Nature Reviews Urology - Table of Contents alert Volume 13 Issue 2

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TABLE OF CONTENTS
February 2016 Volume 13 Number 2
Impact Factor 4.840 *	In this issue Research Highlights Year in Review Reviews Also this month  Featured article: The interplay of extracellular matrix and microbiome in urothelial bladder cancer Massimo Alfano, Filippo Canducci, Manuela Nebuloni, Massimo Clementi, Francesco Montorsi & Andrea Salonia
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RESEARCH HIGHLIGHTS Top Prostate cancer: Changing standard of care in hormone-sensitive disease Published online: 20 January 2016 p61 | doi:10.1038/nrurol.2016.4 PDF Testicular cancer: PD-L1: a promising target for TGCTs Published online: 15 December 2015 p62 | doi:10.1038/nrurol.2015.299 PDF Prostate cancer: Avoiding unnecessary MRIs Published online: 22 December 2015 p62 | doi:10.1038/nrurol.2015.304 PDF Urinary tract obstruction: NLRP3 inhibition prevents BOO Published online: 12 January 2016 p62 | doi:10.1038/nrurol.2016.1 PDF Prostate cancer: A walk on the wild side — wild-type kinases promote metastasis Published online: 22 December 2015 p63 | doi:10.1038/nrurol.2015.300 PDF Sexual dysfunction: Shockwaves for erectile dysfunction Published online: 31 December 2015 p63 | doi:10.1038/nrurol.2015.310 PDF Prostate cancer: Proteomics provides a prognostic marker Published online: 22 December 2015 p64 | doi:10.1038/nrurol.2015.305 PDF Prostate cancer: SLCO2B1 variants correlate with castration resistance Published online: 31 December 2015 p65 | doi:10.1038/nrurol.2015.306 PDF Kidney cancer: Programmed death ligand 1 regulation in ccRCC Published online: 12 January 2016 p65 | doi:10.1038/nrurol.2016.2 PDF Prostate cancer: Suppressing a wrong kind of transition Published online: 22 December 2015 p66 | doi:10.1038/nrurol.2015.302 PDF Male circumcision: Circumcision does not affect sensitivity Published online: 20 January 2016 p66 | doi:10.1038/nrurol.2016.3 PDF IN BRIEF Prostate cancer: Increased adverse event risk with GnRHa therapy | Clinical trials: Novel topical gel treatment for Peyronie's disease | Prostate cancer: Gene expression signature in tumours of smokers | Prostate cancer: Adverse events associated with intermittent ADT PDF Nature Reviews Urology JOBS of the week Faculty Position in Urology Research Job Mayo Clinic More Science jobs from
YEAR IN REVIEW		Top
Sexual dysfunction in 2015: Recovering sex drive in women — progress and opportunities Rossella E. Nappi & Francesca Albani Published online: 12 January 2016 p67 | doi:10.1038/nrurol.2015.314 In 2015, the approval of flibanserin opened a debate about diagnosis and treatment of female sexual dysfunction. Designing clinical trials with suitable end points is difficult, but some studies indicate correlations between hormone levels and low desire. New research demonstrates opportunities for a better understanding of this multifaceted condition. Full Text | PDF
Bladder dysfunction in 2015: Novel findings continue to challenge researchers and clinicians Rose Khavari & Tim Boone Published online: 31 December 2015 p69 | doi:10.1038/nrurol.2015.303 2015 has seen advances in various bladder conditions. MicroRNAs might become therapeutic targets, the MAPP network characterized central neurological changes in chronic pelvic pain syndrome, and urologists were reminded to consider cognitive effects of long-term anticholinergics use. A study of obstetric vesicovaginal fistula repair shows how evidence-based research might improve public health in poorly resourced countries. Full Text | PDF
Stones in 2015: Changes in stone management — suspending belief for evidence Sapan N. Ambani & Khurshid R. Ghani Published online: 08 December 2015 p71 | doi:10.1038/nrurol.2015.290 In 2015, population-based studies in patients with urinary stones informed us of the changing trends in contemporary stone management and identified areas for improvement. Although meta-analyses aim to provide the highest level of evidence, a randomized controlled trial of medical expulsive therapy challenged current paradigms and was the defining publication of the year. Full Text | PDF
Infection in 2015: HIV protection with PrEP — implications for controlling other STIs Douglas S. Krakower & Kenneth H. Mayer Published online: 01 December 2015 p72 | doi:10.1038/nrurol.2015.282 HIV and bacterial sexually transmitted infection incidence remains persistently high for men who have sex with men. Results of new studies show that clinicians might be able to address this challenge by providing oral HIV pre-exposure prophylaxis and by intensifying efforts to diagnose and treat other sexually transmitted infections. Full Text | PDF
Bladder cancer in 2015: Improving indication, technique and outcome of radical cystectomy J. Alfred Witjes Published online: 24 November 2015 p74 | doi:10.1038/nrurol.2015.272 Radical cystectomy is the standard treatment for patients with bladder cancer, but the prognosis of patients undergoing this procedure has not changed for decades. Small steps towards improvement include better selection of high-risk T1 patients, the use of perioperative chemotherapy and, maybe, robotic cystectomy. Full Text | PDF
REVIEWS		Top
The interplay of extracellular matrix and microbiome in urothelial bladder cancer Massimo Alfano, Filippo Canducci, Manuela Nebuloni, Massimo Clementi, Francesco Montorsi & Andrea Salonia Published online: 15 December 2015 p77 | doi:10.1038/nrurol.2015.292 The interaction between tumour cells and their microenvironment has an important role in cancer pathogenesis. Alfano et al. review how dysregulation of the extracellular matrix and microbiota associated with the human epithelium might influence the development and progression of urothelial carcinomas. Abstract | Full Text | PDF
The challenging landscape of medical device approval in localized prostate cancer Massimo Valerio, Mark Emberton, Scott E. Eggener & Hashim U. Ahmed Published online: 15 December 2015 p91 | doi:10.1038/nrurol.2015.289 The introduction of a targeted approach to treatment of prostate cancer requires the approval of novel medical devices. Here, authors describe the regulatory pathways that govern the approval of novel medical devices for clinical use. Owing to differences in legislation, these approval pathways differ substantially between the European Union and the USA, often resulting in patients receiving different treatments for prostate cancer in Europe, compared with the USA. Abstract | Full Text | PDF
Prostate cancer in men of African origin Kathleen F. McGinley, Kae Jack Tay & Judd W. Moul Published online: 31 December 2015 p99 | doi:10.1038/nrurol.2015.298 Men of African origin are disproportionately affected by prostate cancer; in this Review, McGinley and colleagues discuss the disparities in treatment, the cancer-survivorship experience, and quality-of-life outcomes, as well as aspects that might contribute to these differences including socioeconomic, cultural, and genetic factors. Abstract | Full Text | PDF
Lower urinary tract symptoms, benign prostatic hyperplasia and metabolic syndrome Linda Vignozzi, Mauro Gacci & Mario Maggi Published online: 12 January 2016 p108 | doi:10.1038/nrurol.2015.301 In this Review, Vignozzi and colleagues describe how metabolic syndrome and its components contribute to the development of lower urinary tract symptoms during ageing, highlighting the influence of inflammation and sex steroid imbalance. They also discuss whether lifestyle modification and weight loss are effective in prevention and treatment of this urological condition. Abstract | Full Text | PDF
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*Journal Citation Reports, Thomson, 2015. Nature Reviews Urology was previously published as Nature Clinical Practice Urology.

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