Molecular Systems Biology - New articles published - 1 Jun 2014

May 2014 | Volume 10, Number 5 Submit Table of Contents Articles Volume 10, Number 5 Articles Metabolic shifts toward glutamine regulate tumor growth, invasion and bioenergetics in ovarian cancer Glutamine plays an important role in cellular growth in several cancers. In this study, a further link between glutamine dependency and tumor invasiveness is established in ovarian cancer. Glutamine maintains the high‐invasive phenotype by regulating STAT3 signaling. Lifeng Yang, Tyler Moss, Lingegowda S Mangala, Juan Marini, Hongyun Zhao, Stephen Wahlig, Guillermo Armaiz‐Pena, Dahai Jiang, Abhinav Achreja, Julia Win, Rajesha Roopaimoole, Cristian Rodriguez‐Aguayo, Imelda Mercado‐Uribe, Gabriel Lopez‐Berestein, Jinsong Liu, Takashi Tsukamoto, Anil K. Sood, Prahlad T Ram, and Deepak Nagrath Published online 05.05.2014 Structure‐energy‐based predictions and network modelling of RASopathy and cancer missense mutations Mutations in Ras/MAPK pathway components can cause either cancer or developmental disorders (‘RASopathies’). Combined network‐based and structural analyses show that quantitative changes rather than all‐or‐none rewiring underlie the difference between these classes of mutations. Christina Kiel and Luis Serrano Published online 06.05.2014 Genetic regulation of mouse liver metabolite levels Mouse liver metabolites were quantified by mass spectrometry and mapped by genome‐wide association. Genetic factors were shown to contribute substantially to metabolite levels and adenoviral overexpression validated several of the identified loci. Anatole Ghazalpour, Brian J Bennett, Diana Shih, Nam Che, Luz Orozco, Calvin Pan, Raffi Hagopian, Aiqing He, Paul Kayne, Wen‐pin Yang, Todd Kirchgessner, and Aldons J Lusis Published online 23.05.2014   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2014 by the European Molecular Biology Organisation.