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Visit our open access funding page or contact openaccess@nature.com to learn more about APC funding. | | | | | | Latest Articles | View all Articles | | | | | A cholinergic-sympathetic pathway primes immunity in hypertension and mediates brain-to-spleen communication OPEN | | | Daniela Carnevale, Marialuisa Perrotta, Fabio Pallante, Valentina Fardella, Roberta Iacobucci, Stefania Fardella, Lorenzo Carnevale, Raimondo Carnevale, Massimiliano De Lucia, Giuseppe Cifelli and Giuseppe Lembo | | | Immune system participates in the development of high blood pressure. Here the authors show that cholinergic-sympathetic pathway mediated by the α7nAChR receptor and the activation of splenic T cells prime immunity during hypertension and that selective splenic denervation protects against the onset of hypertension in mice. | | | 27 September 2016 | doi: 10.1038/ncomms13035 | | |
| Tissue engineering of acellular vascular grafts capable of somatic growth in young lambs OPEN | | | Zeeshan Syedain, Jay Reimer, Matthew Lahti, James Berry, Sandra Johnson and Robert T. Tranquillo | | | Current vessel grafts must be surgically replaced when the recipient outgrows them. Here, Syedain et al. bioengineer a tube of acellular matrix produced from sheep fibroblasts that is capable of cellularizaton and somatic growth when transplanted into growing lambs, eliminating the need for multiple graft surgeries. | | | 27 September 2016 | doi: 10.1038/ncomms12951 | | |
| Bony cranial ornamentation linked to rapid evolution of gigantic theropod dinosaurs OPEN | | | Terry A. Gates, Chris Organ and Lindsay E. Zanno | | | Many of the theropod dinosaurs, the group including Tyrannosaurus rex, had bony ornamentation on their skulls. Here, Gates et al. show that such ornaments are associated with greater body size and accelerated body size evolution in theropods; however, these relationships are absent in the maniraptoriform dinosaurs, which had evolved pennaceous feathers. | | | 27 September 2016 | doi: 10.1038/ncomms12931 | | |
| Super-elastic and fatigue resistant carbon material with lamellar multi-arch microstructure OPEN | | | Huai-Ling Gao, Yin-Bo Zhu, Li-Bo Mao, Feng-Chao Wang, Xi-Sheng Luo, Yang-Yi Liu, Yang Lu, Zhao Pan, Jin Ge, Wei Shen, Ya-Rong Zheng, Liang Xu, Lin-Jun Wang, Wei-Hong Xu, Heng-An Wu and Shu-Hong Yu | | | Low-density compressible materials often suffer from fatigue-induced failure or limited elasticity. Here, the authors create a hierarchical multi-arch carbon material that achieves high compressibility, superior elasticity and fatigue resistance simultaneously, inspired by properties of arches in daily life. | | | 27 September 2016 | doi: 10.1038/ncomms12920 | | |
| Programming temporal shapeshifting OPEN | | | Xiaobo Hu, Jing Zhou, Mohammad Vatankhah-Varnosfaderani, William F. M. Daniel, Qiaoxi Li, Aleksandr P. Zhushma, Andrey V. Dobrynin and Sergei S. Sheiko | | | Actuation of shape-shifting materials has typically required an external trigger. Here, the authors design a shape-memory hydrogel, regulated by a dual network of covalent and temporary hydrogen bonds, whose actuations are encoded by an intrinsic temporal mechanism. | | | 27 September 2016 | doi: 10.1038/ncomms12919 | | |
| Megacity pumping and preferential flow threaten groundwater quality OPEN | | | Mahfuzur R. Khan, Mohammad Koneshloo, Peter S. K. Knappett, Kazi M. Ahmed, Benjamin C. Bostick, Brian J. Mailloux, Rajib H. Mozumder, Anwar Zahid, Charles F. Harvey, Alexander van Geen and Holly A. Michael | | | Megacities rely on groundwater from aquifers that may be over-exploited and be at risk of contamination. Khan et al. evaluate the complex aquifers supplying Dhaka, Bangladesh and show that extensive groundwater pumping could lead to unpredictable future arsenic contamination in deep aquifers outside the city. | | | 27 September 2016 | doi: 10.1038/ncomms12833 | | |
| MicroRNA-155 influences B-cell function through PU.1 in rheumatoid arthritis OPEN | | | Stefano Alivernini, Mariola Kurowska-Stolarska, Barbara Tolusso, Roberta Benvenuto, Aziza Elmesmari, Silvia Canestri, Luca Petricca, Antonella Mangoni, Anna Laura Fedele, Clara Di Mario, Maria Rita Gigante, Elisa Gremese, Iain B. McInnes and Gianfranco Ferraccioli | | | MiR-155 is thought to inhibit PU.1 and thereby drive antigen-induced B-cell maturation. Here the authors show that patients with rheumatoid arthritis have high B-cell miR-155 expression and that an antagomir can rescue PU.1 expression, suggesting potential therapeutic avenues to treat rheumatoid arthritis. | | | 27 September 2016 | doi: 10.1038/ncomms12970 | | |
| Observation of a new superfluid phase for 3He embedded in nematically ordered aerogel OPEN | | | N. Zhelev, M. Reichl, T. S. Abhilash, E. N. Smith, K. X. Nguyen, E. J. Mueller and J. M. Parpia | | | Anisotropic disorder is predicted to change the stability of the superfluid state in 3He and leads to new phases. Here, Zhelev et al. report signatures of the phase transitions in 3He confined in an extremely anisotropic ordered aerogel including a new polar phase. | | | 27 September 2016 | doi: 10.1038/ncomms12975 | | |
