2017/02/07

Scientific Reports Biology Table of Contents e-alert: 07 February 2017

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  07 February 2017   
 
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Welcome to your Table of Contents e-alert for Scientific Reports

 
 
 
Biological Sciences
 
 
 
 
 
 
 

High-throughput sequencing of multiple amplicons for barcoding and integrative taxonomy

 
 

Perrine Cruaud, Jean-Yves Rasplus, Lillian Jennifer Rodriguez et al.

 
 

Until now, the potential of NGS for the construction of barcode libraries or integrative taxonomy has been seldom realised. Here, we amplified (two-step PCR) and simultaneously …

 
 
 
 
 
 

The interrelated effect of sleep and learning in dogs (Canis familiaris); an EEG and behavioural study

 
 

Anna Kis, Sára Szakadát, Márta Gácsi et al.

 
 

The active role of sleep in memory consolidation is still debated, and due to a large between-species variation, the investigation of a wide range of different animal species …

 
 
 
 
 
 

Post-polyploidisation morphotype diversification associates with gene copy number variation

 
 

Sarah Schiessl, Bruno Huettel, Diana Kuehn et al.

 
 

Genetic models for polyploid crop adaptation provide important information relevant for future breeding prospects. A well-suited model is Brassica napus, a recent allopolyploid …

 
 
 
 
 
 

Microbial shifts in the porcine distal gut in response to diets supplemented with Enterococcus Faecalis as alternatives to antibiotics

 
 

Pinghua Li, Qing Niu, Qingtian Wei et al.

 
 

Gut microbiota plays an important role in host health and nutrient digestion of animals. Probiotics have become one of effective alternatives to antibiotics enhancing animal …

 
 
 
 
 
 

Relationship between auxiliary gamma subunits and mallotoxin on BK channel modulation

 
 

Xin Guan, Qin Li, Jiusheng Yan

 
 

The large-conductance, calcium- and voltage-activated K+(BK) channel consists of the pore-forming α subunits (BKα) and auxiliary subunits. The auxiliary γ1-3 subunits potently …

 
 
 
 
 
 

The Promotion of Erythropoiesis via the Regulation of Reactive Oxygen Species by Lactic Acid

 
 

Shun-Tao Luo, Dong-Mei Zhang, Qing Qin et al.

 
 

The simultaneous increases in blood lactic acid and erythrocytes after intense exercise could suggest a link between lactate and the erythropoiesis. However, the effects of …

 
 
 
 
 
 

High affinity anchoring of the decoration protein pb10 onto the bacteriophage T5 capsid

 
 

Emeline Vernhes, Madalena Renouard, Bernard Gilquin et al.

 
 

Bacteriophage capsids constitute icosahedral shells of exceptional stability that protect the viral genome. Many capsids display on their surface decoration proteins whose …

 
 
 
 
 
 

A potent synthetic inorganic antibiotic with activity against drug-resistant pathogens

 
 

Shelby Hubick, Arumugam Jayaraman, Alexander McKeen et al.

 
 

The acronymously named “ESKAPE” pathogens represent a group of bacteria that continue to pose a serious threat to human health, not only due to their propensity for repeated …

 
 
 
 
 
 

Enhancing the biocatalytic manufacture of the key intermediate of atorvastatin by focused directed evolution of halohydrin dehalogenase

 
 

Yu Luo, Yangzi Chen, Hongmin Ma et al.

 
 

Halohydrin dehalogenases (HHDHs) are biocatalytically interesting enzymes due to their ability to form C-C, C-N, C-O, and C-S bonds. One of most important application of HHDH was …

 
 
 
 
 
 

Human embryonic and induced pluripotent stem cells maintain phenotype but alter their metabolism after exposure to ROCK inhibitor

 
 

Spyros I. Vernardis, Konstantinos Terzoudis, Nicki Panoskaltsis et al.

 
 

Human pluripotent stem cells (hPSCs) are adhesion-dependent cells that require cultivation in colonies to maintain growth and pluripotency. Robust differentiation protocols …

 
 
 
 
 
 

Recombinant Phage Elicits Protective Immune Response against Systemic S. globosa Infection in Mouse Model

 
 

Feng Chen, Rihua Jiang, Yicun Wang et al.

 
 

Sporothrix globosa is a type of fungus that typically infects immunocompromised patients. Its prevention continues to pose a challenge. A 70-KDa glycoprotein (Gp70) of Sporothrix

 
 
 
 
 
 

Novel Treatment of Chronic Graft-Versus-Host Disease in Mice Using the ER Stress Reducer 4-Phenylbutyric Acid

 
 

Shin Mukai, Yoko Ogawa, Fumihiko Urano et al.

 
 

Chronic graft-versus-host disease (cGVHD) is a notorious complication of allogeneic hematopoietic stem cell transplantation and causes disabling systemic inflammation and …

 
 
 
 
 
 

Spectrally monitoring the response of the biocrust moss Syntrichia caninervis to altered precipitation regimes

 
 

Kristina E. Young, Sasha C. Reed

 
 

Climate change is expected to impact drylands worldwide by increasing temperatures and changing precipitation patterns. These effects have known feedbacks to the functional roles …

 
 
 
 
 
 

Microbial Typing by Machine Learned DNA Melt Signatures

 
 

Nadya Andini, Bo Wang, Pornpat Athamanolap et al.

 
 

There is still an ongoing demand for a simple broad-spectrum molecular diagnostic assay for pathogenic bacteria. For this purpose, we developed a single-plex High Resolution Melt …

 
 
 
 
 
 

Identification of two novel Rhizoctonia solani-inducible cis-acting elements in the promoter of the maize gene, GRMZM2G315431

 
 

Ning Li, Jing Chen, Fangfang Yang et al.

 
 

Plants are continuously exposed to myriad pathogen stresses. However, the molecular mechanisms by which these stress signals are perceived and transduced are poorly understood. …

 
 
 
 
 
 

Implementation of a method to visualize noise-induced hearing loss in mass stranded cetaceans

 
 

Maria Morell, Andrew Brownlow, Barry McGovern et al.

 
 

Assessment of the impact of noise over-exposure in stranded cetaceans is challenging, as the lesions that lead to hearing loss occur at the cellular level and inner ear cells are …

 
 
 
 
 
 

Potential role of corneal epithelial cell-derived exosomes in corneal wound healing and neovascularization

 
 

Kyu-Yeon Han, Jennifer A. Tran, Jin-Hong Chang et al.

 
 

Specific factors from the corneal epithelium underlying the stimulation of stromal fibrosis and myofibroblast formation in corneal wound healing have not been fully elucidated. …

 
 
 
 
 
 

Modulation of Microglial Cell Fcγ Receptor Expression Following Viral Brain Infection

 
 

Priyanka Chauhan, Shuxian Hu, Wen S. Sheng et al.

 
 

Fcγ receptors (FcγRs) for IgG couple innate and adaptive immunity through activation of effector cells by antigen-antibody complexes. We investigated relative levels of …

 
 
 
 
 
 

New Insights on Signal Propagation by Sensory Rhodopsin II/Transducer Complex

 
 

A. Ishchenko, E. Round, V. Borshchevskiy et al.

 
 

The complex of two membrane proteins, sensory rhodopsin II (NpSRII) with its cognate transducer (NpHtrII), mediates negative phototaxis in halobacteria N. pharaonis. Upon light …

 
 
 
 
 
 

Generation of PDGFRα+ Cardioblasts from Pluripotent Stem Cells

 
 

Seon Pyo Hong, Sukhyun Song, Sung Woo Cho et al.

 
 

Isolating actively proliferating cardioblasts is the first crucial step for cardiac regeneration through cell implantation. However, the origin and identity of putative …

 
 
 
 
 
 

Paeoniflorin Ameliorates Experimental Autoimmune Encephalomyelitis via Inhibition of Dendritic Cell Function and Th17 Cell Differentiation

 
 

Han Zhang, Yuanyuan Qi, Yuanyang Yuan et al.

 
 

Paeoniflorin (PF) is a monoterpene glycoside and exhibits multiple effects, including anti-inflammation and immunoregulation. To date, the effect of PF on multiple sclerosis (MS) …

 
 
 
 
 
 

Structural analysis and evolution of specificity of the SUMO UFD E1-E2 interactions

 
 

Bing Liu, L. Maria Lois, David Reverter

 
 

SUMO belongs to the ubiquitin-like family (UbL) of protein modifiers. SUMO is conserved among eukaryotes and is essential for the regulation of processes such as DNA damage …

 
 
 
 
 
 

Relevance of mortalin to cancer cell stemness and cancer therapy

 
 

Chae-Ok Yun, Priyanshu Bhargava, Youjin Na et al.

 
 

Mortalin/mtHsp70 is a member of Hsp70 family of proteins. Enriched in a large variety of cancers, it has been shown to contribute to the process of carcinogenesis by multiple …

 
 
 
 
 
 

Small RNA-directed epigenetic programming of embryonic stem cell cardiac differentiation

 
 

Hossein Ghanbarian, Nicole Wagner, Jean-François Michiels et al.

 
 

Microinjection of small noncoding RNAs in one-cell embryos was reported in several instances to result in transcriptional activation of target genes. To determine the molecular …

 
 
 
 
 
 

A universal computational model for predicting antigenic variants of influenza A virus based on conserved antigenic structures

 
 

Yousong Peng, Dayan Wang, Jianhong Wang et al.

 
 

Rapid determination of the antigenicity of influenza A virus could help identify the antigenic variants in time. Currently, there is a lack of computational models for predicting …

 
 
 
 
 
 

Novel flow cytometry approach to identify bronchial epithelial cells from healthy human airways

 
 

Danay Maestre-Batlle, Olga M. Pena, Jeremy A. Hirota et al.

 
 

Sampling various compartments within the lower airways to examine human bronchial epithelial cells (HBEC) is essential for understanding numerous lung diseases. Conventional …

 
 
 
 
 
 

Seawater acidification induced immune function changes of haemocytes in Mytilus edulis: a comparative study of CO2 and HCl enrichment

 
 

Tianli Sun, Xuexi Tang, Yongshun Jiang et al.

 
 

The present study was performed to evaluate the effects of CO2− or HCl-induced seawater acidification (pH 7.7 or 7.1; control: pH 8.1) on haemocytes of Mytilus edulis, and the …

 
 
 
 
 
 

Transcriptome sequencing identifies novel persistent viruses in herbicide resistant wild-grasses

 
 

Federico Sabbadin, Rachel Glover, Rebecca Stafford et al.

 
 

Herbicide resistance in wild grasses is widespread in the UK, with non-target site resistance (NTSR) to multiple chemistries being particularly problematic in weed control. As a …

 
 
 
 
 
 

Corrigendum: Modulation of AMPA receptor mediated current by nicotinic acetylcholine receptor in layer I neurons of rat prefrontal cortex

 
 

Bo Tang, Dong Luo, Jie Yang et al.

 
 

 
 
 
 
 
 

Hybridogenesis and a potential case of R2 non-LTR retrotransposon horizontal transmission in Bacillus stick insects (Insecta Phasmida)

 
 

Claudia Scavariello, Andrea Luchetti, Francesco Martoni et al.

 
 

Horizontal transfer (HT) is an event in which the genetic material is transferred from one species to another, even if distantly related, and it has been demonstrated as a …

 
 
 
 
 
 

Expression of human endogenous retrovirus-K is strongly associated with the basal-like breast cancer phenotype

 
 

Gary L. Johanning, Gabriel G. Malouf, Xiaofeng Zheng et al.

 
 

Human endogenous retroviruses (HERVs), which make up approximately 8% of the human genome, are overexpressed in some breast cancer cells and tissues but without regard to cancer …

 
 
 
 
 
 

MicroRNA-130b targets PTEN to mediate drug resistance and proliferation of breast cancer cells via the PI3K/Akt signaling pathway

 
 

Yuan Miao, Wei Zheng, Nana Li et al.

 
 

Multidrug resistance (MDR) correlates with treatment failure and poor prognosis among breast cancer patients. This study was aimed to investigate the possible mechanism by which …

 
 
 
 
 
 

The interaction of perceptual biases in bistable perception

 
 

Xue Zhang, Qian Xu, Yi Jiang et al.

 
 

When viewing ambiguous stimuli, people tend to perceive some interpretations more frequently than others. Such perceptual biases impose various types of constraints on visual …

 
 
 
 
 
 

Insights into structure and activity of natural compound inhibitors of pneumolysin

 
 

Hongen Li, Xiaoran Zhao, Xuming Deng et al.

 
 

Pneumolysin is the one of the major virulence factor of the bacterium Streptococcus pneumoniae. In previous report, it is shown that β-sitosterol, a natural compound without …

 
 
 
 
 
 

Flavonol-induced changes in PIN2 polarity and auxin transport in the Arabidopsis thaliana rol1-2 mutant require phosphatase activity

 
 

Benjamin M. Kuhn, Tomasz Nodzyński, Sanae Errafi et al.

 
 

The phytohormone auxin is a major determinant and regulatory component important for plant development. Auxin transport between cells is mediated by a complex system of …

 
 
 
 
 
 

The ATP binding cassette transporter, ABCG1, localizes to cortical actin filaments

 
 

Elvis Pandzic, Ingrid C. Gelissen, Renee Whan et al.

 
 

The ATP-binding cassette sub-family G member 1 (ABCG1) exports cellular cholesterol to high-density lipoproteins (HDL). However, a number of recent studies have suggested ABCG1 …

 
 
 
 
 
 

Corrigendum: Fishing-induced life-history changes degrade and destabilize harvested ecosystems

 
 

Anna Kuparinen, Alice Boit, Fernanda S. Valdovinos et al.

 
 

 
 
 
 
 
 

Alterations in rice chloroplast integrity, photosynthesis and metabolome associated with pathogenesis of Rhizoctonia solani

 
 

Srayan Ghosh, Poonam Kanwar, Gopaljee Jha

 
 

Sheath blight disease is caused by a necrotrophic fungal pathogen Rhizoctonia solani and it continues to be a challenge for sustainable rice cultivation. In this study, we …

 
 
 
 
 
 

Limb proportions show developmental plasticity in response to embryo movement

 
 

A. S. Pollard, B. G. Charlton, J. R. Hutchinson et al.

 
 

Animals have evolved limb proportions adapted to different environments, but it is not yet clear to what extent these proportions are directly influenced by the environment …

 
 
 
 
 
 

Microbial nitrification, denitrification and respiration in the leached cinnamon soil of the upper basin of Miyun Reservoir

 
 

Wen Xu, Yan-Peng Cai, Zhi-Feng Yang et al.

 
 

Leached cinnamon soil is the main agricultural soil distributed in the North China Plain. In this research, leached cinnamon soil samples were collected in the upper basin of …

 
 
 
 
 
 

Micheliolide provides protection of mice against Staphylococcus aureus and MRSA infection by down-regulating inflammatory response

 
 

Xinru Jiang, Yuli Wang, Yifei Qin et al.

