The EMBO Journal Table of Contents for 02 January 2015; Vol. 34, No. 1

02 January 2015 | Volume 34, Number 1 Submit Table of Contents Have you seen? Articles Volume 34, Number 1 Have you seen? Escaping the endoplasmic reticulum: why does a molecular chaperone leave home for greener pastures? Selective secretion of an ER‐resident chaperone upon activation of the unfolded protein response contributes to extracellular proteostasis. Teresa M Buck and Jeffrey L Brodsky Published online 25.11.2014 Articles Unfolded protein response‐induced ERdj3 secretion links ER stress to extracellular proteostasis The unfolded protein response triggers secretion of ER chaperone ERdj3 to prevent formation of toxic aggregates, providing the first mechanistic link between intracellular stress signaling and extracellular proteostasis. Joseph C Genereux, Song Qu, Minghai Zhou, Lisa M Ryno, Shiyu Wang, Matthew D Shoulders, Randal J Kaufman, Corinne I Lasmézas, Jeffery W Kelly, and R Luke Wiseman Published online 31.10.2014 ARGONAUTE 6 bridges transposable element mRNA‐derived siRNAs to the establishment of DNA methylation Transcriptional activation of transposable elements (TEs) in plants leads to initial mRNA destruction through RNAi. AGO6 incorporates the resulting siRNAs and induces DNA methylation at TE target loci, thus establishing de novo epigenetic silencing. Andrea D McCue, Kaushik Panda, Saivageethi Nuthikattu, Sarah G Choudury, Erica N Thomas, and R Keith Slotkin Published online 11.11.2014 A secretagogin locus of the mammalian hypothalamus controls stress hormone release Bodily responses to acute stress are orchestrated by the hierarchical release of stress hormones along the hypothalamic‐pituitary‐adrenal axis. Corticotropin‐releasing hormone (CRH)‐secreting neurons in the paraventricular nucleus of the hypothalamus are first order neurons in this axis, priming subsequent hormonal cascades upon CRH release into the portal circulation at the median eminence. Roman A Romanov, Alán Alpár, Ming‐Dong Zhang, Amit Zeisel, André Calas, Marc Landry, Matthew Fuszard, Sally L Shirran, Robert Schnell, Árpád Dobolyi, Márk Oláh, Lauren Spence, Jan Mulder, Henrik Martens, Miklós Palkovits, Mathias Uhlen, Harald H Sitte, Catherine H Botting, Ludwig Wagner, Sten Linnarsson, Tomas Hökfelt, and Tibor Harkany Published online 27.11.2014 GRIM REAPER peptide binds to receptor kinase PRK5 to trigger cell death in Arabidopsis In plants, ROS‐induced cell death requires Metacaspase‐9‐mediated processing of secreted protein GRIM REAPER to produce the peptide ligand for PRK5. Michael Wrzaczek, Julia P Vainonen, Simon Stael, Liana Tsiatsiani, Hanna Help‐Rinta‐Rahko, Adrien Gauthier, David Kaufholdt, Benjamin Bollhöner, Airi Lamminmäki, An Staes, Kris Gevaert, Hannele Tuominen, Frank Van Breusegem, Ykä Helariutta, and Jaakko Kangasjärvi Published online 14.11.2014 Differential retrotranslocation of mitochondrial Bax and Bak Pro‐apoptotic proteins Bax and Bak kill cells by permeabilizing the outer mitochondrial membrane. Mitochondrial localization and thus apoptosis induction by both proteins is controlled by their retrotranslocation dynamics governed by the hydrophobicity of the C‐terminal membrane anchor. Franziska Todt, Zeynep Cakir, Frank Reichenbach, Frederic Emschermann, Joachim Lauterwasser, Andrea Kaiser, Gabriel Ichim, Stephen WG Tait, Stephan Frank, Harald F Langer, and Frank Edlich Published online 05.11.2014 Identification of Cdk targets that control cytokinesis Phosphoproteomic analyses of mitotic exit reveals target proteins through which cyclin‐dependent kinase and its counteracting Cdc14 phosphatase control sequential steps of budding yeast cytokinesis. Thomas Kuilman, Alessio Maiolica, Molly Godfrey, Noémie Scheidel, Ruedi Aebersold, and Frank Uhlmann Published online 04.11.2014 RBM14 prevents assembly of centriolar protein complexes and maintains mitotic spindle integrity Characterization of a novel centriole biogenesis regulator uncovers a non‐canonical, cartwheel‐independent pathway allowing formation of procentriole‐like structures even in the presence of pre‐existing centrioles. Gen Shiratsuchi, Katsuyoshi Takaoka, Tomoko Ashikawa, Hiroshi Hamada, and Daiju Kitagawa Published online 10.11.2014 Fission yeast Cactin restricts telomere transcription and elongation by controlling Rap1 levels Cactin emerges from a genomewide screen for factors controlling telomeric transcription, regulating Rap1 expression both on the level of splicing efficiency and protein stability. Luca E Lorenzi, Amadou Bah, Harry Wischnewski, Vadim Shchepachev, Charlotte Soneson, Marco Santagostino, and Claus M Azzalin Published online 14.11.2014   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2015 by the European Molecular Biology Organisation.