Scientific Reports Biology Table of Contents e-alert: October 2013

01 October 2013      • Visit Scientific Reports • Submit your manuscript to Scientific Reports     Welcome to your Table of Contents e-alert for Scientific Reports         Frontiers research network enables you make the most of your valuable professional network through our unique platform. Connect to colleagues, increase your impact and benefit from a 30% increase in downloads to any publication you link to your profile. Over 100,000 researchers are already here - we are just waiting for you:register today            Biological Sciences               Olfactory imprinting is triggered by MHC peptide ligands ▶     Cornelia Hinz, ri Namekawa, Jasminca Behrmann-Godel et al.     Olfactory imprinting on environmental, population- and kin-specific cues is a specific form of life-long memory promoting homing of salmon to their natal rivers and the return of …             Inhibition of the hypoxia-inducible factor pathway by a G-quadruplex binding small molecule ▶     Sarah J. Welsh, Aaron G. Dale, Caterina M. Lombardo et al.     The hypoxia-inducible transcription factor (HIF) co-ordinates the response of tumours to low oxygen by stimulating genes involved in metabolism and angiogenesis. HIF pathway …             In situ label-free imaging for visualizing the biotransformation of a bioactive polyphenol ▶     Yoon Hee Kim, Yoshinori Fujimura, Takatoki Hagihara et al.     Although understanding the high-resolution spatial distribution of bioactive small molecules is indispensable for elucidating their biological or pharmacological effects, there …             Interaction between the transcriptional corepressor Sin3B and voltage-gated sodium channels modulates functional channel expression ▶     Ana V. Vega, Guillermo Avila, Gary Matthews     Proteins that interact with voltage-gated sodium (Nav) channels are important in channel sorting and modulation. In this study, we identified the transcriptional regulator, Sin3B, …             Metabolic Characterization of a Sirt5 deficient mouse model ▶     Jiujiu Yu, Sushabhan Sadhukhan, Lilia G. Noriega et al.     Sirt5, localized in the mitochondria, is a member of sirtuin family of NAD-dependent deacetylases. Sirt5 was shown to deacetylate and activate carbamoyl phosphate synthase 1. Most …             Nuclear targeting of dystroglycan promotes the expression of androgen regulated transcription factors in prostate cancer ▶     G. Mathew, A. Mitchell, J. M. Down et al.     Dystroglycan is frequently lost in adenocarcinoma, but the mechanisms and consequences are poorly understood. We report an analysis of β-dystroglycan in prostate cancer in human …             A serotonin-induced N-glycan switch regulates platelet aggregation ▶     Charles P. Mercado, Maritza V. Quintero, Yicong Li et al.     Serotonin (5-HT) is a multifunctional signaling molecule that plays different roles in a concentration-dependent manner. We demonstrated that elevated levels of plasma 5-HT …             Multiple genetic origins of histidine-rich protein 2 gene deletion in Plasmodium falciparum parasites from Peru ▶     Sheila Akinyi, Tonya Hayden, Dionicia Gamboa et al.     The majority of malaria rapid diagnostic tests (RDTs) detect Plasmodium falciparum histidine-rich protein 2 (PfHRP2), encoded by the pfhrp2 gene. Recently, P. falciparum isolates …             Controlling Cellular Uptake of Nanoparticles with pH-Sensitive Polymers ▶     Hong-ming Ding, Yu-qiang Ma     The major challenge in cancer therapy is to efficiently translocate drug molecules into cancer tumors without doing any damage to healthy tissues. Since there exist pH gradients …             Chromosome position at the spindle equator is regulated by chromokinesin and a bipolar microtubule array ▶     Jun Takagi, Takeshi Itabashi, Kazuya Suzuki et al.     The chromosome alignment is mediated by polar ejection and poleward forces acting on the chromosome arm and kinetochores, respectively. Although components of the motile machinery …             Penguin tissue as a proxy for relative krill abundance in East Antarctica during the Holocene ▶     Tao Huang, Liguang Sun, Nanye Long et al.     Antarctic krill (Euphausia superba) is a key component of the Southern Ocean food web. It supports a large number of upper trophic-level predators, and is also a major fishery …             Medium-term Outcomes of Cemented Prostheses and Cementless Modular Prostheses in Revision Total Hip Arthroplasty ▶     Long Wang, Pengfei Lei, Jie Xie et al.     There is an increasing trend towards cementless modular femoral prostheses for revision hip replacement surgery, especially in patients with severe proximal femoral bone defects. …             Development and validation of a lifetime exposure questionnaire for use among Chinese populations ▶     ShengHui Wu, Suzanne C. Ho, Tsz-ping Lam et al.     