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| | 22 October 2014 | | Featured image: | | | | Toju et al. reveal fundamental differences in the structure of plant-fungus networks when compared to other ecological communities. | | | | | | | Advertisement | | Announcing npj Microgravity npj Microgravity is a new open access journal specifically dedicated to publishing research which enables space exploration and research that is enabled by spaceflight and ground-based spaceflight analogues. npj Microgravity is published in cooperation the Biodesign Institute at Arizona State University, and is part of the Nature Partner Journals series. Find out more: bit.ly/1v0fJQW | | | | | | Latest Editorial | View all Editorials | | | Opening up communications OPEN | | The transition to fully open access publishing establishes Nature Communications as the flagship Nature-branded open access journal. | | 20 October 2014 | doi: 10.1038/ncomms6523 | | | | | | | | Latest Articles | View all Articles | | | Camelid genomes reveal evolution and adaptation to desert environments | | Huiguang Wu, Xuanmin Guang, Mohamed B. Al-Fageeh, Junwei Cao, Shengkai Pan, Huanmin Zhou, Li Zhang, Mohammed H. Abutarboush, Yanping Xing, Zhiyuan Xie, Ali S. Alshanqeeti, Yanru Zhang, Qiulin Yao, Badr M. Al-Shomrani, Dong Zhang, Jiang Li, Manee M. Manee, Zili Yang, Linfeng Yang, Yiyi Liu et al. | | Comparative genomics can provide valuable insights on adaptations to hostile environments. Here, the authors sequence the genomes and transcriptomes of the Bactrian camel, dromedary and alpaca, to reveal the demographic history of the group as well as metabolic adaptations to the desert environment. | | 21 October 2014 | doi: 10.1038/ncomms6188 | | Biological Sciences Evolution Genetics | Calcitonin controls bone formation by inhibiting the release of sphingosine 1-phosphate from osteoclasts OPEN | | Johannes Keller, Philip Catala-Lehnen, Antje K. Huebner, Anke Jeschke, Timo Heckt, Anja Lueth, Matthias Krause, Till Koehne, Joachim Albers, Jochen Schulze, Sarah Schilling, Michael Haberland, Hannah Denninger, Mona Neven, Irm Hermans-Borgmeyer, Thomas Streichert, Stefan Breer, Florian Barvencik, Bodo Levkau, Birgit Rathkolb et al. | | The regulatory role of calcitonin in bone homeostasis is well studied, yet its molecular activity is poorly understood. The authors show that calcitonin regulates bone cells function by inhibiting the osteoclast secretion of sphingosine 1-phosphate, a lipid mediator of osteoclast–osteoblast crosstalk. | | 21 October 2014 | doi: 10.1038/ncomms6215 | | Biological Sciences Cell biology Medical research | Genome flux and stasis in a five millennium transect of European prehistory OPEN | | Cristina Gamba, Eppie R. Jones, Matthew D. Teasdale, Russell L. McLaughlin, Gloria Gonzalez-Fortes, Valeria Mattiangeli, László Domboróczki, Ivett KÅ‘vári, Ildikó Pap, Alexandra Anders, Alasdair Whittle, János Dani, Pál Raczky, Thomas F. G. Higham, Michael Hofreiter, Daniel G. Bradley and Ron Pinhasi | | Recent advances in high-throughput sequencing techniques have enabled the analysis of ancient human genomes. Here the authors sequence ancient human genomes that span a period of 5,000 years, to understand the ancestral influence on Europe's genetic landscape. | | 21 October 2014 | doi: 10.1038/ncomms6257 | | Biological Sciences Evolution Genetics | Red fluorescent genetically encoded indicator for intracellular hydrogen peroxide | | Yulia G. Ermakova, Dmitry S. Bilan, Mikhail E. Matlashov, Natalia M. Mishina, Ksenia