Nature Reviews Neurology - Table of Contents alert Volume 9 Issue 6

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TABLE OF CONTENTS
June 2013 Volume 9 Number 6
Impact Factor 12.461 *	In this issue Research Highlights News and Views Correction Reviews Perspectives Correspondence Also this month  Featured article: The emerging roles of microRNAs in CNS injuries Oneil G. Bhalala, Maya Srikanth & John A. Kessler
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RESEARCH HIGHLIGHTS Top Epilepsy: Implantable device advises patients with epilepsy of seizure likelihood Published online: 21 May 2013 p297 | doi:10.1038/nrneurol.2013.94 PDF Motor neuron disease: Two new ALS susceptibility loci identified in Han Chinese Published online: 21 May 2013 p298 | doi:10.1038/nrneurol.2013.96 PDF Neural repair and rehabilitation: Fibroblast-derived OPCs—hope for remyelination therapy? Published online: 07 May 2013 p299 | doi:10.1038/nrneurol.2013.85 PDF Alzheimer disease: Alzheimer disease biomarkers in healthy individuals can predict cognitive decline several years later Published online: 30 April 2013 p300 | doi:10.1038/nrneurol.2013.81 PDF Neurodegenerative disease: Oxidative stress in cells near amyloid plaques linked to neuronal death Published online: 21 May 2013 p300 | doi:10.1038/nrneurol.2013.87 PDF IN BRIEF Parkinson disease: History of concussion associated with high risk of PD | Neurodegenerative disease: The influence of Apo-E on soluble amyloid-β metabolism—study suggests novel mechanism of action | Migraine: Migraine phases linked to plasma levels of PACAP-38 | Movement disorders: Novel MRI measure for diagnosis of progressive supranuclear palsy | Sleep: Obstructive sleep apnoea raises the risk of cerebral white matter change | Movement disorders: SCA37—a new subtype of spinocerebellar ataxia | Stroke: Could PTEN nuclear translocation be a target for therapy after stroke? | Multiple sclerosis: On the TRAIL of IFN-β response PDF Neurology JOBS of the week Postdoctoral Fellow / Research Associate University of Wisconsin - Madison School of Medicine and Public Health Assistant Professor Positions - Brain Image Sciences The University of Calgary Director, Alzheimer’s Disease and Dementia Initiative The New York Academy of Sciences (NYAS) Postdoctoral Research Associate University of Texas at Dallas More Science jobs from Neurology EVENT Imaging Structure & Function in the Nervous System 24.07.13 Cold Spring, US More science events from
NEWS AND VIEWS		Top
Dementia: A link between microbial infection and cognition? Walter Swardfager & Sandra E. Black Published online: 28 May 2013 p301 | doi:10.1038/nrneurol.2013.93 A recent study of a large multi-ethnic cohort has shown that cumulative serum titres of antibodies against five common microbial pathogens are associated with an increased risk of cognitive impairment. Further studies are needed to better understand this risk and enable translation of the findings into effective preventative strategies. Full Text | PDF
Multiple sclerosis: Oligoclonal bands—a useful tool to avoid MS misdiagnosis Jose C. Álvarez-Cermeñoo & Luisa M. Villar Published online: 16 April 2013 p303 | doi:10.1038/nrneurol.2013.74 Oligoclonal IgG bands are present in the cerebrospinal fluid of most patients with multiple sclerosis (MS) and constitute a useful tool to enable accurate diagnosis. A recent meta-analysis has explored the precise prevalence of these antibodies in MS and their possible relationship with geographical location and patient outcome. Full Text | PDF
Neurodegenerative disease: Frontotemporal dementia—time to target inflammation? Olivier Piguet Published online: 30 April 2013 p304 | doi:10.1038/nrneurol.2013.84 Systemic inflammation has been associated with dementia. A new study has found an increased rate of autoimmune disorders and elevated serum levels of tumour necrosis factor in patients with frontotemporal dementia associated with TDP-43 pathology. These findings help in understanding disease mechanisms and in identification of biomarkers of this heterogeneous disease. Full Text | PDF
Epilepsy: Poststroke epilepsy—old definitions fit best W. Allen Hauser Published online: 23 April 2013 p305 | doi:10.1038/nrneurol.2013.80 Cerebrovascular disease is the most frequently identified antecedent of new-onset seizures or epilepsy in industrialized countries. Three recent publications have evaluated the risk of epilepsy following a first cerebrovascular insult. Each report provides evidence for a substantial risk in some patient subgroups, although the study methodologies and definitions of epilepsy vary. Full Text | PDF
