Sponsor

2014/10/22

Nature Communications - 22 October 2014

If you are unable to see the message below, click here to view.
 
Nature Communications
 
 
Weekly Content Alert
22 October 2014 
Featured image:
Featured image
Toju et al. reveal fundamental differences in the structure of plant-fungus networks when compared to other ecological communities.
Latest content:
Editorial
Review
Articles
Corrigendum
Journal homepage
Recommend to library
Web feed
 

Advertisement
Announcing npj Microgravity
 
npj Microgravity is a new open access journal specifically dedicated to publishing research which enables space exploration and research that is enabled by spaceflight and ground-based spaceflight analogues. npj Microgravity is published in cooperation the Biodesign Institute at Arizona State University, and is part of the Nature Partner Journals series.
 
Find out more: bit.ly/1v0fJQW
 
 
  Latest Editorial View all Editorials  
 
Opening up communications OPEN
The transition to fully open access publishing establishes Nature Communications as the flagship Nature-branded open access journal.
20 October 2014 | doi: 10.1038/ncomms6523
 
 
  Latest Review View all Reviews  
 
Renormalization group running of neutrino parameters
Tommy Ohlsson and Shun Zhou
Neutrinos are ghost-like particles that interact only very weakly with other particles. As ongoing experiments to measure their properties improve, Ohlsson and Zhou review neutrino mass models and the renormalization group running of neutrino parameters that aim to understand the origin of neutrino mass.
17 October 2014 | doi: 10.1038/ncomms6153
Physical Sciences  Particle physics  Theoretical physics 
 
 
  Latest Articles View all Articles  
 
Camelid genomes reveal evolution and adaptation to desert environments
Huiguang Wu, Xuanmin Guang, Mohamed B. Al-Fageeh, Junwei Cao, Shengkai Pan, Huanmin Zhou, Li Zhang, Mohammed H. Abutarboush, Yanping Xing, Zhiyuan Xie, Ali S. Alshanqeeti, Yanru Zhang, Qiulin Yao, Badr M. Al-Shomrani, Dong Zhang, Jiang Li, Manee M. Manee, Zili Yang, Linfeng Yang, Yiyi Liu et al.
Comparative genomics can provide valuable insights on adaptations to hostile environments. Here, the authors sequence the genomes and transcriptomes of the Bactrian camel, dromedary and alpaca, to reveal the demographic history of the group as well as metabolic adaptations to the desert environment.
21 October 2014 | doi: 10.1038/ncomms6188
Biological Sciences  Evolution  Genetics 

Calcitonin controls bone formation by inhibiting the release of sphingosine 1-phosphate from osteoclasts OPEN
Johannes Keller, Philip Catala-Lehnen, Antje K. Huebner, Anke Jeschke, Timo Heckt, Anja Lueth, Matthias Krause, Till Koehne, Joachim Albers, Jochen Schulze, Sarah Schilling, Michael Haberland, Hannah Denninger, Mona Neven, Irm Hermans-Borgmeyer, Thomas Streichert, Stefan Breer, Florian Barvencik, Bodo Levkau, Birgit Rathkolb et al.
The regulatory role of calcitonin in bone homeostasis is well studied, yet its molecular activity is poorly understood. The authors show that calcitonin regulates bone cells function by inhibiting the osteoclast secretion of sphingosine 1-phosphate, a lipid mediator of osteoclast–osteoblast crosstalk.
21 October 2014 | doi: 10.1038/ncomms6215
Biological Sciences  Cell biology  Medical research 

Genome flux and stasis in a five millennium transect of European prehistory OPEN
Cristina Gamba, Eppie R. Jones, Matthew D. Teasdale, Russell L. McLaughlin, Gloria Gonzalez-Fortes, Valeria Mattiangeli, László Domboróczki, Ivett KÅ‘vári, Ildikó Pap, Alexandra Anders, Alasdair Whittle, János Dani, Pál Raczky, Thomas F. G. Higham, Michael Hofreiter, Daniel G. Bradley and Ron Pinhasi
Recent advances in high-throughput sequencing techniques have enabled the analysis of ancient human genomes. Here the authors sequence ancient human genomes that span a period of 5,000 years, to understand the ancestral influence on Europe's genetic landscape.
21 October 2014 | doi: 10.1038/ncomms6257
Biological Sciences  Evolution  Genetics 

