Scientific Reports Biology Table of Contents e-alert: July 2013

01 July 2013      • Visit Scientific Reports • Submit your manuscript to Scientific Reports     Welcome to your Table of Contents e-alert for Scientific Reports           Frontiers Research Topics   RTs enable you and your colleagues to drive your field where you want to take it, by encouraging dialogue and collaboration between researchers.   A collection of papers in an evolving field around a topic that you choose. Papers submitted are rigorously peer-reviewed and freely available under a CC-BY license.   Your Topic - Your Way - Your Frontiers            Biological Sciences               p38γ overexpression in gliomas and its role in proliferation and apoptosis ▶     Kui Yang, Yunsheng Liu, Zhixiong Liu et al.     The objective of this study was to confirm the biological role of p38γ in human gliomas. The expression profiles of p38γ and hTERT in human glioma samples were detected by Western …             Diacylglycerol lipase α manipulation reveals developmental roles for intercellular endocannabinoid signaling ▶     Erik Keimpema, Alán Alpár, Fiona Howell et al.     Endocannabinoids are small signaling lipids, with 2-arachidonoylglycerol (2-AG) implicated in modulating axonal growth and synaptic plasticity. The concept of short-range …             CORRIGENDUM: A novel human endogenous retroviral protein inhibits cell-cell fusion ▶     Jun Sugimoto, Makiko Sugimoto, Helene Bernstein et al.                 Concentration polarization of ox-LDL activates autophagy and apoptosis via regulating LOX-1expression ▶     Zufeng Ding, Shijie Liu, Changqing Sun et al.     Here we demonstrate that “concentration polarization” of ox-LDL enhances LOX-1 expression and ox-LDL uptake. It damages cell surface heparan sulfate proteoglycans (HSPG) and …             Impaired automatic and unconscious motor processes in Parkinson's disease ▶     Kevin D'Ostilio, Julien Cremers, Valérie Delvaux et al.     While it is increasingly recognized that voluntary movements are produced by an interaction between conscious and unconscious processes, the role of the latter in Parkinson's …             Sustained production of ROS triggers compensatory proliferation and is required for regeneration to proceed ▶     Carole Gauron, Christine Rampon, Mohamed Bouzaffour et al.     A major issue in regenerative medicine is the role of injury in promoting cell plasticity. Here we explore the function of reactive oxygen species (ROS) induced through lesions in …             A right antenna for social behaviour in honeybees ▶     Lesley J. Rogers, Elisa Rigosi, Elisa Frasnelli et al.     Sophisticated cognitive abilities have been documented in honeybees, possibly an aspect of their complex sociality. In vertebrates brain asymmetry enhances cognition and …             ERRATUM: Three-Dimensional Volume Containing Multiple Two-Dimensional Information Patterns ▶     Hirotaka Nakayama, Atsushi Shiraki, Ryuji Hirayama et al.                 On the near-wall accumulation of injectable particles in the microcirculation: smaller is not better ▶     Tae-Rin Lee, Myunghwan Choi, Adrian M. Kopacz et al.     Although most nanofabrication techniques can control nano/micro particle (NMP) size over a wide range, the majority of NMPs for biomedical applications exhibits a diameter of …             Computational microscopy of cyclodextrin mediated cholesterol extraction from lipid model membranes ▶     Cesar A. López, Alex H. de Vries, Siewert J. Marrink     Beta-cyclodextrins (β-CDs) can form inclusion complexes with cholesterol, and are commonly used to manipulate cholesterol levels of biomembranes. In this work, we have used …             The transition state structure for coupled binding and folding of disordered protein domains ▶     Jakob Dogan, Xin Mu, Åke Engström et al.     Intrinsically disordered proteins are abundant in the eukaryotic proteome, and they are implicated in a range of different diseases. However, there is a paucity of experimental …             The Wnt signaling pathway is involved in the regulation of phagocytosis of virus in Drosophila ▶     Fei Zhu, Xiaobo Zhang     Phagocytosis is crucial for triggering host defenses against invading pathogens in animals. However, the receptors on phagocyte surface required for phagocytosis of virus have not …             In vitro circadian period is associated with circadian/sleep preference ▶     Akiko Hida, Shingo Kitamura, Yosuke Ohsawa et al.     