N. Markvicheva, Oksana M. Subach, Fedor V. Subach, Ivan Bogeski, Markus Hoth, Grigori Enikolopov and Vsevolod V. Belousov | | Current genetically encoded sensors for hydrogen peroxide, such as HyPer, emit in the green region giving potential for overlap with other probes. Here, the authors report HyPerRed, a red fluorescent redox probe capable of monitoring intracellular hydrogen peroxide. | | 21 October 2014 | doi: 10.1038/ncomms6222 | | Biological Sciences Biochemistry Biophysics Cell biology | Two-dimensional quasi-freestanding molecular crystals for high-performance organic field-effect transistors | | Daowei He, Yuhan Zhang, Qisheng Wu, Rui Xu, Haiyan Nan, Junfang Liu, Jianjun Yao, Zilu Wang, Shijun Yuan, Yun Li, Yi Shi, Jinlan Wang, Zhenhua Ni, Lin He, Feng Miao, Fengqi Song, Hangxun Xu, K. Watanabe, T. Taniguchi, Jian-Bin Xu et al. | | Inorganic two-dimensional atomic crystals exhibit a variety of unusual but practically useful properties. Here, the authors produce an organic counterpart, atomically smooth monolayers of a molecular crystal, and use this organic analogue of graphene in high-performance organic field-effect transistors. | | 21 October 2014 | doi: 10.1038/ncomms6162 | | Physical Sciences Materials science | The cavefish genome reveals candidate genes for eye loss OPEN | | Suzanne E. McGaugh, Joshua B. Gross, Bronwen Aken, Maryline Blin, Richard Borowsky, Domitille Chalopin, Hélène Hinaux, William R. Jeffery, Alex Keene, Li Ma, Patrick Minx, Daniel Murphy, Kelly E. O’Quin, Sylvie Rétaux, Nicolas Rohner, Steve M. J. Searle, Bethany A. Stahl, Cliff Tabin, Jean-Nicolas Volff, Masato Yoshizawa et al. | | Populations of the cave fish Astyanax mexicanus exhibit a variety of traits that evolved repeatedly and independently from its surface counterparts. Here the authors present a de novo genome assembly for A. mexicanus and identify candidate genes for eye loss and reduced pigmentation. | | 20 October 2014 | doi: 10.1038/ncomms6307 | | Biological Sciences Evolution Genetics | Genome-wide association study of breast cancer in Latinas identifies novel protective variants on 6q25 | | Laura Fejerman, Nasim Ahmadiyeh, Donglei Hu, Scott Huntsman, Kenneth B. Beckman, Jennifer L. Caswell, Karen Tsung, Esther M. John, Gabriela Torres-Mejia, Luis Carvajal-Carmona, María Magdalena Echeverry, Anna Marie D. Tuazon, Carolina Ramirez, COLUMBUS Consortium, Luis Carvajal-Carmona, María Magdalena Echeverry, Mabel Elena Bohórquez, Rodrigo Prieto, Ángel Criollo, Carolina Ramírez et al. | | Genome-wide association studies (GWAS) have revealed gene variants associated with breast cancer, but their association with breast cancer development in Latinas is not clear. Here, the authors carry out a GWAS of breast cancer in Latinas and identify a significant protective variant of Indigenous American origin in the 6q25 region. | | 20 October 2014 | doi: 10.1038/ncomms6260 | | Biological Sciences Cancer Genetics | Transparent and flexible low noise graphene electrodes for simultaneous electrophysiology and neuroimaging | | Duygu Kuzum, Hajime Takano, Euijae Shim, Jason C. Reed, Halvor Juul, Andrew G. Richardson, Julius de Vries, Hank Bink, Marc A. Dichter, Timothy H. Lucas, Douglas A. Coulter, Ertugrul Cubukcu and Brian Litt | | Monitoring neuronal activity of large populations of neurons at high-temporal and spatial resolution is important to understand neurophysiology but requires improved tools and methods. Here the authors develop a transparent and flexible electrode based on graphene that allows them to combine