A viral peptide that targets mitochondria protects against neuronal degeneration in models of Parkinson’s disease
Marion Szelechowski, Alexandre Bétourné, Yann Monnet, Cécile A. Ferré, Anne Thouard, Charlotte Foret, Jean-Michel Peyrin, Stéphane Hunot and Daniel Gonzalez-Dunia
Mitochondrial dysfunction is associated with a number of neurodegenerative diseases. Szelechowski et al. take advantage of a viral protein that suppresses apoptosis in neurons to isolate a peptide that protects mitochondria and reduces neuronal cell death in a mouse model of Parkinson’s disease.
21 October 2014 | doi: 10.1038/ncomms6181
Biological Sciences  Neuroscience 

Oestrogen signalling in white adipose progenitor cells inhibits differentiation into brown adipose and smooth muscle cells
Kfir Lapid, Ajin Lim, Deborah J. Clegg, Daniel Zeve and Jonathan M. Graff
Oestrogen has various metabolic and physiological effects. Here the authors show that oestrogen receptor alpha signalling determines lineage commitment of murine adipose progenitor cells, regulating their differentiation into white adipocytes, beige adipocytes or smooth muscle cells.
21 October 2014 | doi: 10.1038/ncomms6196
Biological Sciences  Cell biology  Medical research 

Red fluorescent genetically encoded indicator for intracellular hydrogen peroxide
Yulia G. Ermakova, Dmitry S. Bilan, Mikhail E. Matlashov, Natalia M. Mishina, Ksenia N. Markvicheva, Oksana M. Subach, Fedor V. Subach, Ivan Bogeski, Markus Hoth, Grigori Enikolopov and Vsevolod V. Belousov
Current genetically encoded sensors for hydrogen peroxide, such as HyPer, emit in the green region giving potential for overlap with other probes. Here, the authors report HyPerRed, a red fluorescent redox probe capable of monitoring intracellular hydrogen peroxide.
21 October 2014 | doi: 10.1038/ncomms6222
Biological Sciences  Biochemistry  Biophysics  Cell biology 

Probing biomechanical properties with a centrifugal force quartz crystal microbalance
Aaron Webster, Frank Vollmer and Yuki Sato
Knowing the response of biomolecules to mechanical load is vital in understanding various biological processes. Here, the authors report a new force-based biosensing technique, in which applying centrifugal forces to small particles and molecules allows mechanical properties to be probed.
21 October 2014 | doi: 10.1038/ncomms6284
Biological Sciences  Biophysics  Materials science 

RNaseH1 regulates TERRA-telomeric DNA hybrids and telomere maintenance in ALT tumour cells OPEN
Rajika Arora, Yongwoo Lee, Harry Wischnewski, Catherine M. Brun, Tobias Schwarz and Claus M. Azzalin
A subset of cancers maintains telomere length independently of telomerase by activating alternative lengthening of telomeres (ALT) pathways. Here the authors show that RNaseH1 modulates telomeric homologous recombination frequencies in ALT cells by regulating the levels of RNA–DNA hybrids between TERRA and telomeric DNA.
21 October 2014 | doi: 10.1038/ncomms6220
Biological Sciences  Cancer  Molecular biology 

Two-dimensional quasi-freestanding molecular crystals for high-performance organic field-effect transistors
Daowei He, Yuhan Zhang, Qisheng Wu, Rui Xu, Haiyan Nan, Junfang Liu, Jianjun Yao, Zilu Wang, Shijun Yuan, Yun Li, Yi Shi, Jinlan Wang, Zhenhua Ni, Lin He, Feng Miao, Fengqi Song, Hangxun Xu, K. Watanabe, T. Taniguchi, Jian-Bin Xu et al.
Inorganic two-dimensional atomic crystals exhibit a variety of unusual but practically useful properties. Here, the authors produce an organic counterpart, atomically smooth monolayers of a molecular crystal, and use this organic analogue of graphene in high-performance organic field-effect transistors.
21 October 2014 | doi: 10.1038/ncomms6162
Physical Sciences  Materials science 

The cavefish genome reveals candidate genes for eye loss OPEN
Suzanne E. McGaugh, Joshua B. Gross, Bronwen Aken, Maryline Blin, Richard Borowsky, Domitille Chalopin, Hélène Hinaux, William R. Jeffery, Alex Keene, Li Ma, Patrick Minx, Daniel Murphy, Kelly E. O’Quin, Sylvie Rétaux, Nicolas Rohner, Steve M. J. Searle, Bethany A. Stahl, Cliff Tabin, Jean-Nicolas Volff, Masato Yoshizawa et al.
Populations of the cave fish Astyanax mexicanus exhibit a variety of traits that evolved repeatedly and independently from its surface counterparts. Here the authors present a de novo genome assembly for A. mexicanus and identify candidate genes for eye loss and reduced pigmentation.
20 October 2014 | doi: 10.1038/ncomms6307
Biological Sciences  Evolution  Genetics 

