Nature Reviews Nephrology - Table of Contents alert Volume 12 Issue 5

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Nature Reviews Nephrology focus: Translational immunology  New technologies and improved understanding of immune processes have led to advances in the treatment of autoimmune diseases; however, effective therapies for treatment of immune-mediated kidney diseases are limited. This focus provides insights as to how the translation of therapies to the clinic can be improved.
TABLE OF CONTENTS
May 2016 Volume 12 Number 5		Advertisement
Impact Factor 8.542 *	In this issue Research Highlights News and Views Reviews Also this month  Featured article: Mitochondrial dysfunction in inherited renal disease and acute kidney injury Francesco Emma, Giovanni Montini, Samir M. Parikh & Leonardo Salviati	Do you know of an innovative approach to selectively deliver new chemical entities to podocytes in diabetic nephropathy patients? If so, Boehringer Ingelheim invites you to enter their InnoCentive Challenge. A $20,000 award fund is available along with options for Research Collaborations. The deadline for submissions is May 13, 2016. See the full details and enter here
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RESEARCH HIGHLIGHTS Top Acute kidney injury: Improved fuel metabolism protects against AKI Published online: 30 March 2016 p255 | doi:10.1038/nrneph.2016.45 PDF Glomerular disease: Novel candidate genes implicated in FSGS Published online: 07 March 2016 p256 | doi:10.1038/nrneph.2016.30 PDF Anaemia: Regulation of renal erythropoietin via HIF Published online: 14 March 2016 p256 | doi:10.1038/nrneph.2016.32 PDF Renal fibrosis: PDGF-D in renal fibrosis Published online: 07 March 2016 p257 | doi:10.1038/nrneph.2016.31 PDF Cystic kidney disease: mTORC1-PC-1 crosstalk in TSC Published online: 21 March 2016 p257 | doi:10.1038/nrneph.2016.43 PDF Genetics: Evolving risks of UMOD variants Published online: 30 March 2016 p257 | doi:10.1038/nrneph.2016.46 PDF Hypertension: Regulation of salt appetite and blood pressure Published online: 21 March 2016 p258 | doi:10.1038/nrneph.2016.42 PDF IN BRIEF Acute kidney injury: Atorvastatin does not reduce the risk of AKI after cardiac surgery | Transplantation: Renal function after kidney donation | Polycystic kidney disease: Sirolimus is ineffective in ADPKD | Acute kidney injury: Postoperative FGF-23 levels are associated with AKI PDF
NEWS AND VIEWS		Top
Thrombotic microangiopathy: Caplacizumab accelerates resolution of acute acquired TTP Bernhard Lämmle Published online: 04 April 2016 p259 | doi:10.1038/nrneph.2016.47 New data demonstrate that caplacizumab treatment accelerates normalization of platelet count in patients with acute episodes of acquired thrombotic thrombocytopenic purpura (TTP). Although not curative, this drug might reduce ischaemic organ damage and be potentially lifesaving for patients with TTP who do not respond to conventional therapy. Full Text | PDF
Transplantation: BENEFIT of belatacept: kidney transplantation moves forward Maarten Naesens & Olivier Thaunat Published online: 30 March 2016 p261 | doi:10.1038/nrneph.2016.34 New data from the BENEFIT study demonstrate that belatacept improves long-term allograft and patient survival after kidney transplantation, despite higher rates of biopsy-proven acute rejection than with ciclosporin. The noninferiority design of BENEFIT represents a feasible strategy to further the development of innovator drugs to reduce late graft loss. Full Text | PDF
Acute kidney injury: Clinical trials in AKI: is the end in sight? Monica Parks & Kathleen D. Liu Published online: 30 March 2016 p263 | doi:10.1038/nrneph.2016.35 Clinical trials in patients with acute kidney injury (AKI) have been stymied by a lack of consensus on suitable renal-specific end points. In a recent analysis, Grams et al. suggest that a sustained 30-40% reduction in estimated glomerular filtration rate after hospital discharge might be a suitable intermediate end point for AKI clinical trials. Full Text | PDF
Mineral metabolism: The perils of a falling PTH due to high dialysate calcium Wei Chen & David A. Bushinsky Published online: 21 March 2016 p264 | doi:10.1038/nrneph.2016.36 New data suggest that a fall in parathyroid hormone (PTH) 12 months after initiating haemodialysis is associated with cardiovascular death at 12-24 months. The main independent predictor for the fall in PTH is a high dialysate calcium concentration, which might not only reduce PTH but also induce vascular calcification. Full Text | PDF
REVIEWS		Top
Mitochondrial dysfunction in inherited renal disease and acute kidney injury Francesco Emma, Giovanni Montini, Samir M. Parikh & Leonardo Salviati Published online: 25 January 2016 p267 | doi:10.1038/nrneph.2015.214 Healthy mitochondria are essential for normal kidney function and mitochondrial dysfunction has been implicated in various types of renal disorders, both inherited and acquired. In this article, the authors review mitochondrial cytopathies with renal manifestations and the role of mitochondrial dysfunction in acute kidney injury (AKI). Abstract | Full Text | PDF
Role of TLRs and DAMPs in allograft inflammation and transplant outcomes Faouzi Braza, Sophie Brouard, Steve Chadban & Daniel R. Goldstein Published online: 30 March 2016 p281 | doi:10.1038/nrneph.2016.41 Graft necrosis resulting from ischaemia-reperfusion injury leads to the release of endogenous molecules — damage-associated molecular patterns (DAMPs) — which trigger a sterile inflammatory reaction. The resulting immune response can impair transplant tolerance or result in acute or chronic graft rejection. In this Review, Braza et al. discuss the nature of DAMPs and their downstream signalling pathways, with a focus on Toll-like receptors. They outline various strategies to inhibit DAMP-induced inflammation with the aim of improving the outcomes of solid organ transplantation, and discuss the challenge of inhibiting the innate immune response within the graft without compromising the patient's response to pathogens. Abstract | Full Text | PDF
HIV-associated immune complex kidney disease Ehsan Nobakht, Scott D. Cohen, Avi Z. Rosenberg & Paul L. Kimmel Published online: 19 January 2016 p291 | doi:10.1038/nrneph.2015.216 Renal disease is a frequent complication of HIV infection, and a spectrum of renal disorders has been described with diverse histopathologic forms. In this Review, Scott Cohen and colleagues outline the epidemiology of renal disease in HIV and how it has changed since the introduction of combined antiretroviral therapy. They discuss the clinical manifestations and mechanisms underlying renal disease development in patients with HIV, and the issues pertaining to diagnosis and therapeutics. Abstract | Full Text | PDF
Long-term effects of paediatric kidney transplantation Christer Holmberg & Hannu Jalanko Published online: 14 December 2015 p301 | doi:10.1038/nrneph.2015.197 Renal transplantation can be successfully performed in patients of all ages, and the short-term and medium-term outcomes have improved over the past decades. In this Review, Christer Holmberg and Hannu Jalanko discuss the long-term effects of kidney transplantation on paediatric recipients. They outline the adverse effects that can occur with regard to growth, bone health, metabolic and cardiovascular complications, and malignancies, and highlight the challenges that remain in managing the care of paediatric renal transplant recipients. Abstract | Full Text | PDF
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Paediatric kidney disease collection   The focus of this year's World Kidney Day was 'kidney disease and children'. To mark this, Nature Reviews Nephrology presents a collection on paediatric kidney disease. Topics include; new insights into the genetic basis of the disease and the effects of nutrition on long-term outcomes.
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*Journal Citation Reports, Thomson, 2008. Nature Reviews Nephrology was previously published as Nature Clinical Practice Nephrology.

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