Nature Reviews Immunology Contents October 2014 Volume 14 Number 10 pp 647-711

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TABLE OF CONTENTS
October 2014 Volume 14 Number 10
Impact Factor 33.836 *	In this issue Research Highlights Reviews Perspectives Correspondence Also this month  Featured article: Regional specialization within the intestinal immune system Allan M. Mowat & William W. Agace
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Nature Immunology Focus on TCR Signaling The development and effector function of T cells depends on signaling initiated via the T cell antigen receptor (TCR). Nature Immunology presents a Focus on TCR signaling with four specially commissioned Reviews.  Click here to access the Focus.
RESEARCH HIGHLIGHTS Top T cell memory: Warning — here comes a pathogen! p647 | doi:10.1038/nri3750 Activation of tissue-resident memory CD8+ T cells leads to a state of pathogen alert that induces both innate and adaptive immune responses. PDF Pattern recognition receptors: Binding mycobacterial sugars p648 | doi:10.1038/nri3744 Dectin 2 specifically binds the mycobacterial cell wall component mannose-capped lipoarabinomannan. PDF Natural killer T cells: Lyme scaled back p648 | doi:10.1038/nri3748 Invariant natural killer T cells can directly limit bacterial dissemination into the joints. PDF Dendritic cells: The true face of migratory DCs p649 | doi:10.1038/nri3741 FLT3L-activated classical dendritic cells (DCs) drive immune responses following subcutaneous immunization, whereas migratory skin DCs dampen them. PDF Microbiota: A 'natural' vaccine adjuvant p650 | doi:10.1038/nri3745 Intestinal bacteria stimulate TLR5 on B cells and macrophages to promote antibody responses to subunit vaccination. PDF In the news p650 | doi:10.1038/nri3747 New vaccine protects monkeys from Ebola virus. PDF Signalling: BCL-6 curbs glycolysis p650 | doi:10.1038/nri3749 The transcription factor BCL-6 suppresses the expression of a subset of important genes in the glycolytic pathway in transitional effector T cells. PDF Immune signalling: Waste sorting p651 | doi:10.1038/nri3746 The TAM receptors MER and AXL regulate apoptotic cell uptake in diverse immune settings. PDF IN BRIEF Regulatory T cells: Expanding TReg cell numbers in vivo | Immunogenetics: Human CTLA4 mutations described | Macrophages: Gut needs a steady supply of reinforcements PDF Immunology JOBS of the week Postdoctoral fellowship in T cell immunology University of Pennsylvania Post-doctoral Fellowship Position in Cancer Immunology Cornell University Doctoral Fellowships in the Areas of Infection Biology and Immunology in Berlin ZIBI Graduate School Signaling mechanisms and transcriptional regulation of immune gene expression Tsinghua University School of Medicine Post Doc in Human Mucosal Immunology Inserm More Science jobs from Immunology EVENT IMMUNOLOGY 2015 AAI Annual Meeting 08.05.15 New Orleans, USA More science events from
REVIEWS		Top
Siglec-mediated regulation of immune cell function in disease Matthew S. Macauley, Paul R. Crocker & James C. Paulson p653 | doi:10.1038/nri3737 Siglecs are sialic acid-binding cell-surface proteins that can help the immune system to distinguish between self and non-self. In this Review, the authors describe how Siglecs can modulate immune cell signalling, outline the role of Siglecs in disease and discuss targeting Siglecs for therapeutic purposes. Abstract | Full Text | PDF
Regional specialization within the intestinal immune system Allan M. Mowat & William W. Agace p667 | doi:10.1038/nri3738 In this Review, the authors describe the unique and varied immune microenvironments that are found along the length of the intestinal tract. They explain how both host-derived and environmental factors shape this regional specialization and discuss the implications for intestinal pathologies, such as inflammatory bowel diseases and cancers. Abstract | Full Text | PDF
The role of airway epithelial cells and innate immune cells in chronic respiratory disease Michael J. Holtzman, Derek E. Byers, Jennifer Alexander-Brett & Xinyu Wang p686 | doi:10.1038/nri3739 This Review details how the activation of airway epithelial cells and innate immune cells can drive chronic diseases of the lungs, such as asthma and chronic obstructive pulmonary disease. The authors discuss how a better understanding of the mechanisms involved is leading to new treatments for these diseases. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Lymphocyte fate specification as a deterministic but highly plastic process Steven L. Reiner & William C. Adams p699 | doi:10.1038/nri3734 Reiner and Adams propose a deterministic scenario for diversifying the fates of the cellular progeny of a single antigen-selected lymphocyte, with an element of plasticity based on the nature of the pathogen and the number of responding cells. Abstract | Full Text | PDF
OPINION Dendritic cell-targeted vaccines — hope or hype? Wolfgang Kastenmuller, Kathrin Kastenmuller, Christian Kurts & Robert A. Seder p705 | doi:10.1038/nri3727 Studies in mice indicate that targeting antigens to dendritic cells (DCs) can elicit strong CD4+ T cell responses. In this Opinion article, the authors summarize the existing DC-targeting approaches; they discuss whether these vaccines are superior to current vaccines and what future studies should entail to successfully introduce these vaccines into a clinical setting. Abstract | Full Text | PDF | Supplementary information
CORRESPONDENCE		Top
Correspondence: Why the immune system takes its chances with randomness Philip D. Hodgkin, Mark R. Dowling & Ken R. Duffy p711 | doi:10.1038/nri3734-c1 Full Text | PDF
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*2013 Journal Citation Report (Thomson Reuters, 2014)

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