 
 

A major obstacle to therapy in intensive care units is sepsis caused by severe infection. In recent years gram-positive (G+) bacteria, most commonly staphylococci, are thought to …

 
 
 
 
 
 

Pharmacological Inhibition of c-Jun N-terminal Kinase Reduces Food Intake and Sensitizes Leptin’s Anorectic Signaling Actions

 
 

Su Gao, Shannon Howard, Philip V. LoGrasso

 
 

The role for c-Jun N-terminal Kinase (JNK) in the control of feeding and energy balance is not well understood. Here, by use of novel and highly selective JNK inhibitors, we …

 
 
 
 
 
 

Fungal endophyte-derived Fritillaria unibracteata var. wabuensis: diversity, antioxidant capacities in vitro and relations to phenolic, flavonoid or saponin compounds

 
 

Feng Pan, Tian-Jiao Su, Shi-Mei Cai et al.

 
 

Diverse fungal endophytes are rich fungal resources for the production of an enormous quantity of natural products. In the present study, 53 fungal endophytes were isolated from …

 
 
 
 
 
 

Goliath catfish spawning in the far western Amazon confirmed by the distribution of mature adults, drifting larvae and migrating juveniles

 
 

Ronaldo B. Barthem, Michael Goulding, Rosseval G. Leite et al.

 
 

We mapped the inferred long-distance migrations of four species of Amazonian goliath catfishes (Brachyplatystoma rousseauxii, B. platynemum, B. juruense and B. vaillantii) based …

 
 
 
 
 
 

Multi-Instance Metric Transfer Learning for Genome-Wide Protein Function Prediction

 
 

Yonghui Xu, Huaqing Min, Qingyao Wu et al.

 
 

Multi-Instance (MI) learning has been proven to be effective for the genome-wide protein function prediction problems where each training example is associated with multiple …

 
 
 
 
 
 

Enhanced Development of Skeletal Myotubes from Porcine Induced Pluripotent Stem Cells

 
 

Nicholas J. Genovese, Timothy L. Domeier, Bhanu Prakash V. L. Telugu et al.

 
 

The pig is recognized as a valuable model in biomedical research in addition to its agricultural importance. Here we describe a means for generating skeletal muscle efficiently …

 
 
 
 
 
 

Acellular Urethra Bioscaffold: Decellularization of Whole Urethras for Tissue Engineering Applications

 
 

Irina N. Simões, Paulo Vale, Shay Soker et al.

 
 

Patients with stress urinary incontinence mainly suffer from malfunction of the urethra closure mechanism. We established the decellularization of porcine urethras to produce …

 
 
 
 
 
 

Genome-wide indel/SSR scanning reveals significant loci associated with excellent agronomic traits of a cabbage (Brassica oleracea) elite parental line ‘01–20’

 
 

Honghao Lv, Qingbiao Wang, Fengqing Han et al.

 
 

Elite parental lines are of great significance to crop breeding. To discover unique genomic loci associated with excellent economic traits in the elite cabbage inbred-line …

 
 
 
 
 
 

Combined analysis of mRNA and miRNA identifies dehydration and salinity responsive key molecular players in citrus roots

 
 

Rangjin Xie, Jin Zhang, Yanyan Ma et al.

 
 

Citrus is one of the most economically important fruit crops around world. Drought and salinity stresses adversely affected its productivity and fruit quality. However, the …

 
 
 
 
 
 

Future forest aboveground carbon dynamics in the central United States: the importance of forest demographic processes

 
 

Wenchi Jin, Hong S. He, Frank R. Thompson III et al.

 
 

The Central Hardwood Forest (CHF) in the United States is currently a major carbon sink, there are uncertainties in how long the current carbon sink will persist and if the CHF …

 
 
 
 
 
 

High-resolution traction force microscopy on small focal adhesions - improved accuracy through optimal marker distribution and optical flow tracking

 
 

Claude N. Holenstein, Unai Silvan, Jess G. Snedeker

 
 

The accurate determination of cellular forces using Traction Force Microscopy at increasingly small focal attachments to the extracellular environment presents an important yet …

 
 
 
 
 
 

A Noise Trimming and Positional Significance of Transposon Insertion System to Identify Essential Genes in Yersinia pestis

 
 

Zheng Rong Yang, Helen L. Bullifent, Karen Moore et al.

 
 

Massively parallel sequencing technology coupled with saturation mutagenesis has provided new and global insights into gene functions and roles. At a simplistic level, the …

 
 
 
 
 
 

β1- and β2-adrenergic stimulation-induced electrogenic transport by human endolymphatic sac epithelium and its clinical implications

 
 

Bo Gyung Kim, Jin Young Kim, JinSei Jung et al.

 
 

The endolymphatic sac (ES) is a cystic structure of the inner ear connected to the cochlea and vestibule, which plays a role in regulating ion homeostasis in inner ear fluid. …

 
 
 
 
 
 

Heavy Chain-Hyaluronan/Pentraxin 3 from Amniotic Membrane Suppresses Inflammation and Scarring in Murine Lacrimal Gland and Conjunctiva of Chronic Graft-versus-Host Disease

 
 

Yoko Ogawa, Hua He, Shin Mukai et al.

 
 

Chronic graft-versus-host disease (cGVHD) is a major complication of hematopoietic stem cell transplantation. Dry eye disease is the prominent ocular sequel of cGVHD and is …

 
 
 
 
 
 

Characteristics, chemical compositions and biological activities of propolis from Al-Bahah, Saudi Arabia

 
 

Yasser A. Elnakady, Ahmed I. Rushdi, Raimo Franke et al.

 
 

Propolis has been used to treat several diseases since ancient times, and is an important source of bioactive natural compounds and drug derivatives. These properties have kept …

 
 
 
 
 
 

GPR155 Serves as a Predictive Biomarker for Hematogenous Metastasis in Patients with Gastric Cancer

 
 

Dai Shimizu, Mitsuro Kanda, Haruyoshi Tanaka et al.

 
 

The prognosis of patients with gastric cancer (GC) with hematogenous metastasis is dismal. Identification of biomarkers specific for hematogenous metastasis is required to …

 
 
 
 
 
 

Therapeutic effects of Euphorbia Pekinensis and Glycyrrhiza glabra on Hepatocellular Carcinoma Ascites Partially Via Regulating the Frk-Arhgdib-Inpp5d-Avpr2-Aqp4 Signal Axis

 
 

Yanqiong Zhang, Chen Yan, Yuting Li et al.

 
 

To clarify unknown rationalities of herbaceous compatibility of Euphorbia Pekinensis (DJ) and Glycyrrhiza glabra (GC) acting on hepatocellular carcinoma (HCC) ascites, peritoneum …

 
 
 
 
 
 

Bet-hedging in bacteriocin producing Escherichia coli populations: the single cell perspective

 
 

Bihter Bayramoglu, David Toubiana, Simon van Vliet et al.

 
 

Production of public goods in biological systems is often a collaborative effort that may be detrimental to the producers. It is therefore sustainable only if a small fraction of …

 
 
 
 
 
 

Alcohol and nicotine codependence-associated DNA methylation changes in promoter regions of addiction-related genes

 
 

Hongqin Xu, Fan Wang, Henry R. Kranzler et al.

 
 

Altered DNA methylation in addiction-related genes may modify the susceptibility to alcohol or drug dependence (AD or ND). We profiled peripheral blood DNA methylation levels of …

 
 
 
 
 
 

Light-sheet fluorescence imaging to localize cardiac lineage and protein distribution

 
 

Yichen Ding, Juhyun Lee, Jianguo Ma et al.

 
 

Light-sheet fluorescence microscopy (LSFM) serves to advance developmental research and regenerative medicine. Coupled with the paralleled advances in fluorescence-friendly …

 
 
 
 
 
 

Novel Protective Role of Myeloid Differentiation 1 in Pathological Cardiac Remodelling

 
 

Xiaojv Xiong, Yu Liu, Yang Mei et al.

 
 

Myeloid differentiation 1 (MD-1), a secreted protein interacting with radioprotective 105 (RP105), plays an important role in Toll-like receptor 4 (TLR4) signalling pathway. …

 
 
 
 
 
 

Role of E-type prostaglandin receptor EP3 in the vasoconstrictor activity evoked by prostacyclin in thromboxane-prostanoid receptor deficient mice

 
 

Zhenhua Li, Yingzhan Zhang, Bin Liu et al.

 
 

Prostacyclin, also termed as prostaglandin I2 (PGI2), evokes contraction in vessels with limited expression of the prostacyclin receptor. Although the thromboxane-prostanoid …

 
 
 
 
 
 

Anodically Grown Titania Nanotube Induced Cytotoxicity has Genotoxic Origins

 
 

M. Sheikh Mohamed, Aida Torabi, Maggie Paulose et al.

 
 

Nanoarchitectures of titania (TiO2) have been widely investigated for a number of medical applications including implants and drug delivery. Although titania is extensively used …

 
 
 
 
 
 

The Demographic Features, Clinicopathological Characteristics and Cancer-specific Outcomes for Patients with Microinvasive Breast Cancer: A SEER Database Analysis

 
 

Wenna Wang, Wenjie Zhu, Feng Du et al.

 
 

To investigate the clinicopathological characteristics and survival outcomes of microinvasive breast cancer, we conducted an observational study of female diagnosed with DCIS or …

 
 
 
 
 
 

Personality and Augmenting/Reducing (A/R) in auditory event-related potentials (ERPs) during emotional visual stimulation

 
 

Vilfredo De Pascalis, Francesca Fracasso, Philip J. Corr

 
 

An auditory augmenting/reducing ERP paradigm recorded for 5 intensity tones with emotional visual stimulation was used, for the first time, to test predictions derived from the …

 
 
 
 
 
 

Serum bilirubin levels and risk of type 2 diabetes: results from two independent cohorts in middle-aged and elderly Chinese

 
 

Jing Wang, Yaru Li, Xu Han et al.

 
 

Serum bilirubin is a potent endogenous antioxidant and has been identified as cardiovascular risk in cohort studies, while the relation to type 2 diabetes (T2D) in the elderly …

 
 
 
 
 
 

Coptisine from Rhizoma Coptidis Suppresses HCT-116 Cells-related Tumor Growth in vitro and in vivo

 
 

Tao Huang, Yubo Xiao, Lin Yi et al.

 
 

Colorectal cancer is one of the most common causes of cancer-related death in humans. Coptisine (COP) is a natural alkaloid from Coptidis Rhizoma with unclear antitumor …

 
 
 
 
 
 

A novel indication of platonin, a therapeutic immunomodulating medicine, on neuroprotection against ischemic stroke in mice

 
 

Joen-Rong Sheu, Zhih-Cherng Chen, Thanasekaran Jayakumar et al.

 
 

Thrombosis and stroke are major causes of disability and death worldwide. However, the regular antithrombotic drugs may have unsatisfactory results and side effects. Platonin, a …

 
 
 
 
 
 

Quantitative global proteome and lysine succinylome analyses provide insights into metabolic regulation and lymph node metastasis in gastric cancer

 
 

Yongxi Song, Jun Wang, Zhongyi Cheng et al.

 
 

With the rapid development of high-throughput quantitative proteomic and transcriptomic approaches, the molecular mechanisms of cancers have been comprehensively explored. …

 
 
 
 
 
 

Restenosis Inhibition and Re-differentiation of TGFβ/Smad3-activated Smooth Muscle Cells by Resveratrol

 
 

Yichen Zhu, Toshio Takayama, Bowen Wang et al.

 
 

To date, there is no periadventitial drug delivery method available in the clinic to prevent restenotic failure of open vascular reconstructions. Resveratrol is a promising …

 
 
 
 
 
 

Wnt7a Inhibits IL-1β Induced Catabolic Gene Expression and Prevents Articular Cartilage Damage in Experimental Osteoarthritis

 
 

Averi L. Gibson, Carrie K. Hui Mingalone, Andrea T. Foote et al.

 
 

Wnt7a is a protein that plays a critical role in skeletal development. However, its effect on cartilage homeostasis under pathological conditions is not known. In this study, we …

 
 
 
 
 
 

Molecular mutagenesis of ppGpp: turning a RelA activator into an inhibitor

 
 

Jelena Beljantseva, Pavel Kudrin, Steffi Jimmy et al.

 
 

The alarmone nucleotide (p)ppGpp is a key regulator of bacterial metabolism, growth, stress tolerance and virulence, making (p)ppGpp-mediated signaling a promising target for …

 
 
 
 
 
 

Synergetic effects of DNA methylation and histone modification during mouse induced pluripotent stem cell generation

 
 

Guiying Wang, Rong Weng, Yuanyuan Lan et al.

 
 

DNA methylation and histone methylation (H3K27me3) have been reported as major barriers to induced pluripotent stem cell (iPSC) generation using four core transcription factors …

 
 
 
 
 
 

New perspectives on corpora amylacea in the human brain

 
 

Elisabet Augé, Itsaso Cabezón, Carme Pelegrí et al.

 
 

Corpora amylacea are structures of unknown origin and function that appear with age in human brains and are profuse in selected brain areas in several neurodegenerative …

 
 
 
 
 
 

The Neuroeconomics of Tobacco Demand: An Initial Investigation of the Neural Correlates of Cigarette Cost-Benefit Decision Making in Male Smokers

 
 

Joshua C. Gray, Michael T. Amlung, Max Owens et al.

 
 

How the brain processes cigarette cost-benefit decision making remains largely unknown. Using functional magnetic resonance imaging (fMRI), this study investigated the neural …

 
 
 
 
 
 

Dual origins of the intracellular circadian calcium rhythm in the suprachiasmatic nucleus

 
 

Ryosuke Enoki, Daisuke Ono, Shigeru Kuroda et al.

 
 

In mammals, the master circadian clock is located in the suprachiasmatic nucleus (SCN), where most neurons show circadian rhythms of intracellular Ca2+ levels. However, the …

 
 
 
 
 
 

Kynurenine pathway metabolomics predicts and provides mechanistic insight into multiple sclerosis progression

 
 

Chai K. Lim, Ayse Bilgin, David B. Lovejoy et al.

 
 

Activation of the kynurenine pathway (KP) of tryptophan metabolism results from chronic inflammation and is known to exacerbate progression of neurodegenerative disease. To gain …

 
 
 
 
 
 

Subjective craving and event-related brain response to olfactory and visual chocolate cues in binge-eating and healthy individuals

 
 

I. Wolz, A. Sauvaget, R. Granero et al.

 
 

High-sugar/high-fat foods are related to binge-eating behaviour and especially people with low inhibitory control may encounter elevated difficulties to resist their intake. …

 
 
 
 
 
 

Effects of nutritional and ambient oxygen condition on biofilm formation in Mycobacterium avium subsp. hominissuis via altered glycolipid expression

 
 

Takahiro Totani, Yukiko Nishiuchi, Yoshitaka Tateishi et al.

 
 

Mycobacterium avium subsp. hominissuis (MAH) is the major causative agent of nontuberculous mycobacteriosis, the representative case of environment-related infectious diseases …

 
 
 
 
 
 

Platelet activating factor-induced expression of p21 is correlated with histone acetylation

 
 

Elisabetta Damiani, Nahum Puebla-Osorio, Bree M. Lege et al.

