Nature Reviews Neurology - Table of Contents alert Volume 10 Issue 11

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TABLE OF CONTENTS
November 2014 Volume 10 Number 11
Impact Factor 14.103 *	In this issue Research Highlights News and Views Reviews Correspondence Review Also this month  Featured article: Brain connectivity in neurodegenerative diseases—from phenotype to proteinopathy Michela Pievani, Nicola Filippini, Martijn P. van den Heuvel, Stefano F. Cappa & Giovanni B. Frisoni
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RESEARCH HIGHLIGHTS Top Alzheimer disease: Altered functional connectivity in preclinical dementia Published online: 21 October 2014 p609 | doi:10.1038/nrneurol.2014.195 PDF Migraine: Migraine in midlife could be connected to increased risk of late-life parkinsonism Published online: 30 September 2014 p610 | doi:10.1038/nrneurol.2014.186 PDF Alzheimer disease: Alzheimer disease risk factor CALM modulates tau turnover Published online: 14 October 2014 p610 | doi:10.1038/nrneurol.2014.188 PDF Traumatic brain injury: Simulations of TBI highlight the importance of impact direction Published online: 21 October 2014 p611 | doi:10.1038/nrneurol.2014.192 PDF Multiple sclerosis: Blood-based biomarkers provide insight into progressive MS Published online: 07 October 2014 p612 | doi:10.1038/nrneurol.2014.189 PDF IN BRIEF Spinal cord injury: Acute hyperglycaemia exacerbates spinal cord injury in mice, and predicts poor recovery in human patients | Peripheral neuropathies: New recommendations for use of temperature threshold testing in the diagnosis of small-fibre neuropathy | Multiple sclerosis: Survey uncovers the needs of people with severe MS | Stroke: Transcranial laser therapy for stroke fails futility analysis | Alzheimer disease: Common polymorphisms in APOE and BDNF might predict cognitive decline in individuals with amyloid-β deposition | Migraine: Saccular aneurysm clipping decreases migraine prevalence | Parkinson disease: Serum uric acid level could be a diagnostic biomarker for PD | Motor neuron disease: A large case–control study finds no association between living near power lines and risk of ALS PDF Neurology JOBS of the week PostDoctoral Research Associate, Neurology - Postdoctoral Research Associate University of Virginia postdoctoral researcher Yale University School of Medicine Neuromodulation Faculty Scholars University of Minnesota More Science jobs from Neurology EVENT The Lancet Neurology Autoimmune Disorders Conference 27.03.15 Barcelona, Spain More science events from
NEWS AND VIEWS		Top
Dementia: Does vitamin D modulate cognition? John E. Morley Published online: 21 October 2014 p613 | doi:10.1038/nrneurol.2014.193 Epidemiological evidence strongly suggests that circulatory levels of 25-hydroxyvitamin D below 50 nmol/l are associated with cognitive impairment and the development of dementia. A number of biochemical mechanisms could explain these effects; however, interventional studies to date have revealed disappointingly little. Full Text | PDF
Epilepsy: Pregnancy in women with epilepsy—risks and management Kimford J. Meador Published online: 30 September 2014 p614 | doi:10.1038/nrneurol.2014.179 The risks of seizures and antiepileptic drug (AED) teratogenicity must be balanced when treating pregnant women with epilepsy. Two recent articles address these risks for newer AEDs. Lamotrigine and levetiracetam carried low risks of malformations, and topiramate exhibited a dose-dependent risk. Levetiracetam controlled seizures more effectively than lamotrigine and topiramate. Full Text | PDF
Neuroimmunology: Disease mechanisms in narcolepsy remain elusive Ilkka Julkunen & Markku Partinen Published online: 14 October 2014 p616 | doi:10.1038/nrneurol.2014.191 A pandemic influenza vaccine with a specific type of vaccine antigen has been linked to an increased incidence of narcolepsy in children from 2009-2010. However, the recent retraction of an article that reported a putative autoantigen means that the search for the mechanisms behind the vaccine-narcolepsy connection continues. Full Text | PDF
Alzheimer disease: The search for a blood-based biomarker for Alzheimer disease Alan Rembach Published online: 30 September 2014 p618 | doi:10.1038/nrneurol.2014.182 Finding a peripheral biomarker for early Alzheimer disease (AD) is a major challenge. A recent study has validated a plasma protein signature that is associated with mild cognitive impairment and AD, and could predict conversion; however, longitudinal cohort studies of presymptomatic individuals are needed to confirm the findings. Full Text | PDF