Genome-wide association study of breast cancer in Latinas identifies novel protective variants on 6q25
Laura Fejerman, Nasim Ahmadiyeh, Donglei Hu, Scott Huntsman, Kenneth B. Beckman, Jennifer L. Caswell, Karen Tsung, Esther M. John, Gabriela Torres-Mejia, Luis Carvajal-Carmona, María Magdalena Echeverry, Anna Marie D. Tuazon, Carolina Ramirez, COLUMBUS Consortium, Luis Carvajal-Carmona, María Magdalena Echeverry, Mabel Elena Bohórquez, Rodrigo Prieto, Ángel Criollo, Carolina Ramírez et al.
Genome-wide association studies (GWAS) have revealed gene variants associated with breast cancer, but their association with breast cancer development in Latinas is not clear. Here, the authors carry out a GWAS of breast cancer in Latinas and identify a significant protective variant of Indigenous American origin in the 6q25 region.
20 October 2014 | doi: 10.1038/ncomms6260
Biological Sciences  Cancer  Genetics 

Structure-guided discovery of potent and dual-acting human parainfluenza virus haemagglutinin–neuraminidase inhibitors
Patrice Guillon, Larissa Dirr, Ibrahim M. El-Deeb, Moritz Winger, Benjamin Bailly, Thomas Haselhorst, Jeffrey C. Dyason and Mark von Itzstein
Human parainfluenza viruses (hPIVs) cause common respiratory diseases in children. Here the authors rationally design small molecules targeting the hPIV haemagglutinin–neuraminidase protein, and show that the compounds inhibit viral entry and exit from cultured cells.
20 October 2014 | doi: 10.1038/ncomms6268
Biological Sciences  Chemical biology  Medicinal chemistry  Virology 

The meta-epigenomic structure of purified human stem cell populations is defined at cis-regulatory sequences
N. Ari Wijetunga, Fabien Delahaye, Yong M. Zhao, Aaron Golden, Jessica C. Mar, Francine H. Einstein and John M. Greally
There is epigenetic variability in the same cell type among healthy individuals, but the mechanism or significance of this variability is not clear. Here, the authors purify CD34+ cells from different individuals and use meta-epigenomic approaches to analyse and explain the epigenetic variability observed.
20 October 2014 | doi: 10.1038/ncomms6195
Biological Sciences  Genetics  Molecular biology 

Transparent and flexible low noise graphene electrodes for simultaneous electrophysiology and neuroimaging
Duygu Kuzum, Hajime Takano, Euijae Shim, Jason C. Reed, Halvor Juul, Andrew G. Richardson, Julius de Vries, Hank Bink, Marc A. Dichter, Timothy H. Lucas, Douglas A. Coulter, Ertugrul Cubukcu and Brian Litt
Monitoring neuronal activity of large populations of neurons at high-temporal and spatial resolution is important to understand neurophysiology but requires improved tools and methods. Here the authors develop a transparent and flexible electrode based on graphene that allows them to combine electrophysiological recordings with calcium imaging.
20 October 2014 | doi: 10.1038/ncomms6259
Biological Sciences  Neuroscience 

Translocation path of a substrate protein through its Omp85 transporter
Catherine Baud, Jérémy Guérin, Emmanuelle Petit, Elodie Lesne, Elian Dupré, Camille Locht and Françoise Jacob-Dubuisson
The two-partner secretion system transports proteins across the bacterial outer membrane but the molecular mechanisms involved are poorly understood. Here, Baud et al. use site-specific crosslinking to track the path of a protein substrate through the β-barrel of its Omp85 transporter.
20 October 2014 | doi: 10.1038/ncomms6271
Biological Sciences  Chemical biology  Medicinal chemistry 

Characterizing the genetic basis of innate immune response in TLR4-activated human monocytes
Sarah Kim, Jessica Becker, Matthias Bechheim, Vera Kaiser, Mahdad Noursadeghi, Nadine Fricker, Esther Beier, Sven Klaschik, Peter Boor, Timo Hess, Andrea Hofmann, Stefan Holdenrieder, Jens R. Wendland, Holger Fröhlich, Gunther Hartmann, Markus M. Nöthen, Bertram Müller-Myhsok, Benno Pütz, Veit Hornung and Johannes Schumacher et al.
Toll-like receptors (TLRs) are an essential component of innate immunity. Here, the authors identify expression quantitative trait loci that are unique to TLR4-stimulation and highlight genes that may have a role in innate immune response.
20 October 2014 | doi: 10.1038/ncomms6236
Biological Sciences  Genetics  Immunology 

