Cell Death & Disease Contents: 31 Mar 2022

The latest content from Cell Death & Disease: 31 March 2022

Reduced protection of RIPK3-deficient mice against influenza by matrix protein 2 ectodomain targeted active and passive vaccination strategies Teodora Oltean, Lorena Itati Ibanez [...] Peter Vandenabeele Article | 29 March 2022 | Article number: 280 |  doi: 10.1038/s41419-022-04710-2

Complement induces podocyte pyroptosis in membranous nephropathy by mediating mitochondrial dysfunction Hui Wang, Daoyuan Lv [...] Limin Li Article | 29 March 2022 | Article number: 281 |  doi: 10.1038/s41419-022-04737-5

Acox2 is a regulator of lysine crotonylation that mediates hepatic metabolic homeostasis in mice Yuan Zhang, Yuling Chen [...] Xiangyu Zhou Article | 29 March 2022 | Article number: 279 |  doi: 10.1038/s41419-022-04725-9

Bevacizumab attenuates osteosarcoma angiogenesis by suppressing MIAT encapsulated by serum-derived extracellular vesicles and facilitating miR-613-mediated GPR158 inhibition Bao-Dong Wang, Xiao-Jun Yu [...] Yang Cao Article | 28 March 2022 | Article number: 272 |  doi: 10.1038/s41419-022-04620-3

Fibroblast growth factor 20 attenuates pathological cardiac hypertrophy by activating the SIRT1 signaling pathway Yunjie Chen, Ning An [...] Xu Wang Article | 28 March 2022 | Article number: 276 |  doi: 10.1038/s41419-022-04724-w

Bone marrow mesenchymal stem cell-derived exosomal microRNA-381-3p alleviates vascular calcification in chronic kidney disease by targeting NFAT5 Yingjie Liu, Yan Guo [...] Weikang Guo Article | 28 March 2022 | Article number: 278 |  doi: 10.1038/s41419-022-04703-1

LPS/Bcl3/YAP1 signaling promotes Sox9+HNF4α+ hepatocyte-mediated liver regeneration after hepatectomy Changchun Shao, Yingying Jing [...] Lixin Wei Article | 28 March 2022 | Article number: 277 |  doi: 10.1038/s41419-022-04715-x

Osimertinib and anti-HER3 combination therapy engages immune dependent tumor toxicity via STING activation in trans J. M. Vicencio, R. Evans [...] T. Ng Article | 28 March 2022 | Article number: 274 |  doi: 10.1038/s41419-022-04701-3

Hepatic deficiency of selenoprotein S exacerbates hepatic steatosis and insulin resistance Lu Qiao, Lili Men [...] Jianling Du Article | 28 March 2022 | Article number: 275 |  doi: 10.1038/s41419-022-04716-w

Mesenchymal stem cells protect against ferroptosis via exosome-mediated stabilization of SLC7A11 in acute liver injury Feiyan Lin, Wenyi Chen [...] Hongcui Cao Article | 26 March 2022 | Article number: 271 |  doi: 10.1038/s41419-022-04708-w

Complex roles of nicotinamide N-methyltransferase in cancer progression Weixuan Wang, Changmei Yang [...] Haiteng Deng Review Article | 25 March 2022 | Article number: 267 |  doi: 10.1038/s41419-022-04713-z

Trefoil factor 3 promotes pancreatic carcinoma progression via WNT pathway activation mediated by enhanced WNT ligand expression Feifei Cheng, Xuejuan Wang [...] Peter E. Lobie Article | 25 March 2022 | Article number: 265 |  doi: 10.1038/s41419-022-04700-4

Pseudophosphatase STYX is induced by Helicobacter pylori and promotes gastric cancer progression by inhibiting FBXO31 function Jiansong Liu, Yichen Zang [...] Zhifang Liu Article | 25 March 2022 | Article number: 268 |  doi: 10.1038/s41419-022-04696-x

CircTHBS1 drives gastric cancer progression by increasing INHBA mRNA expression and stability in a ceRNA- and RBP-dependent manner Shengkui Qiu, Bowen Li [...] Zekuan Xu Article | 25 March 2022 | Article number: 266 |  doi: 10.1038/s41419-022-04720-0

STING agonist diABZI induces PANoptosis and DNA mediated acute respiratory distress syndrome (ARDS) Yasmine Messaoud-Nacer, Elodie Culerier [...] Dieudonnée Togbe Article | 25 March 2022 | Article number: 269 |  doi: 10.1038/s41419-022-04664-5

