Scientific Reports Biology Table of Contents e-alert: 4 August 2015

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04 August 2015      • Visit Scientific Reports • Submit your manuscript to Scientific Reports     Welcome to your Table of Contents e-alert for Scientific Reports         Nature Publishing Group offers a free open access funding support service to enable authors to discover and apply for article processing charge funding available to them. Visit our website for further advice on the funding options available, and guidance in approaching funders and institutions, or email openaccess@nature.com for more information.           Biological Sciences               Corrigendum: 3D-Printed Microfluidic Device for the Detection of Pathogenic Bacteria Using Size-based Separation in Helical Channel with Trapezoid Cross-Section ▶     Wonjae Lee, Donghoon Kwon, Woong Choi et al.                 Bioluminescent imaging of vaccinia virus infection in immunocompetent and immunodeficient rats as a model for human smallpox ▶     Qiang Liu, Changfa Fan, Shuya Zhou et al.     Due to the increasing concern of using smallpox virus as biological weapons for terrorist attack, there is renewed interest in studying the pathogenesis of human smallpox and …             Self-assembled Messenger RNA Nanoparticles (mRNA-NPs) for Efficient Gene Expression ▶     Hyejin Kim, Yongkuk Park, Jong Bum Lee     Although mRNA has several advantages over plasmid DNA when delivered into cells for gene expression, mRNA transfection is a very rare occurrence in gene delivery. This is mainly …             Corrigendum: A method for human teratogen detection by geometrically confined cell differentiation and migration ▶     Jiangwa Xing, Yi-Chin Toh, Shuoyu Xu et al.                 Chemokine polyreactivity of IL7Rα+CSF-1R+ lympho-myeloid progenitors in the developing fetal liver ▶     Katja Kajikhina, Fritz Melchers, Motokazu Tsuneto     In murine ontogeny, fetal liver is the major hemato- and B-lymphopoietic site until birth. Hematopoiesis develops in largely non-hematopoietic niches, which provide contacts, …             Improved canine exome designs, featuring ncRNAs and increased coverage of protein coding genes ▶     Bart J.G. Broeckx, Christophe Hitte, Frank Coopman et al.     By limiting sequencing to those sequences transcribed as mRNA, whole exome sequencing is a cost-efficient technique often used in disease-association studies. We developed two …             Corrigendum: Epidermal growth factor receptor subunit locations determined in hydrated cells with environmental scanning electron microscopy ▶     Diana B. Peckys, Jean-Pierre Baudoin, Magdalena Eder et al.                 Lack of Correlation Between Liver Tests Abnormalities and Trabectedin Efficacy in the Treatment of Soft Tissue Sarcoma: a Retrospective Study ▶     Bruno Vincenzi, Luciano Stumbo, Giuseppina Maltese et al.     Elevation in liver transaminases is common in patients treated with the marine antitumor agent trabectedin. However, the impact of trabectedin-related transaminase elevations on …             Copy number variation-based genome wide association study reveals additional variants contributing to meat quality in Swine ▶     Ligang Wang, Lingyang Xu, Xin Liu et al.     Pork quality is important both to the meat processing industry and consumers’ purchasing attitude. Copy number variation (CNV) is a burgeoning kind of variants that may influence …             Corrigendum: Diosgenin-induced cognitive enhancement in normal mice is mediated by 1,25D3-MARRS ▶     Chihiro Tohda, Young-A. Lee, Yukiori Goto et al.                 Corrigendum: Direct Identification of On-Bead Peptides Using Surface-Enhanced Raman Spectroscopic Barcoding System for High-Throughput Bioanalysis ▶     Homan Kang, Sinyoung Jeong, Yul Koh et al.                 Molecular architecture of silk fibroin of Indian golden silkmoth, Antheraea assama ▶     Adarsh Gupta K, Kazuei Mita, Kallare P. Arunkumar et al.     The golden silk spun by Indian golden silkmoth Antheraea assama, is regarded for its shimmering golden luster, tenacity and value as biomaterial. This report describes the gene …             The role of silicon in physiology of the medicinal plant (Lonicera japonica L.) under salt stress ▶     Zhao Gengmao, Li Shihui, Sun Xing et al.     Silicon(Si) is the only element which can enhance the resistance to multiple stresses. However, the role of silicon in medicinal plants under salt stress is not yet understood. …             Protease recognition sites in Bet v 1a are cryptic, explaining its slow processing relevant to its allergenicity ▶     Regina Freier, Elfriede Dall, Hans Brandstetter     Despite a high similarity with homologous protein families, only few proteins trigger an allergic immune response with characteristic TH2 polarization. This puzzling observation …             Density-dependent adjustment of inducible defenses ▶     Ralph Tollrian, Sonja Duggen, Linda C. Weiss et al.     Predation is a major factor driving evolution, and organisms have evolved adaptations increasing their survival chances. However, most defenses incur trade-offs between benefits …             Local-scale Partitioning of Functional and Phylogenetic Beta Diversity in a Tropical Tree Assemblage ▶     Jie Yang, Nathan G. Swenson, Guocheng Zhang et al.     The relative degree to which stochastic and deterministic processes underpin community assembly is a central problem in ecology. Quantifying local-scale phylogenetic and …             Potential Role of Acetyl-CoA Synthetase (acs) and Malate Dehydrogenase (mae) in the Evolution of the Acetate Switch in Bacteria and Archaea ▶     Elliott P. Barnhart, Marcella A. McClure, Kiki Johnson et al.     Although many Archaea have AMP-Acs (acetyl-coenzyme A synthetase) and ADP-Acs, the extant methanogenic genus Methanosarcina is the only identified Archaeal genus that can utilize …             Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles ▶     Troy D. Hubbard, Iain A. Murray, William H. Bisson et al.     Ligand activation of the aryl hydrocarbon (AHR) has profound effects upon the immunological status of the gastrointestinal tract, establishing and maintaining signaling networks, …             Eyes on words: A fixation-related fMRI study of the left occipito-temporal cortex during self-paced silent reading of words and pseudowords ▶     Sarah Schuster, Stefan Hawelka, Fabio Richlan et al.     The predominant finding of studies assessing the response of the left ventral occipito-temporal cortex (vOT) to familiar words and to unfamiliar, but pronounceable letter strings …             Sodium butyrate alleviates adipocyte inflammation by inhibiting NLRP3 pathway ▶     Xukai Wang, Gang He, Yan Peng et al.     Insulin resistance (IR) is a common feature of Type II diabetes, metabolic disorders, hypertension and other vascular diseases. Recent studies showed that obesity-induced …             Identification of a DYRK1A Inhibitor that Induces Degradation of the Target Kinase using Co-chaperone CDC37 fused with Luciferase nanoKAZ ▶     Rie Sonamoto, Isao Kii, Yuka Koike et al.     