Cell Death & Disease Contents: 28 Feb 2022

The latest research from Cell Death & Disease: 28. February 2022

CircCYP24A1 hampered malignant phenotype of renal cancer carcinoma through modulating CMTM-4 expression via sponging miR-421 Xiaorong Wu , Jiale Zhou [...] Wei Xue Article | 26 February 2022 | Article number: 190 |  doi: 10.1038/s41419-022-04623-0

Identification of Nanog as a novel inhibitor of Rad51 Ying Xin , Juanjuan Wang [...] Weiwei Zhang Article | 26 February 2022 | Article number: 193 |  doi: 10.1038/s41419-022-04644-9

Circ-PKD2 promotes Atg13-mediated autophagy by inhibiting miR-646 to increase the sensitivity of cisplatin in oral squamous cell carcinomas Ling Gao , Qian Zhang [...] Keqian Zhi Article | 26 February 2022 | Article number: 192 |  doi: 10.1038/s41419-021-04497-8

Dichotomy in hypoxia-induced mitochondrial fission in placental mesenchymal cells during development and preeclampsia: consequences for trophoblast mitochondrial homeostasis Taylor Gillmore , Abby Farrell [...] Isabella Caniggia Article | 26 February 2022 | Article number: 191 |  doi: 10.1038/s41419-022-04641-y

Oxethazaine inhibits esophageal squamous cell carcinoma proliferation and metastasis by targeting aurora kinase A Zhuo Bao , Ang Li [...] Kangdong Liu Article | 25 February 2022 | Article number: 189 |  doi: 10.1038/s41419-022-04642-x

Asparaginyl endopeptidase protects against podocyte injury in diabetic nephropathy through cleaving cofilin-1 Chuntao Lei , Mengran Li [...] Chun Zhang Article | 25 February 2022 | Article number: 184 |  doi: 10.1038/s41419-022-04621-2

Massive iron accumulation in PKAN-derived neurons and astrocytes: light on the human pathological phenotype Paolo Santambrogio , Maddalena Ripamonti [...] Sonia Levi Article | 25 February 2022 | Article number: 185 |  doi: 10.1038/s41419-022-04626-x

Salt-inducible kinases inhibitor HG-9-91-01 targets RIPK3 kinase activity to alleviate necroptosis-mediated inflammatory injury Dongxuan Huang , Pengfei Chen [...] Mengtao Cao Article | 25 February 2022 | Article number: 188 |  doi: 10.1038/s41419-022-04633-y

CCDC12 promotes tumor development and invasion through the Snail pathway in colon adenocarcinoma Fengying Du , Lipan Peng [...] Jizhun Zhang Article | 25 February 2022 | Article number: 187 |  doi: 10.1038/s41419-022-04617-y

Stathmin 1 is a biomarker for diagnosis of microvascular invasion to predict prognosis of early hepatocellular carcinoma Yongchao Cai , Yong Fu [...] Zhiying He Article | 24 February 2022 | Article number: 176 |  doi: 10.1038/s41419-022-04625-y

SF3B4 promotes ovarian cancer progression by regulating alternative splicing of RAD52 Yuchao Diao , Yingwei Li [...] Beihua Kong Article | 24 February 2022 | Article number: 179 |  doi: 10.1038/s41419-022-04630-1

PCLAF promotes neuroblastoma G1/S cell cycle progression via the E2F1/PTTG1 axis Xiaowei Liu , Yuanxia Cai [...] Zhixiang Wu Article | 24 February 2022 | Article number: 178 |  doi: 10.1038/s41419-022-04635-w

Targeting ferroptosis in acute kidney injury Lihua Ni, Cheng Yuan & Xiaoyan Wu Article | 24 February 2022 | Article number: 182 |  doi: 10.1038/s41419-022-04628-9