 
 

Ultraviolet (UV)-irradiated keratinocytes secrete the lipid mediator of inflammation, platelet-activating factor (PAF). PAF plays an essential role in UV-induced immune …

 
 
 
 
 
 

Unraveling the evolutionary dynamics of ancient and recent polypoidization events in Avena (Poaceae)

 
 

Qing Liu, Lei Lin, Xiangying Zhou et al.

 
 

Understanding the diversification of polyploid crops in the circum-Mediterranean region is a challenging issue in evolutionary biology. Sequence data of three nuclear genes and …

 
 
 
 
 
 

Virtual touch tissue imaging and quantification (VTIQ) in the evaluation of thyroid nodules: the associated factors leading to misdiagnosis

 
 

Cheng-Yu Sun, Kai-Rong Lei, Bo-Ji Liu et al.

 
 

To evaluate the associated factors leading to misdiagnosis with VTIQ for differentiation between benign from malignant thyroid nodules (TNs). The study included 238 benign TNs …

 
 
 
 
 
 

Roles of N-glycans in the polymerization-dependent aggregation of mutant Ig-μ chains in the early secretory pathway

 
 

Chiara Giannone, Claudio Fagioli, Caterina Valetti et al.

 
 

The polymeric structure of secretory IgM allows efficient antigen binding and complement fixation. The available structural models place the N-glycans bound to asparagines 402 …

 
 
 
 
 
 

Immune Signature of Enhanced Functional Avidity CD8+ T Cells in vivo Induced by Vaccinia Vectored Vaccine

 
 

Zhidong Hu, Lingyan Zhu, Jing Wang et al.

 
 

Functional avidity of T cells is a critical determinant for clearing viral infection and eliminating tumor. Understanding how functional avidity is maintained in T cells is …

 
 
 
 
 
 

Forensic SNP Genotyping using Nanopore MinION Sequencing

 
 

Senne Cornelis, Yannick Gansemans, Lieselot Deleye et al.

 
 

One of the latest developments in next generation sequencing is the Oxford Nanopore Technologies’ (ONT) MinION nanopore sequencer. We studied the applicability of this system to …

 
 
 
 
 
 

Mapping the basal ganglia alterations in children chronically exposed to manganese

 
 

Yi Lao, Laurie-Anne Dion, Guillaume Gilbert et al.

 
 

Chronic manganese (Mn) exposure is associated with neuromotor and neurocognitive deficits, but the exact mechanism of Mn neurotoxicity is still unclear. With the advent of …

 
 
 
 
 
 

A Genome-Wide Association Study Identifies Genetic Variants Associated with Mathematics Ability

 
 

Huan Chen, Xiao-hong Gu, Yuxi Zhou et al.

 
 

Mathematics ability is a complex cognitive trait with polygenic heritability. Genome-wide association study (GWAS) has been an effective approach to investigate genetic …

 
 
 
 
 
 

Microbial modulation of bacoside A biosynthetic pathway and systemic defense mechanism in Bacopa monnieri under Meloidogyne incognita stress

 
 

Rupali Gupta, Akanksha Singh, Madhumita Srivastava et al.

 
 

Plant-associated beneficial microbes have been explored to fulfill the imperative function for plant health. However, their impact on the host secondary metabolite production and …

 
 
 
 
 
 

Effect of polarization on HIV-1protease and fluoro-substituted inhibitors binding energies by large scale molecular dynamics simulations

 
 

Li L. Duan, T. Zhu, Yu C. Li et al.

 
 

Molecular dynamics simulations in explicit water are carried out to study the binding of six inhibitors to HIV-1 protease (PR) for up to 700 ns using the standard AMBER force …

 
 
 
 
 
 

Promoting Cas9 degradation reduces mosaic mutations in non-human primate embryos

 
 

Zhuchi Tu, Weili Yang, Sen Yan et al.

 
 

CRISPR-Cas9 is a powerful new tool for genome editing, but this technique creates mosaic mutations that affect the efficiency and precision of its ability to edit the genome. …

 
 
 
 
 
 

WNT/β-Catenin signaling pathway regulates non-tumorigenesis of human embryonic stem cells co-cultured with human umbilical cord mesenchymal stem cells

 
 

Yu-Hsun Chang, Tang-Yuan Chu, Dah-Ching Ding

 
 

Human pluripotent stem cells harbor hope in regenerative medicine, but have limited application in treating clinical diseases due to teratoma formation. Our previous study has …

 
 
 
 
 
 

The formation of multivesicular bodies in activated blastocysts is influenced by autophagy and FGF signaling in mice

 
 

Hyejin Shin, Soyoung Bang, Jiyeon Kim et al.

 
 

Dormant blastocysts during delayed implantation undergo autophagic activation, which is an adaptive response to prolonged survival in utero during less favorable environment. We …

 
 
 
 
 
 

Faithful SGCE imprinting in iPSC-derived cortical neurons: an endogenous cellular model of myoclonus-dystonia

 
 

Karen Grütz, Philip Seibler, Anne Weissbach et al.

 
 

In neuropathology research, induced pluripotent stem cell (iPSC)-derived neurons are considered a tool closely resembling the patient brain. Albeit in respect to epigenetics, …

 
 
 
 
 
 

Reduced Activity of SRY and its Target Enhancer Sox9-TESCO in a Mouse Species with X*Y Sex Reversal

 
 

Liang Zhao, Alexander Quinn, Ee Ting Ng et al.

 
 

In most eutherian mammals, sex determination is governed by the Y-linked gene Sry, but in African pygmy mice Mus minutoides, Sry action is overridden by a variant X chromosome …

 
 
 
 
 
 

Assessment of the efficacy of two novel DNA vaccine formulations against highly pathogenic Porcine Reproductive and Respiratory Syndrome Virus

 
 

Luping Du, Fengjiao Pang, Zhengyu Yu et al.

 
 

Since May 2006, a highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) has emerged and prevailed in mainland China, affecting over 2 million pigs. …

 
 
 
 
 
 

Obtaining spontaneously beating cardiomyocyte-like cells from adipose-derived stromal vascular fractions cultured on enzyme-crosslinked gelatin hydrogels

 
 

Gang Yang, Zhenghua Xiao, Xiaomei Ren et al.

 
 

Heart failure often develops after acute myocardial infarction because the injured myocardial tissue fails to recover or regenerate. Stem cell transplantation using adult cell …

 
 
 
 
 
 

Mass Spectrometry Imaging of Kidney Tissue Sections of Rat Subjected to Unilateral Ureteral Obstruction

 
 

Huihui Liu, Wan Li, Qing He et al.

 
 

Chronic kidney disease (CKD) poses a serious threat to the quality of human life and health with an increasing incidence worldwide. Renal fibrosis is closely related to CKD and …

 
 
 
 
 
 

Repurposing doxycycline for synucleinopathies: remodelling of α-synuclein oligomers towards non-toxic parallel beta-sheet structured species

 
 

Florencia González-Lizárraga, Sergio B. Socías, César L. Ávila et al.

 
 

Synucleinophaties are progressive neurodegenerative disorders with no cure to date. An attractive strategy to tackle this problem is repurposing already tested safe drugs against …

 
 
 
 
 
 

Conserved gene regulation during acute inflammation between zebrafish and mammals

 
 

G. Forn-Cuní, M. Varela, P. Pereiro et al.

 
 

Zebrafish (Danio rerio), largely used as a model for studying developmental processes, has also emerged as a valuable system for modelling human inflammatory diseases. However, …

 
 
 
 
 
 

Epigenetic origin of evolutionary novel centromeres

 
 

Doron Tolomeo, Oronzo Capozzi, Roscoe R. Stanyon et al.

 
 

Most evolutionary new centromeres (ENC) are composed of large arrays of satellite DNA and surrounded by segmental duplications. However, the hypothesis is that ENCs are seeded in …

 
 
 
 
 
 

Evolutionary clade affects resistance of Clostridium difficile spores to Cold Atmospheric Plasma

 
 

Mairéad Connor, Padrig B. Flynn, Derek J. Fairley et al.

 
 

Clostridium difficile is a spore forming bacterium and the leading cause of colitis and antibiotic associated diarrhoea in the developed world. Spores produced by C. difficile

 
 
 
 
 
 

Successful post-exposure prophylaxis of Ebola infected non-human primates using Ebola glycoprotein-specific equine IgG

 
 

Oleg V. Pyankov, Yin Xiang Setoh, Sergey A. Bodnev et al.

 
 

Herein we describe production of purified equine IgG obtained from horses immunized with plasmid DNA followed by boosting with Kunjin replicon virus-like particles both encoding …

 
 
 
 
 
 

Effect of Different Titanium Surfaces on Maturation of Murine Bone Marrow-Derived Dendritic Cells

 
 

Xiaofei Zheng, Fengjuan Zhou, Yifei Gu et al.

 
 

Dendritic cells (DCs) play a pivotal role in the host response to implanted biomaterials. Osseointegration of titanium (Ti) implant is an immunological and inflammatory-driven …

 
 
 
 
 
 

Efficient genome replication of hepatitis B virus using adenovirus vector: a compact pregenomic RNA-expression unit

 
 

Mariko Suzuki, Saki Kondo, Manabu Yamasaki et al.

 
 

The complicated replication mechanisms of hepatitis B virus (HBV) have impeded HBV studies and anti-HBV therapy development as well. Herein we report efficient genome replication …

 
 
 
 
 
 

MISSA 2.0: an updated synthetic biology toolbox for assembly of orthogonal CRISPR/Cas systems

 
 

Hai-Yan Zhang, Xing-Hui Wang, Li Dong et al.

 
 

Efficient generation of plants carrying mutations in multiple genes remains a challenge. Using two or more orthogonal CRISPR/Cas systems can generate plants with multi-gene …

 
 
 
 
 
 

Signatures of malaria-associated pathology revealed by high-resolution whole-blood transcriptomics in a rodent model of malaria

 
 

Jing-wen Lin, Jan Sodenkamp, Deirdre Cunningham et al.

 
 

The influence of parasite genetic factors on immune responses and development of severe pathology of malaria is largely unknown. In this study, we performed genome-wide …

 
 
 
 
 
 

The molecular basis of talin2’s high affinity toward β1-integrin

 
 

Yaxia Yuan, Liqing Li, Yanyan Zhu et al.

 
 

Talin interacts with β-integrin tails and actin to control integrin activation, thus regulating focal adhesion dynamics and cell migration. There are two talin genes, Tln1 and

 
 
 
 
 
 

Age, but not anthelmintic treatment, is associated with urinary neopterin levels in semi-free ranging Barbary macaques

 
 

Nadine Müller, Michael Heistermann, Christina Strube et al.

 
 

Studying host parasite interactions and their implications for evolution and ecology recently received increasing attention, particularly with regard to host physiology and …

 
 
 
 
 
 

Unravelling the genetic basis of simplex Retinitis Pigmentosa cases

 
 

Nereida Bravo-Gil, María González-del Pozo, Marta Martín-Sánchez et al.

 
 

Retinitis Pigmentosa (RP) is the most common form of inherited retinal dystrophy (IRD) characterized ultimately by photoreceptors degeneration. Exhibiting great clinical and …

 
 
 
 
 
 

iTRAQ-based quantitative proteomic analysis of the global response to 17β-estradiol in estrogen-degradation strain Pseudomonas putida SJTE-1

 
 

Jing Xu, Lei Zhang, Jingli Hou et al.

 
 

Microorganism degradation is efficient to remove the steroid hormones like 17β-estradiol (E2); but their degradation mechanism and metabolic network to these chemicals are still …

 
 
 
 
 
 

Predictors of facial attractiveness and health in humans

 
 

Yong Zhi Foo, Leigh W. Simmons, Gillian Rhodes

 
 

Facial attractiveness has been suggested to provide signals of biological quality, particularly health, in humans. The attractive traits that have been implicated as signals of …

 
 
 
 
 
 

Understanding cancer complexome using networks, spectral graph theory and multilayer framework

 
 

Aparna Rai, Priodyuti Pradhan, Jyothi Nagraj et al.

 
 

Cancer complexome comprises a heterogeneous and multifactorial milieu that varies in cytology, physiology, signaling mechanisms and response to therapy. The combined framework of …

 
 
 
 
 
 

Mapping the distribution of specific antibody interaction forces on individual red blood cells

 
 

Natasha Yeow, Rico F. Tabor, Gil Garnier

 
 

Current blood typing methods rely on the agglutination of red blood cells (RBCs) to macroscopically indicate a positive result. An indirect agglutination mechanism is required …

 
 
 
 
 
 

Toxicity of iron oxide nanoparticles to grass litter decomposition in a sandy soil

 
 

Muhammad Imtiaz Rashid, Tanvir Shahzad, Muhammad Shahid et al.

 
 

We examined time-dependent effect of iron oxide nanoparticles (IONPs) at a rate of 2000 mg kg−1 soil on Cynodon dactylon litter (3 g kg−1) decomposition in an arid sandy soil. …

 
 
 
 
 
 

Mechanisms underlying the cardiac antifibrotic effects of losartan metabolites

 
 

José Luis Miguel-Carrasco, Javier Beaumont, Gorka San José et al.

 
 

Excessive myocardial collagen deposition and cross-linking (CCL), a process regulated by lysyl oxidase (LOX), determines left ventricular (LV) stiffness and dysfunction. The …

 
 
 
 
 
 

Aberrant Neuronal Dynamics during Working Memory Operations in the Aging HIV-Infected Brain

 
 

Tony W. Wilson, Amy L. Proskovec, Elizabeth Heinrichs-Graham et al.

 
 

Impairments in working memory are among the most prevalent features of HIV-associated neurocognitive disorders (HAND), yet their origins are unknown, with some studies arguing …

 
 
 
 
 
 

Longitudinal in vivo bioimaging of hepatocyte transcription factor activity following cholestatic liver injury in mice

 
 

Juliette M. K. M. Delhove, Suzanne M. K. Buckley, Dany P. Perocheau et al.

 
 

Molecular mechanisms regulating liver repair following cholestatic injury remain largely unknown. We have combined a mouse model of acute cholestatic liver injury, partial bile …

 
 
 
 
 
 

EpEX/EpCAM and Oct4 or Klf4 alone are sufficient to generate induced pluripotent stem cells through STAT3 and HIF2α

 
 

I.-I. Kuan, Kang-Hao Liang, Yi-Ping Wang et al.

 
 

Epithelial cell adhesion molecule (EpCAM) was reported to be cleaved into extracellular domain of EpCAM (EpEX) and intracellular domain of EpCAM (EpICD). We previously reported …

 
 
 
 
 
 

Regulation of pairing between broken DNA-containing chromatin regions by Ku80, DNA-PKcs, ATM, and 53BP1

 
 

Motohiro Yamauchi, Atsushi Shibata, Keiji Suzuki et al.

 
 

Chromosome rearrangement is clinically and physiologically important because it can produce oncogenic fusion genes. Chromosome rearrangement requires DNA double-strand breaks …

 
 
 
 
 
 

Designing a new cropping system for high productivity and sustainable water usage under climate change

 
 

Qingfeng Meng, Hongfei Wang, Peng Yan et al.