electrophysiological recordings with calcium imaging. | | 20 October 2014 | doi: 10.1038/ncomms6259 | | Biological Sciences Neuroscience | Characterizing the genetic basis of innate immune response in TLR4-activated human monocytes | | Sarah Kim, Jessica Becker, Matthias Bechheim, Vera Kaiser, Mahdad Noursadeghi, Nadine Fricker, Esther Beier, Sven Klaschik, Peter Boor, Timo Hess, Andrea Hofmann, Stefan Holdenrieder, Jens R. Wendland, Holger Fröhlich, Gunther Hartmann, Markus M. Nöthen, Bertram Müller-Myhsok, Benno Pütz, Veit Hornung and Johannes Schumacher et al. | | Toll-like receptors (TLRs) are an essential component of innate immunity. Here, the authors identify expression quantitative trait loci that are unique to TLR4-stimulation and highlight genes that may have a role in innate immune response. | | 20 October 2014 | doi: 10.1038/ncomms6236 | | Biological Sciences Genetics Immunology | Towards intrinsic charge transport in monolayer molybdenum disulfide by defect and interface engineering | | Zhihao Yu, Yiming Pan, Yuting Shen, Zilu Wang, Zhun-Yong Ong, Tao Xu, Run Xin, Lijia Pan, Baigeng Wang, Litao Sun, Jinlan Wang, Gang Zhang, Yong Wei Zhang, Yi Shi and Xinran Wang | | Impurities in molybdenum disulfide are known to reduce charge mobility to below its intrinsic limit. Here, the authors demonstrate that impurities are associated with lattice defects and that a chemical route can repair sulfur vacancies and improve interface quality with a substrate, enhancing device performance. | | 20 October 2014 | doi: 10.1038/ncomms6290 | | Physical Sciences Materials science Nanotechnology | Assembly of complex plant–fungus networks OPEN | | Hirokazu Toju, Paulo R. Guimarães, Jens M. Olesen and John N. Thompson | | Ecological communities consist of complex networks of interacting species whose linkages may be difficult to follow. Using next-generation sequencing, Toju et al. uncover the architecture of a plant-fungus network and find clear structural differences when compared with other communities. | | 20 October 2014 | doi: 10.1038/ncomms6273 | | Biological Sciences Ecology | Graphene-based carbon-layered electrode array technology for neural imaging and optogenetic applications OPEN | | Dong-Wook Park, Amelia A. Schendel, Solomon Mikael, Sarah K. Brodnick, Thomas J. Richner, Jared P. Ness, Mohammed R. Hayat, Farid Atry, Seth T. Frye, Ramin Pashaie, Sanitta Thongpang, Zhenqiang Ma and Justin C. Williams | | Monitoring neuronal activity in the rodent in vivo brain is commonly done using micro-electrode arrays but these devices are not normally compatible with optical technologies. Here the authors design a transparent and flexible electrode array based on graphene that allows them to combine electrophysiological recordings with optogenetic and imaging experiments. | | 20 October 2014 | doi: 10.1038/ncomms6258 | | Biological Sciences Neuroscience | Fine tuning of sub-millisecond conformational dynamics controls metabotropic glutamate receptors agonist efficacy | | Linnea Olofsson, Suren Felekyan, Etienne Doumazane, Pauline Scholler, Ludovic Fabre, Jurriaan M. Zwier, Philippe Rondard, Claus A. M. Seidel, Jean-Philippe Pin and Emmanuel Margeat | | Understanding the molecular basis of receptor activation requires characterizing the dynamic equilibrium of conformational states. Here the authors show that the metabotropic glutamate receptor oscillates between conformations on a sub-millisecond timescale, and agonists quantitatively shift the equilibrium towards the activated state based on their