The sunlight exposure questionnaire for use in the Chinese population was constructed based on extensive literature review and item suitability for measuring life-time exposure. …             Culture-dependent and independent approaches for identifying novel halogenases encoded by Crambe crambe (marine sponge) microbiota ▶     Başak Öztürk, Lenny de Jaeger, Hauke Smidt et al.     Sponges harbour microbial communities that contribute to the genetic and metabolic potential of their host. Among metabolites produced by sponge-associated microbial communities, …             α-Helical Structures Drive Early Stages of Self-Assembly of Amyloidogenic Amyloid Polypeptide Aggregate Formation in Membranes ▶     Martina Pannuzzo, Antonio Raudino, Danilo Milardi et al.     The human islet amyloid polypeptide (hIAPP) is the primary component in the toxic islet amyloid deposits in type-2 diabetes. hIAPP self-assembles to aggregates that permeabilize …             Density dependence in Caenorhabditis larval starvation ▶     Alexander B. Artyukhin, Frank C. Schroeder, Leon Avery     Availability of food is often a limiting factor in nature. Periods of food abundance are followed by times of famine, often in unpredictable patterns. Reliable information about …             Autologous transplantation of GDNF-expressing mesenchymal stem cells protects against MPTP-induced damage in cynomolgus monkeys ▶     Zhenhua Ren, Jiayin Wang, Shuyan Wang et al.     Glial cell-derived neurotrophic factor (GDNF) has shown beneficial effects in models of Parkinson's disease. The mild results observed in the double-blind clinical trial by …             Endocrine Protection of Ischemic Myocardium by FGF21 from the Liver and Adipose Tissue ▶     Shu Q. Liu, Derek Roberts, Alexei Kharitonenkov et al.     Myocardial ischemia, while causing cardiomyocyte injury, can activate innate protective processes, enhancing myocardial tolerance to ischemia. Such processes are present in not …             The CCHamide 1 receptor modulates sensory perception and olfactory behavior in starved Drosophila ▶     Abu Farhan, Jyotasana Gulati, Ewald Groβe-Wilde et al.     The olfactory response of the vinegar fly Drosophila melanogaster to food odor is modulated by starvation. Here we show that this modulation is not restricted to food odors and …             Metabolic Profiling Framework for Discovery of Candidate Diagnostic Markers of Malaria ▶     Lucienne Tritten, Jennifer Keiser, Markus Godejohann et al.     Despite immense efforts to combat malaria in tropical and sub-tropical regions, the potency of this vector-borne disease and its status as a major driver of morbidity and …             The mitochondrial Na+-Ca2+ exchanger, NCLX, regulates automaticity of HL-1 cardiomyocytes ▶     Ayako Takeuchi, Bongju Kim, Satoshi Matsuoka     Mitochondrial Ca2 is known to change dynamically, regulating mitochondrial as well as cellular functions such as energy metabolism and apoptosis. The NCLX gene encodes the …             Assignment of the Q-Bands of the Chlorophylls: Coherence Loss via Qx − Qy Mixing ▶     Jeffrey R. Reimers, Zheng-Li Cai, Rika Kobayashi et al.     We provide a new and definitive spectral assignment for the absorption, emission, high-resolution fluorescence excitation, linear dichroism, and/or magnetic circular dichroism …             Exceptional preservation of Palaeozoic steroids in a diagenetic continuum ▶     Ines Melendez, Kliti Grice, Lorenz Schwark     The occurrence of intact sterols has been restricted to immature Cretaceous (~125 Ma) sediments with one report from the Late Jurassic (~165 Ma). Here we report the oldest …             Direct visualization and quantitative analysis of water diffusion in complex biological tissues using CARS microscopy ▶     Ying-Chun Yu, Yoshiro Sohma, Shinichi Takimoto et al.     To date, it has not been possible to measure microscopic diffusive water movements in epithelia and in the interstitial space of complex tissues and organs. Diffusive water …             Prediction stability in a data-based, mechanistic model of σF regulation during sporulation in Bacillus subtilis ▶     Georgios Fengos, Dagmar Iber     Mathematical modeling of biological networks can help to integrate a large body of information into a consistent framework, which can then be used to arrive at novel mechanistic …             The intrinsic microglial molecular clock controls synaptic strength via the circadian expression of cathepsin S ▶     Yoshinori Hayashi, Satoru Koyanagi, Naoki Kusunose et al.     Microglia are thought to play important roles in the maintenance of neuronal circuitry and the regulation of behavior. We found that the cortical microglia contain an intrinsic …             Complexity and diversity of eyes in Early Cambrian ecosystems ▶     Fangchen Zhao, David J. Bottjer, Shixue Hu et al.     Here we report exceptionally preserved non-biomineralized compound eyes of a non-trilobite arthropod Cindarella eucalla from the lower Cambrian Chengjiang Lagerstätte, China. The …             Lab on a Biomembrane: Rapid prototyping and manipulation of 2D fluidic lipid bilayers circuits ▶     Alar Ainla, Irep Gözen, Bodil Hakonen et al.     