 
 

The food supply is being increasingly challenged by climate change and water scarcity. However, incremental changes in traditional cropping systems have achieved only limited …

 
 
 
 
 
 

Subregional structural and connectivity damage in the visual cortex in neuromyelitis optica

 
 

Huanhuan Cai, Jiajia Zhu, Ningnannan Zhang et al.

 
 

Patients with neuromyelitis optica (NMO) have shown structural and functional impairments in the visual cortex. We aimed to characterize subregional grey matter volume (GMV) and …

 
 
 
 
 
 

A critical role for p38MAPK signalling pathway during reprogramming of human fibroblasts to iPSCs

 
 

Irina Neganova, Valeria Chichagova, Lyle Armstrong et al.

 
 

Reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) holds enormous promise for regenerative medicine. Reprogramming is a stepwise process with well-defined …

 
 
 
 
 
 

Toxic metabolites, MAPK and Nrf2/Keap1 signaling pathways involved in oxidative toxicity in mice liver after chronic exposure to Mequindox

 
 

Qianying Liu, Zhixin Lei, Anxiong Huang et al.

 
 

Mequindox (MEQ) is a synthetic antimicrobial agent of quinoxaline-1,4-dioxide group (QdNOs). The liver is regarded as the toxicity target of QdNOs, and the role of N → O …

 
 
 
 
 
 

Early exposure to thirdhand cigarette smoke affects body mass and the development of immunity in mice

 
 

Bo Hang, Antoine M. Snijders, Yurong Huang et al.

 
 

Thirdhand smoke (THS) is the fraction of cigarette smoke that persists in indoor environments after smoking. We investigated the effects of neonatal and adult THS exposure on …

 
 
 
 
 
 

Self-assemble nanoparticles based on polypeptides containing C-terminal luminescent Pt-cysteine complex

 
 

E. G. Vlakh, E. V. Grachova, D. D. Zhukovsky et al.

 
 

The growing attention to the luminescent nanocarriers is strongly stimulated by their potential application as drug delivery systems and by the necessity to monitor their …

 
 
 
 
 
 

The citrus flavanone naringenin impairs dengue virus replication in human cells

 
 

Sandra Frabasile, Andrea Cristine Koishi, Diogo Kuczera et al.

 
 

Dengue is one of the most significant health problems in tropical and sub-tropical regions throughout the world. Nearly 390 million cases are reported each year. Although a …

 
 
 
 
 
 

Surface mediated cooperative interactions of drugs enhance mechanical forces for antibiotic action

 
 

Joseph W. Ndieyira, Joe Bailey, Samadhan B. Patil et al.

 
 

The alarming increase of pathogenic bacteria that are resistant to multiple antibiotics is now recognized as a major health issue fuelling demand for new drugs. Bacterial …

 
 
 
 
 
 

Cover crops support ecological intensification of arable cropping systems

 
 

Raphaël A. Wittwer, Brigitte Dorn, Werner Jossi et al.

 
 

A major challenge for agriculture is to enhance productivity with minimum impact on the environment. Several studies indicate that cover crops could replace anthropogenic inputs …

 
 
 
 
 
 

IL1B-CGTC haplotype is associated with colorectal cancer in admixed individuals with increased African ancestry

 
 

María Carolina Sanabria-Salas, Gustavo Hernández-Suárez, Adriana Umaña-Pérez et al.

 
 

Single-nucleotide polymorphisms (SNPs) in cytokine genes can affect gene expression and thereby modulate inflammation and carcinogenesis. However, the data on the association …

 
 
 
 
 
 

Fingolimod alters the transcriptome profile of circulating CD4+ cells in multiple sclerosis

 
 

Jörg Friess, Michael Hecker, Luisa Roch et al.

 
 

Multiple sclerosis is a demyelinating disease affecting the central nervous system. T cells are known to contribute to this immune-mediated condition. Fingolimod modulates …

 
 
 
 
 
 

An Engineered Herpesvirus Activates Dendritic Cells and Induces Protective Immunity

 
 

Yijie Ma, Min Chen, Huali Jin et al.

 
 

Herpes simplex viruses (HSV) are human pathogens that switch between lytic and latent infection. While attenuated HSV is explored for vaccine, the underlying event remains poorly …

 
 
 
 
 
 

Efficient N-tailing of blunt DNA ends by Moloney murine leukemia virus reverse transcriptase

 
 

Yoshiyuki Ohtsubo, Yuji Nagata, Masataka Tsuda

 
 

Moloney murine leukemia virus reverse transcriptase (MMLV-RT) is a widely used enzyme for cDNA synthesis. Here we show that MMLV-RT has a strong template-independent polymerase …

 
 
 
 
 
 

Manipulation of lignin metabolism by plant densities and its relationship with lodging resistance in wheat

 
 

Mengjing Zheng, Jin Chen, Yuhua Shi et al.

 
 

Increasing plant density is one of the most efficient ways of increasing wheat (Triticum aestivum L.) grain production. However, overly dense plant populations have an increased …

 
 
 
 
 
 

An inhibitory role of Arg-84 in anion channelrhodopsin-2 expressed in Escherichia coli

 
 

Satoko Doi, Takashi Tsukamoto, Susumu Yoshizawa et al.

 
 

Anion channelrhodopsin-2 (ACR2) was recently identified from the cryptophyte algae Guillardia theta and has become a focus of interest in part because of its novel light-gated …

 
 
 
 
 
 

Microfluidic cell isolation technology for drug testing of single tumor cells and their clusters

 
 

Swastika S. Bithi, Siva A. Vanapalli

 
 

Drug assays with patient-derived cells such as circulating tumor cells requires manipulating small sample volumes without loss of rare disease-causing cells. Here, we report an …

 
 
 
 
 
 

Characterisation of a divergent progenitor cell sub-populations in human osteoarthritic cartilage: the role of telomere erosion and replicative senescence

 
 

Christopher R. Fellows, Rebecca Williams, Iwan R. Davies et al.

 
 

In recent years it has become increasingly clear that articular cartilage harbours a viable pool of progenitor cells and interest has focussed on their role during development …

 
 
 
 
 
 

Astragaloside IV ameliorates 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis implicating regulation of energy metabolism

 
 

Xu-Guang Jiang, Kai Sun, Yu-Ying Liu et al.

 
 

Dysfunction of energy metabolism is involved in inflammatory bowel disease (IBD). This study was designed to investigate the potential of astragaloside IV (ASIV), an active …

 
 
 
 
 
 

PhCESA3 silencing inhibits elongation and stimulates radial expansion in petunia

 
 

Weiyuan Yang, Yuanping Cai, Li Hu et al.

 
 

Cellulose synthase catalytic subunits (CESAs) play important roles in plant growth, development and disease resistance. Previous studies have shown an essential role of

 
 
 
 
 
 

Intein-mediated backbone cyclization of VP1 protein enhanced protection of CVB3-induced viral myocarditis

 
 

Xingmei Qi, Sidong Xiong

 
 

CVB3 is a common human pathogen to be highly lethal to newborns and causes viral myocarditis and pancreatitis in adults. However, there is no vaccine available for clinical use. …

 
 
 
 
 
 

Discovering missing reactions of metabolic networks by using gene co-expression data

 
 

Zhaleh Hosseini, Sayed-Amir Marashi

 
 

Flux coupling analysis is a computational method which is able to explain co-expression of metabolic genes by analyzing the topological structure of a metabolic network. It has …

 
 
 
 
 
 

Short-term monocular occlusion produces changes in ocular dominance by a reciprocal modulation of interocular inhibition

 
 

Eva Chadnova, Alexandre Reynaud, Simon Clavagnier et al.

 
 

Ocular dominance can be modulated by short-term monocular deprivation. This changes the contribution that each eye makes to binocular vision, an example of adult cortical …

 
 
 
 
 
 

MiR-27a rs895819 is involved in increased atrophic gastritis risk, improved gastric cancer prognosis and negative interaction with Helicobacter pylori

 
 

Qian Xu, Tie-jun Chen, Cai-yun He et al.

 
 

MiR-27a rs895819 is a loop-stem structure single nucleotide polymorphism affecting mature miR-27a function. In this study, we performed a comprehensive analysis about the …

 
 
 
 
 
 

Epigenetic regulation of nitric oxide synthase 2, inducible (Nos2) by NLRC4 inflammasomes involves PARP1 cleavage

 
 

Carina de Lima Buzzo, Tiago Medina, Laura M. Branco et al.

 
 

Nitric oxide synthase 2, inducible (Nos2) expression is necessary for the microbicidal activity of macrophages. However, NOS2 over-activation causes multiple inflammatory …

 
 
 
 
 
 

Enhanced corrosion resistance and cytocompatibility of biodegradable Mg alloys by introduction of Mg(OH)2 particles into poly (L-lactic acid) coating

 
 

Yong-juan Shi, Jia Pei, Jian Zhang et al.

 
 

A strategy of suppressing the fast degradation behaviour of Mg-based biomaterials by the introduction of one of Mg degradation products Mg(OH)2 was proposed according to the …

 
 
 
 
 
 

Quercetin Inhibits Inflammasome Activation by Interfering with ASC Oligomerization and Prevents Interleukin-1 Mediated Mouse Vasculitis

 
 

Talita P. Domiciano, Daiko Wakita, Heather D. Jones et al.

 
 

Interleukin-1β (IL-1β) is a highly inflammatory cytokine that significantly contributes to both acute and chronic inflammatory diseases. The secretion of IL-1β requires a unique …

 
 
 
 
 
 

MISTIC-fusion proteins as antigens for high quality membrane protein antibodies

 
 

Natalia Silva Alves, Susanne Adina Astrinidis, Nathalie Eisenhardt et al.

 
 

Lack of high-quality antibodies against transmembrane proteins is a widely recognized hindrance in biomedical and cell biological research. Here we present a robust pipeline for …

 
 
 
 
 
 

The Fecal Microbial Community of Breast-fed Infants from Armenia and Georgia

 
 

Zachery T Lewis, Ketevan Sidamonidze, Vardan Tsaturyan et al.

 
 

Multiple factors help shape the infant intestinal microbiota early in life. Environmental conditions such as the presence of bioactive molecules from breast milk dictate gut …

 
 
 
 
 
 

Antennal transcriptomes of three tortricid moths reveal putative conserved chemosensory receptors for social and habitat olfactory cues

 
 

Francisco Gonzalez, Peter Witzgall, William B. Walker

 
 

Insects use chemical signals to find mates, food and oviposition sites. The main chemoreceptor gene families comprise odorant receptors (ORs), ionotropic receptors (IRs) and …

 
 
 
 
 
 

Field background odour should be taken into account when formulating a pest attractant based on plant volatiles

 
 

Xiaoming Cai, Lei Bian, Xiuxiu Xu et al.

 
 

Attractants for pest monitoring and controlling can be developed based on plant volatiles. Previously, we showed that tea leafhopper (Empoasca onukii) preferred grapevine, peach …

 
 
 
 
 
 

The conserved macrodomains of the non-structural proteins of Chikungunya virus and other pathogenic positive strand RNA viruses function as mono-ADP-ribosylhydrolases

 
 

Laura Eckei, Sarah Krieg, Mareike Bütepage et al.

 
 

Human pathogenic positive single strand RNA ((+)ssRNA) viruses, including Chikungunya virus, pose severe health problems as for many neither efficient vaccines nor therapeutic …

 
 
 
 
 
 

The evolution of conditional moral assessment in indirect reciprocity

 
 

Tatsuya Sasaki, Isamu Okada, Yutaka Nakai

 
 

Indirect reciprocity is a major mechanism in the maintenance of cooperation among unrelated individuals. Indirect reciprocity leads to conditional cooperation according to social …

 
 
 
 
 
 

Palmdelphin promotes myoblast differentiation and muscle regeneration

 
 

Yaping Nie, Hu Chen, Cilin Guo et al.

 
 

Differentiation of myoblasts is essential in the development and regeneration of skeletal muscles to form multinucleated, contractile muscle fibers. However, the process of …

 
 
 
 
 
 

Engineering an endocrine Neo-Pancreas by repopulation of a decellularized rat pancreas with islets of Langerhans

 
 

H. Napierala, K.-H. Hillebrandt, N. Haep et al.

 
 

Decellularization of pancreata and repopulation of these non-immunogenic matrices with islets and endothelial cells could provide transplantable, endocrine Neo- Pancreata. In …

 
 
 
 
 
 

Fear of predation drives stable and differentiated social relationships in guppies

 
 

Robert J. P. Heathcote, Safi K. Darden, Daniel W. Franks et al.

 
 

Social relationships can have important consequences for fitness in animals. Whilst numerous studies have shown that individuals often join larger groups in response to perceived …

 
 
 
 
 
 

Temporal course of implicit emotion regulation during a Priming-Identify task: an ERP study

 
 

Yi Wang, Xuebing Li

 
 

Implicit emotion regulation defined as goal-driven processes modulates emotion experiences and responses automatically without awareness. However, the temporal course of implicit …

 
 
 
 
 
 

Distinct requirement of Runx complexes for TCRβ enhancer activation at distinct developmental stages

 
 

Wooseok Seo, Sawako Muroi, Kaori Akiyama et al.

 
 

A TCRβ enhancer, known as the Eβ enhancer, plays a critical role in V(D)J recombination and transcription of the Tcrb gene. However, the coordinated action of trans-acting …

 
 
 
 
 
 

De novo hybrid assembly of the rubber tree genome reveals evidence of paleotetraploidy in Hevea species

 
 

Wirulda Pootakham, Chutima Sonthirod, Chaiwat Naktang et al.

 
 

Para rubber tree (Hevea brasiliensis) is an important economic species as it is the sole commercial producer of high-quality natural rubber. Here, we report a de novo hybrid …

 
 
 
 
 
 

First real-time observation of transverse division in azooxanthellate scleractinian corals

 
 

Yuki Tokuda, Hiroko Haraguchi, Yoichi Ezaki

 
 

Asexual reproduction is one of the most important traits in the evolutionary history of corals. No real-time observations of asexual reproduction in azooxanthellate solitary …

 
 
 
 
 
 

Transcriptomic investigation of wound healing and regeneration in the cnidarian Calliactis polypus

 
 

Zachary K. Stewart, Ana Pavasovic, Daniella H. Hock et al.

 
 

Wound healing and regeneration in cnidarian species, a group that forms the sister phylum to Bilateria, remains poorly characterised despite the ability of many cnidarians to …

 
 
 
 
 
 

Simvastatin suppresses the DNA replication licensing factor MCM7 and inhibits the growth of tamoxifen-resistant breast cancer cells

 
 

Zheyong Liang, Wenjie Li, Jie Liu et al.

