Nature Reviews Neurology - Table of Contents alert Volume 10 Issue 11

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Nature Reviews Neurology

November 2014 Volume 10 Number 11
Nature Reviews Neurology cover
Impact Factor 14.103 *
In this issue
Research Highlights
News and Views

Also this month
 Featured article:
Brain connectivity in neurodegenerative diseases—from phenotype to proteinopathy
Michela Pievani, Nicola Filippini, Martijn P. van den Heuvel, Stefano F. Cappa & Giovanni B. Frisoni

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Alzheimer disease: Altered functional connectivity in preclinical dementia
Published online: 21 October 2014
p609 | doi:10.1038/nrneurol.2014.195


Migraine: Migraine in midlife could be connected to increased risk of late-life parkinsonism
Published online: 30 September 2014
p610 | doi:10.1038/nrneurol.2014.186


Alzheimer disease: Alzheimer disease risk factor CALM modulates tau turnover
Published online: 14 October 2014
p610 | doi:10.1038/nrneurol.2014.188


Traumatic brain injury: Simulations of TBI highlight the importance of impact direction
Published online: 21 October 2014
p611 | doi:10.1038/nrneurol.2014.192


Multiple sclerosis: Blood-based biomarkers provide insight into progressive MS
Published online: 07 October 2014
p612 | doi:10.1038/nrneurol.2014.189



Spinal cord injury: Acute hyperglycaemia exacerbates spinal cord injury in mice, and predicts poor recovery in human patients | Peripheral neuropathies: New recommendations for use of temperature threshold testing in the diagnosis of small-fibre neuropathy | Multiple sclerosis: Survey uncovers the needs of people with severe MS | Stroke: Transcranial laser therapy for stroke fails futility analysis | Alzheimer disease: Common polymorphisms in APOE and BDNF might predict cognitive decline in individuals with amyloid-β deposition | Migraine: Saccular aneurysm clipping decreases migraine prevalence | Parkinson disease: Serum uric acid level could be a diagnostic biomarker for PD | Motor neuron disease: A large case–control study finds no association between living near power lines and risk of ALS

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Dementia: Does vitamin D modulate cognition?
John E. Morley
Published online: 21 October 2014
p613 | doi:10.1038/nrneurol.2014.193
Epidemiological evidence strongly suggests that circulatory levels of 25-hydroxyvitamin D below 50 nmol/l are associated with cognitive impairment and the development of dementia. A number of biochemical mechanisms could explain these effects; however, interventional studies to date have revealed disappointingly little.
Full Text | PDF

Epilepsy: Pregnancy in women with epilepsy—risks and management
Kimford J. Meador
Published online: 30 September 2014
p614 | doi:10.1038/nrneurol.2014.179
The risks of seizures and antiepileptic drug (AED) teratogenicity must be balanced when treating pregnant women with epilepsy. Two recent articles address these risks for newer AEDs. Lamotrigine and levetiracetam carried low risks of malformations, and topiramate exhibited a dose-dependent risk. Levetiracetam controlled seizures more effectively than lamotrigine and topiramate.
Full Text | PDF

Neuroimmunology: Disease mechanisms in narcolepsy remain elusive
Ilkka Julkunen & Markku Partinen
Published online: 14 October 2014
p616 | doi:10.1038/nrneurol.2014.191
A pandemic influenza vaccine with a specific type of vaccine antigen has been linked to an increased incidence of narcolepsy in children from 2009-2010. However, the recent retraction of an article that reported a putative autoantigen means that the search for the mechanisms behind the vaccine-narcolepsy connection continues.
Full Text | PDF

Alzheimer disease: The search for a blood-based biomarker for Alzheimer disease
Alan Rembach
Published online: 30 September 2014
p618 | doi:10.1038/nrneurol.2014.182
Finding a peripheral biomarker for early Alzheimer disease (AD) is a major challenge. A recent study has validated a plasma protein signature that is associated with mild cognitive impairment and AD, and could predict conversion; however, longitudinal cohort studies of presymptomatic individuals are needed to confirm the findings.
Full Text | PDF

