The EMBO Journal Table of Contents for 1 March 2016; Vol. 35, No. 5

1 March 2016 | Volume 35, Number 5 Submit Table of Contents News & Views Articles Corrigendum Volume 35, Number 5 News & Views Eradicating tumor drug resistance at its YAP‐biomechanical roots New findings report that melanoma cells acquire resistance to BRAF inhibitors by changing cell shape, modifying their cytoskeleton and, in turn, activating the YAP/TAZ mechanotransduction pathway. Francesca Zanconato and Stefano Piccolo Published online 28.12.2015 Articles Actin remodeling confers BRAF inhibitor resistance to melanoma cells through YAP/TAZ activation Adaptive resistance to the BRAF inhibitor PLX4032 in BRAF V600E mutant melanoma cells involves increased actin stress fiber formation, impinging on the growth‐regulating YAP/TAZ signaling axis. Min Hwan Kim, Jongshin Kim, Hyowon Hong, Si‐Hyung Lee, June‐Koo Lee, Eunji Jung, and Joon Kim Published online 14.12.2015 TFEB and TFE3 are novel components of the integrated stress response The transcription factors TFEB and TFE3 are activated upon starvation‐induced mTORC1 inhibition, but also respond to ER stress in a PERK‐dependent manner. This finding reveals a hitherto unknown level of crosstalk between cellular stress pathways. José A Martina, Heba I Diab, Owen A Brady, and Rosa Puertollano Published online 25.01.2016 PAQR3 controls autophagy by integrating AMPK signaling to enhance ATG14L‐associated PI3K activity Golgi‐resident protein PAQR3 facilitates formation of the autophagy‐initiating ATG14L–VPS34 complex. Upon glucose starvation, AMPK phosphorylates PAQR3 to enhance this function, thus integrating nutrient sensing with VPS34 activity. Da‐Qian Xu, Zheng Wang, Chen‐Yao Wang, De‐Yi Zhang, Hui‐Da Wan, Zi‐Long Zhao, Jin Gu, Yong‐Xian Zhang, Zhi‐Gang Li, Kai‐Yang Man, Yi Pan, Zhi‐Fei Wang, Zun‐Ji Ke, Zhi‐Xue Liu, Lu‐Jian Liao, and Yan Chen Published online 01.02.2016 Inducible chromatin priming is associated with the establishment of immunological memory in T cells Naïve T cells become epigenetically imprinted when activated and stably maintain regions of accessible active chromatin to support efficient reactivation of genes in primed T cells. Sarah L Bevington, Pierre Cauchy, Jason Piper, Elisabeth Bertrand, Naveen Lalli, Rebecca C Jarvis, Liam Niall Gilding, Sascha Ott, Constanze Bonifer, and Peter N Cockerill Published online 21.01.2016 p38γ and p38δ reprogram liver metabolism by modulating neutrophil infiltration Mice lacking p38γ/δ in myeloid cells are protected against diet‐induced fatty liver. This effect is due to defective migration of p38γ/δ‐deficient neutrophils to the damaged liver, where they normally induce inflammation and metabolic changes. Bárbara González‐Terán, Nuria Matesanz, Ivana Nikolic, María Angeles Verdugo, Vinatha Sreeramkumar, Lourdes Hernández‐Cosido, Alfonso Mora, Georgiana Crainiciuc, María Laura Sáiz, Edgar Bernardo, Luis Leiva‐Vega, Elena Rodríguez, Victor Bondía, Jorge L Torres, Sonia Perez‐Sieira, Luis Ortega, Ana Cuenda, Francisco Sanchez‐Madrid, Rubén Nogueiras, Andrés Hidalgo, Miguel Marcos, and Guadalupe Sabio Published online 03.02.2016 Corrigendum Two isoforms of Serpent containing either one or two GATA zinc fingers have different roles in Drosophila haematopoiesis Lucas Waltzer, Laetitia Bataillé, Sandrine Peyrefitte, and Marc Haenlin Published online 29.02.2016   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2016 by the European Molecular Biology Organisation.