The protein kinase family includes attractive targets for drug development. Methods for screening of kinase inhibitors remain largely limited to in vitro catalytic assays. It has …             Performance comparison of four commercial human whole-exome capture platforms ▶     Daichi Shigemizu, Yukihide Momozawa, Testuo Abe et al.     Whole exome sequencing (WXS) is widely used to identify causative genetic mutations of diseases. However, not only have several commercial human exome capture platforms been …             Label-free single-cell protein quantification using a drop-based mix-and-read system ▶     Alireza Abbaspourrad, Huidan Zhang, Ye Tao et al.     Quantitative protein analysis of single cells is rarely achieved due to technical difficulties of detecting minute amounts of proteins present in one cell. We develop a …             Generation of a Homozygous Transgenic Rat Strain Stably Expressing a Calcium Sensor Protein for Direct Examination of Calcium Signaling ▶     Kornélia Szebényi, András Füredi, Orsolya Kolacsek et al.     In drug discovery, prediction of selectivity and toxicity require the evaluation of cellular calcium homeostasis. The rat is a preferred laboratory animal for pharmacology and …             Innate positive chemotaxis to pollen from crops and banker plants in predaceous biological control agents: towards new field lures? ▶     Shu Li, Xiaoling Tan, Nicolas Desneux et al.     Predator-prey interactions form the core of biological control of arthropod pests. Which tools can be used to monitor and collect carnivorous arthropods in natural habitats and …             Csk-Induced Phosphorylation of Src at Tyrosine 530 is Essential for H2O2-Mediated Suppression of ERK1/2 in Human Umbilical Vein Endothelial Cells ▶     Bo Kyung Jeon, Kihwan Kwon, Jihee Lee Kang et al.     Mitogen-activated protein kinases (MAPKs) are key signal transducers involved in various cellular events such as growth, proliferation, and differentiation. Previous studies have …             Unsaturated fatty acids as high-affinity ligands of the C-terminal Per-ARNT-Sim domain from the Hypoxia-inducible factor 3α ▶     Angela M. Fala, Juliana F. Oliveira, Douglas Adamoski et al.     Hypoxia-inducible transcription factors (HIF) form heterodimeric complexes that mediate cell responses to hypoxia. The oxygen-dependent stability and activity of the HIF-α …             Detection and Differentiation of Threonine- and Tyrosine-Monophosphorylated Forms of ERK1/2 by Capillary Isoelectric Focusing-Immunoassay ▶     Inga Kraus, Daniela Besong Agbo, Markus Otto et al.     The extracellular signal regulated kinases ERK1/2 play important roles in the regulation of diverse cellular functions and have been implicated in several human diseases. In …             BCRP and P-gp relay overexpression in triple negative basal-like breast cancer cell line: a prospective role in resistance to Olaparib ▶     Robin Dufour, Pierre Daumar, Emmanuelle Mounetou et al.     The triple negative basal-like (TNBL) breast carcinoma is an aggressive and unfavorable prognosis disease. Inhibitors of poly(ADP-ribose) polymerase such as Olaparib could …             Erratum: Identification of the gene defect responsible for severe hypercholesterolaemia using whole-exome sequencing ▶     Li-Yuan Sun, Yong-Biao Zhang, Long Jiang et al.                 Akt2 knock-down reveals its contribution to human lung cancer cell proliferation, growth, motility, invasion and endothelial cell tube formation ▶     Samir Attoub, Kholoud Arafat, Nasseredine Kamel Hammadi et al.     The Akt/PKB serine/threonine protein kinase consists of three isoforms: Akt-1, −2 and −3. Their overexpression has been detected in human cancers, but their roles in cancer …             Corrigendum: DW-F5: A novel formulation against malignant melanoma from Wrightia tinctoria ▶     Jayesh Antony, Minakshi Saikia, Vinod. V et al.                 Erratum: Effects of time delay and space on herbivore dynamics: linking inducible defenses of plants to herbivore outbreak ▶     Gui-Quan Sun, Su-Lan Wang, Qian Ren et al.                 Corrigendum: Simultaneous submicrometric 3D imaging of the micro-vascular network and the neuronal system in a mouse spinal cord ▶     Michela Fratini, Inna Bukreeva, Gaetano Campi et al.                 A computer-designed scaffold for bone regeneration within cranial defect using human dental pulp stem cells ▶     Doo Yeon Kwon, Jin Seon Kwon, Seung Hun Park et al.     A computer-designed, solvent-free scaffold offer several potential advantages such as ease of customized manufacture and in vivo safety. In this work, we firstly used a …             The de novo synthesis of ubiquitin: identification of deubiquitinases acting on ubiquitin precursors ▶     Cláudia P. Grou, Manuel P. Pinto, Andreia V. Mendes et al.     Protein ubiquitination, a major post-translational modification in eukaryotes, requires an adequate pool of free ubiquitin. Cells maintain this pool by two pathways, both …             YIP1 family member 4 (YIPF4) is a novel cellular binding partner of the papillomavirus E5 proteins ▶     Marietta Müller, Christopher W. Wasson, Ramya Bhatia et al.     E5 proteins are amongst the least understood of the Human Papillomavirus (HPV) encoded gene products. They are small, membrane-integrated proteins known to modulate a number of …             Ion channel gene expression predicts survival in glioma patients ▶     Rong Wang, Christopher I. Gurguis, Wanjun Gu et al.     Ion channels are important regulators in cell proliferation, migration, and apoptosis. The malfunction and/or aberrant expression of ion channels may disrupt these important …             Tailored delivery of analgesic ziconotide across a blood brain barrier model using viral nanocontainers ▶     Prachi Anand, Alison O’Neil, Emily Lin et al.     The blood brain barrier (BBB) is often an insurmountable obstacle for a large number of candidate drugs, including peptides, antibiotics, and chemotherapeutic agents. Devising an …             The heat shock response restricts virus infection in Drosophila ▶     Sarah H. Merkling, Gijs J. Overheul, Joël T. van Mierlo et al.     Innate immunity is the first line of defence against pathogens and is essential for survival of the infected host. The fruit fly Drosophila melanogaster is an emerging model to …             Establishment of a new OSCC cell line derived from OLK and identification of malignant transformation-related proteins by differential proteomics approach ▶     Yan Dong, Qun Zhao, Xiaoyan Ma et al.     Oral squamous cell carcinoma (OSCC) is usually preceded by the oral premalignant lesions, mainly oral leukoplakia (OLK) after repeated insults of carcinogens, tobacco. B(a)P and …             Coarse-grained molecular dynamics studies of the translocation mechanism of polyarginines across asymmetric membrane under tension ▶     XiaoCong He, Min Lin, BaoYong Sha et al.     Understanding interactions between cell-penetrating peptides and biomembrane under tension can help improve drug delivery and elucidate mechanisms underlying fundamental cellular …             Formulation of Biologically-Inspired Silk-Based Drug Carriers for Pulmonary Delivery Targeted for Lung Cancer ▶     Sally Yunsun Kim, Deboki Naskar, Subhas C. Kundu et al.     