| Advertisement | | Enable Your Omics Research Find the critical information in your sample through proteomics, metabolomics or systems biology with Agilent LC/MS and GC/MS systems. Together with powerful statistical analysis and pathway visualization software, Agilent provides one single, consistent user interface that transforms data into deeper biological understanding. Learn more about the Agilent Integrated Biology solutions. | |
|
| | | Systems biology technologies series | | New technologies are pushing the limits of biological measurements in terms of scale, resolution and accuracy, which is enabling the engineering of living organisms in unprecedented ways. Increasingly sophisticated computational methods are used to analyze and integrate quantitative and large-scale biological data. This series features Reviews on the technological platforms and methodologies that are driving the fields of systems and synthetic biology forward to reach new frontiers in biology. See full series page |
| | | Biomedically relevant circuit-design strategies in mammalian synthetic biology |
| This review covers the burgeoning field of mammalian synthetic biology. New designs for potential clinical applications are discussed with examples of circuits that directly interface with endogenous cellular activities, enable intercellular communication or function as prothetic networks. William Bacchus, Dominique Aubel & Martin Fussenegger Molecular Systems Biology 9:691; doi:10.1038/msb.2013.48; published 24 September 2013 Full Text | PDF | | Featured Article | | | Dissection of a Krox20 positive feedback loop driving cell fate choices in hindbrain patterning |
| A positive autoregulatory loop required for the expression of the transcription factor Krox20 was dissected using in vivo quantitative data and biophysical modelling to demonstrate how Krox20 controls cell fate decision and rhombomere size in the hindbrain. Yassine X Bouchoucha, Jürgen Reingruber, Charlotte Labalette, Michel A Wassef, Elodie Thierion, Carole Desmarquet-Trin Dinh, David Holcman, Pascale Gilardi-Hebenstreit & Patrick Charnay Molecular Systems Biology 9:690; doi:10.1038/msb.2013.46; published 24 September 2013 Full Text | PDF | Supp. Inf. | Review Process | | Research Articles | | | Human disease locus discovery and mapping to molecular pathways through phylogenetic profiling |
| By analyzing the conservation of human proteins across 87 species, we sorted proteins into clusters of coevolution. Some clusters are enriched for genes assigned to particular human diseases or molecular pathways; the other genes in the same cluster may function in related pathways and diseases. Yuval Tabach, Tamar Golan, Abrahan Hernández-Hernández, Arielle R Messer, Tomoyuki Fukuda, Anna Kouznetsova, Jian-Guo Liu, Ingrid Lilienthal, Carmit Levy & Gary Ruvkun Molecular Systems Biology 9:692; doi:10.1038/msb.2013.50; published 1 October 2013 Full Text | PDF | Supp. Inf. | Review Process | | | | Genome-scale models of metabolism and gene expression extend and refine growth phenotype prediction |
| A constraint-based approach for integrative modeling of metabolism and gene expression is developed. New constraints on molecular catalysis increase both the accuracy and scope of computable phenotypes corresponding to optimal microbial growth. Edward J O’Brien, Joshua A Lerman, Roger L Chang, Daniel R Hyduke & Bernhard Ø Palsson Molecular Systems Biology 9:693; doi:10.1038/msb.2013.52; published 1 October 2013 Full Text | PDF | Supp. Inf. | Review Process | |
|
| |
| | You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/nams/svc/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department. For print subscription enquiries, please contact our subscription department. For other enquiries, please contact our customer feedback department. Nature Publishing Group | 75 Varick Street, 9th Floor | New York | NY 10013-1917 | USA Nature Publishing Group's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS. © 2013 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. | | |
|
|
|
No comments:
Post a Comment
Keep a civil tongue.