Cell Death & Disease Contents: 31 May 2022

The latest content from Cell Death & Disease: 31 May 2022

The Achilles' heel of cancer: targeting tumors via lysosome-induced immunogenic cell death Taritsa Iulianna, Neote Kuldeep & Fossel Eric Review Article | 30 May 2022 | Article number: 509 |  doi: 10.1038/s41419-022-04912-8

GBA1-dependent membrane glucosylceramide reprogramming promotes liver cancer metastasis via activation of the Wnt/β-catenin signalling pathway Zhidong Qiu, Xuehong Wang [...] Junfei Jin Article | 30 May 2022 | Article number: 508 |  doi: 10.1038/s41419-022-04968-6

Inhibiting multiple forms of cell death optimizes ganglion cells survival after retinal ischemia reperfusion injury Qiyu Qin, Naiji Yu [...] Min Chen Article | 30 May 2022 | Article number: 507 |  doi: 10.1038/s41419-022-04911-9

Exosomal circRNA BTG2 derived from RBP-J overexpressed-macrophages inhibits glioma progression via miR-25-3p/PTEN Lei Shi, Ying Cao [...] Guan Sun Article | 28 May 2022 | Article number: 506 |  doi: 10.1038/s41419-022-04908-4

PARP inhibitor olaparib enhances the efficacy of radiotherapy on XRCC2-deficient colorectal cancer cells Changjiang Qin, Zhiyu Ji [...] Xinming Song Article | 28 May 2022 | Article number: 505 |  doi: 10.1038/s41419-022-04967-7

Cell death regulation by MAMs: from molecular mechanisms to therapeutic implications in cardiovascular diseases Yiran E. Li, James R. Sowers [...] Jun Ren Review Article | 27 May 2022 | Article number: 504 |  doi: 10.1038/s41419-022-04942-2

FANCD2 maintains replication fork stability during misincorporation of the DNA demethylation products 5-hydroxymethyl-2'-deoxycytidine and 5-hydroxymethyl-2'-deoxyuridine María José Peña-Gómez, Paula Moreno-Gordillo [...] Iván V. Rosado Article | 27 May 2022 | Article number: 503 |  doi: 10.1038/s41419-022-04952-0

Card9 protects sepsis by regulating Ripk2-mediated activation of NLRP3 inflammasome in macrophages Zhen Xu, Daoqian Li [...] Tingting Wang Article | 26 May 2022 | Article number: 502 |  doi: 10.1038/s41419-022-04938-y

Blocking STAT3 signaling augments MEK/ERK inhibitor efficacy in esophageal squamous cell carcinoma Zhen-Yuan Zheng, Man-Yu Chu [...] Li-Yan Xu Article | 25 May 2022 | Article number: 496 |  doi: 10.1038/s41419-022-04941-3

FAT10 promotes chemotherapeutic resistance in pancreatic cancer by inducing epithelial-mesenchymal transition via stabilization of FOXM1 expression Jinfeng Zhu, Jiefeng Zhao [...] Rongfa Yuan Article | 25 May 2022 | Article number: 497 |  doi: 10.1038/s41419-022-04960-0

Trans-activation of eotaxin-1 by Brg1 contributes to liver regeneration Zhiwen Fan, Ming Kong [...] Xiaoping Zou Article | 25 May 2022 | Article number: 495 |  doi: 10.1038/s41419-022-04944-0

Inhibitory role of proguanil on the growth of bladder cancer via enhancing EGFR degradation and inhibiting its downstream signaling pathway to induce autophagy Di Xiao, Xin Hu [...] Xiaoping Yang Article | 25 May 2022 | Article number: 499 |  doi: 10.1038/s41419-022-04937-z

miR-188-3p targets skeletal endothelium coupling of angiogenesis and osteogenesis during ageing Wen-Zhen He, Mi Yang [...] Chang-Jun Li Article | 25 May 2022 | Article number: 494 |  doi: 10.1038/s41419-022-04902-w

Characterization of raloxifene as a potential pharmacological agent against SARS-CoV-2 and its variants Daniela Iaconis, Licia Bordi [...] Andrea R. Beccari Article | 25 May 2022 | Article number: 498 |  doi: 10.1038/s41419-022-04961-z

