms …

 
 
 
 
 
 

Enteric neurons from Parkinson’s disease patients display ex vivo aberrations in mitochondrial structure

 
 

A. S. Baumuratov, P. M. A. Antony, M. Ostaszewski et al.

 
 

Based on autopsy material mitochondrial dysfunction has been proposed being part of the pathophysiological cascade of Parkinson’s disease (PD). However, in living patients, …

 
 
 
 
 
 

ASPP2 involvement in p53-mediated HIV-1 envelope glycoprotein gp120 neurotoxicity in mice cerebrocortical neurons

 
 

Zhiying Liu, Yunjin Zang, Luxin Qiao et al.

 
 

The mechanisms behind HIV-1-associated neurocognitive disorders are still unclear. Apoptosis-stimulating protein 2 of p53 (ASPP2) is a damage-inducible p53-binding protein that …

 
 
 
 
 
 

Allergy-specific Phenome-Wide Association Study for Immunogenes in Turkish Children

 
 

Sefayet Karaca, Ersoy Civelek, Mehmet Karaca et al.

 
 

To dissect the role of immunogenetics in allergy and asthma, we performed a phenome-wide association study in 974 Turkish children selected from a cross-sectional study conducted …

 
 
 
 
 
 

An integrative study identifies KCNC2 as a novel predisposing factor for childhood obesity and the risk of diabetes in the Korean population

 
 

Joo-Yeon Hwang, Hyo Jung Lee, Min Jin Go et al.

 
 

Obesity is a major risk factor for type 2 diabetes. To unravel the genetic determinants of obesity-associated diabetes, we performed a genome-wide study using the 1,000 …

 
 
 
 
 
 

Identification of Viruses in Cases of Pediatric Acute Encephalitis and Encephalopathy Using Next-Generation Sequencing

 
 

Jun-ichi Kawada, Yusuke Okuno, Yuka Torii et al.

 
 

Acute encephalitis/encephalopathy is a severe neurological syndrome that is occasionally associated with viral infection. Comprehensive virus detection assays are desirable …

 
 
 
 
 
 

Doped Graphene for DNA Analysis: the Electrochemical Signal is Strongly Influenced by the Kind of Dopant and the Nucleobase Structure

 
 

Huidi Tian, Lu Wang, Zdenek Sofer et al.

 
 

Doping graphene with heteroatoms can alter the electronic and electrochemical properties of the starting material. Contrasting properties should be expected when the doping is …

 
 
 
 
 
 

GLITTER: a web-based application for gene link inspection through tissue-specific coexpression

 
 

Xiangtao Liu, Pengfei Yu, Chao Cheng et al.

 
 

Accumulating evidence supports the polygenic nature of most complex diseases, suggesting the involvement of many susceptibility genes with small effect sizes. Although hundreds …

 
 
 
 
 
 

Deep brain stimulation of the subthalamic nucleus modulates sensitivity to decision outcome value in Parkinson’s disease

 
 

Ben Seymour, Michael Barbe, Peter Dayan et al.

 
 

Deep brain stimulation (DBS) of the subthalamic nucleus in Parkinson’s disease is known to cause a subtle but important adverse impact on behaviour, with impulsivity its most …

 
 
 
 
 
 

Persistent inflammatory state after photoreceptor loss in an animal model of retinal degeneration

 
 

Agustina Noailles, Victoria Maneu, Laura Campello et al.

 
 

Microglia act as the resident immune cells of the central nervous system, including the retina. In response to damaging stimuli microglia adopt an activated state, which can …

 
 
 
 
 
 

Refinement of the androgen response element based on ChIP-Seq in androgen-insensitive and androgen-responsive prostate cancer cell lines

 
 

Stephen Wilson, Jianfei Qi, Fabian V. Filipp

 
 

Sequence motifs are short, recurring patterns in DNA that can mediate sequence-specific binding for proteins such as transcription factors or DNA modifying enzymes. The androgen …

 
 
 
 
 
 

Skin scarification with Plasmodium falciparum peptide vaccine using synthetic TLR agonists as adjuvants elicits malaria sporozoite neutralizing immunity

 
 

Robert A. Mitchell, Rita Altszuler, Ute Frevert et al.