Towards intrinsic charge transport in monolayer molybdenum disulfide by defect and interface engineering
Zhihao Yu, Yiming Pan, Yuting Shen, Zilu Wang, Zhun-Yong Ong, Tao Xu, Run Xin, Lijia Pan, Baigeng Wang, Litao Sun, Jinlan Wang, Gang Zhang, Yong Wei Zhang, Yi Shi and Xinran Wang
Impurities in molybdenum disulfide are known to reduce charge mobility to below its intrinsic limit. Here, the authors demonstrate that impurities are associated with lattice defects and that a chemical route can repair sulfur vacancies and improve interface quality with a substrate, enhancing device performance.
20 October 2014 | doi: 10.1038/ncomms6290
Physical Sciences  Materials science  Nanotechnology 

Quantum oscillations from surface Fermi arcs in Weyl and Dirac semimetals
Andrew C. Potter, Itamar Kimchi and Ashvin Vishwanath
Unlike metals, Weyl and Dirac semimetals possess open discontinuous Fermi surfaces. Here, Potter et al. show how such materials may still exhibit characteristic electronic oscillations under applied magnetic fields via bulk tunnelling between Fermi arcs and predict their experimental signatures.
20 October 2014 | doi: 10.1038/ncomms6161
Physical Sciences  Condensed matter  Theoretical physics 

Assembly of complex plant–fungus networks OPEN
Hirokazu Toju, Paulo R. Guimarães, Jens M. Olesen and John N. Thompson
Ecological communities consist of complex networks of interacting species whose linkages may be difficult to follow. Using next-generation sequencing, Toju et al. uncover the architecture of a plant-fungus network and find clear structural differences when compared with other communities.
20 October 2014 | doi: 10.1038/ncomms6273
Biological Sciences  Ecology 

Graphene-based carbon-layered electrode array technology for neural imaging and optogenetic applications OPEN
Dong-Wook Park, Amelia A. Schendel, Solomon Mikael, Sarah K. Brodnick, Thomas J. Richner, Jared P. Ness, Mohammed R. Hayat, Farid Atry, Seth T. Frye, Ramin Pashaie, Sanitta Thongpang, Zhenqiang Ma and Justin C. Williams
Monitoring neuronal activity in the rodent in vivo brain is commonly done using micro-electrode arrays but these devices are not normally compatible with optical technologies. Here the authors design a transparent and flexible electrode array based on graphene that allows them to combine electrophysiological recordings with optogenetic and imaging experiments.
20 October 2014 | doi: 10.1038/ncomms6258
Biological Sciences  Neuroscience 

Room temperature quantum coherence in a potential molecular qubit
Katharina Bader, Dominik Dengler, Samuel Lenz, Burkhard Endeward, Shang-Da Jiang, Petr Neugebauer and Joris van Slageren
Long quantum coherence time is a fundamental requirement for the realization of any quantum-mechanically operating machine. Here, Bader et al. demonstrate a coherence time as long as 68 μs at low temperature and of 1 μs at room temperature for a transition metal complex.
20 October 2014 | doi: 10.1038/ncomms6304
Physical Sciences  Applied physics  Condensed matter  Theoretical physics 

Fine tuning of sub-millisecond conformational dynamics controls metabotropic glutamate receptors agonist efficacy
Linnea Olofsson, Suren Felekyan, Etienne Doumazane, Pauline Scholler, Ludovic Fabre, Jurriaan M. Zwier, Philippe Rondard, Claus A. M. Seidel, Jean-Philippe Pin and Emmanuel Margeat
Understanding the molecular basis of receptor activation requires characterizing the dynamic equilibrium of conformational states. Here the authors show that the metabotropic glutamate receptor oscillates between conformations on a sub-millisecond timescale, and agonists quantitatively shift the equilibrium towards the activated state based on their potency.
17 October 2014 | doi: 10.1038/ncomms6206
Biological Sciences  Biochemistry 