potency. | | 17 October 2014 | doi: 10.1038/ncomms6206 | | Biological Sciences Biochemistry | Lymphocytes can self-steer passively with wind vane uropods | | Marie-Pierre Valignat, Paulin Nègre, Sophie Cadra, Annemarie C Lellouch, François Gallet, Sylvie Hénon and Olivier Theodoly | | Lymphocytes crawl on blood vessels against the flow of blood, but the mechanism for this directed migration is not known. Here, Valignat et al. show that lymphocytes can use their uropods as wind vanes to passively steer their migration in the presence of fluid flow, without the need for internal guidance cues. | | 17 October 2014 | doi: 10.1038/ncomms6213 | | Biological Sciences Cell biology Immunology | LIF negatively regulates tumour-suppressor p53 through Stat3/ID1/MDM2 in colorectal cancers | | Haiyang Yu, Xuetian Yue, Yuhan Zhao, Xiaoyan Li, Lihua Wu, Cen Zhang, Zhen Liu, Kevin Lin, Zijun Y. Xu-Monette, Ken H. Young, Juan Liu, Zhiyuan Shen, Zhaohui Feng and Wenwei Hu | | Leukaemia inhibitory factor (LIF) is a p53 target but its role in cancer is unclear. Here Hu et al. show that LIF confers chemoresistance in colorectal cancer cells by Stat3-mediated upregulation of inhibitor of DNA-binding 1, leading to MDM2 E3 ubiquitin ligase upregulation and p53 degradation. | | 17 October 2014 | doi: 10.1038/ncomms6218 | | Biological Sciences Cancer Molecular biology | Sub-diffractional volume-confined polaritons in the natural hyperbolic material hexagonal boron nitride | | Joshua D. Caldwell, Andrey V. Kretinin, Yiguo Chen, Vincenzo Giannini, Michael M. Fogler, Yan Francescato, Chase T. Ellis, Joseph G. Tischler, Colin R. Woods, Alexander J. Giles, Minghui Hong, Kenji Watanabe, Takashi Taniguchi, Stefan A. Maier and Kostya S. Novoselov | | Hyperbolic metamaterials exhibit interesting optical phenomena that could provide useful functionalities, if the losses can be reduced. Here Caldwell et al. show that hexagonal boron nitride supports hyperbolic polaritons, presenting a natural alternative to metamaterial systems. | | 17 October 2014 | doi: 10.1038/ncomms6221 | | Physical Sciences Condensed matter Nanotechnology Optical physics | Surfactant-assisted chemical vapour deposition of high-performance small-diameter GaSb nanowires | | Zai-xing Yang, Ning Han, Ming Fang, Hao Lin, Ho-Yuen Cheung, SenPo Yip, Er-Jun Wang, TakFu Hung, Chun-Yuen Wong and Johnny C. Ho | | Antimonide nanowires may have useful applications as semiconductors in optoelectronics. Here, the authors use a sulfur surfactant to produce high-performance GaSb nanowires via chemical vapour deposition, achieving very thin and uniform nanowires with diameters as small as 20 nm. | | 16 October 2014 | doi: 10.1038/ncomms6249 | | Physical Sciences Materials science Nanotechnology | Meiofauna increases bacterial denitrification in marine sediments OPEN | | S. Bonaglia, F. J. A Nascimento, M. Bartoli, I. Klawonn and V. Brüchert | | Excessive nutrient loading is a threat to aquatic ecosystems; however, denitrification may be key in removing large amounts of reactive nitrogen and, therefore, mitigating consequent eutrophication. Here, the authors explore how meiofauna may impact the rate of denitrification in sediments. | | 16 October 2014 | doi: 10.1038/ncomms6133 | | Earth Sciences Biogeochemistry | Interferon regulatory factor 9 is critical for neointima formation following vascular injury OPEN | | Shu-Min Zhang, Li-Hua Zhu, Hou-Zao Chen, Ran Zhang, Peng Zhang, Ding-Sheng Jiang, Lu Gao, Song Tian, Lang Wang, Yan Zhang, Pi-Xiao Wang, Xiao-Fei Zhang, Xiao-Dong