The EMBO Journal Table of Contents for 2 May 2016; Vol. 35, No. 9

2 May 2016 | Volume 35, Number 9 Submit Table of Contents News & Views Reviews Articles Resources Volume 35, Number 9 News & Views Fetal neurogenesis: breathe HIF you can Blood vessel formation and neurogenesis proceed in a coordinated fashion in the developing cerebral cortex, allowing oxygen supply to regulate cell fate decisions via HIF‐1α destabilization. José Manuel Morante‐Redolat and Isabel Fariñas Published online 24.03.2016 It's a family act: the geminin triplets take center stage in motile ciliogenesis Multiciliated cells are key components of epithelia in the respiratory tract, the ependyma, and the oviducts. Four recent articles identify a conserved role for GemC1 at the center of a complex gene regulatory network that controls the differentiation of these cells. Eszter K Vladar and Brian J Mitchell Published online 22.03.2016 Elucidating the DDK‐dependent step in replication initiation The recently developed in vitro reconstitution system of eukaryotic DNA replication reveals how cell cycle‐dependent phosphorylation controls origin firing. Hiroyuki Araki Published online 22.03.2016 Reviews Interplay between Fanconi anemia and homologous recombination pathways in genome integrity Tarsounas and colleagues review the clinical and molecular implications of crosstalk between DNA interstrand crosslink and double‐strand break repair pathways, as manifested by the recurrent identification of homologous recombination factors mutated in Fanconi anemia patients. Johanna Michl, Jutta Zimmer, and Madalena Tarsounas Published online 01.04.2016 Articles Relief of hypoxia by angiogenesis promotes neural stem cell differentiation by targeting glycolysis Blood vessel formation in mammalian brain development promotes neural stem cell differentiation by triggering a cascade of tissue oxygenation, reduced activity of HIF‐1α and blunted glycolytic metabolism that favors the switch towards neurogenesis. Christian Lange, Miguel Turrero Garcia, Ilaria Decimo, Francesco Bifari, Guy Eelen, Annelies Quaegebeur, Ruben Boon, Hui Zhao, Bram Boeckx, Junlei Chang, Christine Wu, Ferdinand Le Noble, Diether Lambrechts, Mieke Dewerchin, Calvin J Kuo, Wieland B Huttner, and Peter Carmeliet Published online 08.02.2016 GEMC1 is a critical regulator of multiciliated cell differentiation In addition to a role in DNA replicaion, Geminin‐like coiled‐coil containing protein 1 (GEMC1) interacts with E2F4/5‐DP1 and Multicilin to control transcriptional programs required for multiciliated cell (MCC) differentiation in mammals. Berta Terré, Gabriele Piergiovanni, Sandra Segura‐Bayona, Gabriel Gil‐Gómez, Sameh A Youssef, Camille Stephan‐Otto Attolini, Michaela Wilsch‐Bräuninger, Carole Jung, Ana M Rojas, Marko Marjanović, Philip A Knobel, Lluís Palenzuela, Teresa López‐Rovira, Stephen Forrow, Wieland B Huttner, Miguel A Valverde, Alain de Bruin, Vincenzo Costanzo, and Travis H Stracker Published online 01.03.2016 Phosphopeptide binding by Sld3 links Dbf4‐dependent kinase to MCM replicative helicase activation In vitro reconstitution of replication initiation reveals the key reader of activatory phosphorylation on MCM helicase subunits. Tom D Deegan, Joseph TP Yeeles, and John FX Diffley Published online 24.02.2016 Distinct modes of recruitment of the CCR4–NOT complex by Drosophila and vertebrate Nanos While Nanos represses target mRNAs by recruiting the CCR4–NOT complex in both flies and mammals, Drosophila Nanos uses a unique, bipartite peptide to contact another CCR4–NOT surface than vertebrate Nanos. Tobias Raisch, Dipankar Bhandari, Kevin Sabath, Sigrun Helms, Eugene Valkov, Oliver Weichenrieder, and Elisa Izaurralde Published online 11.03.2016 Resources Global RNA recognition patterns of post‐transcriptional regulators Hfq and CsrA revealed by UV crosslinking in vivo A new pipeline for CLIP‐seq in Salmonella maps global RNA–protein interactions and offers a tool for improved understanding of post‐transcriptional control in bacteria. Erik Holmqvist, Patrick R Wright, Lei Li, Thorsten Bischler, Lars Barquist, Richard Reinhardt, Rolf Backofen, and Jörg Vogel Published online 04.04.2016   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2016 by the European Molecular Biology Organisation.