Lipid bilayer membranes are among the most ubiquitous structures in the living world, with intricate structural features and a multitude of biological functions. It is attractive …             Green Tea Extract Containing a Highly Absorbent Catechin Prevents Diet-Induced Lipid Metabolism Disorder ▶     Takashi Suzuki, Motofumi Kumazoe, Yoonhee Kim et al.     We investigated the effects of extracts of Benifuuki (a tea cultivar that contains methylated catechins such as epigallocatechin-3-O-(3-O-methyl) gallate (EGCG3”Me)) in mice fed a …             UV induced visual cues in grasses ▶     Sabulal Baby, Anil John Johnson, Balaji Govindan et al.     Grasses are traditionally considered as wind pollinated, however, field observations confirmed frequent insect visits to grass flowers, suggesting insect pollination. Fruit and …             Profiling the Impact of Medium Formulation on Morphology and Functionality of Primary Hepatocytes in vitro ▶     Leonard J. Nelson, Philipp Treskes, A. Forbes Howie et al.     The characterization of fully-defined in vitro hepatic culture systems requires testing of functional and morphological variables to obtain the optimal trophic support, …             An impedance-based integrated biosensor for suspended DNA characterization ▶     Hanbin Ma, Richard W. R. Wallbank, Reza Chaji et al.     Herein, we describe a novel integrated biosensor for performing dielectric spectroscopy to analyze biological samples. We analyzed biomolecule samples with different …             Regulation of the expression of the liver cancer susceptibility gene MICA by microRNAs ▶     Takahiro Kishikawa, Motoyuki Otsuka, Takeshi Yoshikawa et al.     Hepatocellular carcinoma (HCC) is a threat to public health worldwide. We previously identified the association of a single nucleotide polymorphism (SNP) at the promoter region of …             Connexin43 Functions as a Novel Interacting Partner of Heat Shock Cognate Protein 70 ▶     Tomoya Hatakeyama, Ping Dai, Yoshinori Harada et al.     Regulation of connexin43 (Cx43) expression affects cell proliferation, differentiation and apoptosis in a gap junctional intercellular communication (GJIC)-independent manner. …             Pharmacologically Controlled Protein Switch for ON-OFF Regulation of Growth Factor Activity ▶     Maria Karlsson, Balder Rebmann, Philipp S. Lienemann et al.     The precise manipulation of growth factor signaling is central to the progress of tissue engineering. Methods for direct time-resolved activation of signaling pathways through …             Information Measure for Long-Range Correlated Sequences: the Case of the 24 Human Chromosomes ▶     A. Carbone     A new approach to estimate the Shannon entropy of a long-range correlated sequence is proposed. The entropy is written as the sum of two terms corresponding respectively to …             Transgenerational sex determination: the embryonic environment experienced by a male affects offspring sex ratio ▶     Daniel A. Warner, Tobias Uller, Richard Shine     Conditions experienced during embryonic development can have lasting effects, even carrying across generations. Most evidence for transgenerational effects comes from studies of …             Early-light embryonic stimulation suggests a second route, via gene activation, to cerebral lateralization in vertebrates ▶     Cinzia Chiandetti, Jessica Galliussi, Richard J. Andrew et al.     Genetic factors determine the asymmetrical position of vertebrate embryos allowing asymmetric environmental stimulation to shape cerebral lateralization. In birds, late-light …             Functional compensation of glutathione S-transferase M1 (GSTM1) null by another GST superfamily member, GSTM2 ▶     Pritha Bhattacharjee, Somnath Paul, Mayukh Banerjee et al.     The gene for glutathione-S-transferase (GST) M1 (GSTM1), a member of the GST-superfamily, is widely studied in cancer risk with regard to the homozygous deletion of the gene (GSTM1…             Dynamically correlated mutations drive human Influenza A evolution ▶     F. Tria, S. Pompei, V. Loreto     Human Influenza A virus undergoes recurrent changes in the hemagglutinin (HA) surface protein, primarily involved in the human antibody recognition. Relevant antigenic changes, …             A computational approach to chemical etiologies of diabetes ▶     Karine Audouze, Søren Brunak, Philippe Grandjean     Computational meta-analysis can link environmental chemicals to genes and proteins involved in human diseases, thereby elucidating possible etiologies and pathogeneses of …             Anti-LRP/LR specific antibodies and shRNAs impede amyloid beta shedding in Alzheimer's disease ▶     Katarina Jovanovic, Danielle Gonsalves, Bianca Da Costa Dias et al.     