CORRECTION		Top
Progress in gene therapy for neurological disorders Michele Simonato, Jean Bennett, Nicholas M. Boulis, Maria G. Castro, David J. Fink, William F. Goins, Steven J. Gray, Pedro R. Lowenstein, Luk H. Vandenberghe, Thomas J. Wilson, John H. Wolfe & Joseph C. Glorioso Published online: 14 May 2013 p298 | doi:10.1038/nrneurol.2013.103 Full Text | PDF
REVIEWS		Top
Characteristics of Susac syndrome: a review of all reported cases Jan Dörr, Sarah Krautwald, Brigitte Wildemann, Sven Jarius, Marius Ringelstein, Thomas Duning, Orhan Aktas, Erich Bernd Ringelstein, Friedemann Paul & Ilka Kleffner Published online: 30 April 2013 p307 | doi:10.1038/nrneurol.2013.82 Susac syndrome is an important differential diagnosis in many neurological disorders, but our understanding of this rare disease has largely been limited to reports of single cases and small case series. In this article, Dorr and colleagues review all reported cases of Susac syndrome to provide a comprehensive overview of demographic, clinical and diagnostic data on this disorder. On the basis of their findings, Dorr et al. make recommendations for diagnosis and management of individuals with suspected Susac syndrome. Abstract | Full Text | PDF | Supplementary information
Diagnosis and treatment of primary CNS lymphoma Agnieszka Korfel & Uwe Schlegel Published online: 14 May 2013 p317 | doi:10.1038/nrneurol.2013.83 Primary CNS lymphoma (PCNSL) is a rare malignancy with an aggressive course, for which treatment has yet to be optimized. Here, Korfel and Schlegel discuss diagnostic approaches in patients with suspected PCNSL, and review the latest studies on new and more established therapeutic interventions. Ongoing issues—including the utility of whole-brain radiotherapy, and treatment of young, elderly and immunocompromised patients—are also considered. Abstract | Full Text | PDF
The emerging roles of microRNAs in CNS injuries Oneil G. Bhalala, Maya Srikanth & John A. Kessler Published online: 16 April 2013 p328 | doi:10.1038/nrneurol.2013.67 MicroRNAs (miRNAs) are short, single-stranded RNA molecules that inhibit translation of target mRNAs, and are key regulators of molecular and cellular responses in development, health and disease. A role for miRNAs in the regulation of pathology of CNS injuries has recently emerged, and in this Review, Bhalala et al. discuss findings from miRNA microarray studies in stroke, traumatic brain injury and spinal cord injury. They highlight how improved understanding of miRNA changes following CNS injuries can inform novel treatment strategies for these pathologies. Abstract | Full Text | PDF
The history and future of telestroke David C. Hess & Heinrich J. Audebert Published online: 07 May 2013 p340 | doi:10.1038/nrneurol.2013.86 This Review focuses on the growing area of telemedicine in the diagnosis and treatment of patients with acute stroke who are geographically remote from primary care centres. Hess and Audebert discuss telemedicine as a means to improve the availability of care for stroke patients, and the financial implications of this approach. Furthermore they highlight technological advances that might help to overcome barriers to the wider application of telemedicine in acute stroke care. Abstract | Full Text | PDF
PERSPECTIVES		Top
Opinion: A role for placebo therapy in psychogenic movement disorders Karen S. Rommelfanger Published online: 30 April 2013 p351 | doi:10.1038/nrneurol.2013.65 Psychogenic movement disorders (PMDs) manifest with physical symptoms but currently lack a clear pathology and standard of care. However, some physicians support the use of placebo therapy for patients with PMDs. In this Perspectives article, Karen Rommelfanger outlines the need for further research and international dialog regarding the treatment of patients with PMDs, and the use of placebo therapy in these patients. Abstract | Full Text | PDF
CORRESPONDENCE		Top
Can tauopathy shake the amyloid cascade hypothesis? Venugopalan Y. Vishnu Published online: 14 May 2013 p356 | doi:10.1038/nrneurol.2013.21-c1 Full Text | PDF
Reply: The amyloid cascade is not the only pathway to AD Gaël Chételat Published online: 14 May 2013 p356 | doi:10.1038/nrneurol.2013.21-c2 Full Text | PDF
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