Nature Reviews Genetics Contents September 2014 Volume 15 Number 9 pp 571-639

If you are unable to see the message below, click here to view.

TABLE OF CONTENTS
September 2014 Volume 15 Number 9		Advertisement
Impact Factor 39.794 *	In this issue Research Highlights Progress Reviews Also this month Article series: Applications of next-generation sequencing Non-coding RNA Disease mechanisms  Featured article: Investigating human disease using stem cell models Jared L. Sterneckert, Peter Reinhardt & Hans R. Schöler	Visit the enhanced database search engine GenomeCUBE® GenomeCUBE® has a fresh new look including a simplified, powerful search tool, providing instant results using 'Real-time' annotated information from multiple public databases. Purchase all related antibodies, reagents and kits from one source, putting you in control of your research.  Begin your search now >
Subscribe   Facebook   RSS   Recommend to library   Twitter
Advertisement
Nature at War: A special collection of articles originally published between 1914 and 1918.  Science and technology played a key role in World War One. A century later, a selection of articles from our archive reveals how Nature reported and analyzed these developments at the time.  Purchase and download this exclusive PDF for only $1.99.
RESEARCH HIGHLIGHTS Top Stem cells: Epigenome reprogramming — of mice and men p571 | doi:10.1038/nrg3808 PDF DNA methylation: Switching phenotypes with epialleles p572 | doi:10.1038/nrg3797 PDF Complex disease: Piecing together the puzzle of coronary artery disease p572 | doi:10.1038/nrg3799 PDF Population genetics: Living the highlife after archaic introgression p573 | doi:10.1038/nrg3793 PDF Non-coding RNA: Zooming in on lncRNA functions p574 | doi:10.1038/nrg3795 PDF Transcription: Unwinding transcriptional bursting p574 | doi:10.1038/nrg3800 PDF Cancer genomics: Non-coding mutations in the driver seat p574 | doi:10.1038/nrg3801 PDF IN BRIEF Therapeutics: Targeting huntingtin through morpholino oligomers | Technology: Using DNA repair to detect modified bases | Non-coding RNA: MicroRNA stimulates mitochondrial translation | Disease genetics: Loss of rescue factor unmasks epistatic mutation | Evolution: Evolution of olfactory receptors in mammals | Pathogen genetics: Cutting out HIV | Model organisms: Sexual conflict in nematodes | Evolutionary genetics: Homing in on anthropoid evolution PDF Genetics JOBS of the week Research Technician Position in Nanoscale Probing of Gene Expression Albert Einstein College of Medicine in New York Tenure-Track Faculty Positions in Genomics and Computational Biology Yale University School of Medicine Postdoctoral scholar in epigenomics and regulatory genomics University of Iowa Carver College of Medicine Postdoc Fellow MD Anderson Cancer Center More Science jobs from Genetics EVENT Genetics, Genomics and Phenomics of Fish 20.10.14 suzhou, China More science events from
PROGRESS		Top
Article series: Applications of next-generation sequencing Recent advances in genomic DNA sequencing of microbial species from single cells Roger S. Lasken & Jeffrey S. McLean p577 | doi:10.1038/nrg3785 Single-cell sequencing of uncultivated microbial species is rapidly providing a wealth of new information. Here, the authors provide an update on recent progress in capturing novel genomes, large-scale environmental studies and research relating to human health, as well as recent methodological improvements and remaining technical challenges. Abstract | Full Text | PDF
Advertisement
Frontiers Research Topics are collections of articles around a subject area at the cutting edge of knowledge and organized by leading researchers.  Gene interactions in pharmacogenomics In recent years, research in pharmacogenomics has evolved from a candidate-gene approach to genome-wide association studies. This topic, hosted in the open-access journal Frontiers in Genetics, focuses on gene-gene and gene-environment interactions, and on interactions among pharmacogene regulatory elements.
REVIEWS		Top
Mechanisms underlying mutational signatures in human cancers Thomas Helleday, Saeed Eshtad & Serena Nik-Zainal p585 | doi:10.1038/nrg3729 Mutagenic processes leave characteristic imprints on the cancer genome that can help to identify the underlying DNA damaging components as well as DNA repair and replicative pathways that are active or disrupted. This Review discusses these mutational signatures according to different classes of mutations and summarizes how different components contribute mechanistically to produce each signature type. Abstract | Full Text | PDF
Article series: Non-coding RNA Identification and consequences of miRNA-target interactions — beyond repression of gene expression Jean Hausser & Mihaela Zavolan p599 | doi:10.1038/nrg3765 This Review discusses the main experimental approaches for microRNA (miRNA) target identification, as well as the modulators and the consequences of miRNA-target interactions. It also highlights the role of computational modelling in furthering the conceptual understanding of miRNA functions in gene regulatory networks. Abstract | Full Text | PDF
Epigenetic reprogramming in plant sexual reproduction Tomokazu Kawashima & Frédéric Berger p613 | doi:10.1038/nrg3685 DNA and histone modifications undergo extensive reprogramming to reset the epigenomic state between generations. This Review discusses the mechanisms and consequences of epigenetic reprogramming during plant sexual reproduction. Despite various similarities to the equivalent process in mammals, a key difference is the seemingly incomplete reprogramming of plant epigenomes, which has implications for evolution and transgenerational epigenetic inheritance. Abstract | Full Text | PDF
Article series: Disease mechanisms Investigating human disease using stem cell models Jared L. Sterneckert, Peter Reinhardt & Hans R. Schöler p625 | doi:10.1038/nrg3764 Understanding disease pathogenesis and developing potential therapies require accurate and genetically tractable models. This Review discusses how human stem cells — including embryonic stem cells, adult stem cells and induced pluripotent stem cells — can provide informative models of diverse human diseases. Such methods can also be extended through gene editing, co-culture or infectious agent approaches. Abstract | Full Text | PDF
Advertisement
Interested in plant science? Launching in January 2015, Nature Plants will provide an overview of the most important developments in plant sciences through the publication of Primary Research, Reviews, Perspectives, News and Views articles, Commentaries, News Features and Books and Arts Reviews.  Register to receive Nature Plants e-alerts   Like us on Facebook    Follow us on Twitter
Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

*2013 Journal Citation Report (Thomson Reuters, 2014)

You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department For print subscription enquiries, please contact our subscription department For other enquiries, please contact our feedback department Nature Publishing Group | 75 Varick Street, 9th Floor | New York | NY 10013-1917 | USA Nature Publishing Group's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS. © 2014 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.