Nature Reviews Rheumatology - Table of Contents alert Volume 11 Issue 5

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TABLE OF CONTENTS
May 2015 Volume 11 Number 5
Impact Factor 10.252 *	In this issue Research Highlights News and Views Reviews Perspectives Also this month  Featured article: Management of juvenile idiopathic arthritis: hitting the target Claas Hinze, Faekah Gohar & Dirk Foell
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RESEARCH HIGHLIGHTS Top Osteoimmunology: IgG immune complexes directly regulate bone homeostasis Published online: 14 April 2015 p257 | doi:10.1038/nrrheum.2015.51 PDF Experimental arthritis: In vivo noninvasive molecular optical imaging of disease Published online: 24 March 2015 p258 | doi:10.1038/nrrheum.2015.39 PDF Basic research: Synovial surfaces use synergy to slide Published online: 31 March 2015 p259 | doi:10.1038/nrrheum.2015.42 PDF Immunology: BiP peptides induce epitope-specific T-cell reactions in RA Published online: 31 March 2015 p259 | doi:10.1038/nrrheum.2015.43 PDF Connective tissue diseases: ICOS sustains pathogenic T-cell survival in SLE mouse model Published online: 07 April 2015 p260 | doi:10.1038/nrrheum.2015.49 PDF Osteoarthritis: SIRT6 prevents chondrocyte senescence and DNA damage Published online: 14 April 2015 p260 | doi:10.1038/nrrheum.2015.52 PDF IN BRIEF Pain: No effect of opioid use on response to pregabalin in FMS | Spondyloarthropathies: Minimal disease activity linked to better outcomes in PsA | Lupus nephritis: MMF not superior to AZA as maintenance therapy PDF Rheumatology EVENT 10th International Congress on Autoimmunity 06.04.16 Leipzig, Germany More science events from
NEWS AND VIEWS		Top
Autoimmunity: Lungs and citrullination Lars Klareskog & Anca I. Catrina Published online: 17 March 2015 p261 | doi:10.1038/nrrheum.2015.38 Anti-citrullinated protein antibodies are a distinctive feature of a subset of patients with rheumatoid arthritis (RA). A new report investigates how lung inflammation in patients with chronic obstructive pulmonary disease affects protein citrullination, providing an additional piece of information on the potential link between airway inflammation and RA. Full Text | PDF
Connective tissue diseases: SLE classification: plus ca change, plus c'est la meme chose Matthias Schneider & Matthew H. Liang Published online: 17 February 2015 p262 | doi:10.1038/nrrheum.2015.16 The sensitivity of the long-awaited SLICC classification criteria for systemic lupus erythematosus (SLE) has now been examined in a cross-sectional observational study. Will the new criteria enable advances in the management of SLE? Full Text | PDF
Corrigendum: Pharmacogenetics: implications for therapy in rheumatic diseases Lesley Davila & Prabha Ranganathan Published online: 10 March 2015 p258 | doi:10.1038/nrrheum.2015.32 Full Text | PDF
REVIEWS		Top
Advances in biomarkers for paediatric rheumatic diseases Alessandro Consolaro, Giulia C. Varnier, Alberto Martini & Angelo Ravelli Published online: 16 December 2014 p265 | doi:10.1038/nrrheum.2014.208 Promising biomarkers are being developed to predict disease outcome and response to therapy in children with juvenile idiopathic arthritis, childhood lupus nephritis and juvenile idiopathic inflammatory myopathies. These advances are expected to facilitate risk stratification, diagnosis and management of these patients, and thereby lead to more rational and effective clinical care. Abstract | Full Text | PDF
Rheumatoid arthritis therapy reappraisal: strategies, opportunities and challenges Josef S. Smolen & Daniel Aletaha Published online: 17 February 2015 p276 | doi:10.1038/nrrheum.2015.8 Targeted therapies and novel strategies to optimize their use enable many patients with RA to achieve a state of low disease activity or even remission, which can be maintained even after tapering or withdrawal of biologic DMARDs. In this article, Smolen and Aletaha review current concepts of RA treatment and the clinical evidence for their effectiveness, in the context of relevant issues such as factors influencing response to therapy, the 'window of opportunity' hypothesis and definitions of treatment targets. Abstract | Full Text | PDF
Management of juvenile idiopathic arthritis: hitting the target Claas Hinze, Faekah Gohar & Dirk Foell Published online: 06 January 2015 p290 | doi:10.1038/nrrheum.2014.212 The treatment of juvenile idiopathic arthritis (JIA) has improved markedly in past years, but sustained remission off-medication is still rare. In this Review, Hinze et al. discuss existing treatment approaches and guidelines, with a focus on targeted and patient-centred therapies developed to optimize management strategies for patients with JIA. Abstract | Full Text | PDF
The clinical spectrum of autoimmune congenital heart block Pilar Brito-Zerón, Peter M. Izmirly, Manuel Ramos-Casals, Jill P. Buyon & Munther A. Khamashta Published online: 24 March 2015 p301 | doi:10.1038/nrrheum.2015.29 Autoimmune congenital heart block is more likely to occur in the babies of women with rheumatic diseases, particularly women seropositive for anti-Ro or anti-La autoantibodies. Here, the authors provide advice for the management of these women and their babies in juxtaposition to a systematic assessment of the epidemiology and classification of the disease. Abstract | Full Text | PDF | Supplementary information
PERSPECTIVES		Top
SCIENCE AND SOCIETY Article series: APLAR Perspectives A new look at rheumatology in China—opportunities and challenges Zhan-guo Li Published online: 20 January 2015 p313 | doi:10.1038/nrrheum.2014.218 Funding and support for research and development in China is expanding at a rapid rate. In this APLAR Perspectives article, this growth is highlighted by advances in the field of rheumatology that have been catalysed by an increase in funding for Chinese rheumatology and by international partnerships. Abstract | Full Text | PDF
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*Journal Citation Reports, Thomson, 2013. Nature Reviews Rheumatology was previously published as Nature Clinical Practice Rheumatology.

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