 
 

Acquired tamoxifen resistance (TamR) remains a major challenge in breast cancer endocrine therapy. The mechanism of acquiring tamoxifen resistance remains elusive, and no …

 
 
 
 
 
 

Selective binocular vision loss in two subterranean caviomorph rodents: Spalacopus cyanus and Ctenomys talarum

 
 

T. Vega-Zuniga, F. S. Medina, G. Marín et al.

 
 

To what extent can the mammalian visual system be shaped by visual behavior? Here we analyze the shape of the visual fields, the densities and distribution of cells in the …

 
 
 
 
 
 

Transcriptomic analysis of common carp anterior kidney during Cyprinid herpesvirus 3 infection: Immunoglobulin repertoire and homologue functional divergence

 
 

Matthew J. Neave, Agus Sunarto, Kenneth A. McColl

 
 

Cyprinid herpesvirus 3 (CyHV-3) infects koi and common carp and causes widespread mortalities. While the virus is a significant concern for aquaculture operations in many …

 
 
 
 
 
 

Rainbow trout (Oncorhynchus mykiss) secretory component binds to commensal bacteria and pathogens

 
 

Cecelia Kelly, Fumio Takizawa, J. Oriol Sunyer et al.

 
 

Commensal bacteria co-exist on the mucosal surfaces of all vertebrates. The host’s mucosal immune system must tolerate commensals while fighting pathogens. One of the mechanisms …

 
 
 
 
 
 

Allometric analysis of a morphological anti-predator trait in geographic populations of Japanese crucian carp

 
 

Sakie Kodama, Hiroka Fujimori, Hiroshi Hakoyama

 
 

Costly anti-predator traits tend to be expressed only in high-predation conditions. For the cyprinid fish genus Carassius, deeper body depth is more adaptive to avoid predation …

 
 
 
 
 
 

Bioengineering a bacterial pathogen to assemble its own particulate vaccine capable of inducing cellular immunity

 
 

Jason W. Lee, Natalie A. Parlane, D. Neil Wedlock et al.

 
 

Many bacterial pathogens naturally form cellular inclusions. Here the immunogenicity of polyhydroxyalkanoate (PHA) inclusions and their use as particulate vaccines delivering a …

 
 
 
 
 
 

Foliar fungi of Betula pendula: impact of tree species mixtures and assessment methods

 
 

Diem Nguyen, Johanna Boberg, Michelle Cleary et al.

 
 

Foliar fungi of silver birch (Betula pendula) in an experimental Finnish forest were investigated across a gradient of tree species richness using molecular high-throughput …

 
 
 
 
 
 

Methanol-Independent Protein Expression by AOX1 Promoter with trans-Acting Elements Engineering and Glucose-Glycerol-Shift Induction in Pichia pastoris

 
 

Jinjia Wang, Xiaolong Wang, Lei Shi et al.

 
 

The alcohol oxidase 1 promoter (PAOX1) of Pichia pastoris is commonly used for high level expression of recombinant proteins. While the safety risk of methanol and tough process …

 
 
 
 
 
 

Mitochondrial genome diversity in dagger and needle nematodes (Nematoda: Longidoridae)

 
 

J. E. Palomares-Rius, C. Cantalapiedra-Navarrete, A. Archidona-Yuste et al.

 
 

Dagger and needle nematodes included in the family Longidoridae (viz. Longidorus, Paralongidorus, and Xiphinema) are highly polyphagous plant-parasitic nematodes in wild and …

 
 
 
 
 
 

Development of a multilocus-based approach for sponge (phylum Porifera) identification: refinement and limitations

 
 

Qi Yang, Christopher M. M. Franco, Shirley J. Sorokin et al.

 
 

For sponges (phylum Porifera), there is no reliable molecular protocol available for species identification. To address this gap, we developed a multilocus-based Sponge …

 
 
 
 
 
 

Construction of a guide-RNA for site-directed RNA mutagenesis utilising intracellular A-to-I RNA editing

 
 

Masatora Fukuda, Hiromitsu Umeno, Kanako Nose et al.

 
 

As an alternative to DNA mutagenesis, RNA mutagenesis can potentially become a powerful gene-regulation method for fundamental research and applied life sciences. …

 
 
 
 
 
 

Drivers of Cape Verde archipelagic endemism in keyhole limpets

 
 

Regina L. Cunha, Jorge M. Assis, Celine Madeira et al.

 
 

Oceanic archipelagos are the ideal setting for investigating processes that shape species assemblages. Focusing on keyhole limpets, genera Fissurella and Diodora from Cape Verde …

 
 
 
 
 
 

Short stop mediates axonal compartmentalization of mucin-type core 1 glycans

 
 

Takaaki Kinoshita, Chikara Sato, Takashi J. Fuwa et al.

 
 

T antigen, mucin-type core 1 O-glycan, is highly expressed in the embryonic central nervous system (CNS) and co-localizes with a Drosophila CNS marker, BP102 antigen. BP102 …

 
 
 
 
 
 

Wogonin reversed resistant human myelogenous leukemia cells via inhibiting Nrf2 signaling by Stat3/NF-κB inactivation

 
 

Xuefen Xu, Xiaobo Zhang, Yi Zhang et al.

 
 

Constitutive NF-E2-related factor 2 (Nrf2, NFE2L2) activation has been recently reported to play a pivotal role in enhancing cell survival and resistance to anticancer drugs in …

 
 
 
 
 
 

Repair of bone defects with prefabricated vascularized bone grafts and double-labeled bone marrow-derived mesenchymal stem cells in a rat model

 
 

Xiao-Rui Jiang, Hui-Ying Yang, Xin-Xin Zhang et al.

 
 

This study aims to investigate the repair of bone defects with prefabricated vascularized bone grafts and double-labeled bone marrow-derived mesenchymal stem cells (BMSCs) in a …

 
 
 
 
 
 

Allometric scaling of decompression sickness risk in terrestrial mammals; cardiac output explains risk of decompression sickness

 
 

Andreas Fahlman

 
 

A probabilistic model was used to predict decompression sickness (DCS) outcome in pig (70 and 20 kg), hamster (100 g), rat (220 g) and mouse (20 g) following air saturation …

 
 
 
 
 
 

Differential lactate and cholesterol synthetic activities in XY and XX Sertoli cells

 
 

Yurina Shishido, Takashi Baba, Tetsuya Sato et al.

 
 

SRY, a sex-determining gene, induces testis development in chromosomally female (XX) individuals. However, mouse XX Sertoli cells carrying Sry (XX/Sry Sertoli cells) are …

 
 
 
 
 
 

Cell-free measurements of brightness of fluorescently labeled antibodies

 
 

Haiying Zhou, George Tourkakis, Dennis Shi et al.

 
 

Validation of imaging contrast agents, such as fluorescently labeled imaging antibodies, has been recognized as a critical challenge in clinical and preclinical studies. As the …

 
 
 
 
 
 

Association of Genomic Instability with HbA1c levels and Medication in Diabetic Patients

 
 

Annemarie Grindel, Helmut Brath, Armen Nersesyan et al.

 
 

Diabetes Mellitus type 2 (DM2) is associated with increased cancer risk. Instability of the genetic material plays a key role in the aetiology of human cancer. This study aimed …

 
 
 
 
 
 

Photodynamic therapy monitoring with optical coherence angiography

 
 

M. A. Sirotkina, L. A. Matveev, M. V. Shirmanova et al.

 
 

Photodynamic therapy (PDT) is a promising modern approach for cancer therapy with low normal tissue toxicity. This study was focused on a vascular-targeting Chlorine E6 mediated …

 
 
 
 
 
 

Generation of a bile salt export pump deficiency model using patient-specific induced pluripotent stem cell-derived hepatocyte-like cells

 
 

Kazuo Imagawa, Kazuo Takayama, Shigemi Isoyama et al.

 
 

Bile salt export pump (BSEP) plays an important role in hepatic secretion of bile acids and its deficiency results in severe cholestasis and liver failure. Mutation of the ABCB11

 
 
 
 
 
 

Size-dependent cellular uptake mechanism and cytotoxicity toward calcium oxalate on Vero cells

 
 

Xin-Yuan Sun, Qiong-Zhi Gan, Jian-Ming Ouyang

 
 

Urinary crystals with various sizes are present in healthy individuals and patients with kidney stone; however, the cellular uptake mechanism of calcium oxalate of various sizes …

 
 
 
 
 
 

Rapid detection of functional gene polymorphisms of TLRs and IL-17 using high resolution melting analysis

 
 

Johanna Teräsjärvi, Antti Hakanen, Matti Korppi et al.

 
 

Genetic variations in toll-like receptors (TLRs) and IL-17A have been widely connected to different diseases. Associations between susceptibility and resistance to different …

 
 
 
 
 
 

Reduced GABAergic transmission in the ventrobasal thalamus contributes to thermal hyperalgesia in chronic inflammatory pain

 
 

Chan Zhang, Rong-Xiang Chen, Yu Zhang et al.

 
 

The ventrobasal (VB) thalamus is innervated by GABAergic afferents from the thalamic reticular nucleus (TRN) and participates in nociception. But how the TRN-VB pathway regulates …

 
 
 
 
 
 

Cellular prion protein is present in mitochondria of healthy mice

 
 

Robert Faris, Roger A. Moore, Anne Ward et al.

 
 

Cellular prion protein (PrPC) is a mammalian glycoprotein which is usually found anchored to the plasma membrane via a glycophosphatidylinositol (GPI) anchor. PrPC misfolds to a …

 
 
 
 
 
 

Genome-wide DNA methylation reprogramming in response to inorganic arsenic links inhibition of CTCF binding, DNMT expression and cellular transformation

 
 

Matthew Rea, Meredith Eckstein, Rebekah Eleazer et al.

 
 

Chronic low dose inorganic arsenic (iAs) exposure leads to changes in gene expression and epithelial-to-mesenchymal transformation. During this transformation, cells adopt a …

 
 
 
 
 
 

Alterations in the carnitine cycle in a mouse model of Rett syndrome

 
 

Sabrina Mucerino, Anna Di Salle, Nicola Alessio et al.

 
 

Rett syndrome (RTT) is a neurodevelopmental disease that leads to intellectual deficit, motor disability, epilepsy and increased risk of sudden death. Although in up to 95% of …

 
 
 
 
 
 

P-Selectin preserves immune tolerance in mice and is reduced in human cutaneous lupus

 
 

Rafael González-Tajuelo, Javier Silván, Alicia Pérez-Frías et al.

 
 

Mice deficient in P-Selectin presented altered immunity/tolerance balance. We have observed that the absence of P-Selectin promotes splenomegaly with reduced naïve T cell …

 
 
 
 
 
 

The E3 ligase Mule protects the heart against oxidative stress and mitochondrial dysfunction through Myc-dependent inactivation of Pgc-1α and Pink1

 
 

Keith Dadson, Ludger Hauck, Zhenyue Hao et al.

 
 

Cardiac homeostasis requires proper control of protein turnover. Protein degradation is principally controlled by the Ubiquitin-Proteasome System. Mule is an E3 ubiquitin ligase …

 
 
 
 
 
 

Early life antibiotic exposure affects pancreatic islet development and metabolic regulation

 
 

Jiaying Li, Kaiyuan Yang, Tingting Ju et al.

 
 

Childhood antibiotic exposure has been recently linked with increased risk of metabolic disease later in life. A better understanding of this association would potentially …

 
 
 
 
 
 

Structural Connectivity Variances Underlie Functional and Behavioral Changes During Pain Relief Induced by Neuromodulation

 
 

Richard L. Lin, Gwenaëlle Douaud, Nicola Filippini et al.

 
 

An increased understanding of the relationship between structural connections and functional and behavioral outcomes is an essential but under-explored topic in neuroscience. …

 
 
 
 
 
 

Tuning the allosteric regulation of artificial muscarinic and dopaminergic ligand-gated potassium channels by protein engineering of G protein-coupled receptors

 
 

Christophe J. Moreau, Jean Revilloud, Lydia N. Caro et al.

 
 

Ligand-gated ion channels enable intercellular transmission of action potential through synapses by transducing biochemical messengers into electrical signal. We designed …

 
 
 
 
 
 

Corrigendum: Microtubule stabilising peptides rescue tau phenotypes in-vivo

 
 

Shmma Quraishe, Megan Sealey, Louise Cranfield et al.

 
 

 
 
 
 
 
 

Membrane engineering of S. cerevisiae targeting sphingolipid metabolism

 
 

Lina Lindahl, Aline X. S. Santos, Helén Olsson et al.

 
 

The sustainable production of fuels and chemicals using microbial cell factories is now well established. However, many microbial production processes are still limited in scale …

 
 
 
 
 
 

ERAMOSA controls lateral branching in snapdragon

 
 

Chiara Mizzotti, Bianca M. Galliani, Ludovico Dreni et al.

 
 

Plant forms display a wide variety of architectures, depending on the number of lateral branches, internode elongation and phyllotaxy. These are in turn determined by the number, …

 
 
 
 
 
 

The antibacterial activities of aditoprim and its efficacy in the treatment of swine streptococcosis

 
 

Guyue Cheng, Yamei Xu, Xudong Zhu et al.

 
 

Aditoprim (ADP) has potential use as an antimicrobial agent in animals. However, its pharmacodynamic properties have not been systematically studied yet. In this study, the in …

 
 
 
 
 
 

Two strategies to engineer flexible loops for improved enzyme thermostability

 
 

Haoran Yu, Yihan Yan, Cheng Zhang et al.

 
 

Flexible sites are potential targets for engineering the stability of enzymes. Nevertheless, the success rate of the rigidifying flexible sites (RFS) strategy is still low due to …

 
 
 
 
 
 

Seagrass ecophysiological performance under ocean warming and acidification

 
 

Tiago Repolho, Bernardo Duarte, Gisela Dionísio et al.

 
 

Seagrasses play an essential ecological role within coastal habitats and their worldwide population decline has been linked to different types of anthropogenic forces. We …

 
 
 
 
 
 

Induction of Bex genes by curcumin is associated with apoptosis and activation of p53 in N2a neuroblastoma cells

 
 

Himakshi Sidhar, Ranjit K. Giri

 
 

Brain expressed X-linked (Bex) genes are newer group of pro-apoptotic genes. Role of any Bex gene in neuroblastoma and Bex4 and Bex6 in any cancer is completely unknown. …

 
 
 
 
 
 

Effects of Prolonged GRP78 Haploinsufficiency on Organ Homeostasis, Behavior, Cancer and Chemotoxic Resistance in Aged Mice

 
 

Amy S. Lee, Sebastian Brandhorst, Daisy F. Rangel et al.

 
 

GRP78, a multifunctional protein with potent cytoprotective properties, is an emerging therapeutic target to combat cancer development, progression and drug resistance. The …

 
 
 
 
 
 

Attentional deployment impacts neural response to regret

 
 

Zhiyuan Liu, Lin Li, Li Zheng et al.

 
 

Regret results from comparing non-optimal outcomes containing both gain and loss parts to better alternatives during decision-making. The present fMRI study aimed to explore …

 
 
 
 
 
 

Predicting HIV Pre-exposure Prophylaxis Efficacy for Women using a Preclinical Pharmacokinetic-Pharmacodynamic In Vivo Model

 
 

Angela Wahl, Phong T. Ho, Paul W. Denton et al.