Dysfunction of the energy sensor NFE2L1 triggers uncontrollable AMPK signaling and glucose metabolism reprogramming Lu Qiu, Qiufang Yang [...] Yuanming Qi Article | 25 May 2022 | Article number: 501 |  doi: 10.1038/s41419-022-04917-3

Paclitaxel binds and activates C5aR1: A new potential therapeutic target for the prevention of chemotherapy-induced peripheral neuropathy and hypersensitivity reactions Laura Brandolini, Michele d'Angelo [...] Marcello Allegretti Article | 25 May 2022 | Article number: 500 |  doi: 10.1038/s41419-022-04964-w

GSDMEa-mediated pyroptosis is bi-directionally regulated by caspase and required for effective bacterial clearance in teleost Hang Xu, Shuai Jiang [...] Li Sun Article | 24 May 2022 | Article number: 491 |  doi: 10.1038/s41419-022-04896-5

DNAJC24 is a potential therapeutic target in hepatocellular carcinoma through affecting ammonia metabolism Guangtao Li, Yuchao He [...] Hua Guo Article | 24 May 2022 | Article number: 490 |  doi: 10.1038/s41419-022-04953-z

Nkx2.8 promotes chemosensitivity in bladder urothelial carcinoma via transcriptional repression of MDR1 Zhaohui Zhou, Longbin Xiong [...] Chunping Yu Article | 24 May 2022 | Article number: 492 |  doi: 10.1038/s41419-022-04947-x

Disruption of β-catenin-mediated negative feedback reinforces cAMP-induced neuronal differentiation in glioma stem cells Zhijie Chen, Yingqian Zhong [...] Ke Sai Article | 24 May 2022 | Article number: 493 |  doi: 10.1038/s41419-022-04957-9

m6A methylated EphA2 and VEGFA through IGF2BP2/3 regulation promotes vasculogenic mimicry in colorectal cancer via PI3K/AKT and ERK1/2 signaling Xin Liu, Hongjuan He [...] Qiong Wu Article | 21 May 2022 | Article number: 483 |  doi: 10.1038/s41419-022-04950-2

Antibiotic pretreatment attenuates liver ischemia–reperfusion injury by Farnesoid X receptor activation Hanyi Liu, Jinglin Wang [...] Haozhen Ren Article | 21 May 2022 | Article number: 484 |  doi: 10.1038/s41419-022-04955-x

Dedifferentiation-mediated stem cell niche maintenance in early-stage ductal carcinoma in situ progression: insights from a multiscale modeling study Joseph D. Butner, Prashant Dogra [...] Zhihui Wang Article | 21 May 2022 | Article number: 485 |  doi: 10.1038/s41419-022-04939-x

Integrin α3/α6 and αV are implicated in ADAM15-activated FAK and EGFR signalling pathway individually and promote non-small-cell lung cancer progression Jieqi Zhou, Anqi Wang [...] Zeyi Liu Article | 21 May 2022 | Article number: 486 |  doi: 10.1038/s41419-022-04928-0

FASN promotes lymph node metastasis in cervical cancer via cholesterol reprogramming and lymphangiogenesis Qiqiao Du, Pan Liu [...] Shuzhong Yao Article | 21 May 2022 | Article number: 488 |  doi: 10.1038/s41419-022-04926-2

PHF13 epigenetically activates TGFβ driven epithelial to mesenchymal transition Yating Sun, Dan Li [...] Wanhua Xie Article | 21 May 2022 | Article number: 487 |  doi: 10.1038/s41419-022-04940-4

WNT5A promotes the metastasis of esophageal squamous cell carcinoma by activating the HDAC7/SNAIL signaling pathway Yingtong Feng, Zhiqiang Ma [...] Xiaolong Yan Article | 20 May 2022 | Article number: 480 |  doi: 10.1038/s41419-022-04901-x

GLI1 activates pro-fibrotic pathways in myelofibrosis fibrocytes Taghi Manshouri, Ivo Veletic [...] Zeev Estrov Article | 20 May 2022 | Article number: 481 |  doi: 10.1038/s41419-022-04932-4

