Molecular Systems Biology - New articles published 30 April 2013

Latest Articles 30th April 2013   Focus Series Featured Article Research Article   Web feeds About Open access   Advertisement Molecular Systems Biology has a fair and transparent editorial process to publish your best science. • Scooping protection • Pre-decision referee cross-commenting • Single round of major revision • No confidential referee comments • Published anonymous referee reports Submit your paper today!   Systems biology technologies series New technologies are pushing the limits of biological measurements in terms of scale, resolution and accuracy, which is enabling the engineering of living organisms in unprecedented ways. Increasingly sophisticated computational methods are used to analyze and integrate quantitative and large-scale biological data. This series features Reviews on the technological platforms and methodologies that are driving the fields of systems and synthetic biology forward to reach new frontiers in biology. See full series page Basic and applied uses of genome-scale metabolic network reconstructions of Escherichia coli This review summarizes the applications enabled by genome-scale models of metabolism for the bacterium E. coli. It provides an overview of the applications along with a critical assessment of their successes and limitations, and a perspective on likely future developments in the field. Douglas McCloskey, Bernhard Ø Palsson & Adam M Feist Molecular Systems Biology 9:661; doi:10.1038/msb.2013.18; published 30 April 2013 Full Text | PDF | Supp. Inf. Featured Article Systematic identification of proteins that elicit drug side effects Protein–side effects associations are identified by integrating drug–target data with side effects information from drug labels. Benchmarking against the literature and validation with an in vivo mouse model shows that these pairs correspond to causal relations. Michael Kuhn, Mumna Al Banchaabouchi, Monica Campillos, Lars Juhl Jensen, Cornelius Gross, Anne-Claude Gavin & Peer Bork Molecular Systems Biology 9:663; doi:10.1038/msb.2013.10; published 30 April 2013 Full Text | PDF | Supp. Inf. | Review Process Research Article Characterization of drug-induced transcriptional modules: towards drug repositioning and functional understanding Drug-induced transcriptional modules (biclusters) were identified and annotated in three human cell lines and rat liver. These were used to assess conservation across systems and to infer and experimentally validate novel drug effects and gene functions. Murat Iskar, Georg Zeller, Peter Blattmann, Monica Campillos, Michael Kuhn, Katarzyna H Kaminska, Heiko Runz, Anne-Claude Gavin, Rainer Pepperkok, Vera van Noort & Peer Bork Molecular Systems Biology 9:662; doi:10.1038/msb.2013.20; published 30 April 2013 Full Text | PDF | Supp. Inf. | Review Process

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