Nature Reviews Urology - Table of Contents alert Volume 13 Issue 12

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TABLE OF CONTENTS
December 2016 Volume 13 Number 12
2015 2-year Impact Factor 5.957 Journal Metrics 2-year Median 4	In this issue Research Highlights News and Views Reviews
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RESEARCH HIGHLIGHTS Top Kidney cancer: Classifying the unclassified — molecular analysis of uRCC Published online: 25 October 2016 p691 | doi:10.1038/nrurol.2016.214 PDF Infection: Stuck on you — pilus-mediated adherence in chronic UTI Published online: 18 October 2016 p692 | doi:10.1038/nrurol.2016.209 PDF Prostate cancer: Notching up roles in advanced disease Published online: 18 October 2016 p692 | doi:10.1038/nrurol.2016.210 PDF Infection: T cell response to C. trachomatis Published online: 02 November 2016 p692 | doi:10.1038/nrurol.2016.222 PDF Prostate cancer: Analysis of progression through time and space Published online: 25 October 2016 p693 | doi:10.1038/nrurol.2016.219 PDF BPH: Effects of PUL remain stable at 2 years Published online: 18 October 2016 p694 | doi:10.1038/nrurol.2016.207 PDF Penile cancer: Prognostic value of PD-L1 status Published online: 18 October 2016 p694 | doi:10.1038/nrurol.2016.208 PDF Prostate cancer: Postoperative RT response prediction Published online: 02 November 2016 p694 | doi:10.1038/nrurol.2016.223 PDF Prostate cancer: Exosomal AR-V7 is a marker of hormonal therapy resistance Published online: 25 October 2016 p695 | doi:10.1038/nrurol.2016.220 PDF IN BRIEF Prostate cancer: Proteomic assay predicts biochemical recurrence | Urinary incontinence: Interneuron precursors restore bladder function | Transplantation: Ex vivo model of penile transplantation developed | Prostate cancer: N-Myc expression drives neuroendocrine disease PDF Nature Reviews Urology JOBS of the week Postdoctoral researcher in bacterial extracellular RNA and colorectal cancer Université de Luxembourg / LCSB More Science jobs from
NEWS AND VIEWS		Top
Prostate cancer: AR aberrations and resistance to abiraterone or enzalutamide Gerhardt Attard & Emmanuel S. Antonarakis Published online: 02 November 2016 p697 | doi:10.1038/nrurol.2016.212 Resistance to abiraterone or enzalutamide is a major medical burden — the duration of benefit is highly variable and cross-resistance often occurs when these two agents are given sequentially. Blood-based analysis of androgen receptor splice variants and AR copy number gain or mutations could enhance understanding of the mechanisms of resistance and improve management of patients with castration-resistant prostate cancer. Full Text | PDF
Surgery: The surgeon-scientist — a dying breed? Solomon L. Woldu & Ganesh V. Raj Published online: 22 November 2016 p698 | doi:10.1038/nrurol.2016.236 Surgeon-scientists have made fundamental discoveries that have revolutionized medicine. A recent report raises the spectre of a future without surgeon-scientists, owing to an increasing need for clinical productivity and burdensome administrative responsibilities. A pathway forward is needed, to protect and nurture the surgeon-scientist — a critical participant in academic medicine. Full Text | PDF
Bladder cancer: Assessing the conundrum of microscopic haematuria Gary D. Steinberg Published online: 15 November 2016 p700 | doi:10.1038/nrurol.2016.229 The compliance of physicians to current guidelines for asymptomatic microhaematuria is limited and the evidence supporting asymptomatic microhaematuria as an effective screening tool for the early detection of bladder cancer is weak. Medical or surgical treatment is indicated in 13-35% of patients with asymptomatic microhaematuria, albeit mostly for benign conditions, which are more commonly the cause. The high prevalence of asymptomatic microhaematuria in the general population means that this condition poses a considerable challenge to the health-care system. Full Text | PDF
Kidney cancer: Undertreatment of small renal masses by overuse of biopsy Hiten D. Patel & Phillip M. Pierorazio Published online: 02 November 2016 p701 | doi:10.1038/nrurol.2016.213 Recent evidence from series of small renal mass biopsy samples and methodologically robust meta-analyses provides improved guidance on cost-benefit trade-offs for diagnosis and management of this disease. Renal mass biopsy sampling should be reserved for situations in which it will affect management decisions - which it will not do for all patients. Full Text | PDF
Prostate cancer: Determining optimal therapy of early-stage disease remains complicated David Canes Published online: 08 November 2016 p703 | doi:10.1038/nrurol.2016.228 Large-scale randomized trials in early-stage prostate cancer are rare. Data from the recent ProtecT trial enables a cautious endorsement of active monitoring for early-stage, screen-detected prostate cancer: cancer-specific survival was high regardless of treatment approach (monitoring, surgery or radiation). How these findings apply to contemporary prostate cancer care requires careful evaluation. Full Text | PDF
REVIEWS		Top
The management of neurogenic lower urinary tract dysfunction after spinal cord injury Jean-Jacques Wyndaele Published online: 25 October 2016 p705 | doi:10.1038/nrurol.2016.206 Urological complications remain among the most common, and the most bothersome of all complications in patients with a previous spinal cord injury. Minimizing the risks of these various complications, including incontinence, urinary retention, urinary tract infection and bladder cancer requires sustainable long-term management. In this Review, the author describes the optimal management strategy, while outlining the various unmet needs in the management of these patients. Abstract | Full Text | PDF
The present and future of serum diagnostic tests for testicular germ cell tumours Matthew J. Murray, Robert A. Huddart & Nicholas Coleman Published online: 18 October 2016 p715 | doi:10.1038/nrurol.2016.170 A need for improved serum diagnostic tests for testicular germ cell tumours (GCTs) exists owing to the unsatisfactory performance of currently used markers. In this Review, Murray and colleagues discuss the current serum diagnostic tests for testicular GCTs, including [alpha]-fetoprotein, human chorionic gonadotrophin and lactate dehydrogenase, and the future use of novel universal biomarkers such as microRNAs. Abstract | Full Text | PDF
Evaluation of dusting versus basketing — can new technologies improve stone-free rates? Brian Weiss & Ojas Shah Published online: 04 October 2016 p726 | doi:10.1038/nrurol.2016.172 The management of upper-tract urinary stones has dramatically changed towards an increase in the use of ureteroscopic treatment, driven by technological advances. In this Review, Weiss and Shah discuss the unique advantages and disadvantages of the two basic principles for treating stones ureteroscopically — dusting and basketing. Abstract | Full Text | PDF
The translational potential of microRNAs as biofluid markers of urological tumours Annika Fendler et al. Published online: 02 November 2016 p734 | doi:10.1038/nrurol.2016.193 MicroRNA secretion pathways are dysregulated in cancer, making them attractive candidate molecules for liquid biopsies and studies have shown that they are noninvasive diagnostic, prognostic and surveillance markers in urological carcinomas. However, methodological and analytical pitfalls exist and require addressing to enable future translation of microRNA analysis into clinical practice. Abstract | Full Text | PDF
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*Journal Citation Reports, Thomson, 2008. Nature Reviews Urology was previously published as Nature Clinical Practice Urology.

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