 
 

Malaria eradication will require a combination of vector control, chemotherapy and an easily administered vaccine. Sterile immunity can be elicited in humans by immunization with …

 
 
 
 
 
 

NOX2 amplifies acetaldehyde-mediated cardiomyocyte mitochondrial dysfunction in alcoholic cardiomyopathy

 
 

Moritz Brandt, Venkata Garlapati, Matthias Oelze et al.

 
 

Alcoholic cardiomyopathy (ACM) resulting from excess alcohol consumption is an important cause of heart failure (HF). Although it is assumed that the cardiotoxicity of the …

 
 
 
 
 
 

Protease-activated receptor-1 deficiency protects against streptozotocin-induced diabetic nephropathy in mice

 
 

Maaike Waasdorp, JanWillem Duitman, Sandrine Florquin et al.

 
 

Endogenously administered activated protein C ameliorates diabetic nephropathy (DN) in a protease-activated receptor-1 (PAR-1)-dependent manner, suggesting that PAR-1 activation …

 
 
 
 
 
 

Altered Intranetwork and Internetwork Functional Connectivity in Type 2 Diabetes Mellitus With and Without Cognitive Impairment

 
 

Shi-Qi Yang, Zhi-Peng Xu, Ying Xiong et al.

 
 

Type 2 diabetes mellitus (T2DM) is associated with cognitive impairment. We investigated whether alterations of intranetwork and internetwork functional connectivity with T2DM …

 
 
 
 
 
 

Vitamin D treatment attenuates 2,4,6-trinitrobenzene sulphonic acid (TNBS)-induced colitis but not oxazolone-induced colitis

 
 

Tianjing Liu, Yongyan Shi, Jie Du et al.

 
 

Crohn’s disease (CD) and ulcerative colitis (UC) have different immunological mechanisms, while both of them are potential targets of vitamin D treatment. In this study, we have …

 
 
 
 
 
 

Positive Effects of Specific Exercise and Novel Turning-based Treadmill Training on Turning Performance in Individuals with Parkinson’s disease: A Randomized Controlled Trial

 
 

Fang-Yu Cheng, Yea-Ru Yang, Li-Mei Chen et al.

 
 

Two different training strategies to improve turning performance in individuals with Parkinson’s disease (PD) were designed and investigated in this study. Subjects were randomly …

 
 
 
 
 
 

Targeting Motor End Plates for Delivery of Adenoviruses: An Approach to Maximize Uptake and Transduction of Spinal Cord Motor Neurons

 
 

Andrew Paul Tosolini, Renée Morris

 
 

Gene therapy can take advantage of the skeletal muscles/motor neurons anatomical relationship to restrict gene expression to the spinal cord ventral horn. Furthermore, …

 
 
 
 
 
 

The association between phosphatase and tensin homolog hypermethylation and patients with breast cancer, a meta-analysis and literature review

 
 

Yi-Min Lu, Feng Cheng, Li-Song Teng

 
 

The Phosphatase and tensin homolog (PTEN) protein is a negative regulator of the Akt pathway, leading to suppression of apoptois and increased cell survival. Its role as a …

 
 
 
 
 
 

Involvement of Histamine and RhoA/ROCK in Penicillin Immediate Hypersensitivity Reactions

 
 

Jiayin Han, Yan Yi, Chunying Li et al.

 
 

The mechanism of penicillin immediate hypersensitivity reactions has not been completely elucidated. These reactions are generally considered to be mediated by IgE, but …

 
 
 
 
 
 

Platelets confound the measurement of extracellular miRNA in archived plasma

 
 

Adam J. Mitchell, Warren D. Gray, Salim S. Hayek et al.

 
 

Extracellular miRNAs are detectable in biofluids and represent a novel class of disease biomarker. Although many studies have utilized archived plasma for miRNA biomarker …

 
 
 
 
 
 

Annual and seasonal spatial models for nitrogen oxides in Tehran, Iran

 
 

Heresh Amini, Seyed-Mahmood Taghavi-Shahri, Sarah B. Henderson et al.

 
 

Very few land use regression (LUR) models have been developed for megacities in low- and middle-income countries, but such models are needed to facilitate epidemiologic research …

 
 
 
 
 
 

Techniques of TIPS in the treatment of liver cirrhosis combined with incompletely occlusive main portal vein thrombosis

 
 

Mengfei Zhao, Zhendong Yue, Hongwei Zhao et al.

