Nature Reviews Neurology - Table of Contents alert Volume 12 Issue 10

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TABLE OF CONTENTS
October 2016 Volume 12 Number 10
Impact Factor 18.418 *	In this issue Research Highlights News and Views Reviews Perspectives Also this month Featured article: Rare diseases Also this month  Featured article: Angelman syndrome — insights into a rare neurogenetic disorder Karin Buiting, Charles Williams & Bernhard Horsthemke
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Read the latest key research on aging and age-related diseases from npj Aging and Mechanisms of Disease, a new open access journal published in partnership with the Japanese Society of Anti-Aging Medicine (JAAM): Lifespan-regulating genes in C. elegans   Amyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids
RESEARCH HIGHLIGHTS Top Multiple sclerosis: Biomarkers and genetic variants reflect disease course in multiple sclerosis Published online: 12 September 2016 p553 | doi:10.1038/nrneurol.2016.142 PDF Alzheimer disease: Anti-A[beta] antibody treatment shows promise in Alzheimer disease Published online: 16 September 2016 p554 | doi:10.1038/nrneurol.2016.144 PDF Neurodegenerative disorders: Novel CSF assay for [alpha]-synucleinopathies Published online: 16 September 2016 p554 | doi:10.1038/nrneurol.2016.146 PDF Neuromuscular disease: Mitochondrial dysfunction could precipitate motor neuron loss in spinal muscular atrophy Published online: 26 August 2016 p556 | doi:10.1038/nrneurol.2016.126 PDF Alzheimer disease: TREM-2 signalling and Alzheimer disease — striking the right balance Published online: 26 August 2016 p556 | doi:10.1038/nrneurol.2016.132 PDF IN BRIEF Multiple sclerosis: Successful trial of amiselimod for multiple sclerosis | Neuromuscular disease: Benefit of thymectomy in myasthenia gravis | Epilepsy: Tau pathology found in temporal lobe epilepsy | Stroke: Aortic stiffness predicts cognitive impairment | Neuro-oncology: Exercise could help to counteract radiation damage in children with brain tumours | Traumatic brain injury: Impaired medical decision-making capacity in TBI | Parkinson disease: Retinal changes could be an early marker of PD | Multiple sclerosis: Dehydration might contribute to fatigue in MS PDF Nature Reviews Neurology JOBS of the week Postdoctoral Fellow in the Department of Neurology University of Chicago More Science jobs from
NEWS AND VIEWS		Top
Headache: Cluster headache treatment — RCTs versus real-world evidence Paolo Martelletti & Martina Curto Published online: 12 September 2016 p557 | doi:10.1038/nrneurol.2016.134 Recently published American Headache Society evidence-based guidelines for cluster headache management provide updated guidance on which therapies are superior to placebo in randomized controlled trials. These valuable recommendations do not always translate to real-world settings, however, and other criteria should be taken into account when attempting to treat cluster headache. Full Text | PDF
Epilepsy: Beyond seizures — the importance of comorbidities in epilepsy Alberto Verrotti & Chiara Mazzocchetti Published online: 16 September 2016 p559 | doi:10.1038/nrneurol.2016.135 According to a recent study, a high percentage of children with epilepsy show comorbid somatic, neurological, and developmental or psychiatric disorders. To provide comprehensive care for paediatric patients with epilepsy, all their needs must be evaluated and managed, including careful consideration of comorbid disorders. Full Text | PDF
Infectious disease: Diagnostic criteria for neurocysticercosis — a difficult update Robert H. Gilman Published online: 28 September 2016 p560 | doi:10.1038/nrneurol.2016.145 A recent study proposed a modified version of the current diagnostic criteria for neurocysticercosis, but the value of the modifications is unclear and the study design limits conclusions about the validity of the new criteria. Instead, the suggested changes might contribute to future revision of the existing diagnostic criteria. Full Text | PDF
Neuroendocrinology: Oestrogen therapy affects brain structure but not function Roberta Diaz Brinton Published online: 28 September 2016 p561 | doi:10.1038/nrneurol.2016.147 According to new research, oestrogen therapy in postmenopausal women is associated with ventricular enlargement and increased white matter hyperintensities in the brain, but not with cognitive decline. This disconnect between structural and functional effects suggests that brain-derived lipids can be harnessed to meet the bioenergetic demand imposed by normal cognition. Full Text | PDF
REVIEWS		Top
Fluid biomarkers for mild traumatic brain injury and related conditions Henrik Zetterberg & Kaj Blennow Published online: 16 September 2016 p563 | doi:10.1038/nrneurol.2016.127 Owing to a lack of objective diagnostic tools, the diagnosis of mild traumatic brain injury (TBI) and related conditions, such as postconcussive syndrome and chronic traumatic encephalopathy must be made on clinical grounds. Here, Zetterberg and Blennow review the most recent developments in search for biomarkers for mild TBI and related conditions. Abstract | Full Text | PDF
Medication-overuse headache: risk factors, pathophysiology and management Hans-Christoph Diener, Dagny Holle, Kasja Solbach & Charly Gaul Published online: 12 September 2016 p575 | doi:10.1038/nrneurol.2016.124 Medication-overuse headache (MOH) is a common disorder, but it remains under-recognized, and although several risk factors have been identified, the pathophysiology of the disorder is not completely understood. Here, Hans-Christoph Diener and colleagues review the epidemiology and pathophysiology of MOH, and suggest strategies for prevention and treatment. Abstract | Full Text | PDF
Article series: Rare diseases Angelman syndrome — insights into a rare neurogenetic disorder Karin Buiting, Charles Williams & Bernhard Horsthemke Published online: 12 September 2016 p584 | doi:10.1038/nrneurol.2016.133 Angelman syndrome is a severe neurodevelopmental disorder, the characteristics of which include severe learning disability, epilepsy, ataxia, and a happy, sociable disposition. The authors review past and recent developments in Angelman syndrome research, highlighting the role of multicentre and international collaboration in addressing this rare condition. Abstract | Full Text | PDF
Inflammatory risk factors, biomarkers and associated therapy in ischaemic stroke Charles C. Esenwa & Mitchell S. Elkind Published online: 12 September 2016 p594 | doi:10.1038/nrneurol.2016.125 Proinflammatory conditions have been associated with an increased risk of stroke. In this Review, Esenwa and Elkind look at the association between infection, inflammation and ischaemic stroke, and discuss recommended approaches to reducing the risk of stroke associated with inflammation. Abstract | Full Text | PDF
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PERSPECTIVES		Top
OPINION Social networks and neurological illness Amar Dhand, Douglas A. Luke, Catherine E. Lang & Jin-Moo Lee Published online: 12 September 2016 p605 | doi:10.1038/nrneurol.2016.119 Drawing on data from social network studies, Dhand and colleagues suggest that focusing on a patient's personal network can help identify individuals at risk of poor health outcomes. The authors provide an overview of the terminology used in social network studies, discuss social network structures that put patients at risk, and suggest how social network research might be applied in the neurology clinic. Abstract | Full Text | PDF | Supplementary information
Corrigendum: Correction: A dietary supplement for SUDEP prevention? Gordon F. Buchanan & George B. Richerson Published online: 12 September 2016 p612 | doi:10.1038/nrneurol.2016.141 Full Text | PDF
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*Journal Citation Reports, Thomson, 2016. Nature Reviews Neurology was previously published as Nature Clinical Practice Neurology.

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