Cell Death & Disease Contents: 28 Dec 2021

The latest research from Cell Death & Disease: 28. December 2021

Deciphering the tRNA-derived small RNAs: origin, development, and future Bowen Liu , Jinling Cao [...] Tianjiao Wang Review Article | 21 December 2021 | Article number: 24 |  doi: 10.1038/s41419-021-04472-3

Circular RNA circPPP6R3 upregulates CD44 to promote the progression of clear cell renal cell carcinoma via sponging miR-1238-3p Zhiliang Chen , Zaosong Zheng [...] Wenlian Xie Article | 21 December 2021 | Article number: 22 |  doi: 10.1038/s41419-021-04462-5

Single-cell transcriptomic analysis reveals the critical molecular pattern of UV-induced cutaneous squamous cell carcinoma Guorong Yan , Liang Li [...] Xiuli Wang Article | 21 December 2021 | Article number: 23 |  doi: 10.1038/s41419-021-04477-y

Long noncoding RNA Meg3 sponges miR-708 to inhibit intestinal tumorigenesis via SOCS3-repressed cancer stem cells growth Shuo Zhang , Wei-Wei Ji [...] Xuan Huang Article | 21 December 2021 | Article number: 25 |  doi: 10.1038/s41419-021-04470-5

BNIP3L/NIX-mediated mitophagy: molecular mechanisms and implications for human disease Yue Li , Wanqing Zheng [...] Xiangnan Zhang Review Article | 20 December 2021 | Article number: 14 |  doi: 10.1038/s41419-021-04469-y

WTIP upregulates FOXO3a and induces apoptosis through PUMA in acute myeloid leukemia Yunqi Zhu , Xiangmin Tong [...] Xiaoya Lu Article | 20 December 2021 | Article number: 18 |  doi: 10.1038/s41419-021-04467-0

MAP4K4 mediates the SOX6-induced autophagy and reduces the chemosensitivity of cervical cancer Hongxin Huang , Qin Han [...] Jie Wang Article | 20 December 2021 | Article number: 13 |  doi: 10.1038/s41419-021-04474-1

TMEM165 a new player in proteoglycan synthesis: loss of TMEM165 impairs elongation of chondroitin- and heparan-sulfate glycosaminoglycan chains of proteoglycans and triggers early chondrocyte differentiation and hypertrophy Sajida Khan , Malak Sbeity [...] Mohamed Ouzzine Article | 20 December 2021 | Article number: 11 |  doi: 10.1038/s41419-021-04458-1

The MYEOV-MYC association promotes oncogenic miR-17/93-5p expression in pancreatic ductal adenocarcinoma Hongzhang Shen , Fuqiang Ye [...] Juanjuan Zhu Article | 20 December 2021 | Article number: 15 |  doi: 10.1038/s41419-021-04387-z

USP3 promotes gastric cancer progression and metastasis by deubiquitination-dependent COL9A3/COL6A5 stabilisation Xiaosheng Wu , Hao Wang [...] Side Liu Article | 20 December 2021 | Article number: 10 |  doi: 10.1038/s41419-021-04460-7

Nuclear factor I-C disrupts cellular homeostasis between autophagy and apoptosis via miR-200b-Ambra1 in neural tube defects Wanqi Huang , Tianchu Huang [...] Zhengwei Yuan Article | 20 December 2021 | Article number: 17 |  doi: 10.1038/s41419-021-04473-2

CPEB3 deficiency in mice affect ovarian follicle development and causes premature ovarian insufficiency Fang E. , He Zhang [...] Xu Gao Article | 20 December 2021 | Article number: 21 |  doi: 10.1038/s41419-021-04374-4

NLPR3 inflammasome inhibition alleviates hypoxic endothelial cell death in vitro and protects blood–brain barrier integrity in murine stroke Maximilian Bellut , Lena Papp [...] Michael K. Schuhmann Article | 20 December 2021 | Article number: 20 |  doi: 10.1038/s41419-021-04379-z

Colorectal cancer-associated fibroblasts promote metastasis by up-regulating LRG1 through stromal IL-6/STAT3 signaling Beiping Zhong , Bing Cheng [...] Xiao-Jian Wu Article | 20 December 2021 | Article number: 16 |  doi: 10.1038/s41419-021-04461-6

CDK5RAP2 loss-of-function causes premature cell senescence via the GSK3β/β-catenin-WIP1 pathway Xidi Wang , Patrick Sipila [...] Ki-Young Lee Article | 20 December 2021 | Article number: 9 |  doi: 10.1038/s41419-021-04457-2