| Observation of unusual topological surface states in half-Heusler compounds LnPtBi (Ln=Lu, Y) OPEN | | | Z. K. Liu, L. X. Yang, S.-C. Wu, C. Shekhar, J. Jiang, H. F. Yang, Y. Zhang, S.-K. Mo, Z. Hussain, B. Yan, C. Felser and Y. L. Chen | | | Heusler compounds have been predicted to host topological order with other emergent properties, which yet awaits for experimental evidence. Here, Liu et al. report a direct observation of topological surface states on half-Heusler compounds LnPtBi. | | | 27 September 2016 | doi: 10.1038/ncomms12924 | | |
| The mechanism of eutectic growth in highly anisotropic materials OPEN | | | Ashwin J. Shahani, Xianghui Xiao and Peter W. Voorhees | | | The origins of non-periodic growth features observed in irregular eutectics have been a source of controversy. Here authors use time-resolved X-ray microtomography during eutectic growth of an alloy to show how competing models can be extended and reconciled. | | | 27 September 2016 | doi: 10.1038/ncomms12953 | | |
| Population and hierarchy of active species in gold iron oxide catalysts for carbon monoxide oxidation OPEN | | | Qian He, Simon J. Freakley, Jennifer K. Edwards, Albert F. Carley, Albina Y. Borisevich, Yuki Mineo, Masatake Haruta, Graham J. Hutchings and Christopher J. Kiely | | | The identity of active species in supported gold catalysts for low-temperature carbon monoxide oxidation remains an open question. Here, the authors look at the catalytic behaviours of supported catalysts prepared under different conditions and correlate the populations of various species with activity. | | | 27 September 2016 | doi: 10.1038/ncomms12905 | | |
| CARD9 negatively regulates NLRP3-induced IL-1β production on Salmonella infection of macrophages OPEN | | | Milton Pereira, Panagiotis Tourlomousis, John Wright, Tom P. Monie and Clare E. Bryant | | | IL-1β is important for control of bacterial infections, but when deregulated can lead to excessive inflammation. The authors show that the adaptor protein CARD9 suppresses levels of IL-1β and is downregulated during S. Typhimurium infection, thus facilitating an inflammatory response | | | 27 September 2016 | doi: 10.1038/ncomms12874 | | |
| An electrical analogy to Mie scattering OPEN | | | José M. Caridad, Stephen Connaughton, Christian Ott, Heiko B. Weber and Vojislav Krstić | | | Until now experimental evidence of an electrical analogy to Mie scattering is lacking. Here, Caridad and Krstić et al. present an experimental demonstration of an electrical analogue to Mie scattering by using graphene as conductor, and circular potentials arranged in a canted two-dimensional array. | | | 27 September 2016 | doi: 10.1038/ncomms12894 | | |
| Platelet clearance via shear-induced unfolding of a membrane mechanoreceptor OPEN | | | Wei Deng, Yan Xu, Wenchun Chen, David S. Paul, Anum K. Syed, Matthew A. Dragovich, Xin Liang, Philip Zakas, Michael C. Berndt, Jorge Di Paola, Jerry Ware, Francois Lanza, Christopher B. Doering, Wolfgang Bergmeier, X. Frank Zhang and Renhao Li | | | The platelets detect and respond to shear stress generated by blood flow. Here the authors show that the binding of the soluble von Willebrand factor to its receptor GPIba under physiological shear stress induces receptor's domain unfolding on the platelet and signalling into the platelet, leading to platelets clearance. | | | 27 September 2016 | doi: 10.1038/ncomms12863 | | |
| 14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function OPEN | | | Simone M. Schoenwaelder, Roxane Darbousset, Susan L. Cranmer, Hayley S. Ramshaw, Stephanie L. Orive, Sharelle Sturgeon, Yuping Yuan, Yu Yao, James R. Krycer, Joanna Woodcock, Jessica Maclean, Stuart Pitson, Zhaohua Zheng, Darren C. Henstridge, Dianne van der Wal, Elizabeth E. Gardiner, Michael C. Berndt, Robert K. Andrews, David E. James, Angel F. Lopez et al. | | | Platelets express negatively charged phosphatidylserine (PS) on their plasma membrane when propagating coagulation within a developing thrombus. Here the authors show that an adaptor protein 14-3-3 regulates mitochondrial function and PS exposure and thus platelet procoagulant activity, promising a new therapy to reduce thrombosis. | | | 27 September 2016 | doi: 10.1038/ncomms12862 | | |
| Multi-pass microscopy OPEN | | | Thomas Juffmann, Brannon B. Klopfer, Timmo L.I. Frankort, Philipp Haslinger and Mark A. Kasevich | | | Low-damage and high-precision imaging can be achieved by passing the same probe photons through the specimen more than once, and this has been previously achieved in double-pass transmission microscopy. Here, the authors generalize this idea to full-field multi-pass microscopy using a self-imaging cavity. | | | 27 September 2016 | doi: 10.1038/ncomms12858 | | |
| Protein kinase D regulates positive selection of CD4+ thymocytes through phosphorylation of SHP-1 OPEN | | | Eri Ishikawa, Hidetaka Kosako, Tomoharu Yasuda, Masaki Ohmuraya, Kimi Araki, Tomohiro Kurosaki, Takashi Saito and Sho Yamasaki | | | The three isoforms of protein kinase D (PKD) have important but often redundant roles in cell signalling. Here the authors show, by generating PKD2/3 double-deficient mice, that PKD is essential for TCR signalling in thymocytes, and identify SHP-1 as a PKD target critical for development of CD4+ T cells. | | | 27 September 2016 | doi: 10.1038/ncomms12756 | | |
