Molecular Systems Biology - New articles published - 4 Feb 2016

January 2016 | Volume 12, Number 1 Submit Table of Contents Articles News & Views Articles Volume 12, Number 1 Articles Antisense transcription as a tool to tune gene expression A synthetic system developed in Escherichia coli and a computational model provide mechanistic insights into antisense transcription and show that it is a reliable means of controlling gene expression and tuning regulatory circuits. Jennifer AN Brophy and Christopher A Voigt Published online 14.01.2016 Differential dynamics of the mammalian mRNA and protein expression response to misfolding stress The contribution of mRNA and protein level regulation in the mammalian endoplasmic reticulum stress response is deconvoluted by analyzing time‐series protein and matching mRNA concentrations with a new statistical tool. Zhe Cheng, Guoshou Teo, Sabrina Krueger, Tara M Rock, Hiromi WL Koh, Hyungwon Choi, and Christine Vogel Published online 20.01.2016 News & Views The interdependence of transcript and protein abundance: new data–new complexities The relative contribution of transcriptional and translational regulation in gene expression control remains an open question. Vogel and colleagues (Cheng et al, 2016) show that the endoplasmic reticulum stress response is controlled at both the transcript and protein levels. Yansheng Liu and Ruedi Aebersold Published online 20.01.2016 Articles Orthogonal intercellular signaling for programmed spatial behavior The use of multiple homoserine lactone quorum‐sensing signals in synthetic circuits has been hampered by crosstalk. Measurement and modeling of the system allows for rational modifications to minimize crosstalk and create programmed spatial behavior. Paul K Grant, Neil Dalchau, James R Brown, Fernan Federici, Timothy J Rudge, Boyan Yordanov, Om Patange, Andrew Phillips, and Jim Haseloff Published online 25.01.2016   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2016 by the European Molecular Biology Organisation.