Nature Reviews Rheumatology - Table of Contents alert Volume 11 Issue 5

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Nature Reviews Rheumatology

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May 2015 Volume 11 Number 5

Nature Reviews Rheumatology cover
Impact Factor 10.252 *
In this issue
Research Highlights
News and Views

Also this month
 Featured article:
Management of juvenile idiopathic arthritis: hitting the target
Claas Hinze, Faekah Gohar & Dirk Foell

Recommend to library


Osteoimmunology: IgG immune complexes directly regulate bone homeostasis
Published online: 14 April 2015
p257 | doi:10.1038/nrrheum.2015.51


Experimental arthritis: In vivo noninvasive molecular optical imaging of disease
Published online: 24 March 2015
p258 | doi:10.1038/nrrheum.2015.39


Basic research: Synovial surfaces use synergy to slide
Published online: 31 March 2015
p259 | doi:10.1038/nrrheum.2015.42


Immunology: BiP peptides induce epitope-specific T-cell reactions in RA
Published online: 31 March 2015
p259 | doi:10.1038/nrrheum.2015.43


Connective tissue diseases: ICOS sustains pathogenic T-cell survival in SLE mouse model
Published online: 07 April 2015
p260 | doi:10.1038/nrrheum.2015.49


Osteoarthritis: SIRT6 prevents chondrocyte senescence and DNA damage
Published online: 14 April 2015
p260 | doi:10.1038/nrrheum.2015.52



Pain: No effect of opioid use on response to pregabalin in FMS | Spondyloarthropathies: Minimal disease activity linked to better outcomes in PsA | Lupus nephritis: MMF not superior to AZA as maintenance therapy

10th International Congress on Autoimmunity
Leipzig, Germany
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Autoimmunity: Lungs and citrullination
Lars Klareskog & Anca I. Catrina
Published online: 17 March 2015
p261 | doi:10.1038/nrrheum.2015.38
Anti-citrullinated protein antibodies are a distinctive feature of a subset of patients with rheumatoid arthritis (RA). A new report investigates how lung inflammation in patients with chronic obstructive pulmonary disease affects protein citrullination, providing an additional piece of information on the potential link between airway inflammation and RA.
Full Text | PDF

Connective tissue diseases: SLE classification: plus ca change, plus c'est la meme chose
Matthias Schneider & Matthew H. Liang
Published online: 17 February 2015
p262 | doi:10.1038/nrrheum.2015.16
The sensitivity of the long-awaited SLICC classification criteria for systemic lupus erythematosus (SLE) has now been examined in a cross-sectional observational study. Will the new criteria enable advances in the management of SLE?
Full Text | PDF

Corrigendum: Pharmacogenetics: implications for therapy in rheumatic diseases
Lesley Davila & Prabha Ranganathan
Published online: 10 March 2015
p258 | doi:10.1038/nrrheum.2015.32

Full Text | PDF


Advances in biomarkers for paediatric rheumatic diseases
Alessandro Consolaro, Giulia C. Varnier, Alberto Martini & Angelo Ravelli
Published online: 16 December 2014
p265 | doi:10.1038/nrrheum.2014.208
Promising biomarkers are being developed to predict disease outcome and response to therapy in children with juvenile idiopathic arthritis, childhood lupus nephritis and juvenile idiopathic inflammatory myopathies. These advances are expected to facilitate risk stratification, diagnosis and management of these patients, and thereby lead to more rational and effective clinical care.
Abstract | Full Text | PDF

Rheumatoid arthritis therapy reappraisal: strategies, opportunities and challenges
Josef S. Smolen & Daniel Aletaha
Published online: 17 February 2015
p276 | doi:10.1038/nrrheum.2015.8
Targeted therapies and novel strategies to optimize their use enable many patients with RA to achieve a state of low disease activity or even remission, which can be maintained even after tapering or withdrawal of biologic DMARDs. In this article, Smolen and Aletaha review current concepts of RA treatment and the clinical evidence for their effectiveness, in the context of relevant issues such as factors influencing response to therapy, the 'window of opportunity' hypothesis and definitions of treatment targets.
Abstract | Full Text | PDF

Management of juvenile idiopathic arthritis: hitting the target
Claas Hinze, Faekah Gohar & Dirk Foell
Published online: 06 January 2015
p290 | doi:10.1038/nrrheum.2014.212
The treatment of juvenile idiopathic arthritis (JIA) has improved markedly in past years, but sustained remission off-medication is still rare. In this Review, Hinze et al. discuss existing treatment approaches and guidelines, with a focus on targeted and patient-centred therapies developed to optimize management strategies for patients with JIA.
Abstract | Full Text | PDF

The clinical spectrum of autoimmune congenital heart block
Pilar Brito-Zerón, Peter M. Izmirly, Manuel Ramos-Casals, Jill P. Buyon & Munther A. Khamashta
Published online: 24 March 2015
p301 | doi:10.1038/nrrheum.2015.29
Autoimmune congenital heart block is more likely to occur in the babies of women with rheumatic diseases, particularly women seropositive for anti-Ro or anti-La autoantibodies. Here, the authors provide advice for the management of these women and their babies in juxtaposition to a systematic assessment of the epidemiology and classification of the disease.
Abstract | Full Text | PDF | Supplementary information


Article series: APLAR Perspectives
A new look at rheumatology in China—opportunities and challenges
Zhan-guo Li
Published online: 20 January 2015
p313 | doi:10.1038/nrrheum.2014.218
Funding and support for research and development in China is expanding at a rapid rate. In this APLAR Perspectives article, this growth is highlighted by advances in the field of rheumatology that have been catalysed by an increase in funding for Chinese rheumatology and by international partnerships.
Abstract | Full Text | PDF

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*Journal Citation Reports, Thomson, 2013. Nature Reviews Rheumatology was previously published as Nature Clinical Practice Rheumatology.

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