CircMTO1 suppresses hepatocellular carcinoma progression via the miR-541-5p/ZIC1 axis by regulating Wnt/β-catenin signaling pathway and epithelial-to-mesenchymal transition Dandan Li , Jiawei Zhang [...] Rui Zhang Article | 20 December 2021 | Article number: 12 |  doi: 10.1038/s41419-021-04464-3

Sidt2 is a key protein in the autophagy-lysosomal degradation pathway and is essential for the maintenance of kidney structure and filtration function Meng-ya Geng , Lizhuo Wang [...] Jia-lin Gao Article | 18 December 2021 | Article number: 7 |  doi: 10.1038/s41419-021-04453-6

Loss of miR-24-3p promotes epithelial cell apoptosis and impairs the recovery from intestinal inflammation Artin Soroosh , Kai Fang [...] Carl R. Rankin Article | 18 December 2021 | Article number: 8 |  doi: 10.1038/s41419-021-04463-4

Wet-dry-wet drug screen leads to the synthesis of TS1, a novel compound reversing lung fibrosis through inhibition of myofibroblast differentiation Nadja Anneliese Ruth Ring , Maria Concetta Volpe [...] Serena Zacchigna Article | 17 December 2021 | Article number: 2 |  doi: 10.1038/s41419-021-04439-4

TCF4 and HuR mediated-METTL14 suppresses dissemination of colorectal cancer via N6-methyladenosine-dependent silencing of ARRDC4 Hao Wang , Wei Wei [...] Lian-Xin Liu Article | 17 December 2021 | Article number: 3 |  doi: 10.1038/s41419-021-04459-0

RPRD1A stabilizes NRF2 and aggravates HCC progression through competing with p62 for TRIM21 binding Xiaofan Feng , Tianyi Jiang [...] Ning Yang Article | 17 December 2021 | Article number: 6 |  doi: 10.1038/s41419-021-04447-4

The role of RIPK1 mediated cell death in acute on chronic liver failure Takayuki Kondo , Stewart Macdonald [...] Rajiv Jalan Article | 17 December 2021 | Article number: 5 |  doi: 10.1038/s41419-021-04442-9

Knockdown of OLR1 weakens glycolytic metabolism to repress colon cancer cell proliferation and chemoresistance by downregulating SULT2B1 via c-MYC Tiancheng Zhao , Yezhou Li [...] Jiayu Zhang Article | 17 December 2021 | Article number: 4 |  doi: 10.1038/s41419-021-04174-w

GPR120 induces regulatory dendritic cells by inhibiting HK2-dependent glycolysis to alleviate fulminant hepatic failure Hongshuang Yu , Wanlin Yang [...] Min Jin Article | 16 December 2021 | Article number: 1 |  doi: 10.1038/s41419-021-04394-0

Early senescence and production of senescence-associated cytokines are major determinants of radioresistance in head-and-neck squamous cell carcinoma Ulrike Schoetz , Diana Klein [...] Kirsten Lauber Article | 15 December 2021 | Article number: 1162 |  doi: 10.1038/s41419-021-04454-5

Genome-wide identification of microRNA targets reveals positive regulation of the Hippo pathway by miR-122 during liver development Yin Zhang , Ye-Ya Tan [...] Liang-Hu Qu Article | 14 December 2021 | Article number: 1161 |  doi: 10.1038/s41419-021-04436-7

TRPV1 channel mediates NLRP3 inflammasome-dependent neuroinflammation in microglia Yahui Zhang , Baohua Hou [...] Xiaohua He Article | 14 December 2021 | Article number: 1159 |  doi: 10.1038/s41419-021-04450-9

Age-related accumulation of advanced oxidation protein products promotes osteoclastogenesis through disruption of redox homeostasis Jingshen Zhuang , Xuebing Chen [...] Zhaoming Zhong Article | 14 December 2021 | Article number: 1160 |  doi: 10.1038/s41419-021-04441-w

XDeathDB: a visualization platform for cell death molecular interactions Venkat Sundar Gadepalli , Hangil Kim [...] Lijun Cheng Article | 14 December 2021 | Article number: 1156 |  doi: 10.1038/s41419-021-04397-x

Aldehyde dehydrogenase 3B2 promotes the proliferation and invasion of cholangiocarcinoma by increasing Integrin Beta 1 expression Yue Wang , Kangshuai Li [...] Zongli Zhang Article | 14 December 2021 | Article number: 1158 |  doi: 10.1038/s41419-021-04451-8