 
 

The efficacy of HIV pre-exposure prophylaxis (PrEP) relies on adherence and may also depend on the route of HIV acquisition. Clinical studies of systemic tenofovir disoproxil …

 
 
 
 
 
 

Targeted capture to assess neutral genomic variation in the narrow-leaf hopbush across a continental biodiversity refugium

 
 

Matthew J. Christmas, Ed Biffin, Martin F. Breed et al.

 
 

The Adelaide geosyncline, a mountainous region in central southern Australia, is purported to be an important continental refugium for Mediterranean and semi-arid Australian …

 
 
 
 
 
 

TDtest: easy detection of bacterial tolerance and persistence in clinical isolates by a modified disk-diffusion assay

 
 

Orit Gefen, Betty Chekol, Jacob Strahilevitz et al.

 
 

Antibiotic tolerance - the ability for prolonged survival under bactericidal treatments - is a potentially clinically significant phenomenon that is commonly overlooked in the …

 
 
 
 
 
 

Comparison of amino acid profiles and metabolic gene expression in muskrat scented glands in secretion and non-secretion season

 
 

Yimeng Li, Tianxiang Zhang, Mengyuan Fan et al.

 
 

The scented gland is an organ responsible for producing musk in muskrats. During musk secretion season, the metabolism of glandular cells increases in the scented glands and a …

 
 
 
 
 
 

Multidimensional metrics of niche space for use with diverse analytical techniques

 
 

Rachel E. Bowes, James H. Thorp, Daniel C. Reuman

 
 

Multidimensional data are integral to many community-ecological studies and come in various forms, such as stable isotopes, compound specific analyses (e.g., amino acids and …

 
 
 
 
 
 

The association between HDAC9 gene polymorphisms and stroke risk in the Chinese population: A meta-analysis

 
 

Xin Zhou, Tangming Guan, Shuyuan Li et al.

 
 

Several recent genome-wide association studies (GWASs) have suggested that the histone deacetylase 9 (HDAC9) gene is associated with stroke, but the reliability of these findings …

 
 
 
 
 
 

Role of thermal physiology and bioenergetics on adaptation in tree shrew (Tupaia belangeri): the experiment test

 
 

Lin Zhang, Fang Yang, Zheng-kun Wang et al.

 
 

Ambient conditions, as temperature and photoperiod, play a key role in animals’ physiology and behaviors. To test the hypothesis that the maximum thermal physiological and …

 
 
 
 
 
 

Enhanced performance of the microalga Chlorella sorokiniana remotely induced by the plant growth-promoting bacteria Azospirillum brasilense and Bacillus pumilus

 
 

Edgar Amavizca, Yoav Bashan, Choong-Min Ryu et al.

 
 

Remote effects (occurring without physical contact) of two plant growth-promoting bacteria (PGPB) Azospirillum brasilense Cd and Bacilus pumilus ES4 on growth of the green …

 
 
 
 
 
 

Upregulation of MiR-205 transcriptionally suppresses SMAD4 and PTEN and contributes to human ovarian cancer progression

 
 

Juanni Li, Kuan Hu, Guanghui Gong et al.

 
 

MicroRNAs (miRNAs) function as critical regulators of gene expression and their deregulation is associated with the development and progression of various cancers. This study …

 
 
 
 
 
 

miR-34a inhibits pancreatic cancer progression through Snail1-mediated epithelial–mesenchymal transition and the Notch signaling pathway

 
 

Yan Tang, Yong Tang, Ying-sheng Cheng

 
 

Epithelial–mesenchymal transition (EMT) and Notch signaling are important for the growth and invasion of pancreatic cancer, which is a leading cause of cancer-related deaths …

 
 
 
 
 
 

Automatic Marker-free Longitudinal Infrared Image Registration by Shape Context Based Matching and Competitive Winner-guided Optimal Corresponding

 
 

Chia-Yen Lee, Hao-Jen Wang, Jhih-Hao Lai et al.

 
 

Long-term comparisons of infrared image can facilitate the assessment of breast cancer tissue growth and early tumor detection, in which longitudinal infrared image registration …

 
 
 
 
 
 

High prevalence of toxigenic Clostridium difficile in public space lawns in Western Australia

 
 

Peter Moono, Su Chen Lim, Thomas V. Riley

 
 

Clostridium difficile is a well-established hospital pathogen. Recently, it has been detected increasingly in patients without hospital contact. Given this rise in community …

 
 
 
 
 
 

Diffuse Optical Spectroscopy and Imaging to Detect and Quantify Adipose Tissue Browning

 
 

U. S Dinish, Chi Lok Wong, Sandhya Sriram et al.

 
 

Adipose (fat) tissue is a complex metabolic organ that is highly active and essential. In contrast to white adipose tissue (WAT), brown adipose tissue (BAT) is deemed …

 
 
 
 
 
 

Transplanted miR-219-overexpressing oligodendrocyte precursor cells promoted remyelination and improved functional recovery in a chronic demyelinated model

 
 

Hong-Bin Fan, Li-Xia Chen, Xue-Bin Qu et al.

 
 

Oligodendrocyte precursor cells (OPCs) have the ability to repair demyelinated lesions by maturing into myelin-producing oligodendrocytes. Recent evidence suggests that miR-219 …

 
 
 
 
 
 

Interactions of retinoids with the ABC transporters P-glycoprotein and Breast Cancer Resistance Protein

 
 

Szabolcs Tarapcsák, Gábor Szalóki, Ágnes Telbisz et al.

 
 

Retinoids – derivatives of vitamin A – are important cell permeant signaling molecules that regulate gene expression through activation of nuclear receptors. P-glycoprotein (Pgp) …

 
 
 
 
 
 

Eugenol prevents amyloid formation of proteins and inhibits amyloid-induced hemolysis

 
 

Kriti Dubey, Bibin G. Anand, Dolat Singh Shekhawat et al.

 
 

Eugenol has attracted considerable attention because of its potential for many pharmaceutical applications including anti-inflammatory, anti-tumorigenic and anti-oxidant …

 
 
 
 
 
 

Neural Correlates of Sexual Orientation in Heterosexual, Bisexual, and Homosexual Men

 
 

Adam Safron, David Sylva, Victoria Klimaj et al.

 
 

Studies of subjective and genital sexual arousal in monosexual (i.e. heterosexual and homosexual) men have repeatedly found that erotic stimuli depicting men’s preferred sex …

 
 
 
 
 
 

Muscle-specific overexpression of AdipoR1 or AdipoR2 gives rise to common and discrete local effects whilst AdipoR2 promotes additional systemic effects

 
 

Sahar Keshvari, Darren C. Henstridge, Choaping Ng et al.

 
 

Hypoadiponectinemia and adiponectin resistance are implicated in the aetiology of obesity-related cardiometabolic disorders, hence represent a potential therapeutic axis. Here we …

 
 
 
 
 
 

Development of a human vasopressin V1a-receptor antagonist from an evolutionary-related insect neuropeptide

 
 

Maria Giulia Di Giglio, Markus Muttenthaler, Kasper Harpsøe et al.

 
 

Characterisation of G protein-coupled receptors (GPCR) relies on the availability of a toolbox of ligands that selectively modulate different functional states of the receptors. …

 
 
 
 
 
 

Hypocretin/Orexin Peptides Excite Rat Neuroendocrine Dopamine Neurons through Orexin 2 Receptor-Mediated Activation of a Mixed Cation Current

 
 

David J. Lyons, Arash Hellysaz, Rachida Ammari et al.

 
 

Hypocretin/Orexin (H/O) neurons of the lateral hypothalamus are compelling modulator candidates for the chronobiology of neuroendocrine output and, as a consequence, hormone …

 
 
 
 
 
 

Altered expression of miR-181a and miR-146a does not change the expression of surface NCRs in human NK cells

 
 

Mona Rady, Carsten Watzl, Maren Claus et al.

 
 

MicroRNAs (miRNAs) play an important role in regulating gene expression and immune responses. Of interest, miR-181a and miR-146a are key players in regulating immune responses …

 
 
 
 
 
 

Testis-specific transcriptional regulators selectively occupy BORIS-bound CTCF target regions in mouse male germ cells

 
 

Samuel Rivero-Hinojosa, Sungyun Kang, Victor V. Lobanenkov et al.

 
 

Despite sharing the same sequence specificity in vitro and in vivo, CCCTC-binding factor (CTCF) and its paralog brother of the regulator of imprinted sites (BORIS) are …

 
 
 
 
 
 

Pharmacologic ATM but not ATR kinase inhibition abrogates p21-dependent G1 arrest and promotes gastrointestinal syndrome after total body irradiation

 
 

Frank P. Vendetti, Brian J. Leibowitz, Jennifer Barnes et al.

 
 

We show that ATM kinase inhibition using AZ31 prior to 9 or 9.25 Gy total body irradiation (TBI) reduced median time to moribund in mice to 8 days. ATR kinase inhibition using …

 
 
 
 
 
 

Neurotypical Peers are Less Willing to Interact with Those with Autism based on Thin Slice Judgments

 
 

Noah J. Sasson, Daniel J. Faso, Jack Nugent et al.

 
 

Individuals with autism spectrum disorder (ASD), including those who otherwise require less support, face severe difficulties in everyday social interactions. Research in this …

 
 
 
 
 
 

Autophagic flux, a possible mechanism for delayed gentamicin-induced ototoxicity

 
 

Yeon Ju Kim, Chunjie Tian, Jangho Kim et al.

 
 

Aminoglycoside antibiotics including gentamicin (GM) induce delayed ototoxic effects such as hearing loss after long-term use, unlike the early-onset ototoxicity caused by …

 
 
 
 
 
 

Serum protein changes in a rat model of chronic pain show a correlation between animal and humans

 
 

Elisa Bellei, Antonietta Vilella, Emanuela Monari et al.

 
 

In previous works we showed the overexpression of some proteins in biological fluids from patients suffering chronic pain. In this proteomic study we analysed serum from a rat …

 
 
 
 
 
 

M48U1 and Tenofovir combination synergistically inhibits HIV infection in activated PBMCs and human cervicovaginal histocultures

 
 

Giuseppina Musumeci, Isabella Bon, David Lembo et al.

 
 

Microbicides are considered a promising strategy for preventing human immunodeficiency virus (HIV-1) transmission and disease. In this report, we first analyzed the antiviral …

 
 
 
 
 
 

Chloroplastic biosynthesis of melatonin and its involvement in protection of plants from salt stress

 
 

Xiaodong Zheng, Dun X. Tan, Andrew C. Allan et al.

 
 

Within the chloroplasts reactive oxygen species (ROS) are generated during photosynthesis and stressful conditions. Excessive ROS damages chloroplasts and reduces photosynthesis …

 
 
 
 
 
 

The Calcium-Dependent Switch Helix of L-Plastin Regulates Actin Bundling

 
 

Hiroaki Ishida, Katharine V. Jensen, Andrew G. Woodman et al.

 
 

L-plastin is a calcium-regulated actin-bundling protein that is expressed in cells of hematopoietic origin and in most metastatic cancer cells. These cell types are mobile and …

 
 
 
 
 
 

Overcoming the dichotomy between open and isolated populations using genomic data from a large European dataset

 
 

Paolo Anagnostou, Valentina Dominici, Cinzia Battaggia et al.

 
 

Human populations are often dichotomized into “isolated” and “open” categories using cultural and/or geographical barriers to gene flow as differential criteria. Although …

 
 
 
 
 
 

Brain networks involved in tactile speed classification of moving dot patterns: the effects of speed and dot periodicity

 
 

Jiajia Yang, Ryo Kitada, Takanori Kochiyama et al.

 
 

Humans are able to judge the speed of an object’s motion by touch. Research has suggested that tactile judgment of speed is influenced by physical properties of the moving …

 
 
 
 
 
 

Lipidomics reveals dramatic lipid compositional changes in the maturing postnatal lung

 
 

Sydney E. Dautel, Jennifer E. Kyle, Geremy Clair et al.

 
 

Lung immaturity is a major cause of morbidity and mortality in premature infants. Understanding the molecular mechanisms driving normal lung development could provide insights on …

 
 
 
 
 
 

Comparative genomics of Vibrio campbellii strains and core species of the Vibrio Harveyi clade

 
 

Huei-Mien Ke, Anuphap Prachumwat, Chun-Ping Yu et al.

 
 

The core of the Vibrio Harveyi clade contains V. harveyi, V. campbellii, V. owensii, V. jasicida, and V. rotiferianus. They are well recognized aquatic animal pathogens, but …

 
 
 
 
 
 

Impact of salt stress, cell death, and autophagy on peroxisomes: quantitative and morphological analyses using small fluorescent probe N-BODIPY

 
 

Deirdre Fahy, Marwa N. M. E. Sanad, Kerstin Duscha et al.

 
 

Plant peroxisomes maintain a plethora of key life processes including fatty acid β-oxidation, photorespiration, synthesis of hormones, and homeostasis of reactive oxygen species …

 
 
 
 
 
 

The sRNAome mining revealed existence of unique signature small RNAs derived from 5.8SrRNA from Piper nigrum and other plant lineages

 
 

Srinivasan Asha, E. V. Soniya

 
 

Small RNAs derived from ribosomal RNAs (srRNAs) are rarely explored in the high-throughput data of plant systems. Here, we analyzed srRNAs from the deep-sequenced small RNA …

 
 
 
 
 
 

Caffeic Acid Cyclohexylamide Rescues Lethal Inflammation in Septic Mice through Inhibition of IκB Kinase in Innate Immune Process

 
 

Jun Hyeon Choi, Sun Hong Park, Jae-Kyung Jung et al.

 
 

Targeting myeloid differentiation protein 2 (MD-2) or Toll-like receptor 4 (TLR4) with small molecule inhibitor rescues the systemic inflammatory response syndrome (SIRS) in …

 
 
 
 
 
 

Sublethal pesticide doses negatively affect survival and the cellular responses in American foulbrood-infected honeybee larvae

 
 

Javier Hernández López, Sophie Krainer, Antonia Engert et al.

 
 

Disclosing interactions between pesticides and bee infections is of most interest to understand challenges that pollinators are facing and to which extent bee health is …

 
 
 
 
 
 

Enhancing gene regulatory network inference through data integration with markov random fields

 
 

Michael Banf, Seung Y. Rhee

 
 

A gene regulatory network links transcription factors to their target genes and represents a map of transcriptional regulation. Much progress has been made in deciphering gene …

 
 
 
 
 
 

Genetic polymorphisms and their association with brain and behavioural measures in heterogeneous stock mice

 
 

Magdalena Janecka, Sarah J. Marzi, Michael J. Parsons et al.

 
 

Although the search for quantitative trait loci for behaviour remains a considerable challenge, the complicated genetic architecture of quantitative traits is beginning to be …

 
 
 
 
 
 

Targeted nanoparticles encapsulating (−)-epigallocatechin-3-gallate for prostate cancer prevention and therapy

 
 

Vanna Sanna, Chandra K. Singh, Rahime Jashari et al.