Evaluation of circadian phenotypes is crucial for understanding the pathophysiology of diseases associated with disturbed biological rhythms such as circadian rhythm sleep …             Metformin Impairs Glucose Consumption and Survival in Calu-1 Cells by Direct Inhibition of Hexokinase-II ▶     Barbara Salani, Cecilia Marini, Alberto Del Rio et al.     The anti-hyperglycaemic drug metformin has important anticancer properties as shown by the direct inhibition of cancer cells proliferation. Tumor cells avidly use glucose as a …             A novel method for semen collection and artificial insemination in large parrots (Psittaciformes) ▶     Michael Lierz, Matthias Reinschmidt, Heiner Müller et al.     The paper described a novel technique for semen collection in large psittacines (patent pending), a procedure which was not routinely possible before. For the first time, a large …             Cold-induced RNA-binding proteins regulate circadian gene expression by controlling alternative polyadenylation ▶     Yuting Liu, Wenchao Hu, Yasuhiro Murakawa et al.     The body temperature is considered a universal cue by which the master clock synchronizes the peripheral clocks in mammals, but the mechanism is not fully understood. Here we …             Zebrafish crypt neurons project to a single, identified mediodorsal glomerulus ▶     Gaurav Ahuja, Ivan Ivandić, Mehmet Saltürk et al.     Crypt neurons are a third type of olfactory receptor neurons with a highly unusual “one cell type - one receptor” mode of expression, the same receptor being expressed by the …             V-Shaped Dinuclear Pt(II) Complexes: Selective Interaction with Human Telomeric G-quadruplex and Significant Inhibition towards Telomerase ▶     Cui-Xia Xu, Yu-Xuan Zheng, Xiao-Hui Zheng et al.     A quaternized trigeminal ligand, 4-[4,6-di(4-pyridyl)-1,3,5-(2-triazinyl)]-1-methylpyridine-1-ium hexafluorophosphate (dptmp·PF6), and two derivative V-shaped dinuclear Pt(II) …             VEGF significantly restores impaired memory behavior in Alzheimer's mice by improvement of vascular survival ▶     Piotr Religa, Renhai Cao, Dorota Religa et al.     The functional impact of amyloid peptides (Aβs) on the vascular system is less understood despite these pathologic peptides are substantially deposited in the brain vasculature of …             Role of Engrailed-2 (EN2) as a prostate cancer detection biomarker in genetically high risk men ▶     Emma Killick, Richard Morgan, Francesca Launchbury et al.     Controversy surrounds the use of PSA as a biomarker for prostate cancer detection, leaving an unmet need for a novel biomarker in this setting; urinary EN2 may identify …             Dissociable Somatotopic Representations of Chinese Action Verbs in the Motor and Premotor Cortex ▶     Haiyan Wu, Xiaoqin Mai, Honghong Tang et al.     The embodied view of language processing holds that language comprehension involves the recruitment of sensorimotor information, as evidenced by the somatotopic representation of …             A quantitative ratiometric sensor for time-resolved analysis of auxin dynamics ▶     Sabrina Wend, Cristina Dal Bosco, Michael M. Kämpf et al.     Time-resolved quantitative analysis of auxin-mediated processes in plant cells is as of yet limited. By applying a synergistic mammalian and plant synthetic biology approach, we …             STED microscope with Spiral Phase Contrast ▶     Marcel A. Lauterbach, Marc Guillon, Asma Soltani et al.     Stimulated Emission Depletion (STED) microscopy enables superresolution imaging of fluorescently marked nano-structures in vivo. Biological investigations are often hindered by …             Evolution of deceptive and true courtship songs in moths ▶     Ryo Nakano, Takuma Takanashi, Annemarie Surlykke et al.     Ultrasonic mating signals in moths are argued to have evolved via exploitation of the receivers' sensory bias towards bat echolocation calls. We have demonstrated that female …             Generating functionals for autonomous latching dynamics in attractor relict networks ▶     Mathias Linkerhand, Claudius Gros     Coupling local, slowly adapting variables to an attractor network allows to destabilize all attractors, turning them into attractor ruins. The resulting attractor relict network …             Winter food provisioning reduces future breeding performance in a wild bird ▶     K. E. Plummer, S. Bearhop, D. I. Leech et al.     