RBM47/SNHG5/FOXO3 axis activates autophagy and inhibits cell proliferation in papillary thyroid carcinoma Yuan Qin, Wei Sun [...] Hao Zhang Article | 25 March 2022 | Article number: 270 |  doi: 10.1038/s41419-022-04728-6

Single cell transcriptional diversity and intercellular crosstalk of human liver cancer Yan Meng, Yan Sang [...] Lixin Wei Article | 24 March 2022 | Article number: 261 |  doi: 10.1038/s41419-022-04689-w

HMGB3 promotes PARP inhibitor resistance through interacting with PARP1 in ovarian cancer Hanlin Ma, Gonghua Qi [...] Beihua Kong Article | 24 March 2022 | Article number: 263 |  doi: 10.1038/s41419-022-04670-7

Deficiency of N-glycanase 1 perturbs neurogenesis and cerebral development modeled by human organoids Victor J. T. Lin, Jiangnan Hu [...] Yu-Chieh Wang Article | 24 March 2022 | Article number: 262 |  doi: 10.1038/s41419-022-04693-0

Juxtamembrane 2 mimic peptide competitively inhibits mitochondrial trafficking and activates ROS-mediated apoptosis pathway to exert anti-tumor effects Dan He, Zhijie Ma [...] Haiyan Li Article | 24 March 2022 | Article number: 264 |  doi: 10.1038/s41419-022-04639-6

YTHDF1 upregulation mediates hypoxia-dependent breast cancer growth and metastasis through regulating PKM2 to affect glycolysis Xuemei Yao, Wei Li [...] Zhong Luo Article | 23 March 2022 | Article number: 258 |  doi: 10.1038/s41419-022-04711-1

GNG2 acts as a tumor suppressor in breast cancer through stimulating MRAS signaling Anjiang Zhao, Dan Li [...] Ling Li Article | 23 March 2022 | Article number: 260 |  doi: 10.1038/s41419-022-04690-3

Ferroptosis in oligodendrocyte progenitor cells mediates white matter injury after hemorrhagic stroke Danmin Shen, Weihua Wu [...] Qian Li Article | 23 March 2022 | Article number: 259 |  doi: 10.1038/s41419-022-04712-0

MiR-323a regulates ErbB3/EGFR and blocks gefitinib resistance acquisition in colorectal cancer Yuanzhou Zhang, Shunshun Liang [...] Xiaoying Luo Article | 22 March 2022 | Article number: 256 |  doi: 10.1038/s41419-022-04709-9

UPF1 contributes to the maintenance of endometrial cancer stem cell phenotype by stabilizing LINC00963 Hao Chen, Jian Ma [...] Xiaoxin Ma Article | 22 March 2022 | Article number: 257 |  doi: 10.1038/s41419-022-04707-x

Deficiency of thyroid hormone receptor protects retinal pigment epithelium and photoreceptors from cell death in a mouse model of age-related macular degeneration Hongwei Ma, Fan Yang & Xi-Qin Ding Article | 21 March 2022 | Article number: 255 |  doi: 10.1038/s41419-022-04691-2

BMP-7 ameliorates partial epithelial-mesenchymal transition by restoring SnoN protein level via Smad1/5 pathway in diabetic kidney disease Wei Peng, Xingcheng Zhou [...] Bing Guo Article | 21 March 2022 | Article number: 254 |  doi: 10.1038/s41419-022-04529-x

Amyloid β / PKC-dependent alterations in NMDA receptor composition are detected in early stages of Alzheimer´s disease Carolina Ortiz-Sanz, Uxue Balantzategi [...] Elena Alberdi Article | 19 March 2022 | Article number: 253 |  doi: 10.1038/s41419-022-04687-y

Pyruvate kinase L/R links metabolism dysfunction to neuroendocrine differentiation of prostate cancer by ZBTB10 deficiency Yu-Ching Wen, Wei-Yu Chen [...] Yen-Nien Liu Article | 19 March 2022 | Article number: 252 |  doi: 10.1038/s41419-022-04694-z

CMTM6 inhibits tumor growth and reverses chemoresistance by preventing ubiquitination of p21 in hepatocellular carcinoma Yue Huang, Yingqin Zhu [...] Jian Chuan Xia Article | 19 March 2022 | Article number: 251 |  doi: 10.1038/s41419-022-04676-1

Skp2 stabilizes Mcl-1 and confers radioresistance in colorectal cancer Xinfang Yu, Li Zhou [...] Haidan Liu Article | 18 March 2022 | Article number: 249 |  doi: 10.1038/s41419-022-04685-0