Lymphocytes can self-steer passively with wind vane uropods
Marie-Pierre Valignat, Paulin Nègre, Sophie Cadra, Annemarie C Lellouch, François Gallet, Sylvie Hénon and Olivier Theodoly
Lymphocytes crawl on blood vessels against the flow of blood, but the mechanism for this directed migration is not known. Here, Valignat et al. show that lymphocytes can use their uropods as wind vanes to passively steer their migration in the presence of fluid flow, without the need for internal guidance cues.
17 October 2014 | doi: 10.1038/ncomms6213
Biological Sciences  Cell biology  Immunology 

A polyaromatic molecular tube that binds long hydrocarbons with high selectivity
Kohei Yazaki, Yoshihisa Sei, Munetaka Akita and Michito Yoshizawa
Long hydrocarbon chains are important biomolecules, but their selective recognition within synthetic hosts can be problematic due to the lack of specific binding sites. Here, the authors present a polyaromatic molecular tube capable of selectively binding a range of long hydrocarbons.
17 October 2014 | doi: 10.1038/ncomms6179
Chemical Sciences  Nanotechnology  Organic chemistry 

LIF negatively regulates tumour-suppressor p53 through Stat3/ID1/MDM2 in colorectal cancers
Haiyang Yu, Xuetian Yue, Yuhan Zhao, Xiaoyan Li, Lihua Wu, Cen Zhang, Zhen Liu, Kevin Lin, Zijun Y. Xu-Monette, Ken H. Young, Juan Liu, Zhiyuan Shen, Zhaohui Feng and Wenwei Hu
Leukaemia inhibitory factor (LIF) is a p53 target but its role in cancer is unclear. Here Hu et al. show that LIF confers chemoresistance in colorectal cancer cells by Stat3-mediated upregulation of inhibitor of DNA-binding 1, leading to MDM2 E3 ubiquitin ligase upregulation and p53 degradation.
17 October 2014 | doi: 10.1038/ncomms6218
Biological Sciences  Cancer  Molecular biology 

Creation of skyrmions and antiskyrmions by local heating
Wataru Koshibae and Naoto Nagaosa
The manipulation of magnetic skyrmions in thin films has presented new possibilities for emerging devices and technology. Here, Koshibae et al. use numerical simulations to show how localized nanoscale heating can generate such chiral topological spin textures in both dipolar and chiral magnets.
17 October 2014 | doi: 10.1038/ncomms6148
Physical Sciences  Applied physics  Condensed matter  Theoretical physics 

Interleukin-1α released from HSV-1-infected keratinocytes acts as a functional alarmin in the skin
Katelynn A. Milora, Samantha L. Miller, Julio C. Sanmiguel and Liselotte E. Jensen
HSV-1 is known to evade the immune system by retention of interleukin-1β. Here, the authors show that HSV-1-infected keratinocytes circumvent this mechanism by release of interleukin-1α, which recruits leukocytes and prevents viral dissemination.
17 October 2014 | doi: 10.1038/ncomms6230
Biological Sciences  Immunology 

Sub-diffractional volume-confined polaritons in the natural hyperbolic material hexagonal boron nitride
Joshua D. Caldwell, Andrey V. Kretinin, Yiguo Chen, Vincenzo Giannini, Michael M. Fogler, Yan Francescato, Chase T. Ellis, Joseph G. Tischler, Colin R. Woods, Alexander J. Giles, Minghui Hong, Kenji Watanabe, Takashi Taniguchi, Stefan A. Maier and Kostya S. Novoselov
Hyperbolic metamaterials exhibit interesting optical phenomena that could provide useful functionalities, if the losses can be reduced. Here Caldwell et al. show that hexagonal boron nitride supports hyperbolic polaritons, presenting a natural alternative to metamaterial systems.
17 October 2014 | doi: 10.1038/ncomms6221
Physical Sciences  Condensed matter  Nanotechnology  Optical physics 

An authentic imaging probe to track cell fate from beginning to end
Seung Koo Lee, Luke J. Mortensen, Charles P. Lin and Ching-Hsuan Tung
The availability of tracers to track the health of cells over long periods of time will be of value to optimize cell-based therapy. Here, Lee et al. design a nanoparticle that fluoresces red in living cells, but fluoresces green when cells begin to die from apoptosis or necrosis.
17 October 2014 | doi: 10.1038/ncomms6216
Biological Sciences  Biotechnology  Cell biology 