 
 

Earlier we introduced the concept of ‘nanochemoprevention’ i.e. the use of nanotechnology to improve the outcome of cancer chemoprevention. Here, we extended our work and …

 
 
 
 
 
 

Honeybee locomotion is impaired by Am-CaV3 low voltage-activated Ca2+ channel antagonist

 
 

M. Rousset, C. Collet, T. Cens et al.

 
 

Voltage‐gated Ca2+ channels are key transducers of cellular excitability and participate in several crucial physiological responses. In vertebrates, 10 Ca2+ channel genes, …

 
 
 
 
 
 

TDAG8 involved in initiating inflammatory hyperalgesia and establishing hyperalgesic priming in mice

 
 

Shih-Ping Dai, Ya-Han Huang, Chung-Jen Chang et al.

 
 

Chronic pain, resulting from injury, arthritis, and cancer, is often accompanied by inflammation. High concentrations of protons found in inflamed tissues results in tissue …

 
 
 
 
 
 

Intracellular Accumulation of Gold Nanoparticles Leads to Inhibition of Macropinocytosis to Reduce the Endoplasmic Reticulum Stress

 
 

Nuray Gunduz, Hakan Ceylan, Mustafa O. Guler et al.

 
 

Understanding the toxicity of nanomaterials remains largely limited to acute cellular response, i.e., short-term in vitro cell-death based assays, and analyses of tissue- and …

 
 
 
 
 
 

Identification of genomic regions for grain yield and yield stability and their epistatic interactions

 
 

Deepmala Sehgal, Enrique Autrique, Ravi Singh et al.

 
 

The task of identifying genomic regions conferring yield stability is challenging in any crop and requires large experimental data sets in conjunction with complex analytical …

 
 
 
 
 
 

Synergistic effects of metformin with liraglutide against endothelial dysfunction through GLP-1 receptor and PKA signalling pathway

 
 

Jing Ke, Ye Liu, Jin Yang et al.

 
 

Metformin or glucagon-like peptide-1 (GLP-1) analogue liraglutide has cardiovascular benefits. However, it is not clear whether their combined treatment have additive or …

 
 
 
 
 
 

ZP3 is Required for Germinal Vesicle Breakdown in Mouse Oocyte Meiosis

 
 

Lei-Lei Gao, Chun-Xiang Zhou, Xiao-Lan Zhang et al.

 
 

ZP3 is a principal component of the zona pellucida (ZP) of mammalian oocytes and is essential for normal fertility, and knockout of ZP3 causes complete infertility. ZP3 promotes …

 
 
 
 
 
 

Molecular, morphological and survival analysis of 177 resected pancreatic ductal adenocarcinomas (PDACs): Identification of prognostic subtypes

 
 

Anna Melissa Schlitter, Angela Segler, Katja Steiger et al.

 
 

Pancreatic ductal adenocarcinoma (PDAC) has generally a poor prognosis, but recent data suggest that there are molecular subtypes differing in clinical outcome. This study …

 
 
 
 
 
 

Effects of Normothermic Conditioned Microwave Irradiation on Cultured Cells Using an Irradiation System with Semiconductor Oscillator and Thermo-regulatory Applicator

 
 

Mamiko Asano, Minoru Sakaguchi, Satoshi Tanaka et al.

 
 

We investigated the effects of microwave irradiation under normothermic conditions on cultured cells. For this study, we developed an irradiation system constituted with …

 
 
 
 
 
 

Effects of ocean acidification on the potency of macroalgal allelopathy to a common coral

 
 

Carlos Del Monaco, Mark E. Hay, Patrick Gartrell et al.

 
 

Many coral reefs have phase shifted from coral to macroalgal dominance. Ocean acidification (OA) due to elevated CO2 is hypothesised to advantage macroalgae over corals, …

 
 
 
 
 
 

Succinate ester derivative of δ-tocopherol enhances the protective effects against 60Co γ-ray-induced hematopoietic injury through granulocyte colony-stimulating factor induction in mice

 
 

Zhong-Tang Li, Li-Mei Wang, Li-Rong Yi et al.

 
 

α-tocopherol succinate (α-TOS), γ-tocotrienol (GT3) and δ-tocotrienol (DT3) have drawn large attention due to their efficacy as radioprotective agents. α-TOS has been shown to …

 
 
 
 
 
 

Anticancer Drug Camptothecin Test in 3D Hydrogel Networks with HeLa cells

 
 

Jun Liang, Xiuzhi Susan Sun, Zhilong Yang et al.

 
 

Development of a biomimetic 3D culture system for drug screening is necessary to fully understand the in vivo environment. Previously, a self-assembling peptide hydrogel has been …

 
 
 
 
 
 

Improving polygenic risk prediction from summary statistics by an empirical Bayes approach

 
 

Hon-Cheong So, Pak C. Sham

 
 

Polygenic risk scores (PRS) from genome-wide association studies (GWAS) are increasingly used to predict disease risks. However some included variants could be false positives …

 
 
 
 
 
 

Unraveling the cytotoxicity and metabolic pathways of binary natural deep eutectic solvent systems

 
 

Yves Paul Mbous, Maan Hayyan, Won Fen Wong et al.

 
 

In this study, the anticancer potential and cytotoxicity of natural deep eutectic solvents (NADESs) were assessed using HelaS3, PC3, A375, AGS, MCF-7, and WRL-68 hepatic cell …

 
 
 
 
 
 

Primary Human Placental Trophoblasts are Permissive for Zika Virus (ZIKV) Replication

 
 

Kjersti M. Aagaard, Anismrita Lahon, Melissa A. Suter et al.

 
 

Zika virus (ZIKV) is an emerging mosquito-borne (Aedes genus) arbovirus of the Flaviviridae family. Although ZIKV has been predominately associated with a mild or asymptomatic …

 
 
 
 
 
 

Eddy covariance and biometric measurements show that a savanna ecosystem in Southwest China is a carbon sink

 
 

Xuehai Fei, Yanqiang Jin, Yiping Zhang et al.

 
 

Savanna ecosystems play a crucial role in the global carbon cycle. However, there is a gap in our understanding of carbon fluxes in the savanna ecosystems of Southeast Asia. In …

 
 
 
 
 
 

Young Bone-Marrow Sca-1+ Stem Cells Rejuvenate the Aged Heart and Improve Function after Injury through PDGFRβ-Akt pathway

 
 

Shu-Hong Li, Lu Sun, Lei Yang et al.

 
 

Bone marrow (BM) reconstitution with young BM cells in aged recipients restores the functionality of cardiac resident BM-derived progenitors. This study investigated the cell …

 
 
 
 
 
 

The intervening domain from MeCP2 enhances the DNA affinity of the methyl binding domain and provides an independent DNA interaction site

 
 

Rafael Claveria-Gimeno, Pilar M. Lanuza, Ignacio Morales-Chueca et al.

 
 

Methyl-CpG binding protein 2 (MeCP2) preferentially interacts with methylated DNA and it is involved in epigenetic regulation and chromatin remodelling. Mutations in MeCP2 are …

 
 
 
 
 
 

Lysosomal dysfunction and autophagy blockade contribute to IMB-6G-induced apoptosis in pancreatic cancer cells

 
 

Lu Liu, Na Zhang, Yueying Dou et al.

 
 

Targeting the autophagic pathway is currently regarded as an attractive strategy for cancer drug discovery. Our previous work showed that IMB-6G is a novel N-substituted …

 
 
 
 
 
 

Joint genome-wide association and transcriptome sequencing reveals a complex polygenic network underlying hypocotyl elongation in rapeseed (Brassica napus L.)

 
 

Xiang Luo, Zhifei Xue, Chaozhi Ma et al.

 
 

Hypocotyl elongation is considered an important typical seedling trait contributing directly to an increase in and stabilization of the yield in Brassica napus, but its molecular …

 
 
 
 
 
 

Predictive radiogenomics modeling of EGFR mutation status in lung cancer

 
 

Olivier Gevaert, Sebastian Echegaray, Amanda Khuong et al.

 
 

Molecular analysis of the mutation status for EGFR and KRAS are now routine in the management of non-small cell lung cancer. Radiogenomics, the linking of medical images with the …

 
 
 
 
 
 

Identifying the Metabolic Differences of a Fast-Growth Phenotype in Synechococcus UTEX 2973

 
 

Thomas J. Mueller, Justin L. Ungerer, Himadri B. Pakrasi et al.

 
 

The photosynthetic capabilities of cyanobacteria make them interesting candidates for industrial bioproduction. One obstacle to large-scale implementation of cyanobacteria is …

 
 
 
 
 
 

Transcriptional heterogeneity in the lactase gene within cell-type is linked to the epigenome

 
 

Edward Oh, Richie Jeremian, Gabriel Oh et al.

 
 

Transcriptional variation in histologically- and genetically- identical cells is a widespread phenomenon in tissues, yet the processes conferring this heterogeneity are not well …

 
 
 
 
 
 

Corrigendum: Modulation of gut microbiota and delayed immunosenescence as a result of syringaresinol consumption in middle-aged mice

 
 

Si-Young Cho, Juewon Kim, Ji Hae Lee et al.

 
 

 
 
 
 
 
 

Single α-particle irradiation permits real-time visualization of RNF8 accumulation at DNA damaged sites

 
 

Giovanna Muggiolu, Michal Pomorski, Gérard Claverie et al.

 
 

As well as being a significant source of environmental radiation exposure, α-particles are increasingly considered for use in targeted radiation therapy. A better understanding …

 
 
 
 
 
 

Intravenous Formulation of HET0016 Decreased Human Glioblastoma Growth and Implicated Survival Benefit in Rat Xenograft Models

 
 

Meenu Jain, Nipuni-Dhanesha H. Gamage, Meshal Alsulami et al.

 
 

Glioblastoma (GBM) is a hypervascular primary brain tumor with poor prognosis. HET0016 is a selective CYP450 inhibitor, which has been shown to inhibit angiogenesis and tumor …

 
 
 
 
 
 

Drosophila CG3303 is an essential endoribonuclease linked to TDP-43-mediated neurodegeneration

 
 

Pietro Laneve, Lucia Piacentini, Assunta Maria Casale et al.

 
 

Endoribonucleases participate in almost every step of eukaryotic RNA metabolism, acting either as degradative or biosynthetic enzymes. We previously identified the founding …

 
 
 
 
 
 

Rewiring carotenoid biosynthesis in plants using a viral vector

 
 

Eszter Majer, Briardo Llorente, Manuel Rodríguez-Concepción et al.

 
 

Plants can be engineered to sustainably produce compounds of nutritional, industrial or pharmaceutical relevance. This is, however, a challenging task as extensive regulation of …

 
 
 
 
 
 

Platelet activation determines the severity of thrombocytopenia in dengue infection

 
 

Amrita Ojha, Dipika Nandi, Harish Batra et al.

 
 

Thrombocytopenia is common in patients with dengue virus (DENV) infections. With a focus on understanding the possible mechanism of thrombocytopenia in DENV infections we …

 
 
 
 
 
 

Polymorphism of apyrimidinic DNA structures in the nucleosome

 
 

Akihisa Osakabe, Yasuhiro Arimura, Syota Matsumoto et al.

 
 

Huge amounts (>10,000/day) of apurinic/apyrimidinic (AP) sites are produced in genomes, but their structures in chromatin remain undetermined. We determined the crystal structure …

 
 
 
 
 
 

Simple and complex retinal dystrophies are associated with profoundly different disease networks

 
 

Christina Kiel, Claire Lastrucci, Philip J. Luthert et al.

 
 

Retinopathies are a group of monogenetic or complex retinal diseases associated with high unmet medical need. Monogenic disorders are caused by rare genetic variation and usually …

 
 
 
 
 
 

Dynamic evolution of hepatitis C virus resistance-associated substitutions in the absence of antiviral treatment

 
 

Auda A. Eltahla, Preston Leung, Mehdi R. Pirozyan et al.

 
 

Resistance against new hepatitis C virus (HCV) antivirals is an area of increasing interest. Resistance-associated substitutions (RASs) have been identified in treatment-naïve …

 
 
 
 
 
 

Accurate discrimination of the wake-sleep states of mice using non-invasive whole-body plethysmography

 
 

Stefano Bastianini, Sara Alvente, Chiara Berteotti et al.

 
 

A major limitation in the study of sleep breathing disorders in mouse models of pathology is the need to combine whole-body plethysmography (WBP) to measure respiration with …

 
 
 
 
 
 

QuickProbs 2: Towards rapid construction of high-quality alignments of large protein families

 
 

Adam Gudyś, Sebastian Deorowicz

 
 

The ever-increasing size of sequence databases caused by the development of high throughput sequencing, poses to multiple alignment algorithms one of the greatest challenges yet. …

 
 
 
 
 
 

A new model of sperm nuclear architecture following assessment of the organization of centromeres and telomeres in three-dimensions

 
 

Dimitrios Ioannou, Nicole M. Millan, Elizabeth Jordan et al.

 
 

The organization of chromosomes in sperm nuclei has been proposed to possess a unique “hairpin-loop” arrangement, which is hypothesized to aid in the ordered exodus of the …

 
 
 
 
 
 

NF-κB suppresses apoptosis and promotes bladder cancer cell proliferation by upregulating survivin expression in vitro and in vivo

 
 

Xiaolu Cui, Dezhi Shen, Chuize Kong et al.

 
 

Nuclear factor kappa-B (NF-κB) activation is a common phenomenon in cancers, which results in the aberrant expression of NF-κB target genes and leads to malignant transformation, …

 
 
 
 
 
 

Control of Neuropeptide Expression by Parallel Activity-dependent Pathways in Caenorhabditis elegans

 
 

Teresa Rojo Romanos, Jakob Gramstrup Petersen, Roger Pocock

 
 

Monitoring of neuronal activity within circuits facilitates integrated responses and rapid changes in behavior. We have identified a system in Caenorhabditis elegans where …

 
 
 
 
 
 

Thicker three-dimensional tissue from a “symbiotic recycling system” combining mammalian cells and algae

 
 

Yuji Haraguchi, Yuki Kagawa, Katsuhisa Sakaguchi et al.

 
 

In this paper, we report an in vitro co-culture system that combines mammalian cells and algae, Chlorococcum littorale, to create a three-dimensional (3-D) tissue. While the …

 
 
 
 
 
 

Nutritional background changes the hypolipidemic effects of fenofibrate in Nile tilapia (Oreochromis niloticus)

 
 

Li-Jun Ning, An-Yuan He, Dong-Liang Lu et al.

 
 

Peroxisome proliferation activated receptor α (PPARα) is an important transcriptional regulator of lipid metabolism and is activated by high-fat diet (HFD) and fibrates in …

 
 
 
 
 
 

Foveal processing difficulty does not affect parafoveal preprocessing in young readers

 
 

Christina Marx, Stefan Hawelka, Sarah Schuster et al.

 
 

Recent evidence suggested that parafoveal preprocessing develops early during reading acquisition, that is, young readers profit from valid parafoveal information and exhibit a …

 
 
 
 
 
 

Germline large genomic alterations on 7q in patients with multiple primary cancers

 
 

R. A. R. Villacis, T. R. Basso, L. M. Canto et al.

 
 

Patients with multiple primary cancers (MPCs) are suspected to have a hereditary cancer syndrome. However, only a small proportion may be explained by mutations in …

 
 
 
 
 
 

Combination of cephalosporins with vancomycin or teicoplanin enhances antibacterial effect of glycopeptides against heterogeneous vancomycin-intermediate Staphylococcus aureus (hVISA) and VISA

 
 

Chih-Cheng Lai, Chi-Chung Chen, Yin-Ching Chuang et al.

