The EMBO Journal Table of Contents for 1 July 2016; Vol. 35, No. 13

1 July 2016 | Volume 35, Number 13 Submit Table of Contents News & Views Articles Volume 35, Number 13 News & Views Mitochondria just wanna have FUN(DC1) Mitochondrial dynamics and mitophagy are altered upon hypoxia. New work shows that the mitochondrial outer protein FUNDC1 coordinates mitochondrial fission at the ER–mitochondria interface with hypoxia‐induced mitophagy. Alexander M van der Bliek Published online 09.06.2016 Articles FUNDC1 regulates mitochondrial dynamics at the ER–mitochondrial contact site under hypoxic conditions In response to hypoxia, mitophagy receptor FUNDC1 associates with ER‐resident protein calnexin and thereby accumulates at the ER–mitochondrial contact site; this allows for DRP‐1 recruitment and thus mitochondrial fission. Wenxian Wu, Chunxia Lin, Keng Wu, Lei Jiang, Xiaojing Wang, Wen Li, Haixia Zhuang, Xingliang Zhang, Hao Chen, Shupeng Li, Yue Yang, Yue Lu, Jingjing Wang, Runzhi Zhu, Liangqing Zhang, Senfang Sui, Ning Tan, Bin Zhao, Jingjing Zhang, Longxuan Li, and Du Feng Published online 04.05.2016 HSV‐1 ICP27 targets the TBK1‐activated STING signalsome to inhibit virus‐induced type I IFN expression Herpes simplex virus evades cGAS/STING/TBK1‐mediated innate immunity activation in human macrophages by nuclear translocation of its ICP27 effector protein and suppression of IRF3 signaling. Maria H Christensen, Søren B Jensen, Juho J Miettinen, Stefanie Luecke, Thaneas Prabakaran, Line S Reinert, Thomas Mettenleiter, Zhijian J Chen, David M Knipe, Rozanne M Sandri‐Goldin, Lynn W Enquist, Rune Hartmann, Trine H Mogensen, Stephen A Rice, Tuula A Nyman, Sampsa Matikainen, and Søren R Paludan Published online 27.05.2016 SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development Polyubiquitylation of the tumor suppressor Sufu mediated by the F‐box ubiquitin ligase adaptor Fbxl17 facilitates the release of Gli transcription factor upon Hedgehog pathway activation. Madalina Raducu, Ella Fung, Sébastien Serres, Paola Infante, Alessandro Barberis, Roman Fischer, Claire Bristow, Marie‐Laëtitia Thézénas, Csaba Finta, John C Christianson, Francesca M Buffa, Benedikt M Kessler, Nicola R Sibson, Lucia Di Marcotullio, Rune Toftgård, and Vincenzo D'Angiolella Published online 27.05.2016 Novel function of Tau in regulating the effects of external stimuli on adult hippocampal neurogenesis Tau protein plays an unexpected key role in the regulation of adult hippocampal neurogenesis, both under basal conditions and in response to stressing or enriching environmental settings. Noemí Pallas‐Bazarra, Jerónimo Jurado‐Arjona, Marta Navarrete, Jose A Esteban, Félix Hernández, Jesús Ávila, and María Llorens‐Martín Published online 19.05.2016 WRNIP1 protects stalled forks from degradation and promotes fork restart after replication stress Replication fork protection by RAD51 is aided by the ATPase WRNIP, a hitherto poorly characterized interactor of the Werner syndrome helicase. Giuseppe Leuzzi, Veronica Marabitti, Pietro Pichierri, and Annapaola Franchitto Published online 30.05.2016 Histone H3.3 promotes IgV gene diversification by enhancing formation of AID‐accessible single‐stranded DNA The presence of variant histone H3.3 in immunoglobulin V genes promotes the exposure of ssDNA during transcription, thus enabling efficient AID‐mediated antibody diversification. Marina Romanello, Davide Schiavone, Alexander Frey, and Julian E Sale Published online 23.05.2016 Structural evidence for Nap1‐dependent H2A–H2B deposition and nucleosome assembly A co‐crystal structure defines the stoichiometry of H2A–H2B binding to the Nap1 histone chaperone, and shows that higher‐order oligomerization is needed for proper histone incorporation into nucleosomes. Carmen Aguilar‐Gurrieri, Amédé Larabi, Vinesh Vinayachandran, Nisha A Patel, Kuangyu Yen, Rohit Reja, Ima‐O Ebong, Guy Schoehn, Carol V Robinson, B Franklin Pugh, and Daniel Panne Published online 25.05.2016   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2016 by the European Molecular Biology Organisation.