‘Division of labour’ in response to host oxidative burst drives a fatal Cryptococcus gattii outbreak OPEN
Kerstin Voelz, Simon A. Johnston, Leanne M. Smith, Rebecca A. Hall, Alexander Idnurm and Robin C. May
Outbreak strains of the pathogenic fungus Cryptococcus gattii display an increased ability to form tubular mitochondria. Here, Voelz et al. show that mitochondrial tubularization is induced by host reactive oxygen species within macrophages and facilitates rapid growth of neighbouring fungal cells.
17 October 2014 | doi: 10.1038/ncomms6194
Biological Sciences  Cell biology  Microbiology 

Surfactant-assisted chemical vapour deposition of high-performance small-diameter GaSb nanowires
Zai-xing Yang, Ning Han, Ming Fang, Hao Lin, Ho-Yuen Cheung, SenPo Yip, Er-Jun Wang, TakFu Hung, Chun-Yuen Wong and Johnny C. Ho
Antimonide nanowires may have useful applications as semiconductors in optoelectronics. Here, the authors use a sulfur surfactant to produce high-performance GaSb nanowires via chemical vapour deposition, achieving very thin and uniform nanowires with diameters as small as 20 nm.
16 October 2014 | doi: 10.1038/ncomms6249
Physical Sciences  Materials science  Nanotechnology 

Meiofauna increases bacterial denitrification in marine sediments OPEN
S. Bonaglia, F. J. A Nascimento, M. Bartoli, I. Klawonn and V. Brüchert
Excessive nutrient loading is a threat to aquatic ecosystems; however, denitrification may be key in removing large amounts of reactive nitrogen and, therefore, mitigating consequent eutrophication. Here, the authors explore how meiofauna may impact the rate of denitrification in sediments.
16 October 2014 | doi: 10.1038/ncomms6133
Earth Sciences  Biogeochemistry 

Interferon regulatory factor 9 is critical for neointima formation following vascular injury OPEN
Shu-Min Zhang, Li-Hua Zhu, Hou-Zao Chen, Ran Zhang, Peng Zhang, Ding-Sheng Jiang, Lu Gao, Song Tian, Lang Wang, Yan Zhang, Pi-Xiao Wang, Xiao-Fei Zhang, Xiao-Dong Zhang, De-Pei Liu and Hongliang Li
Blood vessels respond to injury by thickening the supportive smooth muscle layer in a process known as neointima formation. Here the authors describe a novel regulatory pathway of neointima formation that involves a transcription factor, Interferon Regulating Factor 9, and its downstream target, the deacetylase SIRT1.
16 October 2014 | doi: 10.1038/ncomms6160
Biological Sciences  Medical research 

Noiseless intensity amplification of repetitive signals by coherent addition using the temporal Talbot effect OPEN
Reza Maram, James Van Howe, Ming Li and José Azaña
The amplification of optical waveforms requires the use of an external power source. Here, using temporal self-imaging, the authors achieve passive amplification of repetitive optical signals by coherently adding identical waveform copies on top of one another at a lower repetition rate.
16 October 2014 | doi: 10.1038/ncomms6163
Physical Sciences  Optical physics 

Deficient Wnt signalling triggers striatal synaptic degeneration and impaired motor behaviour in adult mice OPEN
Soledad Galli, Douglas M. Lopes, Rachida Ammari, Jaakko Kopra, Sarah E. Millar, Alasdair Gibb and Patricia C. Salinas
Synapse degeneration is an early feature of neurodegenerative diseases. Here the authors show that Wnts are endogenous regulators of synaptic maintenance and suggest that dysfunction in Wnt signalling contributes to synaptic degeneration at early stages in neurodegenerative diseases.
16 October 2014 | doi: 10.1038/ncomms5992
Biological Sciences  Neuroscience 

Diffusion driven layer-by-layer assembly of graphene oxide nanosheets into porous three-dimensional macrostructures
Jianli Zou and Franklin Kim
There has been significant research into the preparation of nanosheets, but less on their assembly into functional macroscale architectures. Here, the authors present a diffusion-driven layer-by-layer assembly of graphene oxide into various three-dimensional structures.
16 October 2014 | doi: 10.1038/ncomms6254
Chemical Sciences  Materials science  Nanotechnology 

Evidence for a weakening relationship between interannual temperature variability and northern vegetation activity
Shilong Piao, Huijuan Nan, Chris Huntingford, Philippe Ciais, Pierre Friedlingstein, Stephen Sitch, Shushi Peng, Anders Ahlström, Josep G. Canadell, Nan Cong, Sam Levis, Peter E. Levy, Lingli Liu, Mark R. Lomas, Jiafu Mao, Ranga B. Myneni, Philippe Peylin, Ben Poulter, Xiaoying Shi, Guodong Yin et al.
Northern Hemisphere photosynthesis is thought to respond positively to temperature variations, yet the strength of this relationship may change over time. Here, using a combination of satellite data and models, the authors assess the temporal change of this relationship over the past three decades.
16 October 2014 | doi: 10.1038/ncomms6018
Earth Sciences  Biogeochemistry  Climate science 