Single-cell analysis of skin immune cells reveals an Angptl4-ifi20b axis that regulates monocyte differentiation during wound healing Wei Kiat Jonathan Wee , Zun Siong Low [...] Nguan Soon Tan Article | 24 February 2022 | Article number: 180 |  doi: 10.1038/s41419-022-04638-7

M1 macrophage-derived exosomes and their key molecule lncRNA HOTTIP suppress head and neck squamous cell carcinoma progression by upregulating the TLR5/NF-κB pathway Huaili Jiang , Lei Zhou [...] Xinsheng Huang Article | 24 February 2022 | Article number: 183 |  doi: 10.1038/s41419-022-04640-z

SUMOylation of PDPK1 Is required to maintain glycolysis-dependent CD4 T-cell homeostasis Fei Sun , Fa-Xi Wang [...] Cong-Yi Wang Article | 24 February 2022 | Article number: 181 |  doi: 10.1038/s41419-022-04622-1

Latexin deficiency attenuates adipocyte differentiation and protects mice against obesity and metabolic disorders induced by high-fat diet Shuang Kan , Rong Li [...] Ming Chen Article | 24 February 2022 | Article number: 175 |  doi: 10.1038/s41419-022-04636-9

Cellular fractionation reveals transcriptome responses of human fibroblasts to UV-C irradiation Jiena Liu , Zhenzhen Wu [...] Yuming Wang Article | 24 February 2022 | Article number: 177 |  doi: 10.1038/s41419-022-04634-x

Cell surface nucleolin is a novel ADAMTS5 receptor mediating endothelial cell apoptosis Dogan Can Kirman , Bhuvanasundar Renganathan [...] Ruowen Ge Article | 23 February 2022 | Article number: 172 |  doi: 10.1038/s41419-022-04618-x

Numb-PRRL promotes TGF-β1- and EGF-induced epithelial-to-mesenchymal transition in pancreatic cancer Weiwei Sheng , Jingtong Tang [...] Ming Dong Article | 23 February 2022 | Article number: 173 |  doi: 10.1038/s41419-022-04609-y

SAPCD2 promotes neuroblastoma progression by altering the subcellular distribution of E2F7 Zi-Mu Zhang , Hai-Bo Cao [...] Jian Pan Article | 23 February 2022 | Article number: 174 |  doi: 10.1038/s41419-022-04624-z

FXR1 can bind with the CFIm25/CFIm68 complex and promote the progression of urothelial carcinoma of the bladder by stabilizing TRAF1 mRNA Minhua Deng , Ning Wang [...] Fangjian Zhou Article | 22 February 2022 | Article number: 170 |  doi: 10.1038/s41419-022-04614-1

Degradation of DRAK1 by CUL3/SPOP E3 Ubiquitin ligase promotes tumor growth of paclitaxel-resistant cervical cancer cells Kyoungwha Pang , Jihee Lee [...] Seong-Jin Kim Article | 22 February 2022 | Article number: 169 |  doi: 10.1038/s41419-022-04619-w

Encoding gene RAB3B exists in linear chromosomal and circular extrachromosomal DNA and contributes to cisplatin resistance of hypopharyngeal squamous cell carcinoma via inducing autophagy Changwei Lin , Yifei Chen [...] Yexun Song Article | 22 February 2022 | Article number: 171 |  doi: 10.1038/s41419-022-04627-w

Blocking iASPP/Nrf2/M-CSF axis improves anti-cancer effect of chemotherapy-induced senescence by attenuating M2 polarization Hao Liu , Dong Zhao [...] Ying Hu Article | 21 February 2022 | Article number: 166 |  doi: 10.1038/s41419-022-04611-4

Wnt signaling is boosted during intestinal regeneration by a CD44-positive feedback loop Romina J. Walter , Steffen J. Sonnentag [...] Véronique Orian-Rousseau Article | 21 February 2022 | Article number: 168 |  doi: 10.1038/s41419-022-04607-0