The benefits of using silk fibroin, a major protein in silk, are widely established in many biomedical applications including tissue regeneration, bioactive coating and in vitro …             Erratum: The up-scaling of ecosystem functions in a heterogeneous world ▶     Andrew M. Lohrer, Simon F. Thrush, Judi E. Hewitt et al.                 The relationship between nociceptive brain activity, spinal reflex withdrawal and behaviour in newborn infants ▶     Caroline Hartley, Sezgi Goksan, Ravi Poorun et al.     Measuring infant pain is complicated by their inability to describe the experience. While nociceptive brain activity, reflex withdrawal and facial grimacing have been …             Stochasticity and Spatial Interaction Govern Stem Cell Differentiation Dynamics ▶     Quinton Smith, Evgeny Stukalin, Sravanti Kusuma et al.     Stem cell differentiation underlies many fundamental processes such as development, tissue growth and regeneration, as well as disease progression. Understanding how stem cell …             Trade-off between allocation to reproductive ramets and rhizome buds in Carex brevicuspis populations along a small-scale elevational gradient ▶     Xin-sheng Chen, Ya-fang Li, Yong-hong Xie et al.     The trade-off between allocation to sexual and clonal reproduction in clonal plants is influenced by a variety of environmental factors; however, it has rarely been examined …             Glass is a Viable Substrate for Precision Force Microscopy of Membrane Proteins ▶     Nagaraju Chada, Krishna P. Sigdel, Raghavendar Reddy Sanganna Gari et al.     Though ubiquitous in optical microscopy, glass has long been overlooked as a specimen supporting surface for high resolution atomic force microscopy (AFM) investigations due to …             Erratum: A sensitised RNAi screen reveals a ch-TOG genetic interaction network required for spindle assembly ▶     Alexis R. Barr, Chris Bakal                 Erratum: Structural and Dynamic Features of F-recruitment Site Driven Substrate Phosphorylation by ERK2 ▶     Andrea Piserchio, Venkatesh Ramakrishan, Hsin Wang et al.                 Invasion Expansion: Time since introduction best predicts global ranges of marine invaders ▶     James E. Byers, Rachel S. Smith, James M. Pringle et al.     Strategies for managing biological invasions are often based on the premise that characteristics of invading species and the invaded environment are key predictors of the …             Insulin-degrading enzyme prevents α-synuclein fibril formation in a nonproteolytical manner ▶     Sandeep K. Sharma, Erik Chorell, Pär Steneberg et al.     The insulin-degrading enzyme (IDE) degrades amyloidogenic proteins such as Amyloid β (Αβ) and Islet Amyloid Polypeptide (IAPP), i.e. peptides associated with Alzheimer’s disease …             Generation-based life table analysis reveals manifold effects of inbreeding on the population fitness in Plutella xylostella ▶     Lu Peng, Mingmin Zou, Nana Ren et al.     Understanding how inbreeding affects fitness is biologically important for conservation and pest management. Despite being a worldwide pest of many economically important …             A Computational Model of Innate Directional Selectivity Refined by Visual Experience ▶     Samantha V. Adams, Christopher M. Harris     The mammalian visual system has been extensively studied since Hubel and Wiesel’s work on cortical feature maps in the 1960s. Feature maps representing the cortical neurons’ …             γ-Aminobutyric acid (GABA) administration improves action selection processes: a randomised controlled trial ▶     Laura Steenbergen, Roberta Sellaro, Ann-Kathrin Stock et al.     In order to accomplish a task goal, real-life environments require us to develop different action control strategies in order to rapidly react to fast-moving visual and auditory …             Discovery of Novel Inhibitors and Fluorescent Probe Targeting NAMPT ▶     Xia Wang, Tian-Ying Xu, Xin-Zhu Liu et al.     Nicotinamide phosphoribosyltransferase (NAMPT) is a promising antitumor target. Novel NAMPT inhibitors with diverse chemotypes are highly desirable for development of antitumor …             miR-628, a microRNA that is induced by Toll-like receptor stimulation, regulates porcine innate immune responses ▶     He Jun, He Ying, Chen Daiwen et al.     Mammalian innate and acquired immune responses involve a coordinated, sequential, and self limiting sequence of events controlled by positive and negative regulatory mechanism. …             Genome-wide whole blood microRNAome and transcriptome analyses reveal miRNA-mRNA regulated host response to foodborne pathogen Salmonella infection in swine ▶     Hua Bao, Arun Kommadath, Guanxiang Liang et al.     To understand the role of miRNAs in regulating genes involved in host response to bacterial infection and shedding of foodborne pathogens, a systematic profiling of miRNAs and …             The Folding process of Human Profilin-1, a novel protein associated with familial amyotrophic lateral sclerosis ▶     Edoardo Del Poggetto, Fabrizio Chiti, Francesco Bemporad     Human profilin-1 is a novel protein associated with a recently discovered form of familial amyotrophic lateral sclerosis. This urges the characterization of possible …             Molecular Signatures of Reduced Nerve Toxicity by CeCl3 in Phoxim-exposed Silkworm Brains ▶     Binbin Wang, Fanchi Li, Min Ni et al.     CeCl3 can reduce the damage caused by OP pesticides, in this study we used the brain of silkworms to investigate the mechanism of CeCl3 effects on pesticide resistance. The …             RD-1 encoded EspJ protein gets phosphorylated prior to affect the growth and intracellular survival of mycobacteria ▶     Pramod K Singh, Richa Saxena, Sameer Tiwari et al.     Mycobacterium tuberculosis (MTB) synchronizes a number of processes and controls a series of events to subvert host defense mechanisms for the sake of residing inside …             E-cadherin expression in macrophages dampens their inflammatory responsiveness in vitro, but does not modulate M2-regulated pathologies in vivo ▶     Jan Van den Bossche, Damya Laoui, Thomas Naessens et al.     IL-4/IL-13-induced alternatively activated macrophages (M(IL-4/IL-13), AAMs or M2) are known to express E-cadherin, enabling them to engage in heterotypic cellular interactions …             TRPA1 mediates the hypothermic action of acetaminophen ▶     Clive Gentry, David A. Andersson, Stuart Bevan     Acetaminophen (APAP) is an effective antipyretic and one of the most commonly used analgesic drugs. Unlike antipyretic non-steroidal anti-inflammatory drugs, APAP elicits …             MicroRNA-320a acts as a tumor suppressor by targeting BCR/ABL oncogene in chronic myeloid leukemia ▶     Zhu Xishan, Lin Ziying, Du Jing et al.     Accumulating evidences demonstrated that the induction of epithelial-mesenchymal transition (EMT) and aberrant expression of microRNAs (miRNAs) are associated with tumorigenesis, …             Corrigendum: An embryo of protocells: The capsule of graphene with selective ion channels ▶     Zhan Li, Chunmei Wang, Longlong Tian et al.                 