Ediacaran 2,500-km-long synchronous deep continental subduction in the West Gondwana Orogen
Carlos E. Ganade de Araujo, Daniela Rubatto, Joerg Hermann, Umberto G. Cordani, Renaud Caby and Miguel A. S. Basei
The West Gondwana Orogen is a major continental collision zone exposing numerous eclogites along its strike. Here, the authors present zircon data from eclogites in Mali, Togo and NE Brazil, which indicate that continental subduction occurred simultaneously over at least 2,500 km during the Ediacaran.
16 October 2014 | doi: 10.1038/ncomms6198
Earth Sciences  Geology and geophysics 

Growth and modelling of spherical crystalline morphologies of molecular materials
O. Shalev, S. Biswas, Y. Yang, T. Eddir, W. Lu, R. Clarke and M. Shtein
Micro- and nanostructures have many potential applications, such as in optoelectronic devices and in the pharmaceutical industry. Here, the authors present a spherical, smooth and yet crystalline morphology found in molecular films deposited via guard flow-enhanced organic vapour jet printing.
16 October 2014 | doi: 10.1038/ncomms6204
Physical Sciences  Applied physics  Materials science 

αB-crystallin interacts with and prevents stress-activated proteolysis of focal adhesion kinase by calpain in cardiomyocytes
Michelle B. M. Pereira, Aline M. Santos, Danieli C. Gonçalves, Alisson C. Cardoso, Sílvio R. Consonni, Fabio C. Gozzo, Paulo S. Oliveira, Ana Helena M. Pereira, Alana R. Figueiredo, Ana O. Tiroli-Cepeda, Carlos H. I. Ramos, André A. de Thomaz, Carlos L. Cesar and Kleber G. Franchini
Focal adhesion kinase (FAK) is a scaffold and tyrosine kinase protein, critical for proper cardiac function under stress conditions. Here the authors show that the small heat–shock protein αB-crystallin interacts with FAK and protects it from calpain-mediated proteolysis in stressed rat cardiomyocytes.
16 October 2014 | doi: 10.1038/ncomms6159
Biological Sciences  Cell biology  Medical research 

Lateral opening of the bacterial translocon on ribosome binding and signal peptide insertion OPEN
Yan Ge, Albena Draycheva, Thomas Bornemann, Marina V. Rodnina and Wolfgang Wintermeyer
Integral membrane proteins laterally partition from the SecYEG translocon into the phospholipid bilayer. Here, the authors use photo-induced electron transfer to show that ribosome binding induces the opening of the lateral gate, and demonstrate that lateral opening does not happen at low temperature.
15 October 2014 | doi: 10.1038/ncomms6263
Biological Sciences  Biochemistry 

Motor contributions to the temporal precision of auditory attention OPEN
Benjamin Morillon, Charles E. Schroeder and Valentin Wyart
Motor activities, such as rhythmic movements, are implicated in regulating attention. Here, the authors find that rhythmic movements sharpen the temporal selection of auditory stimuli by facilitating the perception of relevant stimuli, while actively suppressing the interference from irrelevant stimuli.
15 October 2014 | doi: 10.1038/ncomms6255
Biological Sciences  Neuroscience 

Enhanced acoustic sensing through wave compression and pressure amplification in anisotropic metamaterials
Yongyao Chen, Haijun Liu, Michael Reilly, Hyungdae Bae and Miao Yu
Acoustic sensors have myriad important applications, but they are limited by their pressure sensitivity. Chen et al. show how the use of graded anisotropic acoustic metamaterial structures can help overcome this by amplifying the acoustic waves via compression effects.
15 October 2014 | doi: 10.1038/ncomms6247
Physical Sciences  Applied physics  Materials science 

Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations OPEN
Vinay K. Godena, Nicholas Brookes-Hocking, Annekathrin Moller, Gary Shaw, Matthew Oswald, Rosa M. Sancho, Christopher C. J. Miller, Alexander J. Whitworth and Kurt J. De Vos
Mutations in the kinase LRRK2 are associated with Parkinson’s disease. Godena et al. find that disease-associated LRRK2 mutations promote its binding to deacetylated microtubules, and cause defects in axonal transport and Drosophila locomotor behaviour that can be reversed by enhancing tubulin acetylation.
15 October 2014 | doi: 10.1038/ncomms6245
Biological Sciences  Neuroscience 