Alzheimer's disease (AD) is the most prevalent form of dementia. The amyloid beta (Aβ) peptide is the predominant candidate aetiological agent and is generated through the …             Anti-LRP/LR specific antibody IgG1-iS18 and knock-down of LRP/LR by shRNAs rescue cells from Aβ42 induced cytotoxicity ▶     Bianca Da Costa Dias, Katarina Jovanovic, Danielle Gonsalves et al.     Alzheimer's disease (AD) is characterized by neurofibrillary tangles, senile plaques and neuronal loss. Amyloid beta (Aβ) is proposed to elicit neuronal loss through cell surface …             The impact of human-environment interactions on the stability of forest-grassland mosaic ecosystems ▶     Clinton Innes, Madhur Anand, Chris T. Bauch     Forest-grassland mosaic ecosystems can exhibit alternative stables states, whereby under the same environmental conditions, the ecosystem could equally well reside either in one …             Nephrons require Rho-kinase for proximal-distal polarity development ▶     Nils O. Lindström, Peter Hohenstein, Jamie A. Davies     Epithelial tubules must have the right length and pattern for proper function. In the nephron, planar cell polarity controls elongation along the proximal-distal axis. As the …             Epigenetic silencing of microRNA-203 is required for EMT and cancer stem cell properties ▶     Joseph H. Taube, Gabriel G. Malouf, Emily Lu et al.     The epithelial-mesenchymal transition (EMT) imparts metastatic competence on otherwise non-metastatic cancer cells through decreased inter-cellular adhesions, increased migratory …             Good Agreements Make Good Friends ▶     The Anh Han, Luís Moniz Pereira, Francisco C. Santos et al.     When starting a new collaborative endeavor, it pays to establish upfront how strongly your partner commits to the common goal and what compensation can be expected in case the …             Anesthesia-induced hypothermia mediates decreased ARC gene and protein expression through ERK/MAPK inactivation ▶     Robert A. Whittington, Alexis Bretteville, László Virág et al.     Several anesthetics have been reported to suppress the transcription of a number of genes, including Arc, also known as Arg3.1, an immediate early gene that plays a significant …             Subicular activation preceding hippocampal ripples in vitro ▶     Hiroaki Norimoto, Nobuyoshi Matsumoto, Takeyuki Miyawaki et al.     Sharp wave-ripple complexes (SW-Rs), a transient form of high-frequency field oscillations observed in the hippocampus, are thought to mediate memory consolidation. They are …             Music Cognition as Mental Time Travel ▶     Freya Bailes, Roger T. Dean, Marcus T. Pearce     As we experience a temporal flux of events our expectations of future events change. Such expectations seem to be central to our perception of affect in music, but we have little …             Hypoxia Enhances Chondrogenesis and Prevents Terminal Differentiation through PI3K/Akt/FoxO Dependent Anti-Apoptotic Effect ▶     Hsieh-Hsing Lee, Chia-Chi Chang, Ming-Jium Shieh et al.     Hypoxia, a common environmental condition, influences cell signals and functions. Here, we compared the effects of hypoxia (1% oxygen) and normoxia (air) on chondrogenic …             SuperNova, a monomeric photosensitizing fluorescent protein for chromophore-assisted light inactivation ▶     Kiwamu Takemoto, Tomoki Matsuda, Naoki Sakai et al.     Chromophore-assisted light inactivation (CALI) is a powerful technique for acute perturbation of biomolecules in a spatio-temporally defined manner in living specimen with …             In situ recognition of cell-surface glycans and targeted imaging of cancer cells ▶     Xiao-Ding Xu, Han Cheng, Wei-Hai Chen et al.     Fluorescent sensors capable of recognizing cancer-associated glycans, such as sialyl Lewis X (sLex) tetrasaccharide, have great potential for cancer diagnosis and therapy. Studies …             A disorder-to-order structural transition in the COOH-tail of Fz4 determines misfolding of the L501fsX533-Fz4 mutant ▶     Valentina Lemma, Massimo D'Agostino, Maria Gabriella Caporaso et al.     Frizzled 4 belongs to the superfamily of G protein coupled receptors. The unstructured cytosolic tail of the receptor is essential for its activity. The mutation L501fsX533 in the …             Overcoming chemoresistance of small-cell lung cancer through stepwise HER2-targeted antibody-dependent cell-mediated cytotoxicity and VEGF-targeted antiangiogenesis ▶     Toshiyuki Minami, Takashi Kijima, Satoshi Kohmo et al.     Small-cell lung cancer (SCLC) easily recurs with a multidrug resistant phenotype. However, standard therapeutic strategies for relapsed SCLC remain unestablished. We found that …             Nanodiamond Landmarks for Subcellular Multimodal Optical and Electron Imaging ▶     Mark A. Zurbuchen, Michael P. Lake, Sirus A. Kohan et al.     