Supplementation of food to wild birds occurs on an enormous scale worldwide, and is often cited as an exemplar of beneficial human-wildlife interaction. Recently it has been …             Intrinsic Disorder in PTEN and its Interactome Confers Structural Plasticity and Functional Versatility ▶     Prerna Malaney, Ravi Ramesh Pathak, Bin Xue et al.     IDPs, while structurally poor, are functionally rich by virtue of their flexibility and modularity. However, how mutations in IDPs elicit diseases, remain elusive. Herein, we have …             MiR-21/Smad 7 signaling determines TGF-β1-induced CAF formation ▶     Qiong Li, Daoxiang Zhang, Yongbin Wang et al.     How TGF-β1-mediated signaling pathways are finely tuned to orchestrate the generation of carcinoma-associated fibroblasts (CAFs) is poorly understood. Here, we demonstrate that …             Expression of the Streptococcus pneumoniae pilus-1 undergoes on and off switching during colonization in mice ▶     Laura Pancotto, Gabriella De Angelis, Esmeralda Bizzarri et al.     Streptococcus pneumoniae pili contribute to adherence and virulence. The regulation of pilus-1 expression is bistable, thus piliated strains contain a variable proportion of …             Chemical and natural stressors combined: from cryptic effects to population extinction ▶     André Gergs, Armin Zenker, Volker Grimm et al.     In addition to natural stressors, populations are increasingly exposed to chemical pollutants released into the environment. We experimentally demonstrate the loss of resilience …             Desmosine-Inspired Cross-Linkers for Hyaluronan Hydrogels ▶     Valentin Hagel, Markus Mateescu, Alexander Southan et al.     We designed bioinspired cross-linkers based on desmosine, the cross-linker in natural elastin, to prepare hydrogels with thiolated hyaluronic acid. These short, rigid …             A tale of two contribution mechanisms for nonlinear public goods ▶     Yanling Zhang, Feng Fu, Te Wu et al.     Amounts of empirical evidence, ranging from microbial cooperation to collective hunting, suggests public goods produced often nonlinearly depend on the total amount of …             Cognitive interference can be mitigated by consonant music and facilitated by dissonant music ▶     Nobuo Masataka, Leonid Perlovsky     Debates on the origins of consonance and dissonance in music have a long history. While some scientists argue that consonance judgments are an acquired competence based on …             The proteasome factor Bag101 binds to Rad22 and suppresses homologous recombination ▶     Yuichiro Saito, Jun Takeda, Masahiro Okada et al.     Although RAD52 plays a critical role in the initiation of homologous recombination (HR) by facilitating the replacement of RPA with RAD51, the mechanism controlling RAD52 remains …             Acoustic detection of DNA conformation in genetic assays combined with PCR ▶     G. Papadakis, A. Tsortos, A. Kordas et al.     Application of PCR to multiplexing assays is not trivial; it requires multiple fluorescent labels for amplicon detection and sophisticated software for data interpretation. …             Anatomical regulation of ice nucleation and cavitation helps trees to survive freezing and drought stress ▶     A. Lintunen, T. Hölttä, M. Kulmala     Water in the xylem, the water transport system of plants, is vulnerable to freezing and cavitation, i.e. to phase change from liquid to ice or gaseous phase. The former is a …             A Quantitative Meta-Analysis of Functional Imaging Studies of Social Rejection ▶     Stephanie Cacioppo, Chris Frum, Erik Asp et al.     Early neuroimaging studies using Cyberball suggested that social rejection activated the pain matrix, as identified in studies of physical pain. However, these early studies were …             An inorganic CO2 diffusion and dissolution process explains negative CO2 fluxes in saline/alkaline soils ▶     Jie Ma, Zhong-Yuan Wang, Bryan A. Stevenson et al.     An ‘anomalous’ negative flux, in which carbon dioxide (CO2) enters rather than is released from the ground, was studied in a saline/alkaline soil. Soil sterilization disclosed an …             Enhancement of Vibronic and Ground-State Vibrational Coherences in 2D Spectra of Photosynthetic Complexes ▶     Aurélia Chenu, Niklas Christensson, Harald F. Kauffmann et al.     A vibronic-exciton model is applied to investigate the recently proposed mechanism of enhancement of coherent oscillations due to mixing of electronic and nuclear degrees of …             A daily-updated tree of (sequenced) life as a reference for genome research ▶     Hai Fang, Matt E. Oates, Ralph B. Pethica et al.     