Broad impacts of fine-scale dynamics on seascape structure from zooplankton to seabirds OPEN
Arnaud Bertrand, Daniel Grados, François Colas, Sophie Bertrand, Xavier Capet, Alexis Chaigneau, Gary Vargas, Alexandre Mousseigne and Ronan Fablet
Ocean circulations can strongly influence ecological dynamics in marine ecosystem over multiple spatial scales. Here, Bertrand et al. find that the majority of these interactions occur within small-scale hotspots that concentrate interactions across many trophic levels from zooplankton to seabirds.
15 October 2014 | doi: 10.1038/ncomms6239
Biological Sciences  Ecology  Oceanography 

Parkin regulates kainate receptors by interacting with the GluK2 subunit OPEN
AnnaMaria Maraschi, Andrea Ciammola, Alessandra Folci, Francesca Sassone, Giuseppe Ronzitti, Graziella Cappelletti, Vincenzo Silani, Shigeto Sato, Nobutaka Hattori, Michele Mazzanti, Evelina Chieregatti, Christophe Mulle, Maria Passafaro and Jenny Sassone
Loss-of-function mutations in the PARK2 gene are implicated in autosomal recessive juvenile parkinsonism, but the mechanisms are unclear. Here, the authors show that these mutations cause accumulation of the kainate receptor subunit GluK2 in the plasma membrane of neurons, which facilitates neuronal death.
15 October 2014 | doi: 10.1038/ncomms6182
Biological Sciences  Neuroscience 
 
Nature Communications
JOBS of the week
Fellowships of NCT Heidelberg School of Oncology (NCT HSO)
National Center for Tumor Diseases (NCT) Heidelberg
Two PhD Positions
ETH Zurich
Postdoctoral Researcher
NUI Galway
Post-Doctoral Fellowship : Clinical Genomics
CEA French Atomic and Alternative Energies Commission
More Science jobs from
Nature Communications
EVENT
International Symposium Bone Regeneration
11.06.15
Berlin, Germany
More science events from
 
 
  Latest Corrigendum  
 
Corrigendum: X-ray holography with a customizable reference
Andrew V. Martin, Adrian J. D’Alfonso, Fenglin Wang, Richard Bean, Flavio Capotondi, Richard A. Kirian, Emanuele Pedersoli, Lorenzo Raimondi, Francesco Stellato, Chun Hong Yoon and Henry N. Chapman
16 October 2014 | doi: 10.1038/ncomms6279
Physical Sciences  Optical physics 
 
 

Advertisement
Nature Biotechnology
ANIMATION: ANTIBODY-DRUG CONJUGATES 
The challenges facing targeted delivery of antibody-drug conjugates to a tumor are presented in a 3D animation that describes some of the mechanisms by which these agents target cells.

Animation by Nucleus Inc. 

Produced with support from 
Daiichi Sankyo and Takeda Pharmaceuticals
 
 
nature events
Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here.

Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com
 More Nature Events
You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at:www.nature.com/myaccount
(You will need to log in to be recognised as a nature.com registrant)

For further technical assistance, please contact our registration department

For other enquiries, please contact our customer feedback department

Nature Publishing Group | 75 Varick Street, 9th Floor | New York | NY 10013-1917 | USA

Nature Publishing Group's worldwide offices:
London - Paris - Munich - New Delhi - Tokyo - Melbourne
San Diego - San Francisco - Washington - New York - Boston

Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS.

© 2013 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.
NPG logo
 

No comments:

Post a Comment

Keep a civil tongue.

Label Cloud

Technology (1464) News (793) Military (646) Microsoft (542) Business (487) Software (394) Developer (382) Music (360) Books (357) Audio (316) Government (308) Security (300) Love (262) Apple (242) Storage (236) Dungeons and Dragons (228) Funny (209) Google (194) Cooking (187) Yahoo (186) Mobile (179) Adobe (177) Wishlist (159) AMD (155) Education (151) Drugs (145) Astrology (139) Local (137) Art (134) Investing (127) Shopping (124) Hardware (120) Movies (119) Sports (109) Neatorama (94) Blogger (93) Christian (67) Mozilla (61) Dictionary (59) Science (59) Entertainment (50) Jewelry (50) Pharmacy (50) Weather (48) Video Games (44) Television (36) VoIP (25) meta (23) Holidays (14)

Popular Posts