Corrigendum: Ischaemic stroke in young adults: risk factors and long-term consequences
Noortje A. M. M. Maaijwee, Loes C. A. Rutten-Jacobs, Pauline Schaapsmeerders, Ewoud J. van Dijk & Frank-Erik de Leeuw
Published online: 07 October 2014
p612 | doi:10.1038/nrneurol.2014.183

Full Text | PDF
Corrigendum: Guillain–Barre and Miller Fisher syndromes—new diagnostic classification
Benjamin R. Wakerley, Antonino Uncini, Nobuhiro Yuki & the GBS Classification Group
Published online: 07 October 2014
p612 | doi:10.1038/nrneurol.2014.190

Full Text | PDF
Brain connectivity in neurodegenerative diseases—from phenotype to proteinopathy
Michela Pievani, Michela Pievani, Nicola Filippini, Martijn P. van den Heuvel, Stefano F. Cappa & Giovanni B. Frisoni
Published online: 07 October 2014
p620 | doi:10.1038/nrneurol.2014.178
Functional and structural connectivity measures, assessed by means of functional and diffusion MRI, are emerging as potential intermediate biomarkers for Alzheimer disease and other neurodegenerative disorders. In this article, Pievani et al. evaluate the evidence that connectivity biomarkers are associated downstream with clinical phenotypes and topographic brain imaging markers of neurodegeneration, and upstream with molecular determinants of neurodegeneration and susceptibility genes.
Abstract | Full Text | PDF | Supplementary information

Classifying neurocognitive disorders: the DSM-5 approach
Perminder S. Sachdev, Deborah Blacker, Dan G. Blazer, Mary Ganguli, Dilip V. Jeste, Jane S. Paulsen & Ronald C. Petersen
Published online: 30 September 2014
p634 | doi:10.1038/nrneurol.2014.181
The fifth edition of the American Psyciatric Association's Diagnostic and Statistical Manual for Mental Disorders (DSM-5) was published in 2013, and with it came new diagnostic criteria for mild cognitive impairment and dementia. In this Review, members of the working group tasked with writing the DSM-5 criteria for neurocognitive disorders present the new approach to categorization and diagnosis. Three key syndromes are recognized—delirium, mild neurocognitive disorder and major neurocognitive disorder—and each can have distinct aetiological subtypes.
Abstract | Full Text | PDF

Maternal immune activation and abnormal brain development across CNS disorders
Irene Knuesel, Laurie Chicha, Markus Britschgi, Scott A. Schobel, Michael Bodmer, Jessica A. Hellings, Stephen Toovey & Eric P. Prinssen
Published online: 14 October 2014
p643 | doi:10.1038/nrneurol.2014.187
Activation of the immune system during pregnancy can have varied effects on fetal development, and converging evidence highlights maternal immune activation as a risk factor for multiple neurological conditions. In this Review, Knuesel and colleagues discuss the involvement of maternal immune activation in schizophrenia, austim spectrum disorders, epilepsy and other disorders. The authors then discuss how preclinical data indicate a possible link between prenatal exposure to infection and susceptibility to neurodegenerative disease, and they go on to identify fertile ground for further translational research.
Abstract | Full Text | PDF

ALS—dying forward, backward or outward?
Mark R. Baker
Published online: 23 September 2014
p660 | doi:10.1038/nrneurol.2013.221-c1

Full Text | PDF
The phenotypic variability of amyotrophic lateral sclerosis
Bart Swinnen & Wim Robberecht
Published online: 14 October 2014
p661 | doi:10.1038/nrneurol.2014.184
Amyotrophic lateral sclerosis (ALS) is a genotypically and phenotypically heterogeneous disease, as reflected in the variability in age and site of onset, extent of extramotor involvement, and survival. Cognitive involvement is also common, and corroborates the connection between ALS and frontotemporal lobar degeneration. In this article, Robberecht and Swinnen review phenotypic heterogeneity in ALS and discuss some of its implications for understanding ALS pathogenesis and development of therapeutic interventions.
Abstract | Full Text | PDF

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*Journal Citation Reports, Thomson, 2013. Nature Reviews Neurology was previously published as Nature Clinical Practice Neurology.

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