Secrets of life in a spoonful of blood The intricate development of the fetus is yielding its long-held secrets to state-of-the-art molecular technologies that can make use of the mother's blood. Claire Ainsworth
The 5th World Conference on Research Integrity will be held from May 28 – 31, 2017 in Amsterdam, The Netherlands. The conference will be organized around the interlinked themes of transparency and accountability. The program features keynotes on core topics, 100+ oral presentations and interactive workshops. We are looking forward to welcoming researchers, institutional leaders, research administrators, funders, editors, publishers and others from all over the world.
Genomics: Keen insights from quinoa Technological advances have allowed scientists to sequence the complex quinoa genome. This highlights the ongoing expansion of genomics beyond major crops to other plants that have relevance for global food security.
Systems neuroscience: Diversity in sight A systematic analysis of bipolar cells, which act as a central signalling conduit in the retina, reveals that the neurons' diverse responses to light are generated largely by feedback from neighbouring amacrine cells.
Physiology: Gut feeling for food choice One effect of weight-loss surgery is a change in food preferences. An analysis in rats shows that this is caused by altered nutrient signals in the intestine. These activate the vagus nerve to increase signalling in the brain by the neurotransmitter dopamine.
The genome of Chenopodium quinoa OPEN Constructing a reference genome for quinoa (Chenopodium quinoa) allows for genetic diversity during the evolution of sub-genomes in quinoa to be characterized and markers that may be used to develop sweet commercial varieties are identified.
Primordial helium entrained by the hottest mantle plumes Analysis of helium isotope ratios in volcanic hotspot lavas suggests that hotter, more buoyant plumes upwelling from the deep mantle entrain high-3He/4He material, unlike cooler, less buoyant plumes, implying the existence of a dense, relatively undisturbed primordial reservoir in the deep mantle.
Interspecies organogenesis generates autologous functional islets The authors inject mouse pluripotent stem cells into pancreatogenesis-disabled rat blastocysts and thereby generate rats with mouse pancreata from which the islets, when transplanted into mice, can provide a long-term cure for symptoms of diabetes, without continuous immunosuppression. Tomoyuki Yamaguchi, Hideyuki Sato, Megumi Kato-Itoh et al.
An Argonaute phosphorylation cycle promotes microRNA-mediated silencing The application of genome-wide CRISPR–Cas9 screening coupled with a fluorescent reporter to interrogate the microRNA pathway reveals that continual transient phosphorylation of Argonaute 2 is required to maintain the global efficiency of microRNA-mediated repression. Ryan J. Golden, Beibei Chen, Tuo Li et al.
Symmetry-protected collisions between strongly interacting photons Excitations to Rydberg states in a gas of ultracold atoms are used to produce a robust, nonlinear phase shift of exactly π/2 between two photons, which is protected against variations in experimental parameters by a symmetry of the system. Jeff D. Thompson, Travis L. Nicholson, Qi-Yu Liang et al.
Ecosystem restoration strengthens pollination network resilience and function Removal of invasive exotic shrubs from mountaintop communities increased the number of pollinators and positively altered pollinator behaviour, which enhanced native fruit production, indicating that the degradation of ecosystem functions is partly reversible. Christopher N. Kaiser-Bunbury, James Mougal, Andrew E. Whittington et al.
New CRISPR–Cas systems from uncultivated microbes Using a metagenomic approach, three types of CRISPR–Cas systems have been discovered in uncultivated bacterial and archaeal hosts from a variety of different environments. David Burstein, Lucas B. Harrington, Steven C. Strutt et al.
Max Planck Institute for Heart and Lung Research, Bad Nauheim
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