Draft genome of the most devastating insect pest of coffee worldwide: the coffee berry borer, Hypothenemus hampei ▶     Fernando E. Vega, Stuart M. Brown, Hao Chen et al.     The coffee berry borer, Hypothenemus hampei, is the most economically important insect pest of coffee worldwide. We present an analysis of the draft genome of the coffee berry …             An indica rice genotype showed a similar yield enhancement to that of hybrid rice under free air carbon dioxide enrichment ▶     Chunwu Zhu, Xi Xu, Dan Wang et al.     Although the rice growth response to FACE (free-air CO2 enrichment) has been widely studied and is considered important within the scientific community, few studies have …             Simultaneously targeting inflammatory response and parasite sequestration in brain to treat Experimental Cerebral Malaria ▶     Chaitanya Dende, Jairam Meena, Perumal Nagarajan et al.     Malaria afflicts around 200 million people annually, with a mortality number close to 600,000. The mortality rate in Human Cerebral Malaria (HCM) is unacceptably high (15–20%), …             White butterflies as solar photovoltaic concentrators ▶     Katie Shanks, S. Senthilarasu, Richard H. ffrench-Constant et al.     Man’s harvesting of photovoltaic energy requires the deployment of extensive arrays of solar panels. To improve both the gathering of thermal and photovoltaic energy from the sun …             PPARγ stimulates expression of L-type amino acid and taurine transporters in human placentas: the evidence of PPARγ regulating fetal growth ▶     Zhaoguang Chen, Ping He, Xiaoying Ding et al.     Placental amino acid transporters and peroxisome proliferator-activated receptors (PPARs) have been implicated to placental development and therefore regulation of fetal growth. …             Chemical and Physical Characteristics of Doxorubicin Hydrochloride Drug-Doped Salmon DNA Thin Films ▶     Bramaramba Gnapareddy, Sreekantha Reddy Dugasani, Taewoo Ha et al.     Double-stranded salmon DNA (SDNA) was doped with doxorubicin hydrochloride drug molecules (DOX) to determine the binding between DOX and SDNA, and DOX optimum doping …             Gnathostoma spinigerum Mitochondrial Genome Sequence: a Novel Gene Arrangement and its Phylogenetic Position within the Class Chromadorea ▶     Guo-Hua Liu, Renfu Shao, Xian-Quan Cai et al.     Human gnathostomiasis is an emerging food-borne parasitic disease caused by nematodes in the genus Gnathostoma. In spite of their significance as pathogens, these parasites …             Modulation of influenza vaccine immune responses using an epidermal growth factor receptor kinase inhibitor ▶     Joanna A. Pulit-Penaloza, Bishu Sapkota, E. Stein Esser et al.     Systemic use of epidermal growth factor receptor inhibitors (EGFRIs) has been shown to alter MHC expression and that of several chemokines, and to enhance immune cell recruitment …             Prognostic role of the neutrophil-to-lymphocyte ratio in pancreatic cancer: a meta-analysis ▶     Hao Cheng, Feiwu Long, Mukesh Jaiswar et al.     The relationship between the neutrophil-to-lymphocyte ratio (NLR) and tumours as a prognostic factor has been reported in many studies. In this meta-analysis, we evaluated the …             Dual attenuation of proteasomal and autophagic BMAL1 degradation in Clock/+Δ19/+ mice contributes to improved glucose homeostasis ▶     Kwon Jeong, Baokun He, Kazunari Nohara et al.     Circadian clocks orchestrate essential physiology in response to various cues, yet their mechanistic and functional plasticity remains unclear. Here, we investigated ClockΔ19/+ …             Discriminative Learning for Automatic Staging of Placental Maturity via Multi-layer Fisher Vector ▶     Baiying Lei, Yuan Yao, Siping Chen et al.     Currently, placental maturity is performed using subjective evaluation, which can be unreliable as it is highly dependent on the observations and experiences of clinicians. To …             Transcriptional profiling of macrophages derived from monocytes and iPS cells identifies a conserved response to LPS and novel alternative transcription ▶     Kaur Alasoo, Fernando O. Martinez, Christine Hale et al.     Macrophages differentiated from human induced pluripotent stem cells (IPSDMs) are a potentially valuable new tool for linking genotype to phenotype in functional studies. …             Increased Acetylcholinesterase Expression in Bumble Bees During Neonicotinoid-Coated Corn Sowing ▶     Olivier Samson-Robert, Geneviève Labrie, Pierre-Luc Mercier et al.     While honey bee exposure to systemic insecticides has received much attention, impacts on wild pollinators have not been as widely studied. Neonicotinoids have been shown to …             Corrigendum: Differential gene retention as an evolutionary mechanism to generate biodiversity and adaptation in yeasts ▶     Guillaume Morel, Lieven Sterck, Dominique Swennen et al.                 Mixed Linear Model Approaches of Association Mapping for Complex Traits Based on Omics Variants ▶     Fu-Tao Zhang, Zhi-Hong Zhu, Xiao-Ran Tong et al.     Precise prediction for genetic architecture of complex traits is impeded by the limited understanding on genetic effects of complex traits, especially on gene-by-gene (GxG) and …             Rapid Column-Free Enrichment of Mononuclear Cells from Solid Tissues ▶     Steven D. Scoville, Karen A. Keller, Stephanie Cheng et al.     We have developed a rapid negative selection method to enrich rare mononuclear cells from human tissues. Unwanted and antibody-tethered cells are selectively depleted during a …             Histone H4 acetylation required for chromatin decompaction during DNA replication ▶     Kun Ruan, Takaharu G. Yamamoto, Haruhiko Asakawa et al.     Faithful DNA replication is a prerequisite for cell proliferation. Several cytological studies have shown that chromosome structures alter in the S-phase of the cell cycle. …             Corrigendum: Single Fluorescence Channel-based Multiplex Detection of Avian Influenza Virus by Quantitative PCR with Intercalating Dye ▶     Christian D. Ahrberg, Andreas Manz, Pavel Neuzil                 Erratum: Tumor Invasion Optimization by Mesenchymal-Amoeboid Heterogeneity ▶     Inbal Hecht, Yasmin Bar-El, Frederic Balmer et al.                 Erratum: Unraveling novel TF-miRNA regulatory crosstalk in metastasis of Soft Tissue Sarcoma ▶     Devyani Samantarrai, Mousumi Sahu, Jyoti Roy et al.                 First mitochondrial genome for the red crab (Charybdis feriata) with implication of phylogenomics and population genetics ▶     Hongyu Ma, Chunyan Ma, Chenhong Li et al.     In this study, we first described the complete mitochondrial genome for the red crab (Charybdis feriata), elucidated its phylogenetic relationship among 20 species within …             Genome-wide construction of a series of designed segmental aneuploids in Saccharomyces cerevisiae ▶     Waranya Natesuntorn, Kotaro Iwami, Yuki Matsubara et al.     