CircTMTC1 contributes to nasopharyngeal carcinoma progression through targeting miR-495-MET-eIF4G1 translational regulation axis Yajie Zhao, Chao Li [...] Zhanzhan Li Article | 18 March 2022 | Article number: 250 |  doi: 10.1038/s41419-022-04686-z

Therapeutic approaches targeting CD95L/CD95 signaling in cancer and autoimmune diseases Vesna Risso, Elodie Lafont & Matthieu Le Gallo Review Article | 17 March 2022 | Article number: 248 |  doi: 10.1038/s41419-022-04688-x

Dual BTK/SYK inhibition with CG-806 (luxeptinib) disrupts B-cell receptor and Bcl-2 signaling networks in mantle cell lymphoma Elana Thieme, Tingting Liu [...] Alexey V. Danilov Article | 16 March 2022 | Article number: 246 |  doi: 10.1038/s41419-022-04684-1

Lon upregulation contributes to cisplatin resistance by triggering NCLX-mediated mitochondrial Ca2+ release in cancer cells Vidhya Tangeda, Yu Kang Lo [...] Jang-Yang Chang Article | 16 March 2022 | Article number: 241 |  doi: 10.1038/s41419-022-04668-1

Transcriptional control of retinal ganglion cell death after axonal injury Stephanie B. Syc-Mazurek, Hongtian Stanley Yang [...] Richard T. Libby Article | 16 March 2022 | Article number: 244 |  doi: 10.1038/s41419-022-04666-3

Erythropoietin promotes M2 macrophage phagocytosis of Schwann cells in peripheral nerve injury Prem Kumar Govindappa & John C. Elfar Article | 16 March 2022 | Article number: 245 |  doi: 10.1038/s41419-022-04671-6

Hepatic stellate cell mediates transcription of TNFSF14 in hepatocellular carcinoma cells via H2S/CSE-JNK/JunB signaling pathway Yanan Ma, Shanshan Wang [...] Huiguo Ding Article | 15 March 2022 | Article number: 238 |  doi: 10.1038/s41419-022-04678-z

ARL6IP5 reduces cisplatin-resistance by suppressing DNA repair and promoting apoptosis pathways in ovarian carcinoma Ji-Ye Kim, Entaz Bahar [...] Hyun-Soo Kim Article | 15 March 2022 | Article number: 239 |  doi: 10.1038/s41419-022-04568-4

Dopamine D3 receptor signaling alleviates mouse rheumatoid arthritis by promoting Toll-like receptor 4 degradation in mast cells Biao Wang, Xueyi Li [...] Li Xue Article | 15 March 2022 | Article number: 240 |  doi: 10.1038/s41419-022-04695-y

Rubicon-deficiency sensitizes mice to mixed lineage kinase domain-like (MLKL)-mediated kidney ischemia-reperfusion injury Wulf Tonnus, Sophie Locke [...] Andreas Linkermann Article | 14 March 2022 | Article number: 236 |  doi: 10.1038/s41419-022-04682-3

An integrated bioinformatic investigation of mitochondrial solute carrier family 25 (SLC25) in colon cancer followed by preliminary validation of member 5 (SLC25A5) in tumorigenesis Yan-Jie Chen, Wei-Feng Hong [...] Li Liang Article | 14 March 2022 | Article number: 237 |  doi: 10.1038/s41419-022-04692-1

Hypoxia-induced long noncoding RNA NR2F1-AS1 maintains pancreatic cancer proliferation, migration, and invasion by activating the NR2F1/AKT/mTOR axis Yanqing Liu, Shiyu Chen [...] Chengyi Sun Article | 14 March 2022 | Article number: 232 |  doi: 10.1038/s41419-022-04669-0

Plasma proteomic and metabolomic characterization of COVID-19 survivors 6 months after discharge Hongwei Li, Xue Li [...] Huaiyong Chen Article | 14 March 2022 | Article number: 235 |  doi: 10.1038/s41419-022-04674-3

Global profiling reveals common and distinct N6-methyladenosine (m6A) regulation of innate immune responses during bacterial and viral infections Jian Feng, Teng Zhang [...] Shou-Jiang Gao Article | 14 March 2022 | Article number: 234 |  doi: 10.1038/s41419-022-04681-4

Autophagy-associated circRNA circATG7 facilitates autophagy and promotes pancreatic cancer progression Zhiwei He, Kun Cai [...] Xiaowu Li Article | 14 March 2022 | Article number: 233 |  doi: 10.1038/s41419-022-04677-0

YTHDF1 promotes breast cancer cell growth, DNA damage repair and chemoresistance Yu Sun, Dan Dong [...] Chenghai Zhao Article | 12 March 2022 | Article number: 230 |  doi: 10.1038/s41419-022-04672-5

