Mechanisms for targeted, purposeful mutation revealed in an APOBEC-DNA complex pp97 - 98 Emily K Schutsky, Zachary M Hostetler and Rahul M Kohli doi:10.1038/nsmb.3373 Targeted deamination of cytosine bases in DNA by AID/APOBEC-family enzymes is critical for proper immune function, but it also poses risks to genomic integrity. New structures reported by Harris, Aihara and colleagues offer the first glimpses into the enzyme-DNA complex and reveal both expected and unexpected insights into the DNA-binding mode involved in targeting purposeful mutation.
Self-correcting mismatches during high-fidelity DNA replication pp140 - 143 Rafael Fernandez-Leiro, Julian Conrad, Ji-Chun Yang, Stefan M V Freund, Sjors H W Scheres et al. doi:10.1038/nsmb.3348 Cryo-EM and NMR analyses of the E. coli replisome show how DNA-end fraying after mismatch incorporation at the polymerase active site enables substrate ends to reach the /`proofreading/' exonuclease site for mismatch removal.
Structure of the immature Zika virus at 9 Å resolution pp184 - 186 Vidya Mangala Prasad, Andrew S Miller, Thomas Klose, Devika Sirohi, Geeta Buda et al. doi:10.1038/nsmb.3352 The cryo-EM structure of immature Zika virus shows partially ordered capsid proteins and reveals differences between pre-epidemic and epidemic strains at protein interfaces within the trimeric spikes.
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