Long noncoding RNA GSEC promotes neutrophil inflammatory activation by supporting PFKFB3-involved glycolytic metabolism in sepsis Dadong Liu , Wen Sun [...] Jiangtao Yin Article | 14 December 2021 | Article number: 1157 |  doi: 10.1038/s41419-021-04428-7

The BH3-only protein NOXA serves as an independent predictor of breast cancer patient survival and defines susceptibility to microtubule targeting agents Gerlinde Karbon , Manuel D. Haschka [...] Andreas Villunger Article | 13 December 2021 | Article number: 1151 |  doi: 10.1038/s41419-021-04415-y

Identification of an ASC oligomerization inhibitor for the treatment of inflammatory diseases Paula M. Soriano-Teruel , Guillermo García‑Laínez [...] Mar Orzáez Article | 13 December 2021 | Article number: 1155 |  doi: 10.1038/s41419-021-04420-1

HIF-1α-activated long non-coding RNA KDM4A-AS1 promotes hepatocellular carcinoma progression via the miR-411-5p/KPNA2/AKT pathway Tianxiang Chen , Runkun Liu [...] Qingguang Liu Article | 13 December 2021 | Article number: 1152 |  doi: 10.1038/s41419-021-04449-2

LncTRPM2-AS inhibits TRIM21-mediated TRPM2 ubiquitination and prevents autophagy-induced apoptosis of macrophages in asthma Xiaoping Li , Wenwen Wang [...] Jinping Zhang Article | 13 December 2021 | Article number: 1153 |  doi: 10.1038/s41419-021-04437-6

Rho-GEF Trio regulates osteosarcoma progression and osteogenic differentiation through Rac1 and RhoA Junyi Wang , Lichan Yuan [...] Junqing Ma Article | 11 December 2021 | Article number: 1148 |  doi: 10.1038/s41419-021-04448-3

Circulating miR-184 is a potential predictive biomarker of cardiac damage in Anderson–Fabry disease Irene Salamon , Elena Biagini [...] Gianluigi Condorelli Article | 11 December 2021 | Article number: 1150 |  doi: 10.1038/s41419-021-04438-5

CD82 protects against glaucomatous axonal transport deficits via mTORC1 activation in mice Meng Ye , Jingqiu Huang [...] Yin Zhao Article | 11 December 2021 | Article number: 1149 |  doi: 10.1038/s41419-021-04445-6

HMGA1 stimulates MYH9-dependent ubiquitination of GSK-3β via PI3K/Akt/c-Jun signaling to promote malignant progression and chemoresistance in gliomas Tianshi Que , Haojie Zheng [...] Guanglong Huang Article | 10 December 2021 | Article number: 1147 |  doi: 10.1038/s41419-021-04440-x

Retraction Note to: Schnurri-3 regulates BMP9-induced osteogenic differentiation and angiogenesis of human amniotic mesenchymal stem cells through Runx2 and VEGF Yuwan Li , Ziming Liu [...] Wei Huang Retraction | 09 December 2021 | Article number: 1144 |  doi: 10.1038/s41419-021-04443-8

Retraction Note: Alginate oligosaccharide attenuates α2,6- sialylation modification to inhibit prostate cancer cell growth via the Hippo/YAP pathway Yang Han , Lin Zhang [...] Shujing Wang Retraction | 09 December 2021 | Article number: 1143 |  doi: 10.1038/s41419-021-04425-w

Retraction Note to: LISPRO mitigates β-amyloid and associated pathologies in Alzheimer's mice Ahsan Habib , Darrell Sawmiller [...] Jun Tan Retraction | 09 December 2021 | Article number: 1142 |  doi: 10.1038/s41419-021-04444-7

Current landscape of tumor-derived exosomal ncRNAs in glioma progression, detection, and drug resistance Xiao He , Yiwei Qi [...] Qi Zhang Review Article | 09 December 2021 | Article number: 1145 |  doi: 10.1038/s41419-021-04430-z

Targeting of histone methyltransferase DOT1L plays a dual role in chemosensitization of retinoblastoma cells and enhances the efficacy of chemotherapy Yu Mao , Yu Sun [...] Jong Kyong Kim Article | 09 December 2021 | Article number: 1141 |  doi: 10.1038/s41419-021-04431-y