Segmental aneuploidy can play an important role in environmental adaptation. However, study of segmental aneuploids is severely hampered by the difficulty of creating them in a …             Biochemical nature of Russell Bodies ▶     Maria Francesca Mossuto, Diletta Ami, Tiziana Anelli et al.     Professional secretory cells produce and release abundant proteins. Particularly in case of mutations and/or insufficient chaperoning, these can aggregate and become toxic within …             Temporal processing in the auditory brainstem response by full-term 6-week- and 9-month-old infants ▶     Xiaoqin Mai, Twila Tardif, Lin Xu et al.     Early auditory temporal processing abilities are important for language acquisition and for later reading abilities. In the present study, auditory brainstem responses (ABRs) …             Comparative analysis of essential genes in prokaryotic genomic islands ▶     Xi Zhang, Chong Peng, Ge Zhang et al.     Essential genes are thought to encode proteins that carry out the basic functions to sustain a cellular life, and genomic islands (GIs) usually contain clusters of horizontally …             Selective Generation of Dopaminergic Precursors from Mouse Fibroblasts by Direct Lineage Conversion ▶     Changhai Tian, Yuju Li, Yunlong Huang et al.     Degeneration of midbrain dopaminergic (DA) neurons is a key pathological event of Parkinson’s disease (PD). Limited adult dopaminergic neurogenesis has led to novel therapeutic …             Orexin receptors exert a neuroprotective effect in Alzheimer’s disease (AD) via heterodimerization with GPR103 ▶     Julie Davies, Jing Chen, Ryan Pink et al.     Orexins are neuropeptides that regulate the sleep-wake cycle and feeding behaviour. QRFP is a newly discovered neuropeptide which exerts similar orexigenic activity, thus playing …             Identification and characterization of a novel ISG15-ubiquitin mixed chain and its role in regulating protein homeostasis ▶     Jun-Bao Fan, Kei-lchiro Arimoto, Khatereh Motamedchaboki et al.     As a ubiquitin-like modifier, ISG15 is conjugated to many cellular proteins in a process termed protein ISGylation. However, the crosstalk between protein ISGylation and the …             Activation of TRESK channels by the inflammatory mediator lysophosphatidic acid balances nociceptive signalling ▶     Sina Kollert, Benjamin Dombert, Frank Döring et al.     In dorsal root ganglia (DRG) neurons TRESK channels constitute a major current component of the standing outward current IKSO. A prominent physiological role of TRESK has been …             Small molecule and RNAi induced phenotype transition of expanded and primary colonic epithelial cells ▶     Jutta Sharbati, Carlos Hanisch, Robert Pieper et al.     Recent progress in mammalian intestinal epithelial cell culture led to novel concepts of tissue modeling. Especially the development of phenotypically stable cell lines from …             Antiviral Phosphorodiamidate Morpholino Oligomers are Protective against Chikungunya Virus Infection on Cell-based and Murine Models ▶     Shirley Lam, Huixin Chen, Caiyun Karen Chen et al.     Chikungunya virus (CHIKV) infection in human is associated with debilitating and persistent arthralgia and arthritis. Currently, there is no specific vaccine or effective …             Functional diversity and properties of multiple xylanases from Penicillium oxalicum GZ-2 ▶     Hanpeng Liao, Haiping Zheng, Shuixian Li et al.     A multiple xylanase system with high levels of xylanase activity produced from Penicillium oxalicum GZ-2 using agricultural waste as a substrate has been previously reported. …             Volatile organic compounds in truffle (Tuber magnatum Pico): comparison of samples from different regions of Italy and from different seasons ▶     Vita Federico, Taiti Cosimo, Pompeiano Antonio et al.     In this paper volatile organic compounds (VOCs) from Tuber magnatum fruiting bodies were analyzed using a PTR-TOF-MS instrument. The aim was to characterize the VOC's profile of …             Interleukin-35 administration counteracts established murine type 1 diabetes – possible involvement of regulatory T cells ▶     Kailash Singh, Erik Kadesjö, Julia Lindroos et al.     The anti-inflammatory cytokine IL-35 is produced by regulatory T (Treg) cells to suppress autoimmune and inflammatory responses. The role of IL-35 in type 1 diabetes (T1D) …             Decrease of mRNA Editing after Spinal Cord Injury is Caused by Down-regulation of ADAR2 that is Triggered by Inflammatory Response ▶     Antonio Fabio Di Narzo, Alexey Kozlenkov, Yongchao Ge et al.     We recently showed that spinal cord injury (SCI) leads to a decrease in mRNA editing of serotonin receptor 2C (5-HT2CR) contributing to post-SCI spasticity. Here we study …             Grazer-induced morphological defense in Scenedesmus obliquus is affected by competition against Microcystis aeruginosa ▶     Xuexia Zhu, Jun Wang, Yichun Lu et al.     The green alga Scenedesmus is known for its phenotypic plasticity in response to grazing risk. However, the benefits of colony formation induced by infochemicals from zooplankton …             Disinhibition-induced transitions between absence and tonic-clonic epileptic seizures ▶     Denggui Fan, Qingyun Wang, Matjaž Perc     Electrophysiological experiments have long revealed the existence of two-way transitions between absence and tonic-clonic epileptic seizures in the cerebral cortex. Based on a …             miRNA-133 augments coelomocyte phagocytosis in bacteria-challenged Apostichopus japonicus via targeting the TLR component of IRAK-1 in vitro and in vivo ▶     Meng Lu, Peng-Juan Zhang, Cheng-Hua Li et al.     In this study, we explored the potential roles of miRNA-133 in regulating TLR pathways in the sea cucumber Apostichopus japonicus. Target screening of RNA-Seq data successfully …             Mutant p53 promotes ovarian cancer cell adhesion to mesothelial cells via integrin β4 and Akt signals ▶     Jong-Gyu Lee, Ji-Hye Ahn, Tae Jin Kim et al.     Missense mutations in the TP53 gene resulting in the accumulation of mutant proteins are extremely common in advanced ovarian cancer, which is characterised by peritoneal …             Enhanced cuticular penetration as the mechanism for synergy of insecticidal constituents of rosemary essential oil in Trichoplusia ni ▶     Jun-Hyung Tak, Murray B. Isman     Synergistic interactions between constituents of essential oils have been reported for several areas of research. In the present study, mechanisms that could explain the …             Identification of a novel lymphoid population in the murine epidermis ▶     Francisca F. Almeida, Mari Tenno, Joanna Brzostek et al.     T cell progenitors are known to arise from the foetal liver in embryos and the bone marrow in adults; however different studies have shown that a pool of T cell progenitors may …             Dual roles of endogenous and exogenous galectin-1 in the control of testicular immunopathology ▶     Cecilia V. Pérez, Leticia G. Gómez, Gisela S. Gualdoni et al.     