There is a growing need for biolabels that can be used in both optical and electron microscopies, are non-cytotoxic, and do not photobleach. Such biolabels could enable targeted …             Quantitative full time course analysis of nonlinear enzyme cycling kinetics ▶     Wenxiang Cao, Enrique M. De La Cruz     Enzyme inhibition due to the reversible binding of reaction products is common and underlies the origins of negative feedback inhibition in many metabolic and signaling pathways. …             Super-paramagnetic responsive nanofibrous scaffolds under static magnetic field enhance osteogenesis for bone repair in vivo ▶     Jie Meng, Bo Xiao, Yu Zhang et al.     A novel nanofibrous composite scaffold composed of super-paramagnetic γ-Fe2O3 nanoparticles (MNP), hydroxyapatite nanoparticles (nHA) and poly lactide acid (PLA) was prepared …             Multi-petal cyclamen flowers produced by AGAMOUS chimeric repressor expression ▶     Yuri Tanaka, Yoshimi Oshima, Tomomichi Yamamura et al.     Cyclamen persicum (cyclamen) is a commercially valuable, winter-blooming perennial plant. We cloned two cyclamen orthologues of AGAMOUS (AG), CpAG1 and CpAG2, which are mainly …             Does dopamine block the spawning of the acroporid coral Acropora tenuis? ▶     N. Isomura, C. Yamauchi, Y. Takeuchi et al.     Most corals undergo spawning after a particular moon phase, but how moon-related spawning is endogenously regulated in corals remains unknown. The objective of the present study …             The ClC-3 chloride channel associated with microtubules is a target of paclitaxel in its induced-apoptosis ▶     Haifeng Zhang, Huarong Li, Lili Yang et al.     Recent evidences show that cationic fluxes play a pivotal role in cell apoptosis. In this study, the roles of Cl− channels in paclitaxel-induced apoptosis were investigated in …             Feeling the force: Returning haptic signals influence effort inference during motor coordination ▶     G. Ganesh, R. Osu, E. Naito     Our brain is known to automatically optimize effort expenditure during motor coordination, such that for example, during bimanual braking of a bicycle, a well-oiled brake will …             Inhibition of Plk1 and Cyclin B1 Expression Results in Panobinostat-Induced G2 Delay and Mitotic Defects ▶     Michael Prystowsky, Katherine Feeney, Nicole Kawachi et al.     The development of clinically useful histone deacetylase inhibitors has expanded greatly. In a preclinical study, we showed that panobinostat (LBH589) inhibits cell cycle …             Mn3[Co(CN)6]2@SiO2 Core-shell Nanocubes: Novel bimodal contrast agents for MRI and optical imaging ▶     Yimin Huang, Lin Hu, Tingting Zhang et al.     Nanoprobes with dual modal imaging of magnetic resonance imaging (MRI) and two-photon fluorescence (TPF) can serve as promising platforms for clinical diagnosis. A wide range of …             A new form of rapid binocular plasticity in adult with amblyopia ▶     Jiawei Zhou, Benjamin Thompson, Robert F. Hess     Amblyopia is a neurological disorder of binocular vision affecting up to 3% of the population resulting from a disrupted period of early visual development. Recently, it has been …             When a repellent becomes an attractant: harmful saponins are kairomones attracting the symbiotic Harlequin crab ▶     Guillaume Caulier, Patrick Flammang, Pascal Gerbaux et al.     Marine organisms have developed a high diversity of chemical defences in order to avoid predators and parasites. In sea cucumbers, saponins function as repellents and many species …             Size matters: implications of the loss of large individuals for ecosystem function ▶     Alf Norkko, Anna Villnäs, Joanna Norkko et al.     Size is a fundamental organismal trait and an important driver of ecosystem functions. Although large individuals may dominate some functions and provide important habitat …             Engineering of cofactor regeneration enhances (2S,3S)-2,3-butanediol production from diacetyl ▶     Yu Wang, Lixiang Li, Cuiqing Ma et al.     (2S,3S)-2,3-Butanediol ((2S,3S)-2,3-BD) is a potentially valuable liquid fuel and an excellent building block in asymmetric synthesis. In this study, cofactor engineering was …             In vivo Optical Coherence Tomography of Light-Driven Melanosome Translocation in Retinal Pigment Epithelium ▶     Qiu-Xiang Zhang, Rong-Wen Lu, Jeffrey D. Messinger et al.     Optical coherence tomography (OCT) may revolutionize fundamental investigation and clinical management of age-related macular degeneration and other eye diseases. However, …             Feeling Small: Exploring the Tactile Perception Limits ▶     Lisa Skedung, Martin Arvidsson, Jun Young Chung et al.     The human finger is exquisitely sensitive in perceiving different materials, but the question remains as to what length scales are capable of being distinguished in active touch. …             TreeParser-Aided Klee Diagrams Display Taxonomic Clusters in DNA Barcode and Nuclear Gene Datasets ▶     Mark Y. Stoeckle, Cameron Coffran     Indicator vector analysis of a nucleotide sequence alignment generates a compact heat map, called a Klee diagram, with potential insight into clustering patterns in evolution. …             Conferring the ability to utilize inorganic polyphosphate on ATP-specific NAD kinase ▶     Yusuke Nakamichi, Aya Yoshioka, Shigeyuki Kawai et al.     