Drug discovery research grants - awards up to $700,000 Harrington Discovery Institute at University Hospitals in Cleveland, Ohio solicits proposals for the 2018 Harrington Scholar-Innovator Award, offering physician-scientists the resources to advance discoveries into medicines. Letters of Intent accepted through April 5, 2017. Apply now at HarringtonDiscovery.org/Grant.
The Biology of Regenerative Medicine (25-27 April 2017) This conference aims to understand the biology that underpins the success or failure of regenerative processes. We will explore the relationship between stem cell biology and regenerative biology so that both can be fully exploited to treat disease. Deadlines: Bursary: 28 Feb / Abstracts: 14 Mar / Registration: 28 Mar
Nature Outlook: Precision Medicine
Health care that is tailored on the basis of an individual's genes, lifestyle or environment, is not a modern concept. But advances in genetics and the growing availability of health data for researchers and physicians promise to make this new era of medicine more personalized than ever before.
The double edge of cancer immunotherapy p137 doi:10.1038/nm.4286 Immune-related adverse effects are understudied and not easily treatable risks of cancer immunotherapy. Concerted research efforts to understand the mechanisms of immunotherapy-triggered responses are crucial for developing better treatments.
Exhausting alloreactivity of donor-derived CAR T cells pp147 - 148 Maksim Mamonkin and Helen E Heslop doi:10.1038/nm.4276 A study in mouse models of allogeneic stem cell transplantation with donor-derived CD19 chimeric antigen receptor (CAR) T cells for the treatment of relapsed B cell malignancies indicates that T cell exhaustion might have a role in preventing allogeneic reactivity of CD19 CAR T cells.
HDAC3 sets the timer on muscle fuel switching pp148 - 150 Deborah M Muoio doi:10.1038/nm.4282 In a recent study in mice, it is shown that circadian oscillations in genomic histone deactylase 3 (HDAC3) occupancy influence fuel switching and carbon flux in muscle to regulate glucose homeostasis and exercise performance.
Antibody 10-1074 suppresses viremia in HIV-1-infected individuals pp185 - 191 Marina Caskey, Till Schoofs, Henning Gruell, Allison Settler, Theodora Karagounis et al. doi:10.1038/nm.4268 Florian Klein and colleagues report that treating viremic HIV-1-infected individuals with the broadly neutralizing antibody 10-1074 reduced virus levels in blood, but antibody-resistant virus did emerge.
A chikungunya fever vaccine utilizing an insect-specific virus platform pp192 - 199 Jesse H Erasmus, Albert J Auguste, Jason T Kaelber, Huanle Luo, Shannan L Rossi et al. doi:10.1038/nm.4253 New vaccine approaches that safely elicit immunity are needed to protect against infectious disease. Erasmus et al. report their development of an insect-virus-based platform that they use to engineer a protective vaccine against chikungunya fever.
Donor CD19 CAR T cells exert potent graft-versus-lymphoma activity with diminished graft-versus-host activity pp242 - 249 Arnab Ghosh, Melody Smith, Scott E James, Marco L Davila, Enrico Velardi et al. doi:10.1038/nm.4258 Allogeneic chimeric antigen receptor (CAR) T cells are capable of inducing graft-versus-host disease (GVHD) in recipients, yet this is not commonly seen in the clinic. Marcel van den Brink, Michel Sadelain and colleagues show that alloreactive CAR T cells have reduced effector function due to signaling through the CAR and T cell receptor, resulting in reduced GVHD, while the graft-versus-leukemia effect is maintained by non-alloreactive CAR T cells.
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