ETV5-mediated upregulation of lncRNA CTBP1-DT as a ceRNA facilitates HGSOC progression by regulating miR-188-5p/MAP3K3 axis Ping Liu , Ruiting Fu [...] Wei Jia Article | 09 December 2021 | Article number: 1146 |  doi: 10.1038/s41419-021-04256-9

Comprehensive transcriptomic characterization reveals core genes and module associated with immunological changes via 1619 samples of brain glioma Ying Zhang , Wenping Ma [...] Zheng Zhao Article | 08 December 2021 | Article number: 1140 |  doi: 10.1038/s41419-021-04427-8

FDI-6 inhibits the expression and function of FOXM1 to sensitize BRCA-proficient triple-negative breast cancer cells to Olaparib by regulating cell cycle progression and DNA damage repair Shu-Ping Wang , Shi-Qi Wu [...] Yun-Gen Xu Article | 08 December 2021 | Article number: 1138 |  doi: 10.1038/s41419-021-04434-9

Nucleolar stress controls mutant Huntington toxicity and monitors Huntington's disease progression Aynur Sönmez , Rasem Mustafa [...] Rosanna Parlato Article | 08 December 2021 | Article number: 1139 |  doi: 10.1038/s41419-021-04432-x

Rab35 and glucocorticoids regulate APP and BACE1 trafficking to modulate Aβ production Viktoriya Zhuravleva , João Vaz-Silva [...] Clarissa L. Waites Article | 08 December 2021 | Article number: 1137 |  doi: 10.1038/s41419-021-04433-w

TTK inhibition increases cisplatin sensitivity in high-grade serous ovarian carcinoma through the mTOR/autophagy pathway Gonghua Qi , Hanlin Ma [...] Beihua Kong Article | 07 December 2021 | Article number: 1135 |  doi: 10.1038/s41419-021-04429-6

Underlying mechanisms of glucocorticoid-induced β-cell death and dysfunction: a new role for glycogen synthase kinase 3 Etienne Delangre , Junjun Liu [...] Jamileh Movassat Article | 07 December 2021 | Article number: 1136 |  doi: 10.1038/s41419-021-04419-8

Oligodendrocytes depend on MCL-1 to prevent spontaneous apoptosis and white matter degeneration Abigail H. Cleveland , Alejandra Romero-Morales [...] Timothy R. Gershon Article | 06 December 2021 | Article number: 1133 |  doi: 10.1038/s41419-021-04422-z

Matrix stiffness modulates hepatic stellate cell activation into tumor-promoting myofibroblasts via E2F3-dependent signaling and regulates malignant progression Zhikui Liu , Huanye Mo [...] Nan Yang Article | 06 December 2021 | Article number: 1134 |  doi: 10.1038/s41419-021-04418-9

HP1a-mediated heterochromatin formation inhibits high dietary sugar-induced tumor progression Che-Wei Chang, Yu-Chia Shen & Shian-Jang Yan Article | 06 December 2021 | Article number: 1130 |  doi: 10.1038/s41419-021-04414-z

Exosomal long noncoding RNA HOXD-AS1 promotes prostate cancer metastasis via miR-361-5p/FOXM1 axis Yongming Jiang , Hui Zhao [...] Peng Gu Article | 04 December 2021 | Article number: 1129 |  doi: 10.1038/s41419-021-04421-0

Enriched environment and visual stimuli protect the retinal pigment epithelium and photoreceptors in a mouse model of non-exudative age-related macular degeneration Hernán H. Dieguez , Juan S. Calanni [...] Damián Dorfman Article | 04 December 2021 | Article number: 1128 |  doi: 10.1038/s41419-021-04412-1

Amino acid deprivation induces AKT activation by inducing GCN2/ATF4/REDD1 axis Hyeon-Ok Jin , Sung-Eun Hong [...] In-Chul Park Article | 03 December 2021 | Article number: 1127 |  doi: 10.1038/s41419-021-04417-w

LAMTOR5-AS1 regulates chemotherapy-induced oxidative stress by controlling the expression level and transcriptional activity of NRF2 in osteosarcoma cells Youguang Pu , Yiao Tan [...] Dabing Huang Article | 03 December 2021 | Article number: 1125 |  doi: 10.1038/s41419-021-04413-0

Hippo signaling suppresses tumor cell metastasis via a Yki-Src42A positive feedback loop Yan Ding , Guiping Wang [...] Zizhang Zhou Article | 03 December 2021 | Article number: 1126 |  doi: 10.1038/s41419-021-04423-y

