The EMBO Journal Table of Contents for 2 May 2014; Vol. 33, No. 9

2 May 2014 | Volume 33, Number 9 Submit Table of Contents Have you seen? Reviews Articles Volume 33, Number 9 Have you seen? Everything old is new again: (linc)RNAs make proteins! Recent advances in ribosome profiling, combined with computational tools and initial functional validations reveal the existence of numerous small peptides that await future functional characterization. Stephen M Cohen Published online 09.04.2014 Miro1: New wheels for transferring mitochondria The mitochondrial Rho‐GTPase Miro1 regulates intercellular mitochondrial transfer between mesenchymal stem cells and epithelial cells in different models of epithelial lung injury. Guy Las and Orian S Shirihai Published online 07.04.2014 Transcription and processing: multilayer controls of RNA biogenesis by the Hippo pathway A recent study published in Cell uncovers an entirely novel layer of Hippo signaling: direct regulation of miRNA processing to control global miRNA biogenesis. Fa‐Xing Yu and Kun‐Liang Guan Published online 17.03.2014 Reviews Focus: Molecular Memory: Epigenetic memory: the Lamarckian brain As part of our review series on Molecular Memory, Andre Fischer discusses epigenetic processes leading to memory formation and transgenerational inheritance under physiological and pathological conditions such as Alzheimer's disease. Andre Fischer Published online 09.04.2014 Traffic into silence: endomembranes and post‐transcriptional RNA silencing While extensive work has gone into clarifying the mechanistic basis for RNA silencing, our understanding of the cellular compartments involved is still in its infancy. This review discusses accumulating evidence that the endomembrane system plays a central role in orchestrating small RNA pathways. Yun Ju Kim, Alexis Maizel, and Xuemei Chen Published online 25.03.2014 Articles Identification of small ORFs in vertebrates using ribosome footprinting and evolutionary conservation The combination of ORFscore and micPDP enable high confidence prediction of many, small translated ORFs that were functionally not appreciated or previously annotated as lincRNAs. Ariel A Bazzini, Timothy G Johnstone, Romain Christiano, Sebastian D Mackowiak, Benedikt Obermayer, Elizabeth S Fleming, Charles E Vejnar, Miler T Lee, Nikolaus Rajewsky, Tobias C Walther, and Antonio J Giraldez Published online 04.04.2014 Miro1 regulates intercellular mitochondrial transport & enhances mesenchymal stem cell rescue efficacy Repair of injured epithelial cells in mouse models of airway injury and asthma is promoted by transfer of mitochondria from mesenchymal stem cells, facilitated by the mitochondrial Rho‐GTPase Miro1. Tanveer Ahmad, Shravani Mukherjee, Bijay Pattnaik, Manish Kumar, Suchita Singh, Manish Kumar, Rakhshinda Rehman, Brijendra K Tiwari, Kumar A Jha, Amruta P Barhanpurkar, Mohan R Wani, Soumya S Roy, Ulaganathan Mabalirajan, Balaram Ghosh, and Anurag Agrawal Published online 15.01.2014 Loss of the m‐AAA protease subunit AFG3L2 causes mitochondrial transport defects and tau hyperphosphorylation Impaired axonal transport of mitochondria in the absence of AFG3L2 may explain how its mutation in spinocerebellar ataxia impair neuronal development and survival, and suggests possible therapeutic strategies based on counteracting ROS signaling. Arun Kumar Kondadi, Shuaiyu Wang, Sara Montagner, Nikolay Kladt, Anne Korwitz, Paola Martinelli, David Herholz, Michael J Baker, Astrid C Schauss, Thomas Langer, and Elena I Rugarli Published online 28.03.2014 Creb coactivators direct anabolic responses and enhance performance of skeletal muscle The sympathetic nervous system coordinates catabolism of energy stores during exercise with anabolic responses post‐exercise by activating the Crtc/Creb transcriptional complex. Nelson E Bruno, Kimberly A Kelly, Richard Hawkins, Mariam Bramah‐Lawani, Antonio L Amelio, Jerome C Nwachukwu, Kendall W Nettles, and Michael D Conkright Published online 27.03.2014 Regulation of a transcription factor network by Cdk1 coordinates late cell cycle gene expression In yeast, Cdk1‐dependent phosphorylation regulates several conserved transcription factors positively and/or negatively, which is important for cell cycle progression and optimal fitness. Benjamin D Landry, Claudine E Mapa, Heather E Arsenault, Kristin E Poti, and Jennifer A Benanti Published online 08.04.2014 Crystal structures of the structure‐selective nuclease Mus81‐Eme1 bound to flap DNA substrates Co‐crystallization of human Mus81‐Eme1 bound to flap DNA substrates reveals key structural features essential for substrate selection and active site positioning during resolution of recombination intermediates. Gwang Hyeon Gwon, Aera Jo, Kyuwon Baek, Kyeong Sik Jin, Yaoyao Fu, Jong‐Bong Lee, YoungChang Kim, and Yunje Cho Published online 14.04.2014 GTP hydrolysis by EF‐G synchronizes tRNA movement on small and large ribosomal subunits A new dual‐color labeling approach yields dynamic insight on synchronous tRNA movement on both ribosomal subunits and shows that GTP hydrolysis by the translocation factor EF‐G drives rearrangement of the 30S subunit. Wolf Holtkamp, Carlos E Cunha, Frank Peske, Andrey L Konevega, Wolfgang Wintermeyer, and Marina V Rodnina Published online 10.03.2014   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2014 by the European Molecular Biology Organisation.