The EMBO Journal Table of Contents for 01 February 2017; Vol. 36, No. 3

01 February 2017 | Volume 36, Number 3 Submit Table of Contents News & Views Review Articles Resource Volume 36, Number 3 News & Views Global snapshots of bacterial RNA networks Several recent studies have used clever variations of RNA‐seq techniques to comprehensively map small RNA–target networks involved in controlling bacterial gene expression. Jens Hör and Jörg Vogel Published online 28.12.2016 TFIID or not TFIID, a continuing transcriptional SAGA Alternative modes of transcriptional pre‐initiation complex assembly rather than gene‐specific activators differentiate housekeeping gene expression from regulated gene expression. Slawomir Kubik, Maria Jessica Bruzzone, and David Shore Published online 09.01.2017 Brief encounters of cytochrome c The first co‐crystal structure of cytochrome c oxidase and cytochrome c illustrates how transient protein–protein interactions mediate a key step in the electron transport chain. Joseph A Lyons and Poul Nissen Published online 13.01.2017 Review Focus: Metabolism: Hypoxia‐inducible factors: coupling glucose metabolism and redox regulation with induction of the breast cancer stem cell phenotype This review offers a concise summary of our current view of how HIFs mediate glycolytic reprogramming and facilitate breast cancer stem cell survival under hypoxia. Gregg L Semenza Published online 22.12.2016 Articles The pseudophosphatase STYX targets the F‐box of FBXW7 and inhibits SCFFBXW7 function STYX‐mediated stabilization of ubiquitination targets by blocking substrate adaptor recruitment into SCF E3s may represent a general new mode of cullin–RING ligase regulation. Veronika Reiterer, Cristina Figueras‐Puig, Francois Le Guerroue, Stefano Confalonieri, Manuela Vecchi, Dasaradha Jalapothu, Sandip M Kanse, Raymond J Deshaies, Pier Paolo Di Fiore, Christian Behrends, and Hesso Farhan Published online 22.12.2016 Molecular mechanisms that distinguish TFIID housekeeping from regulatable SAGA promoters The different level of responsiveness seen for housekeeping vs. regulatable gene promoters is inherent to the underlying DNA sequence rather than to specific activator use. Wim J de Jonge, Eoghan O'Duibhir, Philip Lijnzaad, Dik van Leenen, Marian JA Groot Koerkamp, Patrick Kemmeren, and Frank CP Holstege Published online 15.12.2016 Complex structure of cytochrome c–cytochrome c oxidase reveals a novel protein–protein interaction mode The Cyt.c–CcO crystal structure delineates the path for electron transfer and illustrates a new mode of transient protein–protein interaction via ordered water molecules. Satoru Shimada, Kyoko Shinzawa‐Itoh, Junpei Baba, Shimpei Aoe, Atsuhiro Shimada, Eiki Yamashita, Jiyoung Kang, Masaru Tateno, Shinya Yoshikawa, and Tomitake Tsukihara Published online 15.12.2016 Replication fork passage drives asymmetric dynamics of a critical nucleoid‐associated protein in Caulobacter Experiments and modeling reveal a simple mechanism by which DNA replication can control spatiotemporal dynamics of bacterial DNA‐binding proteins involved in chromosome organization and global gene expression. Rodrigo Arias‐Cartin, Genevieve S Dobihal, Manuel Campos, Ivan V Surovtsev, Bradley Parry, and Christine Jacobs‐Wagner Published online 23.12.2016 An RNA‐binding atypical tropomyosin recruits kinesin‐1 dynamically to oskar mRNPs Correct localization of oskar mRNPs in the Drosophila oocyte is mediated by motor protein kinesin‐1. Uncoupling of kinesin loading via Tropomyosin1‐I/C from its cargo splicing‐dependent activation ensures coordinated mRNA transport in the oocyte. Imre Gáspár, Vasiliy Sysoev, Artem Komissarov, and Anne Ephrussi Published online 27.12.2016 Hippo kinases maintain polarity during directional cell migration in Caenorhabditis elegans The anterior–posterior migration of neuroblast progeny in C. elegans larvae is regulated by the interplay between Hippo kinases and Rho GTPase MIG‐2 activity. Guoxin Feng, Zhiwen Zhu, Wen‐Jun Li, Qirong Lin, Yongping Chai, Meng‐Qiu Dong, and Guangshuo Ou Published online 23.12.2016 miRNA profiling of human naive CD4 T cells links miR‐34c‐5p to cell activation and HIV replication Transcriptional up‐regulation of miR‐34c‐5p upon TCR stimulation is involved in T‐cell differentiation, while its down‐regulation during HIV infection may be part of an anti‐viral host response. Andreia J Amaral, Jorge Andrade, Russell B Foxall, Paula Matoso, Ana M Matos, Rui S Soares, Cheila Rocha, Christian G Ramos, Rita Tendeiro, Ana Serra‐Caetano, José A Guerra‐Assunção, Mariana Santa‐Marta, João Gonçalves, Margarida Gama‐Carvalho, and Ana E Sousa Published online 19.12.2016 Topoisomerase I‐mediated cleavage at unrepaired ribonucleotides generates DNA double‐strand breaks At sites of newly incorporated ribonucleotides, Top1 may not only induce single‐strand breaks but also sequentially cleave both DNA strands, causing genome damage that requires repair by homologous recombination. Shar‐yin N Huang, Jessica S Williams, Mercedes E Arana, Thomas A Kunkel, and Yves Pommier Published online 08.12.2016 Resource Small RNA interactome of pathogenic E. coli revealed through crosslinking of RNase E A new method using UV‐crosslinking maps the small RNA–RNA interaction network in bacteria and provides transcriptome‐wide information on small RNA function. Shafagh A Waters, Sean P McAteer, Grzegorz Kudla, Ignatius Pang, Nandan P Deshpande, Timothy G Amos, Kai Wen Leong, Marc R Wilkins, Richard Strugnell, David L Gally, David Tollervey, and Jai J Tree Published online 11.11.2016   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2017 by the European Molecular Biology Organisation.