EMBO Reports - Table of Contents alert Volume 14 Issue 7 pp 577-658

TABLE OF CONTENTS June 2013 | Volume 14, Issue 7 Upfront Science & Society Review Scientific Reports Also new AOP Sign up for e-alerts Recommend to your library Web feed Subscribe Advertisement EMBO - Transparency in Scientific Publishing  EMBO reports has a fair and transparent process to rapidly publish your best science. Transparent  - No confidential referee remarks - Published referee reports - Detailed decisions - Source Data published alongside figures Fair - Scooping protection - Pre-decision cross-referee commenting - Fixed bar for revisions - Fast process   Upfront Top Editorial 1914–2014: never again The coming year marks the centenary of the events that lead to the global catastrophe of July 1914. Howy appeals for a worldwide movement to prevent any possibility of such a disaster occurring in today's equally unstable world. Howy Jacobs EMBO reports (2013), 14, 577; 10.1038/embor.2013.78 Full text | PDF Published online: 01 July 2013 Subject Categories: Societal Issues & Politics Opinion The right to care and the expectations of society—controversial stem cell therapy in Italy Claiming that a disease is incurable does not justify the use of unsafe or ineffective therapies. Instead, the process of drug approval as a whole should be improved, with all involved giving clear and honest answers to ensure the dignity of patients and quality of care. Maurizio Bifulco and Patrizia Gazzerro EMBO reports (2013), 14, 578; 10.1038/embor.2013.71 Full text | PDF Published online: 04 June 2013 Subject Categories: Health & Disease | Societal Issues & Politics | Technology, Development & Applications Hot off the Press A dual role of SNAP-25 as carrier and guardian of synaptic transmission In this issue, Matteoli and colleagues show that SNAP-25 levels regulate the efficacy of presynaptic glutamate release and thereby alter short-term plasticity, with potential relevance for psychiatric diseases. Gaga Kochlamazashvili and Volker Haucke EMBO reports (2013), 14, 579 - 580; 10.1038/embor.2013.74 Full text | PDF Published online: 04 June 2013 Subject Categories: Neuroscience Feed backwards model for microRNA processing and splicing in plants Two studies in this issue of EMBO reports show that 3′ adjacent introns of plant miRNAs enhance miRNA biogenesis and that miRNA processing inhibits 3′ intron splicing. Ashish Dhir and Nick J Proudfoot EMBO reports (2013), 14, 581 - 582; 10.1038/embor.2013.77 Full text | PDF Published online: 14 June 2013 Subject Categories: RNA Rejuvenating Tithonus Four recent publications, including one in this issue by Surani and colleagues, report that Prdm14 preserves the pluripotent stem cell state by inhibiting FGF signalling and global DNA methylation. Kyle M Loh and Bing Lim EMBO reports (2013), 14, 583 - 584; 10.1038/embor.2013.81 Full text | PDF Published online: 14 June 2013 Subject Categories: Chromatin & Transcription | Development Meeting Point Seaside transportation—from structure to function of translocation machines The EMBO conference, ‘From Structure to Function of Translocation Machines’, took place in April 2013 in Dubrovnik, Croatia. The meeting brought together a mix of established and aspiring researchers to discuss a wealth of unpublished data and ideas in a lively scientific program of talks designed to shatter the established dogma. Trevor Lithgow and Gabriel Waksman EMBO reports (2013), 14, 585 - 587; 10.1038/embor.2013.79 Full text | PDF Published online: 14 June 2013 Subject Categories: Membranes & Transport | Structural Biology | Molecular Biology of Disease Science & Society Top Sex determination How the sex of offspring is determined has puzzled philosophers and scientists for millennia. Modern science has identified both genetic and environmental factors, but the question is still not yet fully answered. Ursula Mittwoch EMBO reports (2013), 14, 588 - 592; 10.1038/embor.2013.84 Full text | PDF Published online: 14 June 2013 Subject Categories: Philosophy & History of Science | Evolution, Environment & Agriculture Inheritance of poor writing habits More than a century spent lamenting the terrible habits and conceits of scientific writing has done little to improve things. A sea change is going to require the concerted efforts of all those involved in writing up and publishing research. Amin Bredan EMBO reports (2013), 14, 593 - 596; 10.1038/embor.2013.76 Full text | PDF Published online: 04 June 2013 Subject Categories: Science Infrastructures & Publishing Elixirs of death Substandard and fake drugs are increasingly threatening lives in both the developed and developing world, but governments and industry are struggling to improve the situation. Katrin Weigmann EMBO reports (2013), 14, 597 - 600; 10.1038/embor.2013.82 Full text | PDF Published online: 14 June 2013 Subject Categories: Health & Disease | Societal Issues & Politics | Technology, Development & Applications The science of progress and the progress of science Measuring the true impact of