We report a daily-updated sequenced/species Tree Of Life (sTOL) as a reference for the increasing number of cellular organisms with their genomes sequenced. The sTOL builds on a …             The membrane-topogenic vectorial behaviour of Nrf1 controls its post-translational modification and transactivation activity ▶     Yiguo Zhang, John D. Hayes     The integral membrane-bound Nrf1 transcription factor fulfils important functions in maintaining cellular homeostasis and organ integrity, but how it is controlled vectorially is …             The Effect of Unilateral Mean Luminance on Binocular Combination in normal and amblyopic vision ▶     Jiawei Zhou, Wuli Jia, Chang-Bing Huang et al.     Luminance plays a modulating role in the processes of several visual tasks, which in turn provides significant information for the understanding of visual processing. Here, using …             A TRPA1 antagonist reverts oxaliplatin-induced neuropathic pain ▶     Cristina Nativi, Roberta Gualdani, Elisa Dragoni et al.     Neuropathic pain (NeP) is generally considered an intractable problem, which becomes compelling in clinical practice when caused by highly effective chemotherapeutics, such as in …             The fatigue-motor performance paradox in multiple sclerosis ▶     Matteo Pardini, Laura Bonzano, Luca Roccatagliata et al.     Subjective fatigue is a typical symptom in Multiple Sclerosis (MS) even in the earliest stages of the disease. The relationship between persistent fatigue and motor task …             Common dysfunctional variants in ABCG2 are a major cause of early-onset gout ▶     Hirotaka Matsuo, Kimiyoshi Ichida, Tappei Takada et al.     Gout is a common disease which mostly occurs after middle age, but more people nowadays develop it before the age of thirty. We investigated whether common dysfunction of ABCG2, a …             Automated Parallel Recordings of Topologically Identified Single Ion Channels ▶     Ryuji Kawano, Yutaro Tsuji, Koji Sato et al.     Although ion channels are attractive targets for drug discovery, the systematic screening of ion channel-targeted drugs remains challenging. To facilitate automated single …             Modulating lipid dynamics and membrane fluidity to drive rapid folding of a transmembrane barrel ▶     Svetlana Rajkumar Maurya, Deepti Chaturvedi, Radhakrishnan Mahalakshmi     Lipid-protein interactions, critical for the folding, stability and function of membrane proteins, can be both of mechanical and chemical nature. Mechanical properties of lipid …             A splice variant in KRT71 is associated with curly coat phenotype of Selkirk Rex cats ▶     Barbara Gandolfi, Hasan Alhaddad, Shannon E. K. Joslin et al.     One of the salient features of the domestic cat is the aesthetics of its fur. The Selkirk Rex breed is defined by an autosomal dominant woolly rexoid hair (ADWH) abnormality that …             Controlled cellular uptake and drug efficacy of nanotherapeutics ▶     Sungsook Ahn, Eunseok Seo, Kihean Kim et al.     Cellular uptake pathway of nanoparticle (NP) is different from that of free drugs. Therefore, NP-mediated nanotherapeutics can be designed to overcome the adverse effects of free …             Topological insulator bismuth selenide as a theranostic platform for simultaneous cancer imaging and therapy ▶     Juan Li, Fei Jiang, Bo Yang et al.     Employing theranostic nanoparticles, which combine both therapeutic and diagnostic capabilities in one dose, has promise to propel the biomedical field toward personalized …             Comparative population structure of Plasmodium falciparum circumsporozoite protein NANP repeat lengths in Lilongwe, Malawi ▶     Natalie M. Bowman, Seth Congdon, Tisungane Mvalo et al.     Humoral immunity to Plasmodium falciparum circumsporozoite protein is partly mediated by a polymorphic NANP tetra-amino acid repeat. Antibody response to these repeats is the best …             Optofluidic realization and retaining of cell–cell contact using an abrupt tapered optical fibre ▶     Hongbao Xin, Yao Zhang, Hongxiang Lei et al.     Studies reveal that there exists much interaction and communication between bacterial cells, with parts of these social behaviors depending on cell–cell contacts. The cell–cell …             Production of biallelic CMP-Neu5Ac hydroxylase knock-out pigs ▶     Deug-Nam Kwon, Kiho Lee, Man-Jong Kang et al.     