Cancer associated fibroblast–derived CCL5 promotes hepatocellular carcinoma metastasis through activating HIF1α/ZEB1 axis Haixu Xu, Jie Zhao [...] Qiong Xu Article | 20 May 2022 | Article number: 478 |  doi: 10.1038/s41419-022-04935-1

Kindlin-2 promotes Src-mediated tyrosine phosphorylation of androgen receptor and contributes to breast cancer progression Luyao Ma, Yeteng Tian [...] Ying Sun Article | 20 May 2022 | Article number: 482 |  doi: 10.1038/s41419-022-04945-z

Oncogenic circTICRR suppresses autophagy via binding to HuR protein and stabilizing GLUD1 mRNA in cervical cancer Tingjia Zhu, Yixuan Cen [...] Xinyu Wang Article | 20 May 2022 | Article number: 479 |  doi: 10.1038/s41419-022-04943-1

Oxidative stress induces meiotic defects of oocytes in a mouse psoriasis model ZhiQin Zhang, ShouBin Tang [...] ZhiQiang Yin Article | 19 May 2022 | Article number: 474 |  doi: 10.1038/s41419-022-04948-w

NF-κB-inducing kinase (NIK) is activated in pancreatic β-cells but does not contribute to the development of diabetes Peng Xiao, Tatiana Takiishi [...] Alessandra Kupper Cardozo Article | 19 May 2022 | Article number: 476 |  doi: 10.1038/s41419-022-04931-5

circ-Pank1 promotes dopaminergic neuron neurodegeneration through modulating miR-7a-5p/α-syn pathway in Parkinson's disease Qing Liu, Qiyao Li [...] Lei Wang Article | 19 May 2022 | Article number: 477 |  doi: 10.1038/s41419-022-04934-2

The aspartyl protease DDI2 drives adaptation to proteasome inhibition in multiple myeloma Mélanie Op, Sérgio T. Ribeiro [...] Fabio Martinon Article | 19 May 2022 | Article number: 475 |  doi: 10.1038/s41419-022-04925-3

TGF-β1/SH2B3 axis regulates anoikis resistance and EMT of lung cancer cells by modulating JAK2/STAT3 and SHP2/Grb2 signaling pathways Li-Na Wang, Zi-Teng Zhang [...] Shao-Qiang Wang Article | 19 May 2022 | Article number: 472 |  doi: 10.1038/s41419-022-04890-x

Programmed cell death in atherosclerosis and vascular calcification Min Li, Zhen-Wei Wang [...] Nai-Feng Liu Review Article | 18 May 2022 | Article number: 467 |  doi: 10.1038/s41419-022-04923-5

Macrophage migration inhibitory factor (MIF) acetylation protects neurons from ischemic injury Jin-Xia Hu, Wei-Jing Ma [...] Lei Li Article | 18 May 2022 | Article number: 466 |  doi: 10.1038/s41419-022-04918-2

Synovial mesenchymal progenitor derived aggrecan regulates cartilage homeostasis and endogenous repair capacity Roman J. Krawetz, Yiru Elizabeth Wu [...] Paul T. Salo Article | 18 May 2022 | Article number: 470 |  doi: 10.1038/s41419-022-04919-1

A novel 3'tRNA-derived fragment tRF-Val promotes proliferation and inhibits apoptosis by targeting EEF1A1 in gastric cancer Huaiping Cui, Han Li [...] Leping Li Article | 18 May 2022 | Article number: 471 |  doi: 10.1038/s41419-022-04930-6

AK2 is an AMP-sensing negative regulator of BRAF in tumorigenesis Hyunjoo Kim, Muhah Jeong [...] Yong-Keun Jung Article | 18 May 2022 | Article number: 469 |  doi: 10.1038/s41419-022-04921-7

Involvement of FSP1-CoQ10-NADH and GSH-GPx-4 pathways in retinal pigment epithelium ferroptosis Ming Yang, Michelle Grace Tsui [...] Amy Cheuk Yin Lo Article | 18 May 2022 | Article number: 468 |  doi: 10.1038/s41419-022-04924-4