| Loss of RNA expression and allele-specific expression associated with congenital heart disease OPEN | | | David M. McKean, Jason Homsy, Hiroko Wakimoto, Neil Patel, Joshua Gorham, Steven R. DePalma, James S. Ware, Samir Zaidi, Wenji Ma, Nihir Patel, Richard P. Lifton, Wendy K. Chung, Richard Kim, Yufeng Shen, Martina Brueckner, Elizabeth Goldmuntz, Andrew J. Sharp, Christine E. Seidman, Bruce D. Gelb and J. G. Seidman et al. | | | Congenital heart disease (CHD) is a disorder that occurs in ∼1% of live births. Here the authors describe a genome-wide allele-specific expression analyses in CHD patients, identifying five new genes involved in CHD and showing that paternally-expressed imprinted genes are monoallelic, while maternally-expressed imprinted genes are biallelic. | | | 27 September 2016 | doi: 10.1038/ncomms12824 | | |
| Molecular determinants for the strictly compartmentalized expression of kainate receptors in CA3 pyramidal cells OPEN | | | Sabine Fièvre, Mario Carta, Ingrid Chamma, Virginie Labrousse, Olivier Thoumine and Christophe Mulle | | | Kainate receptors are selectively found at CA3-mossy fibre synapses, although the mechanisms regulating this compartmentalisation have yet to be determined. Here, the authors find KAR segregation is dependent on the amount of GluK2a protein and an interaction between the GluK2 C-terminal domain and N-cadherin. | | | 27 September 2016 | doi: 10.1038/ncomms12738 | | |
| Satellite RNAs promote pancreatic oncogenic processes via the dysfunction of YBX1 OPEN | | | Takahiro Kishikawa, Motoyuki Otsuka, Takeshi Yoshikawa, Motoko Ohno, Hideaki Ijichi and Kazuhiko Koike | | | Satellite RNAs are aberrantly transcribed during pancreatic cancer progression. Here, the authors show that major satellite RNA binds to the multifunctional protein YBX1 in the cytoplasm and induces mutations in nuclear and mitochondrial DNA by preventing YBX1 stress-induced intracellular translocation. | | | 26 September 2016 | doi: 10.1038/ncomms13006 | | |
| Atomically thin quantum light-emitting diodes OPEN | | | Carmen Palacios-Berraquero, Matteo Barbone, Dhiren M. Kara, Xiaolong Chen, Ilya Goykhman, Duhee Yoon, Anna K. Ott, Jan Beitner, Kenji Watanabe, Takashi Taniguchi, Andrea C. Ferrari and Mete Atatüre | | | Atomically thin transition metal dichalcogenides hold promise as scalable single-photon sources. Here, the authors demonstrate all-electrical, single-photon generation in tungsten disulphide and diselenide, achieving charge injection into the layers, containing quantum emitters. | | | 26 September 2016 | doi: 10.1038/ncomms12978 | | |
| The tobacco-specific carcinogen-operated calcium channel promotes lung tumorigenesis via IGF2 exocytosis in lung epithelial cells OPEN | | | Hye-Jin Boo, Hye-Young Min, Hyun-Ji Jang, Hye Jeong Yun, John Kendal Smith, Quanri Jin, Hyo-Jong Lee, Diane Liu, Hee-Seok Kweon, Carmen Behrens, J. Jack Lee, Ignacio I. Wistuba, Euni Lee, Waun Ki Hong and Ho-Young Lee | | | The binding of tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) to nicotinic acetylcholine receptors (nAChRs) induces calcium signalling. Here the authors show that NKK-induced calcium influx in airway epithelial cells triggers IGF2 secretion and tumourigenesis. | | | 26 September 2016 | doi: 10.1038/ncomms12961 | | |
| See–saw relationship of the Holocene East Asian–Australian summer monsoon OPEN | | | Deniz Eroglu, Fiona H. McRobie, Ibrahim Ozken, Thomas Stemler, Karl-Heinz Wyrwoll, Sebastian F. M. Breitenbach, Norbert Marwan and Jürgen Kurths | | | Irregular sampling of palaeoproxies can result in the misinterpretation of environmental records. Here, the authors propose a new time series analysis method for irregularly sampled data, and reveal a see-saw relationship between the East Asian and Indonesian–Australian summer monsoons during the Holocene. | | | 26 September 2016 | doi: 10.1038/ncomms12929 | | |
| Breast cancer genome and transcriptome integration implicates specific mutational signatures with immune cell infiltration OPEN | | | Marcel Smid, F. Germán Rodríguez-González, Anieta M. Sieuwerts, Roberto Salgado, Wendy J. C. Prager-Van der Smissen, Michelle van der Vlugt-Daane, Anne van Galen, Serena Nik-Zainal, Johan Staaf, Arie B. Brinkman, Marc J. van de Vijver, Andrea L. Richardson, Aquila Fatima, Kim Berentsen, Adam Butler, Sancha Martin, Helen R. Davies, Reno Debets, Marion E. Meijer-Van Gelder, Carolien H. M. van Deurzen et al. | | | Recent studies using in depth DNA sequencing techniques led to the identification of cancer driver genes but mainly focused on the effect on their expression. Here, the authors analyse 266 cases of breast cancer and report gene expression signatures associated with the number and character of signature mutations. | | | 26 September 2016 | doi: 10.1038/ncomms12910 | | |
