Nature Reviews Rheumatology - Table of Contents alert Volume 11 Issue 1

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TABLE OF CONTENTS
January 2015 Volume 11 Number 1
Impact Factor 10.252 *	In this issue Research Highlights News and Views Reviews Perspectives Also this month  Featured article: New players driving inflammation in monogenic autoinflammatory diseases Fabio Martinon & Ivona Aksentijevich
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RESEARCH HIGHLIGHTS Top Spondyloarthropathies: Gut dysbiosis in ankylosing spondylitis Published online: 09 December 2014 p1 | doi:10.1038/nrrheum.2014.207 PDF Rheumatoid arthritis: Optimizing withdrawal of therapy to sustain remission Published online: 25 November 2014 p2 | doi:10.1038/nrrheum.2014.201 PDF IN BRIEF Vasculitis syndromes: Rituximab as remission maintenance therapy | Lupus nephritis: Multitarget induction therapy versus cyclophosphamide | Osteoarthritis: Arthroscopic debridement and capsular release in OA PDF Rheumatology JOBS of the week KTRR Senior Research Fellows (3 positions) University of Oxford Postdoctoral Researcher NYU School of Medicine - Department of Medicine More Science jobs from
NEWS AND VIEWS		Top
Connective tissue diseases: New criteria improve recognition of early systemic sclerosis Yoshihide Asano & Shinichi Sato Published online: 11 November 2014 p3 | doi:10.1038/nrrheum.2014.191 In systemic sclerosis (SSc), new classification criteria highly sensitive to early and limited forms of the disease could facilitate not only the recognition of early SSc, but also the discovery of biomarkers of poor prognosis, with potential benefits for conducting clinical trials. Full Text | PDF
Rheumatoid arthritis: Developing new oral targeted therapies for RA can be challenging Roy M. Fleischmann Published online: 11 November 2014 p4 | doi:10.1038/nrrheum.2014.187 The positive results of the phase II programme of fostamatinib, developed to target the spleen tyrosine kinase pathway in rheumatoid arthritis (RA), have not been replicated in phase III. What implications might the results have for the development of other oral inhibitors of intracellular kinases in the treatment of RA? Full Text | PDF
Osteoarthritis: Epigenetics of articular cartilage in knee and hip OA John Loughlin & Louise N. Reynard Published online: 04 November 2014 p6 | doi:10.1038/nrrheum.2014.189 Epigenetic regulation is a vital driver of the aetiology of human disease, with research breakthroughs now occurring on a regular basis. Several studies investigating CpG methylation of cartilage DNA from patients with osteoarthritis are generating exciting insight into this common but complex disease. Full Text | PDF
Rheumatoid arthritis: Seronegative and seropositive RA: alike but different? Sofia Ajeganova & Tom W. J. Huizinga Published online: 18 November 2014 p8 | doi:10.1038/nrrheum.2014.194 The presence or absence of autoantibodies in patients with rheumatoid arthritis (RA) can guide clinical practice, but the role of autoantibody status in 'real life' is unclear. A cohort study from Canada provides clinical perspective on the presentation, prognosis and efficacy of treatment of patients with autoantibody-negative RA. Full Text | PDF
REVIEWS		Top
New players driving inflammation in monogenic autoinflammatory diseases Fabio Martinon & Ivona Aksentijevich Published online: 23 September 2014 p11 | doi:10.1038/nrrheum.2014.158 In this Review, Martinon and Aksentijevich highlight the latest developments in research into the pathogenesis of autoinflammatory diseases. Newly discovered disease-causing mutations and molecular pathways underlying inherited autoinflammatory diseases are discussed. Abstract | Full Text | PDF
Repair and tissue engineering techniques for articular cartilage Eleftherios A. Makris, Andreas H. Gomoll, Konstantinos N. Malizos, Jerry C. Hu & Kyriacos A. Athanasiou Published online: 23 September 2014 p21 | doi:10.1038/nrrheum.2014.157 Although osteoarthritis can be slowed by biologic therapy, surgical interventions are necessary to recover cartilage function. In this Review of cartilage repair techniques, the authors outline how currently accepted methods can fall short in providing a long-term solution of hyaline cartilage regeneration and discuss preclinical and clinical trials of new cell scaffold-based, cell-free scaffold-based and scaffold-free procedures. Abstract | Full Text | PDF
Emerging regulators of the inflammatory process in osteoarthritis Ru Liu-Bryan & Robert Terkeltaub Published online: 30 September 2014 p35 | doi:10.1038/nrrheum.2014.162 In osteoarthritis (OA), chronic, low-grade inflammatory processes promote the symptoms and progression of the disease. In this Review, the authors discuss the inflammatory pathophysiology in OA, including networks of inflammatory mediators in OA joints, transcriptional reprogramming of chondrocytes, and abnormal bioenergetics and proteostasis mechanisms, and consider the potential to target these processes for the treatment of OA. Abstract | Full Text | PDF
Fracture healing: mechanisms and interventions Thomas A. Einhorn & Louis C. Gerstenfeld Published online: 30 September 2014 p45 | doi:10.1038/nrrheum.2014.164 In this Review, skeletal ontogeny is compared to fracture healing mechanisms. The authors describe developments in our understanding of the different stages of fracture healing as well as the latest therapies tested in animal models and in clinical trials, focusing on bone morphogenetic proteins or parathyroid hormone based treatments. Abstract | Full Text | PDF
PERSPECTIVES		Top
SCIENCE AND SOCIETY An insight into rheumatology in Thailand Worawit Louthrenoo Published online: 09 September 2014 p55 | doi:10.1038/nrrheum.2014.142 Rheumatic diseases are a common health-care problem in Thailand. Patient care is influenced not only by differences in the prevalence, clinical traits and genetic variants of these diseases in Thailand compared with other countries, but by the country's health-care systems, availability of medicine and physicians, and rheumatology training, education and research. The author provides his expert view of the current challenges and barriers, recent successes and future prospects of rheumatology in Thailand. Abstract | Full Text | PDF
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*Journal Citation Reports, Thomson, 2013. Nature Reviews Rheumatology was previously published as Nature Clinical Practice Rheumatology.

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