NAD kinase (NADK) is a crucial enzyme for production of NADP. ATP-specific NADK prefers ATP to inorganic polyphosphate [poly(P)] as a phosphoryl donor, whereas poly(P)/ATP-NADK …             Next-Generation Anchor Based Phylogeny (NexABP): Constructing phylogeny from Next-generation sequencing data ▶     Tanmoy Roychowdhury, Anchal Vishnoi, Alok Bhattacharya     Whole genome sequences are ideally suited for deriving evolutionary relationship among organisms. With the availability of Next Generation sequencing (NGS) datasets in an …             Epidermal growth factor receptor subunit locations determined in hydrated cells with environmental scanning electron microscopy ▶     Diana B. Peckys, Jean-Pierre Baudoin, Magdalena Eder et al.     Imaging single epidermal growth factor receptors (EGFR) in intact cells is presently limited by the available microscopy methods. Environmental scanning electron microscopy (ESEM) …             Downregulation of ubiquitin level via knockdown of polyubiquitin gene Ubb as potential cancer therapeutic intervention ▶     Choongseob Oh, Soonyong Park, Eun Kyung Lee et al.     Ubiquitin is involved in almost every cellular process, and it is also known to be a stress-inducible protein. Based on previous reports that many types of cancer display an …             A cross-species socio-emotional behaviour development revealed by a multivariate analysis ▶     Mamiko Koshiba, Aya Senoo, Koki Mimura et al.     Recent progress in affective neuroscience and social neurobiology has been propelled by neuro-imaging technology and epigenetic approach in neurobiology of animal behaviour. …             Vision and air flow combine to streamline flying honeybees ▶     Gavin J. Taylor, Tien Luu, David Ball et al.     Insects face the challenge of integrating multi-sensory information to control their flight. Here we study a ‘streamlining’ response in honeybees, whereby honeybees raise their …             Interplay of cytoskeletal activity and lipid phase stability in dynamic protein recruitment and clustering ▶     Jordi Gómez-Llobregat, Javier Buceta, Ramon Reigada     Recent experiments have revealed that some membrane proteins aggregate to form clusters. This type of process has been proven to be dynamic and to be actively maintained by …             A comparative assessment and analysis of 20 representative sequence alignment methods for protein structure prediction ▶     Renxiang Yan, Dong Xu, Jianyi Yang et al.     Protein sequence alignment is essential for template-based protein structure prediction and function annotation. We collect 20 sequence alignment algorithms, 10 published and 10 …             Microbiomic Signatures of Psoriasis: Feasibility and Methodology Comparison ▶     Alexander Statnikov, Alexander V. Alekseyenko, Zhiguo Li et al.     Psoriasis is a common chronic inflammatory disease of the skin. We sought to use bacterial community abundance data to assess the feasibility of developing multivariate molecular …             Pharmacologically Triggered Hydrogel for Scheduling Hepatitis B Vaccine Administration ▶     Raphael J. Gübeli, Katrin Schöneweis, Daniela Huzly et al.     The simplification of current vaccine administration regimes is of crucial interest in order to further sustain and expand the high impact of vaccines for public health. Most …             Involvement of A20 in the molecular switch that activates the non-canonical NF-кB pathway ▶     Noritaka Yamaguchi, Masaaki Oyama, Hiroko Kozuka-Hata et al.     The non-canonical NF-κB pathway is crucial for the immune system. A critical event in activation of the non-canonical pathway is the attenuation of NF-κB-inducing kinase (NIK) …             Transient and selective suppression of neural activity with infrared light ▶     Austin R. Duke, Michael W. Jenkins, Hui Lu et al.     Analysis and control of neural circuitry requires the ability to selectively activate or inhibit neurons. Previous work showed that infrared laser light selectively excited neural …             Distinct cell shapes determine accurate chemotaxis ▶     Luke Tweedy, Börn Meier, Jürgen Stephan et al.     The behaviour of an organism often reflects a strategy for coping with its environment. Such behaviour in higher organisms can often be reduced to a few stereotyped modes of …             Discovery of an uncovered region in fibrin clots and its clinical significance ▶     Yohei Hisada, Masahiro Yasunaga, Shingo Hanaoka et al.     Despite the pathological importance of fibrin clot formation, little is known about the structure of these clots because X-ray and nuclear magnetic resonance (NMR) analyses are …             Rotation-independent representations for haptic movements ▶     Satoshi Shioiri, Takanori Yamazaki, Kazumichi Matsumiya et al.     