| FHF-independent conduction of action potentials along the leak-resistant cerebellar granule cell axon OPEN | | | Katarzyna Dover, Christopher Marra, Sergio Solinas, Marko Popovic, Sathyaa Subramaniyam, Dejan Zecevic, Egidio D’Angelo and Mitchell Goldfarb | | | FHFs are known to regulate voltage-gated sodium channels (NaVs). Here, the authors compare the role of FHFs in cerebellar granule cell propagation, and find NaVs in the distal axon function independently of FHFs, allowing for faster inactivation rates and reducing energy demands during repetitive spiking. | | | 26 September 2016 | doi: 10.1038/ncomms12895 | | |
| Nutrient enrichment induces dormancy and decreases diversity of active bacteria in salt marsh sediments OPEN | | | Patrick J. Kearns, John H. Angell, Evan M. Howard, Linda A. Deegan, Rachel H. R. Stanley and Jennifer L. Bowen | | | Increased anthropogenic nitrogen inputs into the biosphere are fundamentally altering ecosystems worldwide. Here, Kearns et al. show that a decade of nitrogen additions to salt marshes reduces the proportion of active microorganisms, despite no net change to the total microbial community. | | | 26 September 2016 | doi: 10.1038/ncomms12881 | | |
| FMRP regulates an ethanol-dependent shift in GABABR function and expression with rapid antidepressant properties OPEN | | | Sarah A. Wolfe, Emily R. Workman, Chelcie F. Heaney, Farr Niere, Sanjeev Namjoshi, Luisa P. Cacheaux, Sean P. Farris, Michael R. Drew, Boris V. Zemelman, R. Adron Harris and Kimberly F. Raab-Graham | | | Alcohol is thought to lead to neuroadaptive changes, although the underlying molecular mechanisms are unclear. Here, the authors find ethanol treatment alters GABAB-receptor expression via fragile-X mental retardation protein in mice, leading to antidepressant-like behaviours. | | | 26 September 2016 | doi: 10.1038/ncomms12867 | | |
| Structure–function insights reveal the human ribosome as a cancer target for antibiotics OPEN | | | Alexander G. Myasnikov, S. Kundhavai Natchiar, Marielle Nebout, Isabelle Hazemann, Véronique Imbert, Heena Khatter, Jean-François Peyron and Bruno P. Klaholz | | | The ribosome of bacteria and other unicellular pathogens is a common target for antibiotic drugs. Here the authors determine a structure of the human ribosome bound to the translation inhibitor cycloheximide, and provide evidence that targeting the ribosome is a promising avenue for cancer therapy. | | | 26 September 2016 | doi: 10.1038/ncomms12856 | | |
| The RNA-binding protein vigilin regulates VLDL secretion through modulation of Apob mRNA translation OPEN | | | Mehrpouya B. Mobin, Stefanie Gerstberger, Daniel Teupser, Benedetta Campana, Klaus Charisse, Markus H. Heim, Muthiah Manoharan, Thomas Tuschl and Markus Stoffel | | | RNA-binding proteins (RBP) are an emerging group of post-translational regulators. Here the authors show that the RBP vigilin regulates translation of mRNA encoding for proatherogenic proteins—apoB, apoC-III and fibronectin—representing a potential therapeutic target in cardiovascular diseases. | | | 26 September 2016 | doi: 10.1038/ncomms12848 | | |
| Extraction and analysis of signatures from the Gene Expression Omnibus by the crowd OPEN | | | Zichen Wang, Caroline D. Monteiro, Kathleen M. Jagodnik, Nicolas F. Fernandez, Gregory W. Gundersen, Andrew D. Rouillard, Sherry L. Jenkins, Axel S. Feldmann, Kevin S. Hu, Michael G. McDermott, Qiaonan Duan, Neil R. Clark, Matthew R. Jones, Yan Kou, Troy Goff, Holly Woodland, Fabio M R. Amaral, Gregory L. Szeto, Oliver Fuchs, Sophia M. Schüssler-Fiorenza Rose et al. | | | A wealth of gene expression data is publicly available, yet is little use without additional human curation. Ma’ayan and colleagues report a crowdsourcing project involving over 70 participants to annotate and analyse thousands of human disease-related gene expression datasets. | | | 26 September 2016 | doi: 10.1038/ncomms12846 | | |
| The structural basis for CD36 binding by the malaria parasite OPEN | | | Fu-Lien Hsieh, Louise Turner, Jani Reddy Bolla, Carol V. Robinson, Thomas Lavstsen and Matthew K. Higgins | | | Targeting of the CD36 scavenger receptor by the malaria parasite effector PfEMP1 prevents splenic clearance of infected erythrocytes. Here, the authors propose that diverse PfEMP1 achieve this by binding to a conserved phenylalanine residue in CD36 that is also required for lipoprotein binding. | | | 26 September 2016 | doi: 10.1038/ncomms12837 | | |
| Optimization of hierarchical structure and nanoscale-enabled plasmonic refraction for window electrodes in photovoltaics OPEN | | | Bing Han, Qiang Peng, Ruopeng Li, Qikun Rong, Yang Ding, Eser Metin Akinoglu, Xueyuan Wu, Xin Wang, Xubing Lu, Qianming Wang, Guofu Zhou, Jun-Ming Liu, Zhifeng Ren, Michael Giersig, Andrzej Herczynski, Krzysztof Kempa and Jinwei Gao | | | In photovoltaics window electrodes must display uniform current transport, as well as high light transmission from the substrate. Here, Han et al. show that quasi-fractal metallic networks provide a practical realization of an electrode structure with an optimal surface coverage and a uniform current density. | | | 26 September 2016 | doi: 10.1038/ncomms12825 | | |
| Ferroelectricity by Bose–Einstein condensation in a quantum magnet OPEN | | | S. Kimura, K. Kakihata, Y. Sawada, K. Watanabe, M. Matsumoto, M. Hagiwara and H. Tanaka | | | Magnons, quantized spin excitations in magnetic materials, may undergo Bose-Einstein condensation into a macroscopic correlated quantum state at low temperature. Here, the authors demonstrate how magnon condensation in quantum magnet TlCuCl3 generates an electrical polarization. | | | 26 September 2016 | doi: 10.1038/ncomms12822 | | |