Fbxo45 facilitates pancreatic carcinoma progression by targeting USP49 for ubiquitination and degradation Linhui Wu, Ke Yu [...] Jia Ma Article | 12 March 2022 | Article number: 231 |  doi: 10.1038/s41419-022-04675-2

Retraction Note to: Matrine derivate MASM uncovers a novel function for ribosomal protein S5 in osteoclastogenesis and postmenopausal osteoporosis Xiao Chen, Xin Zhi [...] Jiacan Su Retraction | 11 March 2022 | Article number: 225 |  doi: 10.1038/s41419-022-04697-w

Super-enhancers and novel therapeutic targets in colorectal cancer Qian Liu, Lijuan Guo [...] Jimin Shao Review Article | 11 March 2022 | Article number: 228 |  doi: 10.1038/s41419-022-04673-4

Toll-like receptor 3 activation promotes joint degeneration in osteoarthritis Josef Stolberg-Stolberg, Annika Boettcher [...] Jessica Bertrand Article | 11 March 2022 | Article number: 224 |  doi: 10.1038/s41419-022-04680-5

Novel anti-apoptotic L-DOPA precursors SuperDopa and SuperDopamide as potential neuroprotective agents for halting/delaying progression of Parkinson's disease Tom Wiesen & Daphne Atlas Article | 11 March 2022 | Article number: 227 |  doi: 10.1038/s41419-022-04667-2

Oxidative phosphorylation promotes vascular calcification in chronic kidney disease Jia Shi, Yi Yang [...] Fan He Article | 11 March 2022 | Article number: 229 |  doi: 10.1038/s41419-022-04679-y

MESH1 knockdown triggers proliferation arrest through TAZ repression Tianai Sun, Chien-Kuang Cornelia Ding [...] Jen-Tsan Chi Article | 10 March 2022 | Article number: 221 |  doi: 10.1038/s41419-022-04663-6

Downregulation of TPX2 impairs the antitumor activity of CD8+ T cells in hepatocellular carcinoma Xiaochen Wang, Jianchu Wang [...] Xiaojie Lu Article | 10 March 2022 | Article number: 223 |  doi: 10.1038/s41419-022-04645-8

Retraction Note: OCT4 as a target of miR-34a stimulates p63 but inhibits p53 to promote human cell transformation W. L. Ng, G. Chen [...] Y. Wang Retraction | 09 March 2022 | Article number: 219 |  doi: 10.1038/s41419-022-04665-4

SGSM2 inhibits thyroid cancer progression by activating RAP1 and enhancing competitive RAS inhibition Xi Su, Dong Chen [...] Wei Wei Article | 09 March 2022 | Article number: 218 |  doi: 10.1038/s41419-022-04598-y

Bone marrow-independent adventitial macrophage progenitor cells contribute to angiogenesis Florian Kleefeldt, Berin Upcin [...] Süleyman Ergün Article | 09 March 2022 | Article number: 220 |  doi: 10.1038/s41419-022-04605-2

Tumor-derived extracellular vesicles shuttle c-Myc to promote gastric cancer growth and metastasis via the KCNQ1OT1/miR-556-3p/CLIC1 axis Bopei Li, Yeyang Chen [...] Junqiang Chen Article | 08 March 2022 | Article number: 217 |  doi: 10.1038/s41419-021-04446-5

Evolutionary history of the p53 family DNA-binding domain: insights from an Alvinella pompejana homolog Qiang Zhang, Dimitrios-Ilias Balourdas [...] Andreas C. Joerger Article | 07 March 2022 | Article number: 214 |  doi: 10.1038/s41419-022-04653-8

Plasma-activated medium induces ferroptosis by depleting FSP1 in human lung cancer cells Ara Jo, Jin Hee Bae [...] Jin Woong Chung Article | 07 March 2022 | Article number: 212 |  doi: 10.1038/s41419-022-04660-9

Melatonin abolished proinflammatory factor expression and antagonized osteoarthritis progression in vivo Shan-Chi Liu, Chun-Hao Tsai [...] Chih-Hsin Tang Article | 07 March 2022 | Article number: 215 |  doi: 10.1038/s41419-022-04656-5

Heterogeneity induced GZMA-F2R communication inefficient impairs antitumor immunotherapy of PD-1 mAb through JAK2/STAT1 signal suppression in hepatocellular carcinoma Yuxue Gao, Qingguo Xu [...] Tongwang Yang Article | 07 March 2022 | Article number: 213 |  doi: 10.1038/s41419-022-04654-7