The existence of a common mechanism for visual and haptic representations has been reported in object perception. In contrast, representations of movements might be more specific …             The molecular and clinicopathologic characteristics of bilateral breast cancer ▶     S. F. Chen, C. W. Du, P. Yang et al.     In this study, we compared the clinicopathologic characteristics between the bilateral breast cancer (BiBC) and unilateral breast cancer (UBC) and investigated the role of CXC …             Paravascular microcirculation facilitates rapid lipid transport and astrocyte signaling in the brain ▶     Vinita Rangroo Thrane, Alexander S. Thrane, Benjamin A. Plog et al.     In the brain, a paravascular space exists between vascular cells and astroglial end-foot processes, creating a continuous sheath surrounding blood vessels. Using in vivo …             Definition and refinement of the 7q36.3 duplication region associated with schizophrenia ▶     Branko Aleksic, Itaru Kushima, Tamae Ohye et al.     Using a very high-resolution oligonucleotide array for copy number variant (CNV) screening of samples comprising schizophrenic patients, we detected a novel CNV within the …             A single betaproteobacterium dominates the microbial community of the crambescidine-containing sponge Crambe crambe ▶     Julie Croué, Nyree J. West, Marie-Line Escande et al.     Crambe crambe is a marine sponge that produces high concentrations of the pharmacologically significant pentacyclic guanidine alkaloids (PGAs), Crambescines and Crambescidines. …             Analyzing Strawberry Spoilage via its Volatile Compounds Using Longpath Fourier Transform Infrared Spectroscopy ▶     Daming Dong, Chunjiang Zhao, Wengang Zheng et al.     The volatile compounds from fruits vary based on the spoilage stage. We used FTIR spectroscopy to analyze and to attempt to identify the spoilage process of strawberries. To …             Effects of barley chromosome addition to wheat on behavior and development of Locusta migratoria nymphs ▶     Shunji Suematsu, Ken-ichi Harano, Seiji Tanaka et al.     Locusta migratoria feeds on various Poaceae plants but barley. Barley genes related to feeding deterrence may be useful for developing novel resistant crops. We investigated the …             Discovery of a divergent HPIV4 from respiratory secretions using second and third generation metagenomic sequencing ▶     David E. Alquezar-Planas, Tobias Mourier, Christian A. W. Bruhn et al.     Molecular detection of viruses has been aided by high-throughput sequencing, permitting the genomic characterization of emerging strains. In this study, we comprehensively …             Quantitative epigenetic co-variation in CpG islands and co-regulation of developmental genes ▶     Hongbo Liu, Yanjun Chen, Jie Lv et al.     The genome-wide variation of multiple epigenetic modifications in CpG islands (CGIs) and the interactions between them are of great interest. Here, we optimized an entropy-based …             Glucocorticoid Paradoxically Recruits Adipose Progenitors and Impairs Lipid Homeostasis and Glucose Transport in Mature Adipocytes ▶     Jorge-Tonatiuh Ayala-Sumuano, Cristina Velez-delValle, Alicia Beltrán-Langarica et al.     Chronic treatment with glucocorticoids increases the mass of adipose tissue and promotes metabolic syndrome. However little is known about the molecular effects of dexamethasone …             Damped propagation of cell polarization explains distinct PCP phenotypes of epithelial patterning ▶     Hao Zhu, Markus R. Owen     During epithelial patterning in metazoans cells are polarized in the plane of a tissue, a process referred to as planar cell polarity (PCP). Interactions between a few molecules …             The Herbaspirillum seropedicae SmR1 Fnr orthologs controls the cytochrome composition of the electron transport chain ▶     Marcelo B. Batista, Michelle Z. T. Sfeir, Helisson Faoro et al.     The transcriptional regulatory protein Fnr, acts as an intracellular redox sensor regulating a wide range of genes in response to changes in oxygen levels. Genome sequencing of …             Deletions within its subcellular targeting domain enhance the axon protective capacity of Nmnat2 in vivo ▶     Stefan Milde, A. Nicole Fox, Marc R. Freeman et al.     The NAD-synthesising enzyme Nmnat2 is a critical survival factor for axons in vitro and in vivo. We recently reported that loss of axonal transport vesicle association through …             Bacteria Mediate Oviposition by the Black Soldier Fly, Hermetia illucens (L.), (Diptera: Stratiomyidae) ▶     Longyu Zheng, Tawni L. Crippen, Leslie Holmes et al.     There can be substantial negative consequences for insects colonizing a resource in the presence of competitors. We hypothesized that bacteria, associated with an oviposition …             IGF-1R/epithelial-to-mesenchymal transition (EMT) crosstalk suppresses the erlotinib-sensitizing effect of EGFR exon 19 deletion mutations ▶     Alejandro Vazquez-Martin, Sílvia Cufí, Cristina Oliveras-Ferraros et al.     