| Real-time encoding and compression of neuronal spikes by metal-oxide memristors OPEN | | | Isha Gupta, Alexantrou Serb, Ali Khiat, Ralf Zeitler, Stefano Vassanelli and Themistoklis Prodromakis | | | The need for intelligent compression of big data, for example in neuroscience, has sparked interest in neuromorphic data processing. Here, Gupta et al. use memristors as event integrators to encode and compress neuronal spiking activity recorded by multi-electrode arrays. | | | 26 September 2016 | doi: 10.1038/ncomms12805 | | |
| The lncRNA landscape of breast cancer reveals a role for DSCAM-AS1 in breast cancer progression OPEN | | | Yashar S. Niknafs, Sumin Han, Teng Ma, Corey Speers, Chao Zhang, Kari Wilder-Romans, Matthew K. Iyer, Sethuramasundaram Pitchiaya, Rohit Malik, Yasuyuki Hosono, John R. Prensner, Anton Poliakov, Udit Singhal, Lanbo Xiao, Steven Kregel, Ronald F. Siebenaler, Shuang G. Zhao, Michael Uhl, Alexander Gawronski, Daniel F. Hayes et al. | | | LncRNAs have been associated with cancer. Here, the authors carry out a systematic review of lncRNAs in breast cancer and show that DSCAM-AS1 is highly expressed in oestrogen receptor positive tumours and enhances cancer through an interaction with hnRNPL; and is also associated with tamoxifen resistance. | | | 26 September 2016 | doi: 10.1038/ncomms12791 | | |
| Sub-molecular modulation of a 4f driven Kondo resonance by surface-induced asymmetry OPEN | | | Ben Warner, Fadi El Hallak, Nicolae Atodiresei, Philipp Seibt, Henning Prüser, Vasile Caciuc, Michael Waters, Andrew J. Fisher, Stefan Blügel, Joris van Slageren and Cyrus F. Hirjibehedin | | | In the Kondo effect, a bath of conduction electrons screens a localized magnetic moment. Here, the authors demonstrate Kondo screening of a normally isolated 4f-like moment in a magnetic molecule on a Cu(001) surface that is modulated by strong ligand-mediated coupling. | | | 26 September 2016 | doi: 10.1038/ncomms12785 | | |
| Direct-write nanoscale printing of nanogranular tunnelling strain sensors for sub-micrometre cantilevers OPEN | | | Maja Dukic, Marcel Winhold, Christian H. Schwalb, Jonathan D. Adams, Vladimir Stavrov, Michael Huth and Georg E. Fantner | | | Reducing the size of cantilever-based sensors increases the sensitivity and detection speed of techniques such as atomic force microscopy. Here, the authors demonstrate a nanomechanical readout method that can be easily scaled down in size by using electron co-tunnelling through a nanogranular metal. | | | 26 September 2016 | doi: 10.1038/ncomms12487 | | |
| An imbalance between specialized pro-resolving lipid mediators and pro-inflammatory leukotrienes promotes instability of atherosclerotic plaques OPEN | | | Gabrielle Fredman, Jason Hellmann, Jonathan D. Proto, George Kuriakose, Romain A. Colas, Bernhard Dorweiler, E. Sander Connolly, Robert Solomon, David M. Jones, Eric J. Heyer, Matthew Spite and Ira Tabas | | | Atherosclerosis progression is linked to inflammatory processes in the blood vessel wall. Here, the authors show that, with the progression of atherosclerosis, the resolution of inflammation is impaired as the result of an imbalance between specialized pro-resolving lipid mediators and leukotrienes. | | | 23 September 2016 | doi: 10.1038/ncomms12859 | | |
| Intercalated water layers promote thermal dissipation at bio–nano interfaces OPEN | | | Yanlei Wang, Zhao Qin, Markus J. Buehler and Zhiping Xu | | | Thermal management is important for designing bio-nano interfaces for biosensing and thermotherapic applications. Here the authors perform simulations showing that nm-thick water layers between graphene and cell membranes display layered ordering, promoting interfacial thermal coupling and thermal dissipation. | | | 23 September 2016 | doi: 10.1038/ncomms12854 | | |
| A bead-based western for high-throughput cellular signal transduction analyses OPEN | | | Fridolin Treindl, Benjamin Ruprecht, Yvonne Beiter, Silke Schultz, Anette Döttinger, Annette Staebler, Thomas O. Joos, Simon Kling, Oliver Poetz, Tanja Fehm, Hans Neubauer, Bernhard Kuster and Markus F. Templin | | | Dissecting cellular signalling requires the analysis of large numbers of proteins. Here the authors describe DigiWest, a high-throughput protein detection method that combines the concept of western and widely-used bead array systems that allows rapid quantification of hundreds of specific proteins. | | | 23 September 2016 | doi: 10.1038/ncomms12852 | | |
| Primary thermometry triad at 6 mK in mesoscopic circuits OPEN | | | Z. Iftikhar, A. Anthore, S. Jezouin, F. D. Parmentier, Y. Jin, A. Cavanna, A. Ouerghi, U. Gennser and F. Pierre | | | Mesoscopic electrical circuits are an ideal platform to explore quantum phenomena, but this requires cooling the electrons to very low temperature, which is challenging. Here, the authors employ three different in situ thermometers to report electronic quantum transport at 6mK in a micrometer-scale circuit. | | | 23 September 2016 | doi: 10.1038/ncomms12908 | | |