Alpha-(1,6)-fucosyltransferase (FUT8) affects the survival strategy of osteosarcoma by remodeling TNF/NF-κB2 signaling Shanyi Lin , Lenian Zhou [...] Shumin Zhou Article | 02 December 2021 | Article number: 1124 |  doi: 10.1038/s41419-021-04416-x

Targeting SYK of monocyte-derived macrophages regulates liver fibrosis via crosstalking with Erk/Hif1α and remodeling liver inflammatory environment Xuejiao Chen , Ziyi Wang [...] Liyong Pu Article | 01 December 2021 | Article number: 1123 |  doi: 10.1038/s41419-021-04403-2

ALKBH5-mediated m6A demethylation of KCNK15-AS1 inhibits pancreatic cancer progression via regulating KCNK15 and PTEN/AKT signaling Yuan He , HongQin Yue [...] Chuang Chen Article | 01 December 2021 | Article number: 1121 |  doi: 10.1038/s41419-021-04401-4

Loss of DSTYK activates Wnt/β-catenin signaling and glycolysis in lung adenocarcinoma Chenxi Zhong , Ming Chen [...] Wentao Fang Article | 01 December 2021 | Article number: 1122 |  doi: 10.1038/s41419-021-04385-1

Cancer-associated fibroblast-derived exosomal miR-18b promotes breast cancer invasion and metastasis by regulating TCEAL7 Ziqian Yan , Zhimei Sheng [...] Baogang Zhang Article | 01 December 2021 | Article number: 1120 |  doi: 10.1038/s41419-021-04409-w

Chemotoxicity-induced exosomal lncFERO regulates ferroptosis and stemness in gastric cancer stem cells Haiyang Zhang , Meng Wang [...] Yi Ba Article | 29 November 2021 | Article number: 1116 |  doi: 10.1038/s41419-021-04406-z

Autophagy in Spinocerebellar ataxia type 2, a dysregulated pathway, and a target for therapy Adriana Marcelo , Inês T. Afonso [...] Clévio Nóbrega Article | 29 November 2021 | Article number: 1117 |  doi: 10.1038/s41419-021-04404-1

Nicotinamide promotes cardiomyocyte derivation and survival through kinase inhibition in human pluripotent stem cells Ya Meng , Chengcheng Song [...] Guokai Chen Article | 29 November 2021 | Article number: 1119 |  doi: 10.1038/s41419-021-04395-z

Decreased PRC2 activity supports the survival of basal-like breast cancer cells to cytotoxic treatments Iga K. Mieczkowska , Garyfallia Pantelaiou-Prokaki [...] Florian Wegwitz Article | 29 November 2021 | Article number: 1118 |  doi: 10.1038/s41419-021-04407-y

MICU3 regulates mitochondrial Ca2+-dependent antioxidant response in skeletal muscle aging Yun-Fei Yang , Wu Yang [...] Qian Xiao Article | 29 November 2021 | Article number: 1115 |  doi: 10.1038/s41419-021-04400-5

MORC protein family-related signature within human disease and cancer Huan Wang , Ling Zhang [...] Guiling Wang Review Article | 27 November 2021 | Article number: 1112 |  doi: 10.1038/s41419-021-04393-1

SLC25A1 promotes tumor growth and survival by reprogramming energy metabolism in colorectal cancer Ying Yang , Jiaxing He [...] Nan Wang Article | 27 November 2021 | Article number: 1108 |  doi: 10.1038/s41419-021-04411-2

ONECUT2 facilitates hepatocellular carcinoma metastasis by transcriptionally upregulating FGF2 and ACLY Danfei Liu , Tongyue Zhang [...] Limin Xia Article | 27 November 2021 | Article number: 1113 |  doi: 10.1038/s41419-021-04410-3

HER2-specific chimeric antigen receptor-T cells for targeted therapy of metastatic colorectal cancer Jie Xu , Qingtao Meng [...] Rui Chen Article | 27 November 2021 | Article number: 1109 |  doi: 10.1038/s41419-021-04100-0

MLK4 regulates DNA damage response and promotes triple-negative breast cancer chemoresistance Dawid Mehlich , Michał Łomiak [...] Anna A. Marusiak Article | 27 November 2021 | Article number: 1111 |  doi: 10.1038/s41419-021-04405-0

Initiation of hepatic stellate cell activation extends into chronic liver disease Vincent De Smet , Nathalie Eysackers [...] Leo A. van Grunsven Article | 27 November 2021 | Article number: 1110 |  doi: 10.1038/s41419-021-04377-1

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