After the knock-out (KO) of α1,3 galactosyltransfease (Gal-T), the Hanganutziu-Deicher antigen became a major antigen of the "non-Gal antigen" that is implicated in subsequent …             Cartilage tissue engineering identifies abnormal human induced pluripotent stem cells ▶     Akihiro Yamashita, Shiying Liu, Knut Woltjen et al.     Safety is the foremost issue in all human cell therapies, but human induced pluripotent stem cells (iPSCs) currently lack a useful safety indicator. Studies in chimeric mice have …             Antioxidant enzyme, 3-mercaptopyruvate sulfurtransferase-knockout mice exhibit increased anxiety-like behaviors: a model for human mercaptolactate-cysteine disulfiduria ▶     Noriyuki Nagahara, Masatoshi Nagano, Takaaki Ito et al.     Human mercaptolactate-cysteine disulfiduria (MCDU) was first recognized and reported in 1968. Most cases of MCD are associated with mental retardation, while the pathogenesis …             Microbial Oxidation of Fe2+ and Pyrite Exposed to Flux of Micromolar H2O2 in Acidic Media ▶     Yingqun Ma, Chuxia Lin     At an initial pH of 2, while abiotic oxidation of aqueous Fe2 was enhanced by a flux of H2O2 at micromolar concentrations, bio-oxidation of aqueous Fe2 could be impeded due to …             Genetic engineering of yellow betalain pigments beyond the species barrier ▶     Takashi Nakatsuka, Eri Yamada, Hideyuki Takahashi et al.     Betalains are one of the major plant pigment groups found in some higher plants and higher fungi. They are not produced naturally in any plant species outside of the order …             Agonist Activated PKCβII Translocation and Modulation of Cardiac Myocyte Contractile Function ▶     Hyosook Hwang, Dustin Robinson, Julie B. Rogers et al.     Elevated protein kinase C βII (PKCβII) expression develops during heart failure and yet the role of this isoform in modulating contractile function remains controversial. The …             Mahogunin ring finger-1 (MGRN1) Suppresses Chaperone-Associated Misfolded Protein Aggregation and Toxicity ▶     Deepak Chhangani, Amit Mishra     Impairment in the elimination of misfolded proteins generates cellular toxicity and leads to various late-onset neurodegenerative diseases. However, the mechanisms by which cells …             Morphine induced exacerbation of sepsis is mediated by tempering endotoxin tolerance through modulation of miR-146a ▶     Santanu Banerjee, Jingjing Meng, Subhas Das et al.     Development of tolerance to endotoxin prevents sustained hyper inflammation during systemic infections. Here we report for the first time that chronic morphine treatment tempers …             How much metagenomic sequencing is enough to achieve a given goal? ▶     Jiajia Ni, Qingyun Yan, Yuhe Yu     Metagenomic studies have dramatically expanded our knowledge of the microbial world. Furthermore, the amount of sample for sequencing has significantly increased with the …             Effects of genetically modified T2A-1 rice on the GI health of rats after 90-day supplement ▶     Yanfang Yuan, Wentao Xu, Xiaoyun He et al.     Bacillus thuringiensis insecticidal toxin (Bt) rice will be commercialized as a main food source. Traditional safety assessments on genetically modified products pay little …             Hydrodynamic instabilities provide a generic route to spontaneous biomimetic oscillations in chemomechanically active filaments ▶     Abhrajit Laskar, Rajeev Singh, Somdeb Ghose et al.     Non-equilibrium processes which convert chemical energy into mechanical motion enable the motility of organisms. Bundles of inextensible filaments driven by energy transduction of …             Chiral plasmonics of self-assembled nanorod dimers ▶     Wei Ma, Hua Kuang, Libing Wang et al.     Chiral nanoscale photonic systems typically follow either tetrahedral or helical geometries that require four or more different constituent nanoparticles. Smaller number of …             How Many Orai's Does It Take to Make a CRAC Channel? ▶     Jill L. Thompson, Trevor J. Shuttleworth     CRAC (Calcium Release-Activated Calcium) channels represent the primary pathway for so-called “store-operated calcium entry” – the cellular entry of calcium induced by depletion …             Defined lipid analogues induce transient channels to facilitate drug-membrane traversal and circumvent cancer therapy resistance ▶     Albert J. van Hell, Manuel N. Melo, Wim J. van Blitterswijk et al.     