| Hazardous thunderstorm intensification over Lake Victoria OPEN | | | Wim Thiery, Edouard L. Davin, Sonia I. Seneviratne, Kristopher Bedka, Stef Lhermitte and Nicole P. M. van Lipzig | | | Thunderstorm activity over Lake Victoria poses a threat to human life, yet little is known about their evolution under climate change. Here, using satellite observations and high-resolution modelling, the authors project an increase in precipitation extremes over Lake Victoria, twice that of surrounding land. | | | 23 September 2016 | doi: 10.1038/ncomms12786 | | |
| Low-oxygen waters limited habitable space for early animals OPEN | | | R. Tostevin, R. A. Wood, G. A. Shields, S. W. Poulton, R. Guilbaud, F. Bowyer, A. M. Penny, T. He, A. Curtis, K. H. Hoffmann and M. O. Clarkson | | | The importance of oxygen in supporting early animal ecosystems is unclear because most proxies are unable to distinguish well-oxygenated from intermediate waters. Here, the authors show that early skeletal animals were restricted to well-oxygenated habitats, suggesting they had a high metabolic oxygen demand. | | | 23 September 2016 | doi: 10.1038/ncomms12818 | | |
| Transport of a kinesin-cargo pair along microtubules into dendritic spines undergoing synaptic plasticity OPEN | | | Derrick P. McVicker, Adam M. Awe, Karl E. Richters, Rebecca L. Wilson, Diana A. Cowdrey, Xindao Hu, Edwin R. Chapman and Erik W. Dent | | | Transport of cargo into dendritic spines is required for synaptic plasticity. McVicker et al. describe a method of activity-dependent transport of a kinesin KIF1A and its cargo synaptotagmin-IV along microtubules that are transiently polymerized into dendritic spines. | | | 23 September 2016 | doi: 10.1038/ncomms12741 | | |
| Subnatural-linewidth biphotons from a Doppler-broadened hot atomic vapour cell OPEN | | | Chi Shu, Peng Chen, Tsz Kiu Aaron Chow, Lingbang Zhu, Yanhong Xiao, M.M.T. Loy and Shengwang Du | | | Quantum-network protocols based on photon-atom interfaces have stimulated a great demand for single-photon sources with narrow bandwidth. Here the authors report the generation of entangled photon pairs with controllable bandwidth and coherence time from a Doppler-broadened hot atomic vapour cell. | | | 23 September 2016 | doi: 10.1038/ncomms12783 | | |
| The Macronova in GRB 050709 and the GRB-macronova connection OPEN | | | Zhi-Ping Jin, Kenta Hotokezaka, Xiang Li, Masaomi Tanaka, Paolo D’Avanzo, Yi-Zhong Fan, Stefano Covino, Da-Ming Wei and Tsvi Piran | | | A macronova is a clear signature that a short gamma-ray burst has been emitted by a compact-binary merger, but evidence of these events is so far scarce. Here, the authors report signs of a macronova in the optical afterglow of GRB050709, and find similar evidence in other three short bursts. | | | 23 September 2016 | doi: 10.1038/ncomms12898 | | |
| Molecular transport through large-diameter DNA nanopores OPEN | | | Swati Krishnan, Daniela Ziegler, Vera Arnaut, Thomas G. Martin, Korbinian Kapsner, Katharina Henneberg, Andreas R. Bausch, Hendrik Dietz and Friedrich C. Simmel | | | Artificial DNA membrane channels are promising molecular devices for biotechnology but suffer from low affinity for lipid bilayers. Here, the authors report a large DNA nanopore that spontaneously inserts into a flat lipid membrane, driven by engineered hydrophobic or streptavidin-biotin interactions. | | | 23 September 2016 | doi: 10.1038/ncomms12787 | | |
| GDF11 decreases bone mass by stimulating osteoclastogenesis and inhibiting osteoblast differentiation OPEN | | | Weiqing Liu, Liyan Zhou, Chenchen Zhou, Shiwen Zhang, Junjun Jing, Liang Xie, Ningyuan Sun, Xiaobo Duan, Wei Jing, Xing Liang, Hu Zhao, Ling Ye, Qianming Chen and Quan Yuan | | | GDF11 is related to myostatin yet has no known role in postnatal bone turnover. Here the authors show that recombinant GDF11 injection causes bone loss and impairs healing by driving osteoclastogenesis while inhibiting osteoblast differentiation, plus they show that anti-GDF11 Ab can inhibit bone loss in ovariectomy and ageing mouse models. | | | 22 September 2016 | doi: 10.1038/ncomms12794 | | |
| Sizing nanomaterials in bio-fluids by cFRAP enables protein aggregation measurements and diagnosis of bio-barrier permeability OPEN | | | Ranhua Xiong, Roosmarijn E. Vandenbroucke, Katleen Broos, Toon Brans, Elien Van Wonterghem, Claude Libert, Jo Demeester, Stefaan C. De Smedt and Kevin Braeckmans | | | Measuring the size distribution of nanomaterials in biological fluids is crucial to understand their properties in vivo. Here, the authors apply fluorescence recovery after photobleaching to measure protein aggregation in serum and to study permeability of biological membranes in mouse models. | | | 22 September 2016 | doi: 10.1038/ncomms12982 | | |
| Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities OPEN | | | Abdelhakim Ahmed-Belkacem, Lionel Colliandre, Nazim Ahnou, Quentin Nevers, Muriel Gelin, Yannick Bessin, Rozenn Brillet, Olivier Cala, Dominique Douguet, William Bourguet, Isabelle Krimm, Jean-Michel Pawlotsky and Jean- François Guichou | | | Cyclophilins play a key role in the life cycle of many viruses and represent important drug targets for broad-spectrum antiviral therapies. Here, the authors use fragment-based drug discovery to develop non-peptidic inhibitors of human cyclophilins with high activity against replication of a number of viral families. | | | 22 September 2016 | doi: 10.1038/ncomms12777 | | |