Zhang, De-Pei Liu and Hongliang Li | | Blood vessels respond to injury by thickening the supportive smooth muscle layer in a process known as neointima formation. Here the authors describe a novel regulatory pathway of neointima formation that involves a transcription factor, Interferon Regulating Factor 9, and its downstream target, the deacetylase SIRT1. | | 16 October 2014 | doi: 10.1038/ncomms6160 | | Biological Sciences Medical research | Evidence for a weakening relationship between interannual temperature variability and northern vegetation activity | | Shilong Piao, Huijuan Nan, Chris Huntingford, Philippe Ciais, Pierre Friedlingstein, Stephen Sitch, Shushi Peng, Anders Ahlström, Josep G. Canadell, Nan Cong, Sam Levis, Peter E. Levy, Lingli Liu, Mark R. Lomas, Jiafu Mao, Ranga B. Myneni, Philippe Peylin, Ben Poulter, Xiaoying Shi, Guodong Yin et al. | | Northern Hemisphere photosynthesis is thought to respond positively to temperature variations, yet the strength of this relationship may change over time. Here, using a combination of satellite data and models, the authors assess the temporal change of this relationship over the past three decades. | | 16 October 2014 | doi: 10.1038/ncomms6018 | | Earth Sciences Biogeochemistry Climate science | αB-crystallin interacts with and prevents stress-activated proteolysis of focal adhesion kinase by calpain in cardiomyocytes | | Michelle B. M. Pereira, Aline M. Santos, Danieli C. Gonçalves, Alisson C. Cardoso, Sílvio R. Consonni, Fabio C. Gozzo, Paulo S. Oliveira, Ana Helena M. Pereira, Alana R. Figueiredo, Ana O. Tiroli-Cepeda, Carlos H. I. Ramos, André A. de Thomaz, Carlos L. Cesar and Kleber G. Franchini | | Focal adhesion kinase (FAK) is a scaffold and tyrosine kinase protein, critical for proper cardiac function under stress conditions. Here the authors show that the small heat–shock protein αB-crystallin interacts with FAK and protects it from calpain-mediated proteolysis in stressed rat cardiomyocytes. | | 16 October 2014 | doi: 10.1038/ncomms6159 | | Biological Sciences Cell biology Medical research | Motor contributions to the temporal precision of auditory attention OPEN | | Benjamin Morillon, Charles E. Schroeder and Valentin Wyart | | Motor activities, such as rhythmic movements, are implicated in regulating attention. Here, the authors find that rhythmic movements sharpen the temporal selection of auditory stimuli by facilitating the perception of relevant stimuli, while actively suppressing the interference from irrelevant stimuli. | | 15 October 2014 | doi: 10.1038/ncomms6255 | | Biological Sciences Neuroscience | Parkin regulates kainate receptors by interacting with the GluK2 subunit OPEN | | AnnaMaria Maraschi, Andrea Ciammola, Alessandra Folci, Francesca Sassone, Giuseppe Ronzitti, Graziella Cappelletti, Vincenzo Silani, Shigeto Sato, Nobutaka Hattori, Michele Mazzanti, Evelina Chieregatti, Christophe Mulle, Maria Passafaro and Jenny Sassone | | Loss-of-function mutations in the PARK2 gene are implicated in autosomal recessive juvenile parkinsonism, but the mechanisms are unclear. Here, the authors show that these mutations cause accumulation of the kainate receptor subunit GluK2 in the plasma membrane of neurons, which facilitates neuronal death. | | 15 October 2014 | doi: 10.1038/ncomms6182 | | Biological Sciences Neuroscience | | | | | | | | | Latest Corrigendum | | | | | | | | Advertisement | | | | | | | | | | | Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here.
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