CircLIFR suppresses hepatocellular carcinoma progression by sponging miR-624-5p and inactivating the GSK-3β/β-catenin signaling pathway Lei Yang, Wenliang Tan [...] Yajin Chen Article | 17 May 2022 | Article number: 464 |  doi: 10.1038/s41419-022-04887-6

piR-823 inhibits cell apoptosis via modulating mitophagy by binding to PINK1 in colorectal cancer Shuling Wang, Xiaoyu Jiang [...] Huiqing Jiang Article | 17 May 2022 | Article number: 465 |  doi: 10.1038/s41419-022-04922-6

Targeting the apoptosis pathway to treat tumours of the paediatric nervous system Marie-Claire Fitzgerald, Philip J. O'Halloran [...] Brona M. Murphy Review Article | 14 May 2022 | Article number: 460 |  doi: 10.1038/s41419-022-04900-y

m6A methylation mediates LHPP acetylation as a tumour aerobic glycolysis suppressor to improve the prognosis of gastric cancer Jian-Xian Lin, Ning-Zi Lian [...] Chang-Ming Huang Article | 14 May 2022 | Article number: 463 |  doi: 10.1038/s41419-022-04859-w

Sex differences in global metabolomic profiles of COVID-19 patients Rocio Diaz Escarcega, Pedram Honarpisheh [...] Andrey S. Tsvetkov Article | 14 May 2022 | Article number: 461 |  doi: 10.1038/s41419-022-04861-2

Mammalian eIF4E2-GSK3β maintains basal phosphorylation of p53 to resist senescence under hypoxia Lei Sun, He Yang [...] Min Zhang Article | 14 May 2022 | Article number: 459 |  doi: 10.1038/s41419-022-04897-4

Endothelial ETS1 inhibition exacerbate blood–brain barrier dysfunction in multiple sclerosis through inducing endothelial-to-mesenchymal transition Yan Luo, Hang Yang [...] Bo Hu Article | 14 May 2022 | Article number: 462 |  doi: 10.1038/s41419-022-04888-5

Which cell death modality wins the contest for photodynamic therapy of cancer? Tatiana Mishchenko, Irina Balalaeva [...] Dmitri V. Krysko Review Article | 13 May 2022 | Article number: 455 |  doi: 10.1038/s41419-022-04851-4

TARBP2-stablized SNHG7 regulates blood-brain barrier permeability by acting as a competing endogenous RNA to miR-17-5p/NFATC3 in Aβ-microenvironment Hao Ning, Lu Zhang [...] Teng Ma Article | 13 May 2022 | Article number: 457 |  doi: 10.1038/s41419-022-04920-8

DMDRMR promotes angiogenesis via antagonizing DAB2IP in clear cell renal cell carcinoma Yumeng Zhu, Xiaojun Liu [...] Shan Gao Article | 13 May 2022 | Article number: 456 |  doi: 10.1038/s41419-022-04898-3

RP1-59D14.5 triggers autophagy and represses tumorigenesis and progression of prostate cancer via activation of the Hippo signaling pathway Bing Zhong, Zexue Zhao & Xi Jiang Article | 13 May 2022 | Article number: 458 |  doi: 10.1038/s41419-022-04865-y

Tim-3+ decidual Mφs induced Th2 and Treg bias in decidual CD4+T cells and promoted pregnancy maintenance via CD132 Mengdie Li, Fengrun Sun [...] Meirong Du Article | 12 May 2022 | Article number: 454 |  doi: 10.1038/s41419-022-04899-2

Ferutinin induces osteoblast differentiation of DPSCs via induction of KLF2 and autophagy/mitophagy Jyotirindra Maity, Derek Barthels [...] Hiranmoy Das Article | 12 May 2022 | Article number: 452 |  doi: 10.1038/s41419-022-04903-9

UBR5 targets tumor suppressor CDC73 proteolytically to promote aggressive breast cancer Gang Xiang, Shuxuan Wang [...] Jing Yu Article | 12 May 2022 | Article number: 451 |  doi: 10.1038/s41419-022-04914-6

ADAM10-cleaved ephrin-A5 contributes to prostate cancer metastasis Chenchen Cai, Miaomiao Zhang [...] Shibao Li Article | 12 May 2022 | Article number: 453 |  doi: 10.1038/s41419-022-04893-8