Corrigendum: Ischaemic stroke in young adults: risk factors and long-term consequences Noortje A. M. M. Maaijwee, Loes C. A. Rutten-Jacobs, Pauline Schaapsmeerders, Ewoud J. van Dijk & Frank-Erik de Leeuw Published online: 07 October 2014 p612 | doi:10.1038/nrneurol.2014.183 Full Text | PDF
Corrigendum: Guillain–Barre and Miller Fisher syndromes—new diagnostic classification Benjamin R. Wakerley, Antonino Uncini, Nobuhiro Yuki & the GBS Classification Group Published online: 07 October 2014 p612 | doi:10.1038/nrneurol.2014.190 Full Text | PDF
REVIEWS		Top
Brain connectivity in neurodegenerative diseases—from phenotype to proteinopathy Michela Pievani, Michela Pievani, Nicola Filippini, Martijn P. van den Heuvel, Stefano F. Cappa & Giovanni B. Frisoni Published online: 07 October 2014 p620 | doi:10.1038/nrneurol.2014.178 Functional and structural connectivity measures, assessed by means of functional and diffusion MRI, are emerging as potential intermediate biomarkers for Alzheimer disease and other neurodegenerative disorders. In this article, Pievani et al. evaluate the evidence that connectivity biomarkers are associated downstream with clinical phenotypes and topographic brain imaging markers of neurodegeneration, and upstream with molecular determinants of neurodegeneration and susceptibility genes. Abstract | Full Text | PDF | Supplementary information
Classifying neurocognitive disorders: the DSM-5 approach Perminder S. Sachdev, Deborah Blacker, Dan G. Blazer, Mary Ganguli, Dilip V. Jeste, Jane S. Paulsen & Ronald C. Petersen Published online: 30 September 2014 p634 | doi:10.1038/nrneurol.2014.181 The fifth edition of the American Psyciatric Association's Diagnostic and Statistical Manual for Mental Disorders (DSM-5) was published in 2013, and with it came new diagnostic criteria for mild cognitive impairment and dementia. In this Review, members of the working group tasked with writing the DSM-5 criteria for neurocognitive disorders present the new approach to categorization and diagnosis. Three key syndromes are recognized—delirium, mild neurocognitive disorder and major neurocognitive disorder—and each can have distinct aetiological subtypes. Abstract | Full Text | PDF
Maternal immune activation and abnormal brain development across CNS disorders Irene Knuesel, Laurie Chicha, Markus Britschgi, Scott A. Schobel, Michael Bodmer, Jessica A. Hellings, Stephen Toovey & Eric P. Prinssen Published online: 14 October 2014 p643 | doi:10.1038/nrneurol.2014.187 Activation of the immune system during pregnancy can have varied effects on fetal development, and converging evidence highlights maternal immune activation as a risk factor for multiple neurological conditions. In this Review, Knuesel and colleagues discuss the involvement of maternal immune activation in schizophrenia, austim spectrum disorders, epilepsy and other disorders. The authors then discuss how preclinical data indicate a possible link between prenatal exposure to infection and susceptibility to neurodegenerative disease, and they go on to identify fertile ground for further translational research. Abstract | Full Text | PDF
CORRESPONDENCE		Top
ALS—dying forward, backward or outward? Mark R. Baker Published online: 23 September 2014 p660 | doi:10.1038/nrneurol.2013.221-c1 Full Text | PDF
REVIEW		Top
The phenotypic variability of amyotrophic lateral sclerosis Bart Swinnen & Wim Robberecht Published online: 14 October 2014 p661 | doi:10.1038/nrneurol.2014.184 Amyotrophic lateral sclerosis (ALS) is a genotypically and phenotypically heterogeneous disease, as reflected in the variability in age and site of onset, extent of extramotor involvement, and survival. Cognitive involvement is also common, and corroborates the connection between ALS and frontotemporal lobar degeneration. In this article, Robberecht and Swinnen review phenotypic heterogeneity in ALS and discuss some of its implications for understanding ALS pathogenesis and development of therapeutic interventions. Abstract | Full Text | PDF
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*Journal Citation Reports, Thomson, 2013. Nature Reviews Neurology was previously published as Nature Clinical Practice Neurology.

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