Reducing N6AMT1-mediated 6mA DNA modification promotes breast tumor progression via transcriptional repressing cell cycle inhibitors Jiongyu Chen, Yixuan Zhuang [...] Donghong Zhang Article | 07 March 2022 | Article number: 216 |  doi: 10.1038/s41419-022-04661-8

ATG7-enhanced impaired autophagy exacerbates acute pancreatitis by promoting regulated necrosis via the miR-30b-5p/CAMKII pathway Liang Ji, Zhi-hong Wang [...] Gang Wang Article | 07 March 2022 | Article number: 211 |  doi: 10.1038/s41419-022-04657-4

Zeb1-induced metabolic reprogramming of glycolysis is essential for macrophage polarization in breast cancer Huimin Jiang, Huimin Wei [...] Shuang Yang Article | 04 March 2022 | Article number: 206 |  doi: 10.1038/s41419-022-04632-z

A drug repurposing strategy for overcoming human multiple myeloma resistance to standard-of-care treatment Katarina Chroma, Zdenek Skrott [...] Jiri Bartek Article | 04 March 2022 | Article number: 203 |  doi: 10.1038/s41419-022-04651-w

The pro-tumorigenic activity of p38γ overexpression in nasopharyngeal carcinoma De-Pei Yin, Yu-Fan Zheng [...] Ji-Sheng Liu Article | 04 March 2022 | Article number: 210 |  doi: 10.1038/s41419-022-04637-8

Enhanced pro-apoptosis gene signature following the activation of TAp63α in oocytes upon γ irradiation Niclas Fester, Elisabeth Zielonka [...] Volker Dötsch Article | 04 March 2022 | Article number: 204 |  doi: 10.1038/s41419-022-04659-2

The mmu_circRNA_37492/hsa_circ_0012138 function as potential ceRNA to attenuate obstructive renal fibrosis Xu Cheng, Kai Ai [...] Dongshan Zhang Article | 04 March 2022 | Article number: 207 |  doi: 10.1038/s41419-022-04612-3

Ionizing radiation-induced long noncoding RNA CRYBG3 regulates YAP/TAZ through mechanotransduction Lijun Zheng, Chenyu Luo [...] Lei Chang Article | 04 March 2022 | Article number: 209 |  doi: 10.1038/s41419-022-04650-x

Elevated nuclear localization of glycolytic enzyme TPI1 promotes lung adenocarcinoma and enhances chemoresistance Peng Liu, Si-Jia Sun [...] Hai-Xin Yuan Article | 04 March 2022 | Article number: 205 |  doi: 10.1038/s41419-022-04655-6

Leptin secreted from testicular microenvironment modulates hedgehog signaling to augment the endogenous function of Leydig cells Himanshu Arora, Rehana Qureshi [...] Ranjith Ramasamy Article | 04 March 2022 | Article number: 208 |  doi: 10.1038/s41419-022-04658-3

Metformin suppresses the growth of colorectal cancer by targeting INHBA to inhibit TGF-β/PI3K/AKT signaling transduction Qing Xiao, Jiani Xiao [...] Gang Yin Article | 02 March 2022 | Article number: 202 |  doi: 10.1038/s41419-022-04649-4

Extracellular ATP promotes breast cancer chemoresistance via HIF-1α signaling Hui Yang, Yue-Hang Geng [...] Xin-Xia Tian Article | 02 March 2022 | Article number: 199 |  doi: 10.1038/s41419-022-04647-6

Downregulation of MUC15 by miR-183-5p.1 promotes liver tumor-initiating cells properties and tumorigenesis via regulating c-MET/PI3K/AKT/SOX2 axis Tao Han, Hao Zheng [...] Ruoyu Wang Article | 02 March 2022 | Article number: 200 |  doi: 10.1038/s41419-022-04652-9

NEDD4L binds the proteasome and promotes autophagy and bortezomib sensitivity in multiple myeloma Xi Huang, Wen Cao [...] Zhen Cai Article | 02 March 2022 | Article number: 197 |  doi: 10.1038/s41419-022-04629-8

Molecular basis of apoptotic DNA fragmentation by DFF40 Hyun Ji Ha & Hyun Ho Park Article | 02 March 2022 | Article number: 198 |  doi: 10.1038/s41419-022-04662-7

Loss of function of BRCA1 promotes EMT in mammary tumors through activation of TGFβR2 signaling pathway Feng Bai, Chuying Wang [...] Xin-Hai Pei Article | 02 March 2022 | Article number: 195 |  doi: 10.1038/s41419-022-04646-7

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