CircNEIL3 mediates pyroptosis to influence lung adenocarcinoma radiotherapy by upregulating PIF1 through miR-1184 inhibition Ting Zhang , Dong-Ming Wu [...] Ying Xu Article | 21 February 2022 | Article number: 167 |  doi: 10.1038/s41419-022-04561-x

Genome wide CRISPR/Cas9 screen identifies the coagulation factor IX (F9) as a regulator of senescence Paula Carpintero-Fernández , Michela Borghesan [...] Ana O'Loghlen Article | 19 February 2022 | Article number: 163 |  doi: 10.1038/s41419-022-04569-3

HOXA-AS2 contributes to regulatory T cell proliferation and immune tolerance in glioma through the miR-302a/KDM2A/JAG1 axis Chuanhong Zhong , Bei Tao [...] Xiaobo Yang Article | 18 February 2022 | Article number: 160 |  doi: 10.1038/s41419-021-04471-4

Targeting autophagy peptidase ATG4B with a novel natural product inhibitor Azalomycin F4a for advanced gastric cancer Lin Zhong , Bin Yang [...] Junjian Wang Article | 18 February 2022 | Article number: 161 |  doi: 10.1038/s41419-022-04608-z

PINK1-parkin-mediated neuronal mitophagy deficiency in prion disease Jie Li , Mengyu Lai [...] Lifeng Yang Article | 18 February 2022 | Article number: 162 |  doi: 10.1038/s41419-022-04613-2

Targeting CCL2-CCR4 axis suppress cell migration of head and neck squamous cell carcinoma Zihang Ling , Wei Li [...] Xiaoan Tao Article | 17 February 2022 | Article number: 158 |  doi: 10.1038/s41419-022-04610-5

Nanog mediated by FAO/ACLY signaling induces cellular dormancy in colorectal cancer cells Meng Zhang , Ruyi Peng [...] Jing Liu Article | 17 February 2022 | Article number: 159 |  doi: 10.1038/s41419-022-04606-1

CHCHD2 and CHCHD10 regulate mitochondrial dynamics and integrated stress response Yu Ruan , Jiaqiao Hu [...] Qinghua Zhou Article | 16 February 2022 | Article number: 156 |  doi: 10.1038/s41419-022-04602-5

Long non-coding ROR promotes the progression of papillary thyroid carcinoma through regulation of the TESC/ALDH1A1/TUBB3/PTEN axis Yuxia Fan , Xin Fan [...] Yang Yang Article | 16 February 2022 | Article number: 157 |  doi: 10.1038/s41419-021-04210-9

Induction of senescence-associated secretory phenotype underlies the therapeutic efficacy of PRC2 inhibition in cancer Liping Chu , Yuxiu Qu [...] Wei Qi Article | 15 February 2022 | Article number: 155 |  doi: 10.1038/s41419-022-04601-6

UBE2T-mediated Akt ubiquitination and Akt/β-catenin activation promotes hepatocellular carcinoma development by increasing pyrimidine metabolism Zhenru Zhu , Chuanhui Cao [...] Jingyuan Sun Article | 15 February 2022 | Article number: 154 |  doi: 10.1038/s41419-022-04596-0

The proton-activated G protein-coupled receptor GPR4 regulates the development of osteoarthritis via modulating CXCL12/CXCR7 signaling Rong Li , Zijing Guan [...] Jian Luo Article | 14 February 2022 | Article number: 152 |  doi: 10.1038/s41419-021-04455-4

Regulation of P53 signaling in breast cancer by the E3 ubiquitin ligase RNF187 Xin Li , Zhiguo Niu [...] Jian Zhu Article | 14 February 2022 | Article number: 149 |  doi: 10.1038/s41419-022-04604-3

The synergistic antitumor effect of IL-6 neutralization with NVP-BEZ235 in hepatocellular carcinoma Yao Wang , Xiaolong Miao [...] Weihua Gong Article | 14 February 2022 | Article number: 146 |  doi: 10.1038/s41419-022-04583-5