Using non-small cell lung carcinoma (NSCLC) cells harboring the erlotinib-sensitizing Epidermal Growth Factor Receptor (EGFR) exon 19 mutation delE746-A750, we developed …             Toll-like Receptor agonists and alpha-galactosylceramide synergistically enhance the production of interferon-gamma in murine splenocytes ▶     Tatsuya Ando, Hiroyasu Ito, Hirofumi Ohtaki et al.     Vα14 natural killer T (iNKT) cells activated by alpha-galactosylceramide (GalCer) secrete a large amount of cytokines. Toll-like receptors (TLRs) play a critical role in the …             Predicted spatio-temporal dynamics of radiocesium deposited onto forests following the Fukushima nuclear accident ▶     Shoji Hashimoto, Toshiya Matsuura, Kazuki Nanko et al.     The majority of the area contaminated by the Fukushima Dai-ichi nuclear power plant accident is covered by forest. To facilitate effective countermeasure strategies to mitigate …             The flavonoid apigenin improves glucose tolerance through inhibition of microRNA maturation in miRNA103 transgenic mice ▶     Motoko Ohno, Chikako Shibata, Takahiro Kishikawa et al.     Polyphenols are representative bioactive substances with diverse biological effects. Here, we show that apigenin, a flavonoid, has suppressive effects on microRNA (miRNA) …             Diversity and functional significance of cellulolytic microbes living in termite, pill-bug and stem-borer guts ▶     Zeenat Bashir, Vamsi Krishna Kondapalli, Nidhi Adlakha et al.     Arthropods living on plants are able to digest plant biomass with the help of microbial flora in their guts. This study considered three arthropods from different niches - …             Whales Use Distinct Strategies to Counteract Solar Ultraviolet Radiation ▶     Laura M. Martinez-Levasseur, Mark A. Birch-Machin, Amy Bowman et al.     A current threat to the marine ecosystem is the high level of solar ultraviolet radiation (UV). Large whales have recently been shown to suffer sun-induced skin damage from …             Sex differences in sensation-seeking: a meta-analysis ▶     Catharine P. Cross, De-Laine M. Cyrenne, Gillian R. Brown     Men score higher than women on measures of sensation-seeking, defined as a willingness to engage in novel or intense activities. This sex difference has been explained in terms of …             Magnetoresistive Emulsion Analyzer ▶     Gungun Lin, Larysa Baraban, Luyang Han et al.     We realize a magnetoresistive emulsion analyzer capable of detection, multiparametric analysis and sorting of ferrofluid-containing nanoliter-droplets. The operation of the device …             Digital Imprinting of RNA Recognition and Processing on a Self-Assembled Nucleic Acid Matrix ▶     Shiv K. Redhu, Matteo Castronovo, Allen W. Nicholson     The accelerating progress of research in nanomedicine and nanobiotechnology has included initiatives to develop highly-sensitive, high-throughput methods to detect biomarkers at …             Integrative transcriptome analysis reveals dysregulation of canonical cancer molecular pathways in placenta leading to preeclampsia ▶     Roxana Moslehi, James L. Mills, Caroline Signore et al.     We previously suggested links between specific XPD mutations in the fetal genome and the risk of placental maldevelopment and preeclampsia, possibly due to impairment of …             Probing the Transmembrane Structure and Topology of Microsomal Cytochrome-P450 by Solid-State NMR on Temperature-Resistant Bicelles ▶     Kazutoshi Yamamoto, Melissa Gildenberg, Shivani Ahuja et al.     Though the importance of high-resolution structure and dynamics of membrane proteins has been well recognized, optimizing sample conditions to retain the native-like folding and …                     • Careers & Jobs           naturejobs.com Science jobs of the week       Faculty Position     Vanderbilt University            Research Associate     Cardiff University            PhD Research Associate     BOKU - University of Natural Resources and Applied Life Sciences, Vienna            Postdoctoral Fellow In Developmental Neuroscience     CNRS and École Normale Supérieure            Research Associate (x 2)     Cambridge Institute for Medical Research (CIMR)            Postdoctoral Research Associate     University of Oxford            Bioinformatician     University of Oxford            Post-doctoral Researcher     Nationwide Children's Hospital, Research Institute            Research Assistant     Khalifa University of Science, Technology & Research (KUSTAR)            Postdoctoral Fellow     Shantou University          No matter what your career stage, student, postdoc or senior scientist, you will find articles on naturejobs.com to help guide you in your science career. 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