EMBO reports Table of Contents for July 2016; Vol. 17, No. 7

July 2016 | Volume 17, Number 7 Submit Table of Contents Opinion Correspondence News & Views Science & Society Scientific Report Articles Corrigendum Volume 17, Number 7 Opinion Bio‐banking gut microbiome samples An increasing number of academic and private biobanks store faecal samples for research and stool transplantation purposes. As stool samples are unique from other biological tissues and materials, stool biobanks require appropriate regulation and additional research on gut microbiota to ensure safe application in the clinic. Shankar Bolan, Balaji Seshadri, Nicholas J Talley, and Ravi Naidu Published online 09.06.2016 Correspondence Toss the water, keep the child A comment on “Social influence and peer review”. Inna M Sokolova Published online 13.06.2016 Reply to Inna Sokolova The original authors’ response. Daniel Fisher and Nikolaos Parisis Published online 13.06.2016 News & Views TERRA Incognita at chromosome ends A study in this issue shows that the lncRNA TERRA is a positive regulator of telomerase in an organism with human‐like telomeres. Stéphane Coulon and Vincent Géli Published online 03.06.2016 Priming for destruction: septins at the crossroads of mitochondrial fission and bacterial autophagy Two studies in this and the previous issue show that septins interact with the dynamin‐related protein Drp1 to induce mitochondrial fission and that mitochondria promote the assembly of septin cages around cytosolic Shigella bacteria, which targets them for autophagy. Elias T Spiliotis and Lee Dolat Published online 08.06.2016 Science & Society Organoid biobanking: identifying the ethics: Organoids revive old and raise new ethical challenges for basic research and therapeutic use Organoid technology is at the margin of basic research, precision medicine, and regenerative medicine where various research and clinical ethical issues converge. Resolving these interrelated ethical challenges requires an integrated approach rather than assessing each issue individually. Sarah N Boers, Johannes JM van Delden, Hans Clevers, and Annelien L Bredenoord Published online 13.06.2016 90‐day rodent feeding studies on whole GM food/feed: Is the mandatory EU requirement for 90‐day rodent feeding studies on whole GM food/feed fit for purpose and consistent with animal welfare ethics? New EU regulation requires mandatory 90‐day rat feeding studies on whole GM feed to identify unintended hazards with GM food. However, these studies are not only unlikely to fulfil their purpose but are also inconsistent with EU policies to improve animal welfare in research. Yann Devos, Hanspeter Naegeli, Joe N Perry, and Elisabeth Waigmann Published online 09.06.2016 The potential of molecular biology and biotechnology for dealing with global warming: The biosciences will have to play a leading role in developing new technologies for mitigating the impact of greenhouse gas emissions Dealing with the effects of climate change and keeping the level of atmospheric CO2 in check will require considerable efforts by molecular biology and biotechnology. New technologies for energy conversion and plant varieties to cope with a warming climate might help to limit the increase of global temperatures. Philip Hunter Published online 09.06.2016 Consumer reporting of adverse drug reactions: Systems that allow patients to report side effects of the drugs they are taking have yielded valuable information for improving drugs safety and health care Many countries have established systems that allow patients to report adverse drug reactions directly, complementing the reports from healthcare professionals. Experience with these systems has shown that direct consumer reporting on drug side effects provides valuable information for public health and healthcare authorities. Katrin Weigmann Published online 19.05.2016 Scientific Report Loss of CLPP alleviates mitochondrial cardiomyopathy without affecting the mammalian UPRmt Loss of mammalian ClpP does not affect the mitochondrial unfolded protein response (UPRmt) under proteotoxic stress. Instead, loss of ClpP alleviates mitochondrial cardiomyopathy by partially rescuing the mitochondrial translation defect and reducing the level of potentially toxic peptides. Dominic Seiferling, Karolina Szczepanowska, Christina Becker, Katharina Senft, Steffen Hermans, Priyanka Maiti, Tim König, Alexandra Kukat, and Aleksandra Trifunovic Published online 06.05.2016 Articles Mcp3 is a novel mitochondrial outer membrane protein that follows a unique IMP‐dependent biogenesis pathway This study reports that the mitochondrial outer membrane protein Mcp3 is a suppressor of deficiencies in ERMES complex components that cause loss of