Fascin enhances the vulnerability of breast cancer to erastin-induced ferroptosis Cong Chen , Bojian Xie [...] Linbo Wang Article | 14 February 2022 | Article number: 150 |  doi: 10.1038/s41419-022-04579-1

MiR-652-5p elevated glycolysis level by targeting TIGAR in T-cell acute lymphoblastic leukemia Shan Liu , Haobiao Wang [...] Lin Zou Article | 14 February 2022 | Article number: 148 |  doi: 10.1038/s41419-022-04600-7

RIPK1-RIPK3 mediates myocardial fibrosis in type 2 diabetes mellitus by impairing autophagic flux of cardiac fibroblasts Shigang Qiao , Lei Hong [...] Huiling Zhang Article | 14 February 2022 | Article number: 147 |  doi: 10.1038/s41419-022-04587-1

DNAJB8 in small extracellular vesicles promotes Oxaliplatin resistance through TP53/MDR1 pathway in colon cancer Zheng Wang , Yi Li [...] Tongtong Zhang Article | 14 February 2022 | Article number: 151 |  doi: 10.1038/s41419-022-04599-x

Autolysosomes and caspase-3 control the biogenesis and release of immunogenic apoptotic exosomes Déborah Beillevaire , Francis Migneault [...] Marie-Josée Hébert Article | 11 February 2022 | Article number: 145 |  doi: 10.1038/s41419-022-04591-5

Ubiquitin-specific proteases in inflammatory bowel disease-related signalling pathway regulation Rirong Chen , Xiaobai Pang [...] Shenghong Zhang Review Article | 10 February 2022 | Article number: 139 |  doi: 10.1038/s41419-022-04566-6

Immune-responsive gene 1/itaconate activates nuclear factor erythroid 2-related factor 2 in microglia to protect against spinal cord injury in mice Libin Ni , Jian Xiao [...] Xiaolei Zhang Article | 10 February 2022 | Article number: 140 |  doi: 10.1038/s41419-022-04592-4

Early differential responses elicited by BRAFV600E in adult mouse models Giuseppe Bosso , Pablo Lanuza-Gracia [...] Maria A. Blasco Article | 10 February 2022 | Article number: 142 |  doi: 10.1038/s41419-022-04597-z

Genetic and pharmacological inhibition of XBP1 protects against APAP hepatotoxicity through the activation of autophagy Hui Ye , Chaobo Chen [...] Francisco Javier Cubero Article | 10 February 2022 | Article number: 143 |  doi: 10.1038/s41419-022-04580-8

Acquired temozolomide resistance in MGMTlow gliomas is associated with regulation of homologous recombination repair by ROCK2 Xin Zhang , Tao Li [...] Rong Hu Article | 10 February 2022 | Article number: 138 |  doi: 10.1038/s41419-022-04590-6

Blocking the human common beta subunit of the GM-CSF, IL-5 and IL-3 receptors markedly reduces hyperinflammation in ARDS models Hao Wang , Damon J. Tumes [...] Steven Bozinovski Article | 10 February 2022 | Article number: 137 |  doi: 10.1038/s41419-022-04589-z

ADRB3 induces mobilization and inhibits differentiation of both breast cancer cells and myeloid-derived suppressor cells Zhiling Zhou , Jiaxin Zhan [...] Meng Zheng Article | 10 February 2022 | Article number: 141 |  doi: 10.1038/s41419-022-04603-4

ALCAM regulates multiple myeloma chemoresistant side population Fangfang Wang , Zhang Dan [...] Yuhuan Zheng Article | 10 February 2022 | Article number: 136 |  doi: 10.1038/s41419-022-04556-8

Blockade of caspase cascade overcomes malaria-associated acute respiratory distress syndrome in mice Michelle K. Sercundes , Luana S. Ortolan [...] Sabrina Epiphanio Article | 10 February 2022 | Article number: 144 |  doi: 10.1038/s41419-022-04582-6

