Nature Reviews Immunology Contents October 2016 Volume 16 Number 10 pp 593-656

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TABLE OF CONTENTS
October 2016 Volume 16 Number 10
2015 2-year Impact Factor 39.416 Journal Metrics 2-year Median 31	In this issue Research Highlights Reviews Perspectives Also this month  Featured article: T follicular helper cells in space-time Hai Qi	Celebrating 15 years of high-quality Reviews! October 2016 marks the 15th anniversary of the launch of Nature Reviews Immunology! See what's been publishing and view the current issue.
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RESEARCH HIGHLIGHTS Top Innate lymphoid cells: ILC diversity maintained by microbiota p593 | doi:10.1038/nri.2016.101 Single-cell genomic analysis of ILCs from the mouse small intestine identifies high levels of diversity that are maintained by the commensal microbiota. PDF Innate immunity: IL-1β activation under scrutiny p594 | doi:10.1038/nri.2016.102 Interleukin-1β is activated by the group A Streptococcus protease SpeB during infection. PDF B cells: Genomic reorganization in germinal centres p594 | doi:10.1038/nri.2016.108 The genome of germinal centre B cells undergoes a multilayered reorganization to coordinate transcriptional reprogramming. PDF Innate immune cells: A Morrbid way of stayin' alive p595 | doi:10.1038/nri.2016.104 The lncRNA Morrbid controls the lifespan of short-lived myeloid cells. PDF Innate immunity: Threat level adjustments p596 | doi:10.1038/nri.2016.105 Regulatory variant of peptidoglycan recognition receptors in Drosophila resolve immune responses according to threat level. PDF Innate lymphoid cells: Human ILCs face redundancy p596 | doi:10.1038/nri.2016.106 There are no obvious clinical symptoms of long-term deficiency of innate lymphoid cells in humans, which suggests that their postulated functions might be redundant. PDF Immunometabolism: Feast or famine to combat infection p597 | doi:10.1038/nri.2016.109 Fasting metabolism has opposing roles in maintaining tissue tolerance; anorexia improves survival during bacterial infection whereas it has detrimental effects during viral infection. PDF Immunology JOBS of the week Postdoctoral opportunities in Immunology, Keck School of Medicine Keck School of Medicine Postdoctoral researcher position in skin immunology University Hospital Lausanne (CHUV) Assistant Professorship for Clinical Tumor Immunology University of Zurich Postdoctoral Fellow in Immunology Icahn School of Medicine at Mount Sinai Postdoctoral Fellowship in Immunology / Cancer Immunotherapy Oslo University Hospital Radiumhospitalet More Science jobs from Immunology EVENT Cancer Immunology and Immunotherapy: Taking a Place in Mainstream Oncology 19.03.17 Whistler, Canada More science events from
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REVIEWS		Top
Regulatory circuits of T cell function in cancer Daniel E. Speiser, Ping-Chih Ho & Gregory Verdeil p599 | doi:10.1038/nri.2016.80 In this Review, the authors summarize the features and the molecular drivers of T cell dysfunction in cancer and compare these with dysfunctional T cells in chronic viral infection. The metabolic competition in the tumour microenvironment is also discussed. Understanding antitumour T cell responses has important implications for cancer immunotherapy. Abstract | Full Text | PDF
T follicular helper cells in space-time Hai Qi p612 | doi:10.1038/nri.2016.94 This Review discusses our current understanding of the development and functions of follicular helper T (TFH) cells. The author explains how these cells do not fit with the classical instructional model of helper T cell differentiation and, instead, proposes a model of default TFH cell development with inherent spatiotemporal stochasticity. Abstract | Full Text | PDF
Sex differences in immune responses Sabra L. Klein & Katie L. Flanagan p626 | doi:10.1038/nri.2016.90 In this Review the authors discuss some of the key differences that exist between male and female immune functions. They explain how these differences lead to sex biases in susceptibility to infections, inflammatory diseases and cancer. Moreover, they highlight the urgent need for immunologists to consider these sex differences when designing experiments. Abstract | Full Text | PDF
Immunological aspects of intestinal mucus and mucins Malin E. V. Johansson & Gunnar C. Hansson p639 | doi:10.1038/nri.2016.88 This Review describes the unique properties of mucus and mucins, with a focus on the intestine. Mucus and mucus-producing goblet cells contribute to our innate immune defences and, in turn, are regulated by the immune system. The authors discuss the link between defective mucus production and increased susceptibility to infection and inflammatory disease. Abstract | Full Text | PDF
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PERSPECTIVES		Top
VIEWPOINT Élie Metchnikoff (1845-1916): celebrating 100 years of cellular immunology and beyond David M. Underhill et al. p651 | doi:10.1038/nri.2016.89 In this Viewpoint article, Nature Reviews Immunology invites five experts to share their thoughts on the contributions made by Élie Metchnikoff to the fields of phagocytosis, macrophage biology, leukocyte migration, the microbiota and intravital imaging. Abstract | Full Text | PDF
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*2014 Journal Citation Report (Thomson Reuters, 2015)

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