Hexokinase 3 enhances myeloid cell survival via non-glycolytic functions Kristina Seiler, Magali Humbert [...] Bruce E. Torbett Article | 11 May 2022 | Article number: 448 |  doi: 10.1038/s41419-022-04891-w

Energy restriction induced SIRT6 inhibits microglia activation and promotes angiogenesis in cerebral ischemia via transcriptional inhibition of TXNIP Ming-Yu Song, Fang Yi [...] Wen-Ping Gu Article | 11 May 2022 | Article number: 449 |  doi: 10.1038/s41419-022-04866-x

TOPK/PBK is phosphorylated by ERK2 at serine 32, promotes tumorigenesis and is involved in sorafenib resistance in RCC Huimin Sun, Jianzhong Zheng [...] Chen Shao Article | 11 May 2022 | Article number: 450 |  doi: 10.1038/s41419-022-04909-3

Mitochondrial autophagy: molecular mechanisms and implications for cardiovascular disease Anqi Li, Meng Gao [...] Guohua Gong Review Article | 09 May 2022 | Article number: 444 |  doi: 10.1038/s41419-022-04906-6

Halting ErbB-2 isoforms retrograde transport to the nucleus as a new theragnostic approach for triple-negative breast cancer Santiago Madera, Franco Izzo [...] Rosalía I. Cordo Russo Article | 09 May 2022 | Article number: 447 |  doi: 10.1038/s41419-022-04855-0

DNA hypermethylation modification promotes the development of hepatocellular carcinoma by depressing the tumor suppressor gene ZNF334 Dapeng Sun, Xiaojie Gan [...] Weiping Zhou Article | 09 May 2022 | Article number: 446 |  doi: 10.1038/s41419-022-04895-6

FBXO2 targets glycosylated SUN2 for ubiquitination and degradation to promote ovarian cancer development Jing Ji, Jing Shen [...] Bin Liu Article | 07 May 2022 | Article number: 442 |  doi: 10.1038/s41419-022-04892-9

Circular RNA circVAMP3 promotes aerobic glycolysis and proliferation by regulating LDHA in renal cell carcinoma Jun Li, Qian Zhang [...] Jun Pang Article | 07 May 2022 | Article number: 443 |  doi: 10.1038/s41419-022-04863-0

CD4+ T cells are required to improve the efficacy of CIK therapy in non-small cell lung cancer Shaochuan Liu, Yuan Meng [...] Xiubao Ren Article | 06 May 2022 | Article number: 441 |  doi: 10.1038/s41419-022-04882-x

Glutathione prevents high glucose-induced pancreatic fibrosis by suppressing pancreatic stellate cell activation via the ROS/TGFβ/SMAD pathway Jitai Zhang, Juan Bai [...] Ming Li Article | 06 May 2022 | Article number: 440 |  doi: 10.1038/s41419-022-04894-7

Stage IV colon cancer patients without DENND2D expression benefit more from neoadjuvant chemotherapy Wen-juan Ma, Yukun Chen [...] Rong-xin Zhang Article | 06 May 2022 | Article number: 439 |  doi: 10.1038/s41419-022-04885-8

Single-cell characterization of malignant phenotypes and microenvironment alteration in retinoblastoma Cheng Wu, Jiaqi Yang [...] Zhi Xie Article | 06 May 2022 | Article number: 438 |  doi: 10.1038/s41419-022-04904-8

SAPAP3 regulates epileptic seizures involving GluN2A in post-synaptic densities Yanke Zhang, Junhong Wu [...] Xin Tian Article | 05 May 2022 | Article number: 437 |  doi: 10.1038/s41419-022-04876-9

The emerging role of ubiquitin-specific protease 20 in tumorigenesis and cancer therapeutics Qiong Li, Chanqi Ye [...] Jian Ruan Review Article | 04 May 2022 | Article number: 434 |  doi: 10.1038/s41419-022-04853-2

SP1-mediated up-regulation of lncRNA TUG1 underlines an oncogenic property in colorectal cancer Wei Liu, Jin Meng [...] Xiaoxia Li Article | 04 May 2022 | Article number: 433 |  doi: 10.1038/s41419-022-04805-w

