Molecular Systems Biology - New articles published 2 April 2013

Latest Articles 2nd April 2013   Featured Article Research Articles   Web feeds About Open access   Featured Article Construction of human activity-based phosphorylation networks A high-resolution map of human phosphorylation networks was constructed by integrating experimentally determined kinase-substrate relationships with other resources, such as in vivo phosphorylation sites. Robert H Newman, Jianfei Hu, Hee-Sool Rho, Zhi Xie, Crystal Woodard, John Neiswinger, Christopher Cooper, Matthew Shirley, Hillary M Clark, Shaohui Hu, Woochang Hwang, Jun Seop Jeong, George Wu, Jimmy Lin, Xinxin Gao, Qiang Ni, Renu Goel, Shuli Xia, Hongkai Ji, Kevin N Dalby, Morris J Birnbaum, Philip A Cole, Stefan Knapp, Alexey G Ryazanov, Donald J Zack, Seth Blackshaw, Tony Pawson, Anne-Claude Gingras, Stephen Desiderio, Akhilesh Pandey, Benjamin E Turk, Jin Zhang, Heng Zhu & Jiang Qian Molecular Systems Biology 9:655; doi:10.1038/msb.2013.12; published 2 April 2013 Full Text | PDF | Supp. Inf. | Review Process Research Articles Temporal system-level organization of the switch from glycolytic to gluconeogenic operation in yeast Metabolome, proteome and physiology measurements were combined with mathematical modeling to unravel the temporal regulation of the metabolic fluxes during the diauxic shift in Saccharomyces cerevisiae. Guillermo G Zampar, Anne Kümmel, Jennifer Ewald, Stefan Jol, Bastian Niebel, Paola Picotti, Ruedi Aebersold, Uwe Sauer, Nicola Zamboni & Matthias Heinemann Molecular Systems Biology 9:651; doi:10.1038/msb.2013.11; published 2 April 2013 Full Text | PDF | Supp. Inf. | Review Process Dissecting the energy metabolism in Mycoplasma pneumoniae through genome-scale metabolic modeling A new genome-scale metabolic reconstruction of M. pneumonia is used in combination with external metabolite measurement and protein abundance measurements to quantitatively explore the energy metabolism of this genome-reduce human pathogen. Judith A H Wodke, Jacek Puchałka, Maria Lluch-Senar, Josep Marcos, Eva Yus, Miguel Godinho, Ricardo Gutiérrez-Gallego, Vitor A P Martins dos Santos, Luis Serrano, Edda Klipp & Tobias Maier Molecular Systems Biology 9:653; doi:10.1038/msb.2013.6; published 2 April 2013 Full Text | PDF | Supp. Inf. | Review Process Plant stem cell maintenance involves direct transcriptional repression of differentiation program The plant stem cell regulator WUSCHEL is shown to repress differentiation-promoting transcription factors. This regulatory network is analyzed with a computational model of the three-dimensional shoot stem cell niche and a combination of genetic perturbation and live imaging. Ram Kishor Yadav, Mariano Perales, Jérémy Gruel, Carolyn Ohno, Marcus Heisler, Thomas Girke, Henrik Jönsson & G Venugopala Reddy Molecular Systems Biology 9:654; doi:10.1038/msb.2013.8; published 2 April 2013 Full Text | PDF | Supp. Inf. | Review Process SH3 interactome conserves general function over specific form The Caenorhabditis elegans SH3 domain interactome was mapped and compared with the yeast SH3 interactome. Orthologous SH3 domain-mediated interactions are highly rewired, but the general function of the SH3 domain network is conserved between the two species Xiaofeng Xin, David Gfeller, Jackie Cheng, Raffi Tonikian, Lin Sun, Ailan Guo, Lianet Lopez, Alevtina Pavlenco, Adenrele Akintobi, Yingnan Zhang, Jean-François Rual, Bridget Currell, Somasekar Seshagiri, Tong Hao, Xinping Yang, Yun A Shen, Kourosh Salehi-Ashtiani, Jingjing Li, Aaron T Cheng, Dryden Bouamalay, Adrien Lugari, David E Hill, Mark L Grimes, David G Drubin, Barth D Grant, Marc Vidal, Charles Boone, Sachdev S Sidhu & Gary D Bader Molecular Systems Biology 9:652; doi:10.1038/msb.2013.9; published 2 April 2013 Full Text | PDF | Supp. Inf. | Review Process

You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/nams/svc/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department. For print subscription enquiries, please contact our subscription department. For other enquiries, please contact our customer feedback department. Nature Publishing Group | 75 Varick Street, 9th Floor | New York | NY 10013-1917 | USA Nature Publishing Group's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS. © 2013 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.