 
 

Eight heterogeneous vancomycin-intermediate S. aureus (h-VISA) and seven VISA clinical isolates confirmed by the population analysis profile/area under the curve ratio (PAP/AUC) …

 
 
 
 
 
 

Cortisol Awakening Response and Acute Stress Reactivity in First Nations People

 
 

Maximus Berger, Anthony Leicht, Angela Slatcher et al.

 
 

First Nations people globally have a higher incidence of mental disorders and non-communicable diseases. These health inequalities are partially attributed to a complex network …

 
 
 
 
 
 

Independent movement of the voltage sensors in KV2.1/KV6.4 heterotetramers

 
 

Elke Bocksteins, Dirk J. Snyders, Miguel Holmgren

 
 

Heterotetramer voltage-gated K+ (KV) channels KV2.1/KV6.4 display a gating charge-voltage (QV) distribution composed by two separate components. We use state dependent chemical …

 
 
 
 
 
 

A bias-minimising measure of the influence of head orientation on perceived gaze direction

 
 

Tarryn Balsdon, Colin W. G. Clifford

 
 

The orientation of the head is an important cue for gaze direction, and its role has been explained in a dual route model. The model incorporates both an attractive and a

 
 
 
 
 
 

Skeletal Site-specific Effects of Zoledronate on in vivo Bone Remodeling and in vitro BMSCs Osteogenic Activity

 
 

Xue Gong, Wanlu Yu, Hang Zhao et al.

 
 

Bisphosphonate-related osteonecrosis of the jaw (BRONJ) has been associated with long-term oral or intravenous administration of nitrogen-containing bisphosphonates (BPs). …

 
 
 
 
 
 

Genome-Wide Association Study of Polymorphisms Predisposing to Bronchiolitis

 
 

Anu Pasanen, Minna K. Karjalainen, Louis Bont et al.

 
 

Bronchiolitis is a major cause of hospitalization among infants. Severe bronchiolitis is associated with later asthma, suggesting a common genetic predisposition. Genetic …

 
 
 
 
 
 

Small-seeded Hakea species tolerate cotyledon loss better than large-seeded congeners

 
 

Sh-hoob El-Amhir, Byron B. Lamont, Tianhua He et al.

 
 

Six Hakea species varying greatly in seed size were selected for cotyledon damage experiments. The growth of seedlings with cotyledons partially or completely removed was …

 
 
 
 
 
 

Quality Control by Isoleucyl-tRNA Synthetase of Bacillus subtilis Is Required for Efficient Sporulation

 
 

Elizabeth Kermgard, Zhou Yang, Annika-Marisa Michel et al.

 
 

Isoleucyl-tRNA synthetase (IleRS) is an aminoacyl-tRNA synthetase whose essential function is to aminoacylate tRNAIle with isoleucine. Like some other aminoacyl-tRNA synthetases, …

 
 
 
 
 
 

The PRC2-binding long non-coding RNAs in human and mouse genomes are associated with predictive sequence features

 
 

Shiqi Tu, Guo-Cheng Yuan, Zhen Shao

 
 

Recently, long non-coding RNAs (lncRNAs) have emerged as an important class of molecules involved in many cellular processes. One of their primary functions is to shape …

 
 
 
 
 
 

No effect of Bt Cry1Ie toxin on bacterial diversity in the midgut of the Chinese honey bees, Apis cerana cerana (Hymenoptera, Apidae)

 
 

Hui-Ru Jia, Ping-Li Dai, Li-Li Geng et al.

 
 

Cry1Ie protein derived from Bacillus thuringiensis (Bt) has been proposed as a promising candidate for the development of a new Bt-maize variety to control maize pests in China. …

 
 
 
 
 
 

Non-AUG start codons responsible for ABO weak blood group alleles on initiation mutant backgrounds

 
 

Emili Cid, Miyako Yamamoto, Fumiichiro Yamamoto

 
 

Histo-blood group ABO gene polymorphism is crucial in transfusion medicine. We studied the activity and subcellular distribution of ABO gene-encoded A glycosyltransferases with …

 
 
 
 
 
 

The hypothalamic NPVF circuit modulates ventral raphe activity during nociception

 
 

Romain Madelaine, Matthew Lovett-Barron, Caroline Halluin et al.

 
 

RFamide neuropeptide VF (NPVF) is expressed by neurons in the hypothalamus and has been implicated in nociception, but the circuit mechanisms remain unexplored. Here, we studied …

 
 
 
 
 
 

Histone H4 expression is cooperatively maintained by IKKβ and Akt1 which attenuates cisplatin-induced apoptosis through the DNA-PK/RIP1/IAPs signaling cascade

 
 

Ruixue Wang, Xuelian Zheng, Lei Zhang et al.

 
 

While chromatin remodeling mediated by post-translational modification of histone is extensively studied in carcinogenesis and cancer cell’s response to chemotherapy and …

 
 
 
 
 
 

Myosuppressin is involved in the regulation of pupal diapause in the cabbage army moth Mamestra brassicae

 
 

Nobuto Yamada, Hiroshi Kataoka, Akira Mizoguchi

 
 

Diapause, a programmed developmental arrest, is common in insects, enabling them to survive adverse seasons. It is well established that pupal diapause is regulated by …

 
 
 
 
 
 

Suppression of emission rates improves sonar performance by flying bats

 
 

Amanda M. Adams, Kaylee Davis, Michael Smotherman

 
 

Echolocating bats face the challenge of actively sensing their environment through their own emissions, while also hearing calls and echoes of nearby conspecifics. How bats …

 
 
 
 
 
 

Accumulated quiescent neural stem cells in adult hippocampus of the mouse model for the MECP2 duplication syndrome

 
 

Zhifang Chen, Xiao Li, Jingjing Zhou et al.

 
 

Duplications of Methyl CpG binding protein 2 (MECP2) -containing segments lead to the MECP2 duplication syndrome, in which severe autistic symptoms were identified. Whether adult …

 
 
 
 
 
 

Therapeutic properties of Scutellaria baicalensis in db/db mice evaluated using Connectivity Map and network pharmacology

 
 

Bu-Yeo Kim, Kwang Hoon Song, Chi-Yeon Lim et al.

 
 

We have reported that an extract of Scutellaria baicalensis (ESB) has effects against obesity and hypertriglyceridemia in type 2 diabetic animal model (db/db mouse). In the …

 
 
 
 
 
 

Sounds can boost the awareness of visual events through attention without cross-modal integration

 
 

Márta Szabina Pápai, Salvador Soto-Faraco

 
 

Cross-modal interactions can lead to enhancement of visual perception, even for visual events below awareness. However, the underlying mechanism is still unclear. Can purely …

 
 
 
 
 
 

Adaptor Protein 2 (AP-2) complex is essential for functional axogenesis in hippocampal neurons

 
 

Jae Won Kyung, In Ha Cho, Sukmook Lee et al.

 
 

The complexity and diversity of a neural network requires regulated elongation and branching of axons, as well as the formation of synapses between neurons. In the present study …

 
 
 
 
 
 

A sensitive single-enzyme assay system using the non-ribosomal peptide synthetase BpsA for measurement of L-glutamine in biological samples

 
 

Alistair S. Brown, Katherine J. Robins, David F. Ackerley

 
 

The ability to rapidly, economically and accurately measure L-glutamine concentrations in biological samples is important for many areas of research, medicine or industry, …

 
 
 
 
 
 

Isolation and characterization of a spotted leaf 32 mutant with early leaf senescence and enhanced defense response in rice

 
 

Liting Sun, Yihua Wang, Ling-long Liu et al.

 
 

Leaf senescence is a complex biological process and defense responses play vital role for rice development, their molecular mechanisms, however, remain elusive in rice. We herein …

 
 
 
 
 
 

Genome-wide Regulatory Roles of the C2H2-type Zinc Finger Protein ZNF764 on the Glucocorticoid Receptor

 
 

Abeer Fadda, Najeeb Syed, Rafah Mackeh et al.

 
 

The C2H2-type zinc finger protein ZNF764 acts as an enhancer for several steroid hormone receptors, and haploinsufficiency of this gene may be responsible for tissue resistance …

 
 
 
 
 
 

The crystal structure of the Sgt1-Skp1 complex: the link between Hsp90 and both SCF E3 ubiquitin ligases and kinetochores

 
 

Oliver Willhoft, Richard Kerr, Dipali Patel et al.

 
 

The essential cochaperone Sgt1 recruits Hsp90 chaperone activity to a range of cellular factors including SCF E3 ubiquitin ligases and the kinetochore in eukaryotes. In these …

 
 
 
 
 
 

BMP2-coprecipitated calcium phosphate granules enhance osteoinductivity of deproteinized bovine bone, and bone formation during critical-sized bone defect healing

 
 

Tie Liu, Yuanna Zheng, Gang Wu et al.

 
 

Most materials used clinically for filling critical-sized bone defects (CSBD), such as deproteinized bovine bone (DBB), lack osteoinductivity so that their therapeutic effects …

 
 
 
 
 
 

Long Blood Residence and Large Tumor Uptake of Ruthenium Sulfide Nanoclusters for Highly Efficient Cancer Photothermal Therapy

 
 

Zhuoxuan Lu, Feng-ying Huang, Rong Cao et al.

 
 

Transition metal sulfide (TMS) holds great potential in cancer photothermal therapy (PTT) because of the high absorbance in the near-infrared (NIR) region. The short blood …

 
 
 
 
 
 

A Novel Cardiotoxic Mechanism for a Pervasive Global Pollutant

 
 

Fabien Brette, Holly A. Shiels, Gina L. J. Galli et al.

 
 

The Deepwater Horizon disaster drew global attention to the toxicity of crude oil and the potential for adverse health effects amongst marine life and spill responders in the …

 
 
 
 
 
 

SNP variants associated with non-Hodgkin lymphoma (NHL) correlate with human leukocyte antigen (HLA) class II expression

 
 

Lik-Chin Ten, Yoon-Ming Chin, Mei-Chee Tai et al.

 
 

Large consortia efforts and genome-wide association studies (GWASs) have linked a number of genetic variants within the 6p21 chromosomal region to non-Hodgkin lymphoma (NHL). …

 
 
 
 
 
 

Attenuated contact heat-evoked potentials associated with sensory and social-emotional symptoms in individuals with autism spectrum disorder

 
 

Yi-Ling Chien, Shao-Wei Wu, Chih-Pang Chu et al.

 
 

Sensory disturbance is associated with socio-emotional problems in individuals with autism spectrum disorder (ASD). Most studies assess sensory symptoms by self-reports, which …

 
 
 
 
 
 

A Functional IL22 Polymorphism (rs2227473) Is Associated with Predisposition to Childhood Cerebral Malaria

 
 

Sandrine Marquet, Ianina Conte, Belco Poudiougou et al.

 
 

Cerebral malaria (CM) is a severe complication of Plasmodium falciparum infection. This encephalopathy is characterized by coma and is thought to result from mechanical …

 
 
 
 
 
 

The β and γ subunits play distinct functional roles in the α2βγ heterotetramer of human NAD-dependent isocitrate dehydrogenase

 
 

Tengfei Ma, Yingjie Peng, Wei Huang et al.

 
 

Human NAD-dependent isocitrate dehydrogenase existing as the α2βγ heterotetramer, catalyzes the decarboxylation of isocitrate into α-ketoglutarate in the Krebs cycle, and is …

 
 
 
 
 
 

Elevated-temperature-induced acceleration of PACT clearing process of mouse brain tissue

 
 

Tingting Yu, Yisong Qi, Jingtan Zhu et al.

 
 

Tissue optical clearing technique shows a great potential for neural imaging with high resolution, especially for connectomics in brain. The passive clarity technique (PACT) is a …

 
 
 
 
 
 

The fibrogenic actions of lung fibroblast-derived urokinase: a potential drug target in IPF

 
 

Michael Schuliga, Jade Jaffar, Trudi Harris et al.

 
 

The role of urokinase plasminogen activator (uPA) in idiopathic pulmonary fibrosis (IPF) remains unclear. uPA-generated plasmin has potent fibrogenic actions involving protease …

 
 
 
 
 
 

Inhibition of PDGFR signaling prevents muscular fatty infiltration after rotator cuff tear in mice

 
 

Hideyuki Shirasawa, Noboru Matsumura, Masayuki Shimoda et al.

 
 

Fatty infiltration in muscle is often observed in patients with sizable rotator cuff tear (RCT) and is thought to be an irreversible event that significantly compromises muscle …

 
 
 
 
 
 

Development of polymer based cryogel matrix for transportation and storage of mammalian cells

 
 

Jyoti Kumari, Ashok Kumar

 
 

We studied the potential of polymeric cryogel matrices such as 2-hydroxyethyl methacrylate (HEMA)-agarose (HA) and gelatin matrix as a transporting and storage material for …

 
 
 
 
 
 

Prognostic value of marital status on stage at diagnosis in hepatocellular carcinoma

 
 

Wenjie Zhang, Xiaochen Wang, Ruyi Huang et al.

 
 

Marital status have been found as an independent prognostic factor for survival and spousal support could provide a survival advantage in various cancer types. However, the …

 
 
 
 
 
 

Intranasal Delivery of A Novel Amnion Cell Secretome Prevents Neuronal Damage and Preserves Function In A Mouse Multiple Sclerosis Model

 
 

Reas S. Khan, Kimberly Dine, Bailey Bauman et al.

 
 

The ability of a novel intranasally delivered amnion cell derived biologic to suppress inflammation, prevent neuronal damage and preserve neurologic function in the experimental …

 
 
 
 
 
 

Synchrotron-based X-ray fluorescence microscopy enables multiscale spatial visualization of ions involved in fungal lignocellulose deconstruction

 
 

Grant Kirker, Sam Zelinka, Sophie-Charlotte Gleber et al.

 
 

The role of ions in the fungal decay process of lignocellulose biomaterials, and more broadly fungal metabolism, has implications for diverse research disciplines ranging from …

 
 
 
 
 
 

Deferasirox-induced iron depletion promotes BclxL downregulation and death of proximal tubular cells

 
 

Diego Martin-Sanchez, Angel Gallegos-Villalobos, Miguel Fontecha-Barriuso et al.

 
 

Iron deficiency has been associated with kidney injury. Deferasirox is an oral iron chelator used to treat blood transfusion-related iron overload. Nephrotoxicity is the most …

 
 
 
 
 
 

The differential ability of asparagine and glutamine in promoting the closed/active enzyme conformation rationalizes the Wolinella succinogenes L-asparaginase substrate specificity

 
 

Hien Anh Nguyen, Donald L. Durden, Arnon Lavie

 
 

Many side effects of current FDA-approved L-asparaginases have been related to their secondary L-glutaminase activity. The Wolinella succinogenes L-asparaginase (WoA) has been …

 
 
 
 
 
 
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