science is a Herculean task. Meta-science studies are beginning to assess more than just publication metrics to gain a fuller, long-term view of the value of research. Philip Hunter EMBO reports (2013), 14, 601 - 604; 10.1038/embor.2013.83 Full text | PDF Published online: 14 June 2013 Subject Categories: Science Policy & Funding | Societal Issues & Politics | Science Infrastructures & Publishing Review Top The DLK signalling pathway—a double-edged sword in neural development and regeneration This review discusses the multifaceted roles of DLK, a MAPKKK, signalling pathways in neural development and degeneration as well as axon regeneration after injury in diverse model organisms. The authors also outline strategies for how DLK function might be combined with other approaches to promote mammalian axon regeneration. Andrea Tedeschi and Frank Bradke EMBO reports (2013), 14, 605 - 614; 10.1038/embor.2013.64 Abstract | Full text | PDF Published online: 17 May 2013 Subject Categories: Neuroscience | Signal Transduction Scientific Reports Top Enhanced microRNA accumulation through stemloop-adjacent introns This study reveals tight interactions between intron splicing and miRNA processing in plants: introns proximal to plant miRNA stem-loops promote miRNA maturation in a splicing-independent manner, whereas reduced miRNA processing enhances splicing of such miRNA-proximal introns. Rebecca Schwab, Corinna Speth, Sascha Laubinger and Olivier Voinnet EMBO reports (2013), 14, 615 - 621; 10.1038/embor.2013.58 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 10 May 2013 Subject Categories: RNA | Plant Biology Introns of plant pri-miRNAs enhance miRNA biogenesis  EMBO Open miRNA-proximal introns and functional splice sites are required for the accumulation of normal levels and the activity of mature miRNAs in Arabidopsis. Dawid Bielewicz, Malgorzata Kalak, Maria Kalyna, David Windels, Andrea Barta, Franck Vazquez, Zofia Szweykowska-Kulinska and Artur Jarmolowski EMBO reports (2013), 14, 622 - 628; 10.1038/embor.2013.62 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 17 May 2013 Subject Categories: RNA Prdm14 promotes germline fate and naive pluripotency by repressing FGF signalling and DNA methylation  EMBO Open The transcription factor Prdm14 is a critical regulator of pluripotency and germline development. This study shows that Prdm14 represses DNA methylation and FGF signaling, thereby promoting both germ cell fate and naive pluripotency in ESC. Nils Grabole, Julia Tischler, Jamie A Hackett, Shinseog Kim, Fuchou Tang, Harry G Leitch, Erna Magnúsdóttir and M Azim Surani EMBO reports (2013), 14, 629 - 637; 10.1038/embor.2013.67 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 14 May 2013 Subject Categories: Development | Chromatin & Transcription | Development Degradation of IF1 controls energy metabolism during osteogenic differentiation of stem cells The ATPase inhibitory factor 1 (IF1) is a stem cell marker that regulates energy metabolism of human mesenchymal stem cells (hMSCs). The regulated degradation of IF1 hinders self-renewal of stem cells to favour differentiation. María Sánchez-Aragó, Javier García-Bermúdez, Inmaculada Martínez-Reyes, Fulvio Santacatterina and José M Cuezva EMBO reports (2013), 14, 638 - 644; 10.1038/embor.2013.72 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 31 May 2013 Subject Categories: Differentiation & Death | Cellular Metabolism Reduced SNAP-25 alters short-term plasticity at developing glutamatergic synapses SNAP-25, a key component of the synapse, is reduced in brain areas of schizophrenic patients. This study shows that SNAP-25 levels alter short-term plasticity, which might contribute to neural alterations in psychiatric diseases. Flavia Antonucci, Irene Corradini, Raffaella Morini, Giuliana Fossati, Elisabetta Menna, Davide Pozzi, Simone Pacioni, Claudia Verderio, Alberto Bacci and Michela Matteoli EMBO reports (2013), 14, 645 - 651; 10.1038/embor.2013.75 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 04 June 2013 Subject Categories: Structural Biology Arabidopsis ARGONAUTE7 selects miR390 through multiple checkpoints during RISC assembly Plant AGO7 assembles RISC specifically with miR390 and regulates the auxin signalling pathway. This study shows that AGO7 uses multiple checkpoints and a unique passenger ejection mechanism to select miR390. Yayoi Endo, Hiro-oki Iwakawa and Yukihide Tomari EMBO reports (2013), 14, 652 - 658; 10.1038/embor.2013.73 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 04 June 2013 Subject Categories: RNA | Plant Biology | Proteins Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to EMBO reports. In order to do so, please purchase a subscription. You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/nams/svc/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department. For print subscription enquiries, please contact our subscription department. For other enquiries, please contact our customer feedback department. 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