Design and efficacy of bioactive drugs is restricted by their (in)ability to traverse cellular membranes. Therapy resistance, a major cause of ineffective cancer treatment, is …             Dendritic spine dynamics in synaptogenesis after repeated LTP inductions: Dependence on pre-existing spine density ▶     Yuki Oe, Keiko Tominaga-Yoshino, Sho Hasegawa et al.     Not only from our daily experience but from learning experiments in animals, we know that the establishment of long-lasting memory requires repeated practice. However, cellular …             Insights into functional bacterial diversity and its effects on Alpine bog ecosystem functioning ▶     Anastasia Bragina, Christian Berg, Henry Müller et al.     Plant-associated bacteria are important for the growth and health of their host, but little is known about its functional diversity and impact on ecosystem functioning. We studied …             Partition of Myc into Immobile vs. Mobile Complexes within Nuclei ▶     Tilman Rosales, Zuqin Nie, Varun Kapoor et al.     Myc levels are highly regulated and usually low in vivo. Dimerized with Max, it regulates most expressed genes and so directly and indirectly controls most cellular processes. …             Placenta-derived gp96 as a multivalent prophylactic cancer vaccine ▶     Bao Zhao, Yanzhong Wang, Bo Wu et al.     A major challenge for designing prophylactic cancer vaccines is to define immunogenic and safe cancer antigens. Given the striking similarity of antigen expression patterns …             Breakup and then makeup: a predictive model of how cilia self-regulate hardness for posture control ▶     Promode R. Bandyopadhyay, Joshua C. Hansen     Functioning as sensors and propulsors, cilia are evolutionarily conserved organelles having a highly organized internal structure. How a paramecium's cilium produces …             Simple and effective graphene laser processing for neuron patterning application ▶     Matteo Lorenzoni, Fernando Brandi, Silvia Dante et al.     A straightforward fabrication technique to obtain patterned substrates promoting ordered neuron growth is presented. Chemical vapor deposition (CVD) single layer graphene (SLG) …             Oxygen promotes biofilm formation of Shewanellaputrefaciens CN32 through a diguanylate cyclase and an adhesin ▶     Chao Wu, Yuan-Yuan Cheng, Hao Yin et al.     Although oxygen has been reported to regulate biofilm formation by several Shewanella species, the exact regulatory mechanism mostly remains unclear. Here, we identify a direct …             c-Myc modulates microRNA processing via the transcriptional regulation of Drosha ▶     Xingwu Wang, Xiaocheng Zhao, Ping Gao et al.     The c-Myc oncogenic transcription factor is known to regulate microRNA (miRNA) expression at the transcriptional level. However, little is known about the function of c-Myc in …             Generation of Human Epidermis-Derived Mesenchymal Stem Cell-like Pluripotent Cells (hEMSCPCs) ▶     Bing Huang, Kaijing Li, Jie Yu et al.     We isolated human epidermis-derived mesenchymal stem cell-like pluripotent cells (hEMSCPCs) and demonstrate efficient harvesting, maintenance in vitro for at least 30 passages, …             Intravital analysis of vascular permeability in mice using two-photon microscopy ▶     Gyohei Egawa, Satoshi Nakamizo, Yohei Natsuaki et al.     Blood vessel endothelium forms a semi-permeable barrier and its permeability controls the traffics of plasma contents. Here we report an intravital evaluation system for vascular …             Sensorimotor semantics on the spot: brain activity dissociates between conceptual categories within 150 ms ▶     Rachel L. Moseley, Friedemann Pulvermüller, Yury Shtyrov     Although semantic processing has traditionally been associated with brain responses maximal at 350–400 ms, recent studies reported that words of different semantic types elicit …             Three-dimensional volume containing multiple two-dimensional information patterns ▶     Hirotaka Nakayama, Atsushi Shiraki, Ryuji Hirayama et al.     We have developed an algorithm for recording multiple gradated two-dimensional projection patterns in a single three-dimensional object. When a single pattern is observed, …             Metabolic scaling in solid tumours ▶     E. Milotti, V. Vyshemirsky, M. Sega et al.     Tumour metabolism is an outstanding topic of cancer research, as it determines the growth rate and the global activity of tumours. 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