2017/02/08

Nature Biotechnology Contents: Volume 35 pp 97 - 180

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TABLE OF CONTENTS

February 2017 Volume 35, Issue 2

Editorial
News
Correction
Bioentrepreneur
Opinion and Comment
Features
News and Views
Research
Careers and Recruitment

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CRISPR Calendar 2017

To celebrate the continuing rise to fame of the CRISPR system, the Nature Reviews Genetics 2017 CRISPR calendar highlights the underlying biology of CRISPR, as well as its diverse range of exciting potential applications in genetic research, biotechnology and therapeutics.

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Editorial

Top

The problem with neoantigen prediction   p97
doi:10.1038/nbt.3800
Personalized immunotherapy is all the rage, but neoantigen discovery and validation remains a daunting problem.

News

Top

Spinal muscular atrophy approval boosts antisense drugs   pp99 - 100
Elie Dolgin
doi:10.1038/nbt0217-99

Roche breaks with PacBio, opts for Genia   p100
doi:10.1038/nbt0217-100

Grail to pour $1 billion into blood test to detect early cancer   pp101 - 102
Cormac Sheridan
doi:10.1038/nbt0217-101

Shire divests mRNA platform to RaNa   p103
doi:10.1038/nbt0217-103b

Jun Wang's iCarbonX heads consortium using AI in health and wellness   pp103 - 105
David Cyranoski
doi:10.1038/nbt0217-103a

AACR makes public 19,000 cancer genomes   p104
doi:10.1038/nbt0217-104

Correction

Top

Correction   p105
doi:10.1038/nbt0217-105a

News

Top

GE to boost yields with Synpromics' synthetic promoters   p105
doi:10.1038/nbt0217-105b

Novartis snaps up Selexys for sickle cell   p106
Chris Morrison
doi:10.1038/nbt0217-106

Data Page

Drug pipeline: 4Q16   p107
Laura DeFrancesco
doi:10.1038/nbt.3797

News Feature

Fresh from the biotech pipeline—2016   pp108 - 112
Chris Morrison
doi:10.1038/nbt.3783
Despite last year's sharp decline in approvals, registrations of two RNA drugs offer a window into the current state and possible future of drug development. Looking forward, the sector seeks greater clarity on the new presidential administration's priorities and the impact of new healthcare legislation. Chris Morrison reports.


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Bioentrepreneur

Top
Building a business

So you want to be a student entrepreneur?   pp113 - 116
Charles H Jones and Andrew Hill
doi:10.1038/nbt.3778

Opinion and Comment

Top
Correspondence

Industrializing rare disease therapy discovery and development   pp117 - 118
Sean Ekins
doi:10.1038/nbt.3787

Features

Top
Patents

Situating brain regions among patent rights and moral risks   pp119 - 121
Dylan Roskams-Edris, Stacey Anderson-Redick, Zelma H Kiss and Judy Illes
doi:10.1038/nbt.3782
What is the ethical value of awarding patent rights that implicate regions of the brain?

Recent patents in single-cell analysis and microfluidics   p122
doi:10.1038/nbt.3792

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News and Views

Top

Core promoters across the genome   pp123 - 124
Nevena Cvetesic and Boris Lenhard
doi:10.1038/nbt.3788
Promoter strength is measured genome-wide with two high-throughput reporter assays.

See also: Research by Arnold et al. | Research by van Arensbergen et al.

Exploring protein sequence-function landscapes   pp125 - 126
Tyler N Starr and Joseph W Thornton
doi:10.1038/nbt.3786
The effects of sequence variation on function are elucidated by a study of protein evolution.

See also: Research by Hopf et al.

Research Highlights   p127
doi:10.1038/nbt.3785

Stretching sensors by confinement   p127
Irene Jarchum
doi:10.1038/nbt.3789

Biotechnology
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Research

Top
Analysis

Mutation effects predicted from sequence co-variation   pp128 - 135
Thomas A Hopf, John B Ingraham, Frank J Poelwijk, Charlotta P I Scharfe, Michael Springer et al.
doi:10.1038/nbt.3769
The global effects of epistasis on protein and RNA function are revealed by an unsupervised model of amino acid co-conservation in evolutionary sequence variation.

See also: News and Views by Starr & Thornton

Articles

Genome-wide assessment of sequence-intrinsic enhancer responsiveness at single-base-pair resolution   pp136 - 144
Cosmas D Arnold, Muhammad A Zabidi, Michaela Pagani, Martina Rath, Katharina Schernhuber et al.
doi:10.1038/nbt.3739
STAP-seq quantifies the ability of genomic DNA sequences to convert enhancer activities into transcription initiation events.

See also: News and Views by Cvetesic & Lenhard

Genome-wide mapping of autonomous promoter activity in human cells   pp145 - 153
Joris van Arensbergen, Vincent D FitzPatrick, Marcel de Haas, Ludo Pagie, Jasper Sluimer et al.
doi:10.1038/nbt.3754
The intrinsic strength of promoter sequences in driving transcription is measured across the human genome.

See also: News and Views by Cvetesic & Lenhard

Combined small-molecule inhibition accelerates the derivation of functional cortical neurons from human pluripotent stem cells   pp154 - 163
Yuchen Qi, Xin-Jun Zhang, Nicolas Renier, Zhuhao Wu, Talia Atkin et al.
doi:10.1038/nbt.3777
Cortical neurons are rapidly derived from human pluripotent stem cells using a cocktail of small molecules.

Influence of node abundance on signaling network state and dynamics analyzed by mass cytometry   pp164 - 172
Xiao-Kang Lun, Vito R T Zanotelli, James D Wade, Denis Schapiro, Marco Tognetti et al.
doi:10.1038/nbt.3770
Mass-cytometry analysis reveals how signaling networks respond to changes in the abundance of their nodes.

Letter

Lipid production in Yarrowia lipolytica is maximized by engineering cytosolic redox metabolism   pp173 - 177
Kangjian Qiao, Thomas M Wasylenko, Kang Zhou, Peng Xu and Gregory Stephanopoulos
doi:10.1038/nbt.3763
Cytosolic redox metabolism is rewired to improve lipid yield and productivity in the industrial yeast Yarrowia lipolytica

Errata

Erratum: Innovative academic startups 2016   p178
Brady Huggett
doi:10.1038/nbt0217-178a

Erratum: Multiplex gene editing by CRISPR-Cpf1 using a single crRNA array   p178
Bernd Zetsche, Matthias Heidenreich, Prarthana Mohanraju, Iana Fedorova, Jeroen Kneppers et al.
doi:10.1038/nbt0217-178b

Erratum: The cancer bloodhounds   p178
Sarah Webb
doi:10.1038/nbt0217-178c

Careers and Recruitment

Top

Fourth-quarter biotech job picture   p179
Michael Francisco
doi:10.1038/nbt.3794

People

People   p180
doi:10.1038/nbt.3793

Top
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