Galectin-1 (Gal-1), a proto-type member of galectin family, is highly expressed in immune privileged sites, including the testis. However, in spite of considerable progress the …             Ant trophallactic networks: simultaneous measurement of interaction patterns and food dissemination ▶     Efrat Greenwald, Enrico Segre, Ofer Feinerman     Eusocial societies and ants, in particular, maintain tight nutritional regulation at both individual and collective levels. The mechanisms that underlie this control are far from …             Toll-like receptor 4 signaling in neurons of trigeminal ganglion contributes to nociception induced by acute pulpitis in rats ▶     Jia-Ji Lin, Yi Du, Wen-Ke Cai et al.     Pain caused by acute pulpitis (AP) is a common symptom in clinical settings. However, its underlying mechanisms have largely remained unknown. Using AP model, we demonstrated …             Genome-wide analysis of enhancer RNA in gene regulation across 12 mouse tissues ▶     Jen-Hao Cheng, David Zhi-Chao Pan, Zing Tsung-Yeh Tsai et al.     Enhancers play a crucial role in gene regulation but the participation of enhancer transcripts (i.e. enhancer RNA, eRNAs) in regulatory systems remains unclear. We provide a …             Protection against dengue disease by synthetic nucleic acid antibody prophylaxis/immunotherapy ▶     Seleeke Flingai, Emily M. Plummer, Ami Patel et al.     Dengue virus (DENV) is the most important mosquito-borne viral infection in humans. In recent years, the number of cases and outbreaks has dramatically increased worldwide. While …             Polymerase Spiral Reaction (PSR): A novel isothermal nucleic acid amplification method ▶     Wei Liu, Derong Dong, Zhan Yang et al.     In this study, we report a novel isothermal nucleic acid amplification method only requires one pair of primers and one enzyme, termed Polymerase Spiral Reaction (PSR) with high …             DYVIPAC: an integrated analysis and visualisation framework to probe multi-dimensional biological networks ▶     Lan K. Nguyen, Andrea Degasperi, Philip Cotter et al.     Biochemical networks are dynamic and multi-dimensional systems, consisting of tens or hundreds of molecular components. Diseases such as cancer commonly arise due to changes in …             Neuronal Representation of Ultraviolet Visual Stimuli in Mouse Primary Visual Cortex ▶     Zhongchao Tan, Wenzhi Sun, Tsai-Wen Chen et al.     The mouse has become an important model for understanding the neural basis of visual perception. Although it has long been known that mouse lens transmits ultraviolet (UV) light …             Corrigendum: “Turn on” and label-free core−shell Ag@SiO2 nanoparticles-based metal-enhanced fluorescent (MEF) aptasensor for Hg2+ ▶     Yuanfeng Pang, Zhen Rong, Rui Xiao et al.                 Weak Interactions and Instability Cascades ▶     Taku Kadoya, Kevin S. McCann     Food web theory states that a weak interactor which is positioned in the food web such that it tends to deflect, or mute, energy away from a potentially oscillating …             Safety Evaluation of Hemoglobin-Albumin Cluster “HemoAct” as a Red Blood Cell Substitute ▶     Risa Haruki, Takuya Kimura, Hitomi Iwasaki et al.     A hemoglobin (Hb) wrapped covalently by human serum albumins (HSAs), a core–shell structured hemoglobin-albumin cluster designated as “HemoAct”, is an O2-carrier designed for use …             Three-dimensional imaging of microvasculature in the rat spinal cord following injury ▶     Yong Cao, Tianding Wu, Zhou yuan et al.     Research studies on the three-dimensional (3D) morphological alterations of the spinal cord microvasculature after injury provide insight into the pathology of spinal cord injury …             GSTM1 polymorphism contribute to colorectal cancer in Asian populations: a prospective meta-analysis ▶     Jing Li, Wen Xu, Fang Liu et al.     Glutathione S-transferases (GSTs) are enzymes which expressed in many tissues and play important roles in neutralization of toxic compounds, and protecting hosts against cancer. …             Enhanced anti-ischemic stroke of ZL006 by T7-conjugated PEGylated liposomes drug delivery system ▶     Zhongyuan Wang, Yue Zhao, Yan Jiang et al.     The treatment for ischemic stroke is one of the most challenging problems and the therapeutic effect remains unsatisfied due to the poor permeation of drugs across the blood …             LK6/Mnk2a is a new kinase of alpha synuclein phosphorylation mediating neurodegeneration ▶     Shiqing Zhang, Jiang Xie, Ying Xia et al.     Parkinson’s disease (PD) is a movement disorder due to the loss of dopaminergic (DA) neurons in the substantia nigra. Alpha-synuclein phosphorylation and α-synuclein inclusion …             Identification of Estrogen Response Element in Aquaporin-3 Gene that Mediates Estrogen-induced Cell Migration and Invasion in Estrogen Receptor-positive Breast Cancer ▶     Yi-Ting Huang, Jun Zhou, Shuai Shi et al.     Accumulating evidence suggests that aquaporins (AQPs) may facilitate tumor development. The molecular pathways connecting the pathological functions of AQPs are unclear and need …             Study of the Binding Energies between Unnatural Amino Acids and Engineered Orthogonal Tyrosyl-tRNA Synthetases ▶     Wei Ren, Tan M. Truong, Hui-wang Ai     We utilized several computational approaches to evaluate the binding energies of tyrosine (Tyr) and several unnatural Tyr analogs, to several orthogonal aaRSes derived from …             Induction of p53-independent apoptosis by ectopic expression of HOXA5 in human liposarcomas ▶     Dhong Hyun Lee, Charles Forscher, Dolores Di Vizio et al.     Dedifferentiated liposarcoma (DDLPS) is a highly malignant subtype of human liposarcoma (LPS), whose genomic profile is characterized by chromosomal amplification at 12q13-q22. …             Isoliensinine induces apoptosis in triple-negative human breast cancer cells through ROS generation and p38 MAPK/JNK activation ▶     Xiyu Zhang, Xiyao Wang, Tingting Wu et al.     Isoliensinine, liensinine and neferine are major bisbenzylisoquinoline alkaloids in the seed embryo of lotus (Nelumbo nucifera), and exhibit potential anti-cancer activity. Here, …             Bone morphogenetic protein 2 promotes primordial follicle formation in the ovary ▶     Prabuddha Chakraborty, Shyamal K. Roy     Primordial follicles (PF) are formed when somatic cells differentiate into flattened pregranulosa cells, invaginate into the oocyte nests and encircle individual oocytes. We …             Cyclin Y inhibits plasticity-induced AMPA receptor exocytosis and LTP ▶     Eunsil Cho, Dong-Hyun Kim, Young-Na Hur et al.     Cyclin Y (CCNY) is a member of the cyclin protein family, known to regulate cell division in proliferating cells. Interestingly, CCNY is expressed in neurons that do not undergo …             Sirt1-deficiency causes defective protein quality control ▶     Takuya Tomita, Jun Hamazaki, Shoshiro Hirayama et al.     Protein quality control is an important mechanism to maintain cellular homeostasis. Damaged proteins have to be restored or eliminated by degradation, which is mainly achieved by …             Central blockade of salusin β attenuates hypertension and hypothalamic inflammation in spontaneously hypertensive rats ▶     Hong-Bao Li, Da-Nian Qin, Kang Cheng et al.     