Nature Reviews Immunology Contents March 2013 Volume 13 Number 3 pp 151-218

TABLE OF CONTENTS
March 2013 Volume 13 Number 3		Advertisement
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RESEARCH HIGHLIGHTS Top T cells: The plastic virtues of a CD4+ T cell p151 | doi:10.1038/nri3400 Intestinal effector CD4+ T cells downregulate THPOK to differentiate into CD4+CD8α+ CTLs. PDF Autoimmunity: Gut bugs help protect males from diabetes p152 | doi:10.1038/nri3409 Sex differences in the gut microbiota promote testosterone-mediated protection from type 1 diabetes. PDF T cells: Memories of the future p152 | doi:10.1038/nri3411 Virus-specific memory-like CD4+ T cells can be abundant in humans who have not been infected with the virus. PDF STRUCTURE WATCH Viral RNA: a perfect fit for IFIT p153 | doi:10.1038/nri3412 PDF STRUCTURE WATCH Making and breaking MDA5 filaments p153 | doi:10.1038/nri3413 PDF HIV: From one STI to another ... with love p154 | doi:10.1038/nri3402 LL-37 produced by HSV-2-infected keratinocytes increases the susceptibility of neighbouring Langerhans cells to HIV infection. PDF Innate immunity: Caspase 11 hunts down cytosolic bacteria p154 | doi:10.1038/nri3408 Caspase 11 promotes host protection during infection with cytosolic bacteria. PDF B cells: Secrets to plasma cell longevity p156 | doi:10.1038/nri3410 MCL1 and autophagy promote plasma cell survival. PDF Tumour immunology: Give it a rest p156 | doi:10.1038/nri3414 Braümuller, Wieder and colleagues show that T helper 1 cells induce the senescence of tumour cells. PDF Asthma and allergy: Apoptotic cell clearance lets you breathe easy p157 | doi:10.1038/nri3404 Defects in the engulfment of dead cells by airway epithelial cells can contribute to allergic inflammation. PDF IN BRIEF Signal transduction: DNA damage sensor in the interferon response | Inflammation: Group 2 ILCs in the skin | Innate immunity: An innate immune role for TOSO | Immunogenetics: Bat immunology takes off | Reproductive immunology: Hormonal support for regulatory T cells | HIV: IL-7 in semen enhances HIV transmission PDF Immunology JOBS of the week Assistant / Associate Professor of Immunology and Infectious Diseases Harvard School of Public Health Faculty Positions in Immunology / Inflammation / Infectious Diseases University of Utah Postdoc position in Immunology at the Institut Pasteur Laboratory of Humoral Response to Pathogens, The Institut Pasteur falcuty, postdoctoral, assistant professor, Lecturer and associate professor positions Northeast University,China PhD positions Spemann Graduate School of Biology and Medicine (SGBM) More Science jobs from Immunology EVENT Tumor Immunology and Immunotherapy 10.08.13 Suzhou, China More science events from
REVIEWS		Top
Neutrophil recruitment and function in health and inflammation Elzbieta Kolaczkowska & Paul Kubes p159 | doi:10.1038/nri3399 It is becoming clear that the immune functions of neutrophils are more complex than once thought. Here, the authors provide an updated version of the classical neutrophil recruitment cascade and discuss the pro-inflammatory and anti-inflammatory roles of these cells in different immune settings. Abstract | Full Text | PDF
Intravenous immunoglobulin therapy: how does IgG modulate the immune system? Inessa Schwab & Falk Nimmerjahn p176 | doi:10.1038/nri3401 Intravenous immunoglobulin (IVIG) therapy is used to treat immunodeficient patients, but it can also suppress various autoimmune and chronic inflammatory diseases. Despite the clinical success of IVIG therapy, its mechanisms of action remain controversial. Here, the authors discuss the potential models for how IVIG mediates its immunomodulatory effects. Abstract | Full Text | PDF
Circadian control of the immune system Christoph Scheiermann, Yuya Kunisaki & Paul S. Frenette p190 | doi:10.1038/nri3386 Here, the authors discuss recent evidence indicating that components of the immune system are under the control of circadian rhythms. The circadian oscillations of immune mediators may allow the host to anticipate threats more efficiently but may also contribute to circadian exacerbations of chronic diseases. In addition, these circadian rhythms should be considered in the design of preclinical animal models, when harvesting human tissue samples and in vaccine administration. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Effector-triggered versus pattern-triggered immunity: how animals sense pathogens Lynda M. Stuart, Nicholas Paquette & Laurent Boyer p199 | doi:10.1038/nri3398 Lynda Stuart and colleagues discuss the ability of animals to sense perturbations in host cells caused by pathogen effectors. On the basis of recent mechanistic evidence, they suggest that such effector-triggered immunity might be as widespread in animals as in plants. Abstract | Full Text | PDF
OPINION Orchestrated leukocyte recruitment to immune-privileged sites: absolute barriers versus educational gates Ravid Shechter, Anat London & Michal Schwartz p206 | doi:10.1038/nri3391 In this Opinion article, the authors present a model of the barrier systems that control immune cell access to immune-privileged sites. They suggest that immune cell trafficking through 'true' endothelial barriers in the parenchyma results in destructive inflammation, whereas 'educational' epithelial gates allow for selective trafficking to facilitate immunosurveillance of these sites. Abstract | Full Text | PDF
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