| Comparative genomics reveals adaptive evolution of Asian tapeworm in switching to a new intermediate host OPEN | | | Shuai Wang, Sen Wang, Yingfeng Luo, Lihua Xiao, Xuenong Luo, Shenghan Gao, Yongxi Dou, Huangkai Zhang, Aijiang Guo, Qingshu Meng, Junling Hou, Bing Zhang, Shaohua Zhang, Meng Yang, Xuelian Meng, Hailiang Mei, Hui Li, Zilong He, Xueliang Zhu, Xinyu Tan et al. | | | Only one of the three Taenia species causing taeniasis in humans was previously sequenced. Here the authors provide draft genomes of Taenia saginata and Taenia asiatica, analyse genome evolution of all three species, and identify potential targets for developing diagnostic markers or intervention tools. | | | 22 September 2016 | doi: 10.1038/ncomms12845 | | |
| Palmitoyl acyltransferase DHHC21 mediates endothelial dysfunction in systemic inflammatory response syndrome OPEN | | | Richard S. Beard, Xiaoyuan Yang, Jamie E. Meegan, Jonathan W. Overstreet, Clement G.Y. Yang, John A. Elliott, Jason J. Reynolds, Byeong J. Cha, Christopher D. Pivetti, David A. Mitchell, Mack H. Wu, Robert J. Deschenes and Sarah Y. Yuan | | | Breaking down the endothelial barrier is a hallmark of systemic inflammatory response syndrome. Here the authors show that palmitoylation, a post-translational modification of proteins, plays a critical role in altering endothelial function during inflammation, and suggest the targeting of palmitoyl acyltransferase DHHC21 as potential disease therapy. | | | 22 September 2016 | doi: 10.1038/ncomms12823 | | |
| A polyvalent inactivated rhinovirus vaccine is broadly immunogenic in rhesus macaques OPEN | | | Sujin Lee, Minh Trang Nguyen, Michael G. Currier, Joe B. Jenkins, Elizabeth A. Strobert, Adriana E. Kajon, Ranjna Madan-Lala, Yury A. Bochkov, James E. Gern, Krishnendu Roy, Xiaoyan Lu, Dean D. Erdman, Paul Spearman and Martin L. Moore | | | Existence of 150–170 serologically distinct human rhinoviruses (HRV) has hampered vaccine development for this human pathogen. Here, the authors show that a prime-boost regimen with an inactivated 50-valent HRV vaccine induces neutralizing antibody responses to diverse HRV serotypes in rhesus macaques. | | | 22 September 2016 | doi: 10.1038/ncomms12838 | | |
| H2A.Z controls the stability and mobility of nucleosomes to regulate expression of the LH genes OPEN | | | Sergei Rudnizky, Adaiah Bavly, Omri Malik, Lilach Pnueli, Philippa Melamed and Ariel Kaplan | | | Chromatin architecture at promoters can influence gene transcription. Here, the authors use a biophysical approach to elucidate how DNA sequence and histone variant usage modulate the properties of nucleosomes at the promoters of two target genes. | | | 22 September 2016 | doi: 10.1038/ncomms12958 | | |
| Unusual lattice vibration characteristics in whiskers of the pseudo-one-dimensional titanium trisulfide TiS3 OPEN | | | Kedi Wu, Engin Torun, Hasan Sahin, Bin Chen, Xi Fan, Anupum Pant, David Parsons Wright, Toshihiro Aoki, Francois M. Peeters, Emmanuel Soignard and Sefaattin Tongay | | | Transition metal trichalcogenides are layered materials with strong in-plane anisotropy, and their vibrational characteristics remain largely unexplored. Here, the authors present high-pressure Raman studies to uncover unusual vibrational effects within this specific class of materials. | | | 22 September 2016 | doi: 10.1038/ncomms12952 | | |
| Adaptive radiation by waves of gene transfer leads to fine-scale resource partitioning in marine microbes OPEN | | | Jan-Hendrik Hehemann, Philip Arevalo, Manoshi S. Datta, Xiaoqian Yu, Christopher H. Corzett, Andreas Henschel, Sarah P. Preheim, Sonia Timberlake, Eric J. Alm and Martin F. Polz | | | Adaptive radiations are well-known for animals and plants, but not for microbes. Here, Hehemann et al. show that there has been a recent adaptive radiation of bacteria in the Vibrionaceae to use different forms of alginate and that this radiation has been mediated by horizontal gene transfer. | | | 22 September 2016 | doi: 10.1038/ncomms12860 | | |
| Spin–orbit coupled molecular quantum magnetism realized in inorganic solid OPEN | | | Sang-Youn Park, S.-H. Do, K.-Y. Choi, J.-H. Kang, Dongjin Jang, B. Schmidt, Manuel Brando, B.-H. Kim, D.-H. Kim, N. P. Butch, Seongsu Lee, J.-H. Park and Sungdae Ji | | | Molecular magnets may provide fundamental building blocks for future spintronic and quantum information technologies. Here, the authors demonstrate how the Yb4 tetrahedral components of inorganic materials Ba3Yb2Zn5O11 behave as isolated molecular magnets. | | | 21 September 2016 | doi: 10.1038/ncomms12912 | | |
| The DNA cytosine deaminase APOBEC3H haplotype I likely contributes to breast and lung cancer mutagenesis OPEN | | | Gabriel J. Starrett, Elizabeth M. Luengas, Jennifer L. McCann, Diako Ebrahimi, Nuri A. Temiz, Robin P. Love, Yuqing Feng, Madison B. Adolph, Linda Chelico, Emily K. Law, Michael A. Carpenter and Reuben S Harris | | | The APOBEC family of enzymes are cytidine deaminases with APOBEC3A and APOBEC3B thought to contribute to DNA damage signatures detected in cancer genomes. Here, the authors demonstrate an unappreciated role for APOBEC3H haplotype I in the generation of DNA damage in breast cancer. | | | 21 September 2016 | doi: 10.1038/ncomms12918 | | |