 
 

The patients of liver cirrhosis associated with portal vein thrombosis (PVT) can be effectively treated by transjugular intrahepatic portosystemic stent shunt (TIPS). Although …

 
 
 
 
 
 

Discovery of a Metastatic Immune Escape Mechanism Initiated by the Loss of Expression of the Tumour Biomarker Interleukin-33

 
 

Iryna Saranchova, Jeffrey Han, Hui Huang et al.

 
 

A new paradigm for understanding immune-surveillance and immune escape in cancer is described here. Metastatic carcinomas express reduced levels of IL-33 and diminished levels of …

 
 
 
 
 
 

Quadrant Field Pupillometry Detects Melanopsin Dysfunction in Glaucoma Suspects and Early Glaucoma

 
 

Prakash Adhikari, Andrew J. Zele, Ravi Thomas et al.

 
 

It is difficult to detect visual function deficits in patients at risk for glaucoma (glaucoma suspects) and at early disease stages with conventional ophthalmic tests such as …

 
 
 
 
 
 

Matrix metalloproteinase inhibitor, doxycycline and progression of calcific aortic valve disease in hyperlipidemic mice

 
 

Jae-Joon Jung, Mahmoud Razavian, Hye-Yeong Kim et al.

 
 

Calcific aortic valve disease (CAVD) is the most common cause of aortic stenosis. Currently, there is no non-invasive medical therapy for CAVD. Matrix metalloproteinases (MMPs) …

 
 
 
 
 
 

Microwave ablation of hepatocellular carcinoma as first-line treatment: long term outcomes and prognostic factors in 221 patients

 
 

Tao Wang, Xiao-Jie Lu, Jia-Chang Chi et al.

 
 

This retrospective study aimed at evaluating the long-term outcomes and prognostic factors of microwave ablation (MWA) as a first-line treatment for hepatocellular carcinoma …

 
 
 
 
 
 

4-Hydroxy-2-nonenal induces apoptosis by activating ERK1/2 signaling and depleting intracellular glutathione in intestinal epithelial cells

 
 

Yun Ji, Zhaolai Dai, Guoyao Wu et al.

 
 

Excessive reactive oxygen species (ROS) induces oxidative damage to cellular constituents, ultimately leading to induction of apoptotic cell death and the pathogenesis of various …

 
 
 
 
 
 

Protective effects of sirtuin 3 in a murine model of sepsis-induced acute kidney injury

 
 

Wen-Yu Zhao, Lei Zhang, Ming-Xing Sui et al.

 
 

Acute kidney injury (AKI) is a rapid loss of kidney function characterized by damage to renal tubular cells driven by mitochondrial dysregulation and oxidative stress. Here, we …

 
 
 
 
 
 

Molecular organization, localization and orientation of antifungal antibiotic amphotericin B in a single lipid bilayer

 
 

Wojciech Grudzinski, Joanna Sagan, Renata Welc et al.

 
 

Amphotericin B is a popular antifungal antibiotic, a gold standard in treatment of systemic mycotic infections, due to its high effectiveness. On the other hand, applicability of …

 
 
 
 
 
 

Characterization of a knock-in mouse model of the homozygous p.V37I variant in Gjb2

 
 

Ying Chen, Lingxiang Hu, Xueling Wang et al.

 
 

The homozygous p.V37I variant in GJB2 is prevalent in East and Southeast Asians and may lead to mild-to-moderate hearing loss with reduced penetrance. To investigate the …

 
 
 
 
 
 

Trp53 deficient mice predisposed to preterm birth display region-specific lipid alterations at the embryo implantation site

 
 

Ingela Lanekoff, Jeeyeon Cha, Jennifer E. Kyle et al.

 
 

Here we demonstrate that conditional deletion of mouse uterine Trp53 (p53d/d), molecularly linked to mTORC1 activation and causally linked to premature uterine senescence and …

 
 
 
 
 
 

The analysis of heterotaxy patients reveals new loss-of-function variants of GRK5

 
 

Davor Lessel, Tariq Muhammad, Teresa Casar Tena et al.

 
 

G protein-coupled receptor kinase 5 (GRK5) is a regulator of cardiac performance and a potential therapeutic target in heart failure in the adult. Additionally, we have …

 
 
 
 
 
 
 
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