The regulation, function, and role of lipophagy, a form of selective autophagy, in metabolic disorders Sheng Zhang , Xueqiang Peng [...] Qing Fan Review Article | 08 February 2022 | Article number: 132 |  doi: 10.1038/s41419-022-04593-3

CUGBP1, a crucial factor for heart regeneration in mice Yang Liu , Huiwen Wang [...] Guangju Ji Article | 08 February 2022 | Article number: 120 |  doi: 10.1038/s41419-022-04570-w

Myocardin/microRNA-30a/Beclin1 signaling controls the phenotypic modulation of vascular smooth muscle cells by regulating autophagy Danyang Shi , Jinhua Ding [...] Nan Wang Article | 08 February 2022 | Article number: 121 |  doi: 10.1038/s41419-022-04588-0

Targeted activation of androgen receptor signaling in the periosteum improves bone fracture repair Kuo-Chung Lan , Kuo-Ting Wei [...] Hong-Yo Kang Article | 08 February 2022 | Article number: 123 |  doi: 10.1038/s41419-022-04595-1

Pharmacological inhibition of Ref-1 enhances the therapeutic sensitivity of papillary thyroid carcinoma to vemurafenib Linfei Hu , Jun Zhang [...] Ming Gao Article | 08 February 2022 | Article number: 124 |  doi: 10.1038/s41419-022-04550-0

PTBP3 modulates P53 expression and promotes colorectal cancer cell proliferation by maintaining UBE4A mRNA stability Canbin Xie , Fei Long [...] Changwei Lin Article | 08 February 2022 | Article number: 128 |  doi: 10.1038/s41419-022-04564-8

Inhibition of mitoNEET attenuates LPS-induced inflammation and oxidative stress Seunghee Lee , Byeong Geun Seok [...] Su Wol Chung Article | 08 February 2022 | Article number: 127 |  doi: 10.1038/s41419-022-04586-2

Methyl-CpG-binding domain protein 2 contributes to renal fibrosis through promoting polarized M1 macrophages Kai Ai , Jian Pan [...] Dongshan Zhang Article | 08 February 2022 | Article number: 125 |  doi: 10.1038/s41419-022-04577-3

Exosome-mediated miR-7-5p delivery enhances the anticancer effect of Everolimus via blocking MNK/eIF4E axis in non-small cell lung cancer Sile Liu , Weiyuan Wang [...] Songqing Fan Article | 08 February 2022 | Article number: 129 |  doi: 10.1038/s41419-022-04565-7

Stat4 rs7574865 polymorphism promotes the occurrence and progression of hepatocellular carcinoma via the Stat4/CYP2E1/FGL2 pathway Caie Wang , Na Gao [...] Hailing Qiao Article | 08 February 2022 | Article number: 130 |  doi: 10.1038/s41419-022-04584-4

Increased MCL-1 synthesis promotes irradiation-induced nasopharyngeal carcinoma radioresistance via regulation of the ROS/AKT loop Ying-Ying Liang , Fei-Yu Niu [...] Ya-Wei Yuan Article | 08 February 2022 | Article number: 131 |  doi: 10.1038/s41419-022-04551-z

Syntenin-1-mediated small extracellular vesicles promotes cell growth, migration, and angiogenesis by increasing onco-miRNAs secretion in lung cancer cells Okhwa Kim , Cheol Hwangbo [...] Jeong-Hyung Lee Article | 08 February 2022 | Article number: 122 |  doi: 10.1038/s41419-022-04594-2

LncRNA BC200/miR-150-5p/MYB positive feedback loop promotes the malignant proliferation of myelodysplastic syndrome Zhaoping Liu , Pan Wang [...] Ji Zhang Article | 08 February 2022 | Article number: 126 |  doi: 10.1038/s41419-022-04578-2

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