Common Gamma-Chain Cytokines

Sino Biological Created for ignoble.experiment@arconati.us |  Web Version This is a paid advertisement.   The common gamma-chain cytokines signal through cytokine receptors that consist of the common cytokine receptor γ chain (γc/CD132/IL2RG). This family includes at least six short-chain cytokines: IL2, IL4, IL7, IL9, IL15, and IL21. Besides IL2RG, the γc family cytokine receptors include IL2RB (CD122), IL4R (CD124), IL7R (CD127), IL9R (CD129), and IL21R. The γc subunit binds with these different cytokine-specific receptor subunits to form unique heterodimeric receptors for IL4, IL7, IL9, and IL21, or heterotrimeric receptors for IL2 or IL15, respectively. This cytokine family generally activates three major signaling pathways (PI3K-Akt, RAS-MAPK, and JAK-STAT) to exert their central roles in regulating the development, survival, proliferation, differentiation, and function of cells in both the innate and adaptive immune systems. Currently, designer cytokines targeting this family have shown significant therapeutic potential in allergy, immunodeficiency, autoimmunity, and cancer. Sino Biological has developed a panel of high-quality recombinant γc family cytokines and receptor proteins and antibodies to support the study of this cytokine family.     Recombinant γc Family Cytokine & Receptor Proteins • Featured IL-21 Protein Human IL-21 Protein: 10584-HNAE   High-purity   Low-endotoxin   Tag-free   HPLC-verified > 95 % as determined by SEC-HPLC   Ability to induce Interferon-gamma secretion by human natural killer lymphoma NK-92 cells. Batch-to-batch Consistency • Featured IL-2 Protein Human IL-2 (11848-H08H) Rat IL-2 (80075-RNAE) Cell proliferation assay using CTLL2 cells. The ED50 is typically 1-5 ng/mL. Cell proliferation assay using CTLL2 cells. The ED50 is typically 0.5-3 ng/mL. • More Recommended Common Gamma-Chain Cytokines & Receptor Proteins Please visit #Sino Biological to search for these products. Molecule Catalog # Species Tag   IL4 11846-HNAE Human Native IL4 51084-MNAE Mouse Native     IL4R 10402-H08H Human C-His IL4R 80198-R08H Rat C-His     IL7 50217-MNAE Mouse Native IL7 80329-RNAE Rat Native     IL7R 10975-H08H Human C-His IL7R 50090-M08H Mouse C-His IL7R 80083-R08H Rat C-His IL7R 90332-C08H Cynomolgus C-His     IL9 11844-H08B Human C-His IL9 51302-M08B Mouse C-His IL9 80459-R08B Rat C-His     IL9R 80077-R08H Rat C-His     IL15 10360-H07E Human N-His IL15 10360-HNCE Human N-cleavage     IL15 & IL15RA CT094-H02H Human C-human IgG1-Fc IL15RA 18366-H02H1 Human C-human IgG1-Fc     Antibodies for γc Family Cytokines and Receptors Sino Biological has developed a comprehensive panel of antibodies targeting γc family cytokines and receptors, which can be used in ELISA, WB, FCM, Neutralization, IP, and IHC. Matched ELISA antibody pairs are also available. Search for All γc Family Cytokine & Receptor Proteins and Antibodies IL-2   IL-2Rα   IL-2Rβ   γc / IL-2Rγ   IL-4   IL-4R   IL-7   IL-7R   IL-9   IL-9R   IL-15   IL-15Rα   IL-21   IL-21R         U.S.A Sino Biological US Inc. order_us@sinobiologicalus.com Europe Sino Biological Europe GmbH order_eu@sinobiologicaleu.com Global Sino Biological, Inc. order@sinobiological.com About this email: Future will occasionally send emails from our business partners promoting products and services likely to be of interest to our readers. Unsubscribe  |    Privacy Policy Future US LLC © 1100 13th St. NW, Suite 1000, Washington, DC 20005