Nature Reviews Immunology Contents Mh 2016 Volume 16 Number 3 pp 129-201

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TABLE OF CONTENTS
March 2016 Volume 16 Number 3		Advertisement
Impact Factor 30.458 *	In this issue Research Highlights Reviews Perspectives Also this month  Featured article: Harnessing the plasticity of CD4+ T cells to treat immune-mediated disease Michel DuPage & Jeffrey A. Bluestone	Key Advances in Medicine eBook from Nature Reviews - FREE to download!  This essential resource summarizes the groundbreaking clinical and biomedical discoveries of 2015 and highlights the trends to watch out for in 2016, making it a must read eBook for anyone with an interest in medical science.  Download for free
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RESEARCH HIGHLIGHTS Top Macrophages: Embracing those nerves p129 | doi:10.1038/nri.2016.21 Enteric neurons promote pro-reparatory functions in muscularis macrophages. PDF Tumour immunology: Microbiota predicts side-effects of immunotherapy p130 | doi:10.1038/nri.2016.22 Microbiota-associated biomarkers can predict colitis development following immune checkpoint blockade. PDF Allergy: You're born with it p130 | doi:10.1038/nri.2016.25 A pro-inflammatory innate cell profile at birth is linked to the development of food allergy through promotion of T helper 2-type immune responses. PDF Cell death: Find me and eat me p131 | doi:10.1038/nri.2016.23 The release of sphingosine-1-phosphate from dying cells activates erythropoietin signalling in macrophages, which enables immunologically silent clearance of dying cells. PDF Tumour immunology: Innate surveillance p132 | doi:10.1038/nri.2016.20 Unique populations of innate lymphoid cells and innate-like T cells expand in tumours and control tumour growth. PDF Mucosal immunology: Weaning off food allergy p132 | doi:10.1038/nri.2016.24 Weaning onto solid food induces regulatory T cell populations in the small intestine that help protect against food allergy. PDF JOURNAL CLUB The bigger B cell picture p133 | doi:10.1038/nri.2016.3 Fabienne Mackay describes a 2011 paper by Winer et al. that observed an effect of diet on the B cell repertoire. PDF Immunology JOBS of the week Post-Doctoral Research Scientist in Avian Immunology The Pirbright Institute Assistant, Associate, or Full Member, Cancer Immunology Fred Hutchinson Cancer Research Center Postdoctoral positions in Immunology, Cancer, and Stem Cells University of Connecticut (UConn) Postdoctoral Research Associate in Clinical Immunology Benaroya Research Institute at Virginia Mason (BRI) Lung Immunology Program Assistant / Associate Professor, Department of Pediatrics Indiana University School of Medicine More Science jobs from Immunology EVENT Translational Immunology in Kidney Disease - ISN Nexus Symposium 2016 14.04.16 Berlin, Germany More science events from
REVIEWS		Top
Mucosal immunity to pathogenic intestinal bacteria Araceli Perez-Lopez, Judith Behnsen, Sean-Paul Nuccio & Manuela Raffatellu p135 | doi:10.1038/nri.2015.17 Enteric bacterial infections are a major cause of morbidity and mortality. In this Review, the authors describe the different types of mucosal defences - including innate and adaptive immune cells, epithelial cells and commensal microorganisms - that protect us against bacterial pathogens in the intestines. Abstract | Full Text | PDF
Harnessing the plasticity of CD4+ T cells to treat immune-mediated disease Michel DuPage & Jeffrey A. Bluestone p149 | doi:10.1038/nri.2015.18 T cells are inherently flexible and can acquire distinct functions to combat different pathogens or changing circumstances. However, this flexibility can be deleterious or advantageous depending on the disease setting. Here, the authors describe the molecular mechanisms that regulate CD4+ T cell plasticity and how it might be harnessed to treat disease. Abstract | Full Text | PDF
Mutations, kataegis and translocations in B cells: understanding AID promiscuous activity Rafael Casellas et al. p164 | doi:10.1038/nri.2016.2 The targeting of immunoglobulin loci by activation-induced cytidine deaminase (AID) is essential for generating a diverse antibody repertoire. However, AID also has off-target activity in B cells that can lead to oncogenic transformation. Here, the authors review recent advances in our understanding of the mechanisms that drive AID promiscuous activity. Abstract | Full Text | PDF
Purinergic regulation of the immune system Caglar Cekic & Joel Linden p177 | doi:10.1038/nri.2016.4 This Review focuses on how purinergic signalling pathways regulate both innate and adaptive immune responses. The authors discuss the potential of targeting purinergic signalling pathways for the treatment of ischaemia, organ transplantation, autoimmunity and cancer. Abstract | Full Text | PDF
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Nature Immunology & Nature Reviews Immunology: Poster on Innate lymphoid cells This poster provides a visual summary of our current understanding of the development, classification, plasticity and functional diversity of innate lymphoid cells. Available to download free online. The Poster is freely available thanks to support from STEMCELL Technologies Inc.
PERSPECTIVES		Top
OPINION T cell migration, search strategies and mechanisms Matthew F. Krummel, Frederic Bartumeus & Audrey Gérard p193 | doi:10.1038/nri.2015.16 Taking lessons from 'search theory', which is based on migration patterns of animals searching for prey, for example, Krummel and colleagues discuss the intrinsic and extrinsic forces that influence T cell motility patterns as the cell searches for antigen in lymphoid and non-lymphoid tissues. Abstract | Full Text | PDF
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