Novel roles of RTN4 and CLIMP-63 in regulating mitochondrial structure, bioenergetics and apoptosis Rachel J. Carter, Mateus Milani [...] Shankar Varadarajan Article | 04 May 2022 | Article number: 436 |  doi: 10.1038/s41419-022-04869-8

KLF4 regulates TERT expression in alveolar epithelial cells in pulmonary fibrosis Hui Wang, Hongyang Xu [...] Jinghong Dai Article | 04 May 2022 | Article number: 435 |  doi: 10.1038/s41419-022-04886-7

Somatic FOXC1 insertion mutation remodels the immune microenvironment and promotes the progression of childhood acute lymphoblastic leukemia Yaping Wang, Xiaopeng Ma [...] Yongjun Fang Article | 03 May 2022 | Article number: 431 |  doi: 10.1038/s41419-022-04873-y

POU6F1 cooperates with RORA to suppress the proliferation of lung adenocarcinoma by downregulating HIF1A signaling pathway Wenjing Xiao, Wei Geng [...] Yang Jin Article | 03 May 2022 | Article number: 427 |  doi: 10.1038/s41419-022-04857-y

Single-cell transcriptome analysis reveals the immune heterogeneity and the repopulation of microglia by Hif1α in mice after spinal cord injury Jingyu Wang, Lintao Xu [...] Yongjian Zhu Article | 03 May 2022 | Article number: 432 |  doi: 10.1038/s41419-022-04864-z

HMGA1 positively regulates the microtubule-destabilizing protein stathmin promoting motility in TNBC cells and decreasing tumour sensitivity to paclitaxel Michela Sgubin, Silvia Pegoraro [...] Guidalberto Manfioletti Article | 03 May 2022 | Article number: 429 |  doi: 10.1038/s41419-022-04843-4

TDP43 promotes stemness of breast cancer stem cells through CD44 variant splicing isoforms Lu Guo, Hao Ke [...] Baowei Jiao Article | 03 May 2022 | Article number: 428 |  doi: 10.1038/s41419-022-04867-w

Types of necroinflammation, the effect of cell death modalities on sterile inflammation Anett Mázló, Viktória Jenei [...] Gábor Koncz Review Article | 02 May 2022 | Article number: 423 |  doi: 10.1038/s41419-022-04883-w

UHMK1 aids colorectal cancer cell proliferation and chemoresistance through augmenting IL-6/STAT3 signaling Xuedi Gao, Wenfang Bao [...] Yandong Li Article | 02 May 2022 | Article number: 424 |  doi: 10.1038/s41419-022-04877-8

Mxi1 participates in the progression of lung cancer via the microRNA-300/KLF9/GADD34 Axis Yujie Lei, Yunchao Huang [...] Xing Lin Article | 02 May 2022 | Article number: 425 |  doi: 10.1038/s41419-022-04778-w

The dual role of glioma exosomal microRNAs: glioma eliminates tumor suppressor miR-1298-5p via exosomes to promote immunosuppressive effects of MDSCs Yanhua Qi, Chuandi Jin [...] Gang Li Article | 02 May 2022 | Article number: 426 |  doi: 10.1038/s41419-022-04872-z

Mitochondrial calcium uptake regulates tumour progression in embryonal rhabdomyosarcoma Hsin Yao Chiu, Amos Hong Pheng Loh & Reshma Taneja Article | 30 April 2022 | Article number: 419 |  doi: 10.1038/s41419-022-04835-4

MEX3A promotes nasopharyngeal carcinoma progression via the miR-3163/SCIN axis by regulating NF-κB signaling pathway Xin-xin Xiang, Yong-liang Liu [...] Kai Xu Article | 30 April 2022 | Article number: 420 |  doi: 10.1038/s41419-022-04871-0

Deubiquitylase OTUD3 prevents Parkinson's disease through stabilizing iron regulatory protein 2 Fengju Jia, Hongchang Li [...] Lingqiang Zhang Article | 30 April 2022 | Article number: 418 |  doi: 10.1038/s41419-022-04704-0

GCN5-mediated regulation of pathological cardiac hypertrophy via activation of the TAK1-JNK/p38 signaling pathway Jia Li, Chenghui Yan [...] Yaling Han Article | 30 April 2022 | Article number: 421 |  doi: 10.1038/s41419-022-04881-y

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