Nature Reviews Rheumatology - Table of Contents alert Volume 9 Issue 6

TABLE OF CONTENTS
June 2013 Volume 9 Number 6
Impact Factor 8.388 *	In this issue Research Highlights News and Views Reviews Perspectives Also this month  Featured article: To Wnt or not to Wnt: the bone and joint health dilemma Rik J. Lories, Maripat Corr & Nancy E. Lane
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RESEARCH HIGHLIGHTS Top Rheumatoid arthritis: MRI points to inflammation as source of cartilage damage Published online: 21 May 2013 p319 | doi:10.1038/nrrheum.2013.76 PDF Paediatric rheumatology: New risk loci for JIA identified Published online: 07 May 2013 p320 | doi:10.1038/nrrheum.2013.69 PDF Osteoarthritis: Chondroprotection by histone deacetylase inhibition Published online: 30 April 2013 p321 | doi:10.1038/nrrheum.2013.63 PDF Connective tissue diseases: HMGB1 helps elicit anti-dsDNA antibody production in SLE Published online: 14 May 2013 p321 | doi:10.1038/nrrheum.2013.75 PDF Connective tissue diseases: Disease severity directly affected by diet in a mouse model of SLE Published online: 30 April 2013 p322 | doi:10.1038/nrrheum.2013.64 PDF Paediatric rheumatology: uPA–uPAR at the heart of cardiac neonatal lupus Published online: 07 May 2013 p322 | doi:10.1038/nrrheum.2013.70 PDF IN BRIEF Imaging: Colour Doppler ultrasonography in inflammatory disease | Rheumatoid arthritis: Air pollution does not correlate with autoantibodies | Inflammatory myopathies: Pulmonary function correlates with clinical parameters | Osteoarthritis: Specialized footwear improves knee loading PDF Rheumatology EVENT Pan Arab Rheumatology 2014 14.01.14 Dubai More science events from
NEWS AND VIEWS		Top
Rheumatoid arthritis: Erosion defined: back to basics Jonathan Kay & Ellen M. Gravallese Published online: 23 April 2013 p323 | doi:10.1038/nrrheum.2013.60 Current classification criteria for rheumatoid arthritis allow its classification on the basis of the presence of erosions, in the absence of other indicators. Nevertheless, definition or quantitation of erosions was lacking. A European task force has now addressed this issue by analysing radiographic erosions in two cohorts of patients with early disease. Full Text | PDF
Clinical guidelines: Can wise choices solve the health-care crisis? Maarten Boers Published online: 07 May 2013 p324 | doi:10.1038/nrrheum.2013.62 The American College of Rheumatology recently published a list of five strategies (comprising four diagnostic procedures and one therapeutic approach) that they consider to be often unnecessary and thus potentially wasteful. By itself this list is useful, but finding a way to reduce wasteful strategies will be a challenge. Full Text | PDF
Paediatric rheumatology: Where are the innovations in paediatric rheumatology? Thomas J. A. Lehman Published online: 14 May 2013 p326 | doi:10.1038/nrrheum.2013.74 Rapid progress is being made in the field of rheumatology. Nevertheless, disappointingly, the limited resources of the paediatric rheumatology community are being expended on the publication of consensus guidelines that represent fossilization of old ideas rather than real innovation that leads to the improved care of children. Full Text | PDF
REVIEWS		Top
To Wnt or not to Wnt: the bone and joint health dilemma Rik J. Lories, Maripat Corr & Nancy E. Lane Published online: 05 March 2013 p328 | doi:10.1038/nrrheum.2013.25 Wnt signalling has important roles in bone development, growth and homeostasis. Herein, the authors review our current understanding of Wnt signalling in rheumatoid arthritis, osteoarthritis and spondyloarthritis, and discuss the potential therapeutic targeting of the Wnt cascades in these diseases. Abstract | Full Text | PDF
The phenotypic and genetic signatures of common musculoskeletal pain conditions Luda Diatchenko, Roger B. Fillingim, Shad B. Smith & William Maixner Published online: 02 April 2013 p340 | doi:10.1038/nrrheum.2013.43 In this Review, the phenotypic and genetic markers for common musculoskeletal pain conditions are discussed. Furthermore, the authors propose a heuristic approach to evaluation of the different kinds of markers associated with these conditions, which could enable greater understanding of the underlying pathophysiological processes. Abstract | Full Text | PDF | Supplementary information
Determining who should be referred for total hip and knee replacements Lisa A. Mandl Published online: 12 March 2013 p351 | doi:10.1038/nrrheum.2013.27 Total hip and total knee replacements are common treatments for end-stage arthritis with the rates of these procedures projected to increase further over the coming decades. Currently, no evidence-based criteria exists to guide physicians in which patients to refer for these treatments meaning that there is a potential for bias in this decision-making process. Here, Lisa Mandl reviews common misperceptions among physicians regarding these procedures, and discusses data that should be considered by physicians during the referral process. Abstract | Full Text | PDF
Arachnodactyly—a key to diagnosing heritable disorders of connective tissue Rodney Grahame & Alan J. Hakim Published online: 12 March 2013 p358 | doi:10.1038/nrrheum.2013.24 Arachnodactyly–spidery fingers–is typical of patients with one of the heritable diseases of connective tissue. This Review highlights the differences and similarities amongst these diseases and serves as a diagnostic guide to these heritable diseases including Marfan syndrome, joint hypermobility syndrome, and Ehlers–Danlos syndrome. Abstract | Full Text | PDF | Supplementary information
Management of cancer treatment-induced bone loss Robert E. Coleman, Emma Rathbone & Janet E. Brown Published online: 19 March 2013 p365 | doi:10.1038/nrrheum.2013.36 Cancer treatments can have severe adverse effects on bone health, and can thus increase the risk of fragility fractures both during therapy and in later life. This Review focuses on bone loss caused by breast cancer and prostate cancer treatments, and discusses lifestyle and pharmacological management strategies for reducing fracture risk in these patients. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION The role of IL-17-secreting mast cells in inflammatory joint disease Tony J. Kenna & Matthew A. Brown Published online: 11 December 2012 p375 | doi:10.1038/nrrheum.2012.205 The proinflammatory cytokine IL-17 is known to be an important factor in the pathogenesis of autoimmune joint diseases such as rheumatoid arthritis and spondyloarthritis, and therapies targeting this cytokine have shown promise. Although type 17 T helper cells are generally considered to be the main source of IL-17 in these diseases, the range of cell types that secrete this cytokine continues to expand; in particular, mast cells are receiving increased attention. Herein, the authors discuss the potential contribution of IL-17-secreting mast cells to inflammatory joint disease. Abstract | Full Text | PDF
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