| Selective targeting of IL-2 to NKG2D bearing cells for improved immunotherapy OPEN | | | Reza Ghasemi, Eric Lazear, Xiaoli Wang, Saeed Arefanian, Alexander Zheleznyak, Beatriz M. Carreno, Ryuji Higashikubo, Andrew E. Gelman, Daniel Kreisel, Daved H. Fremont and Alexander Sasha Krupnick | | | High-affinity IL-2Rα expressed by Tregs mitigates the potential of IL-2 use in cancer therapy. Here, the authors fuse IL-2 with an NKDG2 binding domain, and show that it induces IL-2 signalling selectively in NKG2D+ cells, delaying tumour growth in mice without the side effects of conventional IL-2 therapy. | | | 21 September 2016 | doi: 10.1038/ncomms12878 | | |
| Even–odd layer-dependent magnetotransport of high-mobility Q-valley electrons in transition metal disulfides OPEN | | | Zefei Wu, Shuigang Xu, Huanhuan Lu, Armin Khamoshi, Gui-Bin Liu, Tianyi Han, Yingying Wu, Jiangxiazi Lin, Gen Long, Yuheng He, Yuan Cai, Yugui Yao, Fan Zhang and Ning Wang | | | Few-layer transition metal dichalcogenides exhibit strong spin-valley entanglement and unconventional quantum Hall states, however their study has been limited by electron mobility. Here, the authors explore how quantum transport varies between even- and odd-layered systems of high mobility. | | | 21 September 2016 | doi: 10.1038/ncomms12955 | | |
| A conserved influenza A virus nucleoprotein code controls specific viral genome packaging OPEN | | | Étori Aguiar Moreira, Anna Weber, Hardin Bolte, Larissa Kolesnikova, Sebastian Giese, Seema Lakdawala, Martin Beer, Gert Zimmer, Adolfo García-Sastre, Martin Schwemmle and Mindaugas Juozapaitis | | | The nucleotide sequence of the eight genomic RNA segments of influenza A virus provides essential packaging signals, but how these sequences are recognized is unknown. Here, Moreira et al. identify conserved amino acids in the viral nucleoprotein that regulate packaging of RNA segments. | | | 21 September 2016 | doi: 10.1038/ncomms12861 | | |
| Weyl magnons in breathing pyrochlore antiferromagnets OPEN | | | Fei-Ye Li, Yao-Dong Li, Yong Baek Kim, Leon Balents, Yue Yu and Gang Chen | | | It was recently demonstrated that particular materials with non-trivial electronic band structure support quasiparticle excitations described by the relativistic Weyl equation. Here, the authors explore how an analogous magnonic band structure may exist in breathing pyrochlore antiferromagnets. | | | 21 September 2016 | doi: 10.1038/ncomms12691 | | |
| Palaeogeographic regulation of glacial events during the Cretaceous supergreenhouse OPEN | | | Jean-Baptiste Ladant and Yannick Donnadieu | | | Indirect evidence indicates the surprising occurrence of glacial events during the peak warmth of the Cretaceous world. Here, based on coupled climate-ice sheet model simulations, the authors show that such events were likely thwarted by palaeogeographic reorganisations and complex ocean-atmosphere feedbacks. | | | 21 September 2016 | doi: 10.1038/ncomms12771 | | |
| Dephosphorylated parafibromin is a transcriptional coactivator of the Wnt/Hedgehog/Notch pathways OPEN | | | Ippei Kikuchi, Atsushi Takahashi-Kanemitsu, Natsuki Sakiyama, Chao Tang, Pei-Jung Tang, Saori Noda, Kazuki Nakao, Hidetoshi Kassai, Toshiro Sato, Atsu Aiba and Masanori Hatakeyama | | | Normal epithelial intestine organisation requires Wnt and Hedgehog signalling activity. Here, the authors show that parafibromin can activate both pathways in a mutually exclusive manner and is important for intestinal homeostasis. | | | 21 September 2016 | doi: 10.1038/ncomms12887 | | |
| Engineering surface atomic structure of single-crystal cobalt (II) oxide nanorods for superior electrocatalysis OPEN | | | Tao Ling, Dong-Yang Yan, Yan Jiao, Hui Wang, Yao Zheng, Xueli Zheng, Jing Mao, Xi-Wen Du, Zhenpeng Hu, Mietek Jaroniec and Shi-Zhang Qiao | | | Surface structure manipulation can manipulate the activity and durability of catalysts. Here, the authors report a series of one-dimensional single crystal cobalt oxide nanorods, and show that surface oxygen vacancy formation modifies electronic and adsorption properties leading to enhanced electrocatalysis. | | | 21 September 2016 | doi: 10.1038/ncomms12876 | | |
| Spatiotemporal dynamics of lesion-induced axonal sprouting and its relation to functional architecture of the cerebellum OPEN | | | Matasha Dhar, Joshua M. Brenner, Kenji Sakimura, Masanobu Kano and Hiroshi Nishiyama | | | Neurodegenerative lesions induce sprouting from surviving axons, but the patterns of re-innervation of these collaterals in relation to existing functional networks remains unclear. Here the authors performed long term in vivo imaging in mice, of sprouts from cerebellar climbing fibers after a lesion, and describe the patterns of connectivity relative to functionally active zones. | | | 21 September 2016 | doi: 10.1038/ncomms12938 | | | | | | | | | | |
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