Salusin β is a multifunctional bioactive peptide and is considered as a promising candidate biomarker for predicting atherosclerotic cardiovascular diseases. The present study …             The Plasmodium berghei translocon of exported proteins reveals spatiotemporal dynamics of tubular extensions ▶     Joachim M. Matz, Christian Goosmann, Volker Brinkmann et al.     The erythrocyte is an extraordinary host cell for intracellular pathogens and requires extensive remodelling to become permissive for infection. Malaria parasites modify their …             Theme and variations: evolutionary diversification of the HET-s functional amyloid motif ▶     Asen Daskalov, Witold Dyrka, Sven J. Saupe     In mammals and fungi, Nod-like receptors (NLR) activate downstream cell death execution proteins by a prion-like mechanism. In Podospora anserina, the NWD2 NLR activates the …             Hydroxyproline Ring Pucker Causes Frustration of Helix Parameters in the Collagen Triple Helix ▶     W. Ying Chow, Dominique Bihan, Chris J. Forman et al.     Collagens, the most abundant proteins in mammals, are defined by their triple-helical structures and distinctive Gly-Xaa-Yaa repeating sequence, where Xaa is often proline and …             7α-Hydroxypregnenolone, a key neuronal modulator of locomotion, stimulates upstream migration by means of the dopaminergic system in salmon ▶     Shogo Haraguchi, Yuzo Yamamoto, Yuko Suzuki et al.     Salmon migrate upstream against an opposing current in their natal river. However, the molecular mechanisms that stimulate upstream migratory behavior are poorly understood. …             A Comparison of Intravenous plus Intraperitoneal Chemotherapy with Intravenous Chemotherapy Alone for the Treatment of Gastric Cancer: A Meta-Analysis ▶     Sheng Yang, Rui Feng, Zhang-Chi Pan et al.     We aimed to evaluate the effectiveness and safety of intravenous (IV) plus intraperitoneal (IP) chemotherapy compared to intravenous (IV) chemotherapy alone for patients with …             In vitro and in vivo host range of Anopheles gambiae densovirus (AgDNV) ▶     Yasutsugu Suzuki, Tapan K. Barik, Rebecca M. Johnson et al.     AgDNV is a powerful gene transduction tool and potential biological control agent for Anopheles mosquitoes. Using a GFP reporter virus system, we investigated AgDNV host range …             RCF1-dependent respiratory supercomplexes are integral for lifespan-maintenance in a fungal ageing model ▶     Fabian Fischer, Christodoulos Filippis, Heinz D. Osiewacz     Mitochondrial respiratory supercomplexes (mtRSCs) are stoichiometric assemblies of electron transport chain (ETC) complexes in the inner mitochondrial membrane. They are …             The temporary and accumulated effects of transcranial direct current stimulation for the treatment of advanced Parkinson’s disease monkeys ▶     Hao Li, Xiaoguang Lei, Ting Yan et al.     Transcranial direct current stimulation (tDCS) is a useful noninvasive technique of cortical brain stimulation for the treatment of neurological disorders. Clinical research has …             Biomechanical tactics of chiral growth in emergent aquatic macrophytes ▶     Zi-Long Zhao, Hong-Ping Zhao, Bing-Wei Li et al.     Through natural selection, many plant organs have evolved optimal morphologies at different length scales. However, the biomechanical strategies for different plant species to …             Corrigendum: Retrophylogenomics Place Tarsiers on the Evolutionary Branch of Anthropoids ▶     Gerrit Hartig, Gennady Churakov, Wesley C. Warren et al.                 Key innovation or adaptive change? A test of leaf traits using Triodiinae in Australia ▶     A. Toon, M. D. Crisp, H. Gamage et al.     The evolution of novel traits (“key innovations”) allows some lineages to move into new environments or adapt to changing climates, whereas other lineages may track suitable …             Double strand break repair by capture of retrotransposon sequences and reverse-transcribed spliced mRNA sequences in mouse zygotes ▶     Ryuichi Ono, Masayuki Ishii, Yoshitaka Fujihara et al.     The CRISPR/Cas system efficiently introduces double strand breaks (DSBs) at a genomic locus specified by a single guide RNA (sgRNA). The DSBs are subsequently repaired through …             The Cipher Code of Simple Sequence Repeats in “Vampire Pathogens” ▶     Geng Zou, Bernardo Bello-Orti, Virginia Aragon et al.     Blood inside mammals is a forbidden area for the majority of prokaryotic microbes; however, red blood cells tropism microbes, like “vampire pathogens” (VP), succeed in matching …             Brain plasticity in aphasic patients: intra- and inter-hemispheric reorganisation of the whole linguistic network probed by N150 and N350 components ▶     Chiara Spironelli, Alessandro Angrilli     The present study examined linguistic plastic reorganization of language through Evoked Potentials in a group of 17 non-fluent aphasic patients who had suffered left perisylvian …             One-step biosynthesis of α-ketoisocaproate from l-leucine by an Escherichia coli whole-cell biocatalyst expressing an l-amino acid deaminase from Proteus vulgaris ▶     Yang Song, Jianghua Li, Hyun-dong Shin et al.     This work aimed to develop a whole-cell biotransformation process for the production of α-ketoisocaproate from L-leucine. A recombinant Escherichia coli strain was constructed by …             Analysis of IS6110 insertion sites provide a glimpse into genome evolution of Mycobacterium tuberculosis ▶     Tanmoy Roychowdhury, Saurav Mandal, Alok Bhattacharya     Insertion sequence (IS) 6110 is found at multiple sites in the Mycobacterium tuberculosis genome and displays a high degree of polymorphism with respect to copy number and …             Nuclear retention of full-length HTT RNA is mediated by splicing factors MBNL1 and U2AF65 ▶     Xin Sun, Pan P. Li, Shanshan Zhu et al.     Huntington’s disease (HD) is caused by a CAG repeat expansion in the huntingtin (HTT) gene. Recent evidence suggests that HD is a consequence of multimodal, non-mutually …             Identification of the miRNA targetome in hippocampal neurons using RIP-seq ▶     Josephine Malmevik, Rebecca Petri, Thies Klussendorf et al.     MicroRNAs (miRNAs) are key players in the regulation of neuronal processes by targeting a large network of target messenger RNAs (mRNAs). However, the identity and function of …             [NiFe]-hydrogenase is essential for cyanobacterium Synechocystis sp. PCC 6803 aerobic growth in the dark ▶     Edith De Rosa, Vanessa Checchetto, Cinzia Franchin et al.     The cyanobacterium Synechocystis sp. PCC 6803 has a bidirectional [NiFe]-hydrogenase (Hox hydrogenase) which reversibly reduces protons to H2. This enzyme is composed of a …             Single fluoxetine treatment before but not after stress prevents stress-induced hippocampal long-term depression and spatial memory retrieval impairment in rats ▶     Huili Han, Chunfang Dai, Zhifang Dong     A growing body of evidence has shown that chronic treatment with fluoxetine, a widely prescribed medication for treatment of depression, can affect synaptic plasticity in the …             Transmembrane protein 106a activates mouse peritoneal macrophages via the MAPK and NF-κB signaling pathways ▶     Hui Dai, Dong Xu, Jing Su et al.     