ER‐mitochondria contacts. Mcp3 follows a novel and unique import pathway, which includes processing by the inner membrane peptidase IMP. Monika Sinzel, Tao Tan, Philipp Wendling, Hubert Kalbacher, Cagakan Özbalci, Xenia Chelius, Benedikt Westermann, Britta Brügger, Doron Rapaport, and Kai Stefan Dimmer Published online 24.05.2016 Urokinase links plasminogen activation and cell adhesion by cleavage of the RGD motif in vitronectin This study identifies a novel function for the plasminogen activation cascade in the regulation of cell adhesion. Urokinase and plasmin cleave the RGD motif of vitronectin in a process that is accelerated by the urokinase receptor and counteracted by the plasminogen activator inhibitor‐1. Valentina De Lorenzi, Gian Maria Sarra Ferraris, Jeppe B Madsen, Michela Lupia, Peter A Andreasen, and Nicolai Sidenius Published online 17.05.2016 TERRA promotes telomerase‐mediated telomere elongation in Schizosaccharomyces pombe In S. pombe, shortened telomeres produce elevated levels of the lncRNA TERRA, which associates with telomerase and promotes telomerase recruitment and telomere elongation in cis. This is the first direct evidence that TERRA is a positive regulator of telomerase in an organism with human‐like telomeres. Martin Moravec, Harry Wischnewski, Amadou Bah, Yan Hu, Na Liu, Lorenzo Lafranchi, Megan C King, and Claus M Azzalin Published online 06.05.2016 Long noncoding RNA EGOT negatively affects the antiviral response and favors HCV replication This study shows that the expression of several cellular lncRNAs is induced in HCV‐infected cells, either directly triggered by the viral infection or activated by the antiviral response. One of these is EGOT, which blocks the interferon response and favors viral replication. Elena Carnero, Marina Barriocanal, Celia Prior, Juan Pablo Unfried, Victor Segura, Elizabeth Guruceaga, Mónica Enguita, Cristian Smerdou, Pablo Gastaminza, and Puri Fortes Published online 09.06.2016 Mitochondria mediate septin cage assembly to promote autophagy of Shigella This study shows a close relationship between mitochondria and the assembly of septin cages around Shigella flexneri in infected mammalian cells, uncovering an unexpected role for mitochondria in antibacterial autophagy and host defence. Andrea Sirianni, Sina Krokowski, Damián Lobato‐Márquez, Stephen Buranyi, Julia Pfanzelter, Dieter Galea, Alexandra Willis, Siân Culley, Ricardo Henriques, Gerald Larrouy‐Maumus, Michael Hollinshead, Vanessa Sancho‐Shimizu, Michael Way, and Serge Mostowy Published online 03.06.2016 Higher‐order assemblies of oligomeric cargo receptor complexes form the membrane scaffold of the Cvt vesicle This study provides a multi‐scale visualization of the cytoplasm‐to‐vacuole targeting (Cvt) pathway from cargo assembly to intact vesicle formation. It reveals the oligomeric organization of Cvt components and shows that higher‐order cargo receptor assemblies provide the membrane scaffold for selective autophagy. Chiara Bertipaglia, Sarah Schneider, Arjen J Jakobi, Abul K Tarafder, Yury S Bykov, Andrea Picco, Wanda Kukulski, Jan Kosinski, Wim JH Hagen, Arvind C Ravichandran, Matthias Wilmanns, Marko Kaksonen, John AG Briggs, and Carsten Sachse Published online 06.06.2016 RAB2A controls MT1‐MMP endocytic and E‐cadherin polarized Golgi trafficking to promote invasive breast cancer programs RAB2A is a novel trafficking determinant essential for the acquisition of a mesenchymal invasive program during breast cancer dissemination. RAB2A acts by controlling both post‐endocytic trafficking of MT1‐MMP and Golgi transport of E‐cadherin. Hiroaki Kajiho, Yuko Kajiho, Emanuela Frittoli, Stefano Confalonieri, Giovanni Bertalot, Giuseppe Viale, Pier Paolo Di Fiore, Amanda Oldani, Massimiliano Garre, Galina V Beznoussenko, Andrea Palamidessi, Manuela Vecchi, Philippe Chavrier, Frank Perez, and Giorgio Scita Published online 02.06.2016 Corrigendum miR‐10b expression in breast cancer stem cells supports self‐renewal through negative PTEN regulation and sustained AKT activation Ivan Bahena‐Ocampo, Magali Espinosa, Gisela Ceballos‐Cancino, Floria Lizarraga, Denise Campos‐Arroyo, Angela Schwarz, Patricia Garcia‐Lopez, Vilma Maldonado, and Jorge Melendez‐Zajgla Published online 01.07.2016 Intellectual disability‐associated dBRWD3 regulates gene expression through inhibition of HIRA/YEM‐mediated chromatin deposition of histone H3.3 Wei‐Yu Chen, Hsueh‐Tzu Shih, Kwei‐Yan Liu, Zong‐Siou Shih, Li‐Kai Chen, Tsung‐Han Tsai, Mei‐Ju Chen, Hsuan Liu, Bertrand Chin‐Ming Tan, Chien‐Yu Chen, Hsiu‐Hsiang Lee, Benjamin Loppin, Ounissa Aït‐Ahmed, and June‐Tai Wu Published online 01.07.2016   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2016 by the European Molecular Biology Organisation.