The M1 and M2 states of macrophage are the two extremes of a physiologic/phenotypic continuum that is dynamically influenced by environmental signals. Molecular mechanism …             Comparison of stimulus-evoked cerebral hemodynamics in the awake mouse and under a novel anesthetic regime ▶     Paul S. Sharp, Kira Shaw, Luke Boorman et al.     Neural activity is closely followed by a localised change in cerebral blood flow, a process termed neurovascular coupling. These hemodynamic changes form the basis of contrast in …             A TLR9 agonist enhances the anti-tumor immunity of peptide and lipopeptide vaccines via different mechanisms ▶     Ying-Chyi Song, Shih-Jen Liu     The toll-like receptor 9 (TLR9) agonists CpG oligodeoxynucleotides (CpG ODNs) have been recognized as promising adjuvants for vaccines against infectious diseases and cancer. …             Haloarchaea Endowed with Phosphorus Solubilization Attribute Implicated in Phosphorus Cycle ▶     Ajar Nath Yadav, Divya Sharma, Sneha Gulati et al.     Archaea are unique microorganisms that are present in ecological niches of high temperature, pH and salinity. A total of 157 archaea were obtained from thirteen sediment, water …             Environmentally Driven Migration in a Social Network Game ▶     Masanori Takano, Kazuya Wada, Ichiro Fukuda     Cooperative behaviors are common in humans, and they are the fundamental basis of our society. Theoretical and experimental studies have modeled environments where the behaviors …             Rapid parallel measurements of macroautophagy and mitophagy in mammalian cells using a single fluorescent biosensor ▶     A. Sargsyan, J. Cai, L. B. Fandino et al.     Mitochondrial dysfunction is implicated in many human diseases and occurs in normal aging. Mitochondrial health is maintained through organelle biogenesis and repair or turnover …             Opening the conformation is a master switch for the dual localization and phosphatase activity of PTEN ▶     Hoai-Nghia Nguyen, Jr-Ming Yang, Takafumi Miyamoto et al.     Tumor suppressor PTEN mainly functions at two subcellular locations, the plasma membrane and the nucleus. At the plasma membrane, PTEN dephosphorylates the tumorigenic second …             Mieap suppresses murine intestinal tumor via its mitochondrial quality control ▶     Masayuki Tsuneki, Yasuyuki Nakamura, Takao Kinjo et al.     Mieap, a novel p53-inducible protein, plays a key role in maintaining healthy mitochondria in various pathophysiological states. Here, we show that Mieap deficiency in ApcMin/+ …             Different gap junction-propagated effects on cisplatin transfer result in opposite responses to cisplatin in normal cells versus tumor cells ▶     Yuan Zhang, Liang Tao, Lixia Fan et al.     Previous work has shown that gap junction intercellular communication (GJIC) enhances cisplatin (Pt) toxicity in testicular tumor cells but decreases it in non-tumor testicular …             Developmental and evolutionary novelty in the serrated teeth of theropod dinosaurs ▶     K. S. Brink, R. R. Reisz, A. R. H. LeBlanc et al.     Tooth morphology and development can provide valuable insights into the feeding behaviour and evolution of extinct organisms. The teeth of Theropoda, the only clade of …             Seagrass meadows (Posidonia oceanica) distribution and trajectories of change ▶     Luca Telesca, Andrea Belluscio, Alessandro Criscoli et al.     Posidonia oceanica meadows are declining at alarming rates due to climate change and human activities. Although P. oceanica is considered the most important and well-studied …             Mitochondrial CB1 receptor is involved in ACEA-induced protective effects on neurons and mitochondrial functions ▶     Lei Ma, Ji Jia, Wen Niu et al.     Mitochondrial dysfunction contributes to cell death after cerebral ischemia/reperfusion (I/R) injury. Cannabinoid CB1 receptor is expressed in neuronal mitochondrial membranes …             Anti-angiogenesis therapy and gap junction inhibition reduce MDA-MB-231 breast cancer cell invasion and metastasis in vitro and in vivo ▶     Kazem Zibara, Zahraa Awada, Leila Dib et al.     Cancer cells secrete VEGF, which plays a key role in their growth, invasion, extravasation and metastasis. Direct cancer cell-endothelial cell interaction, mediated by gap …             PKCζ Promotes Breast Cancer Invasion by Regulating Expression of E-cadherin and Zonula Occludens-1 (ZO-1) via NFκB-p65 ▶     Arindam Paul, Marsha Danley, Biswarup Saha et al.     Atypical Protein Kinase C zeta (PKCζ) forms Partitioning-defective (PAR) polarity complex for apico-basal distribution of membrane proteins essential to maintain normal cellular …             Productivity depends more on the rate than the frequency of N addition in a temperate grassland ▶     Yunhai Zhang, Jinchao Feng, Forest Isbell et al.     Nitrogen (N) is a key limiting resource for aboveground net primary productivity (ANPP) in diverse terrestrial ecosystems. The relative roles of the rate and frequency (additions …             Transactivation of human osteoprotegerin promoter by GATA-3 ▶     Shyan-Yuan Kao, Konstantina M. Stankovic     Osteoprotegerin (OPG) is a key regulator of bone remodeling. Mutations in OPG are involved in a variety of human diseases. We have shown that cochlear spiral ganglion cells …             Colokinetic effect of noradrenaline in the spinal defecation center: implication for motility disorders ▶     Kiyotada Naitou, Takahiko Shiina, Kurumi Kato et al.     Chronic abdominal pain in irritable bowel syndrome (IBS) usually appears in combination with disturbed bowel habits, but the etiological relationship between these symptoms …             High-resolution high-speed dynamic mechanical spectroscopy of cells and other soft materials with the help of atomic force microscopy ▶     M. Dokukin, I. Sokolov     Dynamic mechanical spectroscopy (DMS), which allows measuring frequency-dependent viscoelastic properties, is important to study soft materials, tissues, biomaterials, polymers. …             Mechanisms of hypervirulent Clostridium difficile ribotype 027 displacement of endemic strains: an epidemiological model ▶     Laith Yakob, Thomas V. Riley, David L. Paterson et al.     Following rapid, global clonal dominance of hypervirulent ribotypes, Clostridium difficile now constitutes the primary infectious cause of nosocomial diarrhoea. Evidence …             Human xylosyltransferases – mediators of arthrofibrosis? New pathomechanistic insights into arthrofibrotic remodeling after knee replacement therapy ▶     Isabel Faust, Philipp Traut, Frank Nolting et al.     Total knee replacement (TKR) is a common therapeutic option to restore joint functionality in chronic inflammatory joint diseases. Subsequent arthrofibrotic remodeling occurs in …                 A new online, open access, multi- and cross- disciplinary journal dedicated to publishing the finest research on systems biology and all its approaches. Published by Nature Publishing Group in partnership with the Systems Biology Institute (SBI). 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