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2013/07/22

Clinical Pharmacology and Therapeutics - Table of Contents alert Volume 94 Issue 2

Clinical Pharmacology & Therapeutics

TABLE OF CONTENTS

Volume 94, Issue 2 (August 2013)

In this issue
In This Issue
Editorial
News & Views
Perspectives
Translation
Development
Regulation & Use
State of the Art
Research

Also new
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Original Research - Reviews & Perspectives - Tutorials

CPT: PSP publishes critical content covering the latest advances in quantitative methods as applied in pharmacology, physiology, and therapeutics in humans with a common focus on the application of these two areas on drug development. CPT: PSP is an online open access journal. 
 

In This Issue

Top

In This Issue

Clin Pharmacol Ther 2013 94: 167; 10.1038/clpt.2013.124

Full Text

Editorial

Top

Genomic Medicine, Precision Medicine, Personalized Medicine: What’s in a Name?

D M Roden and R F Tyndale

Clin Pharmacol Ther 2013 94: 169-172; 10.1038/clpt.2013.101

Abstract | Full Text

News & Views

Top

Highlights

Clin Pharmacol Ther 2013 94: 174-175; 10.1038/clpt.2013.123

Full Text

ASCPT News

Clin Pharmacol Ther 2013 94: 176-180; 10.1038/clpt.2013.113

Full Text

MACROSCOPY

The Opportunities and Challenges of Implementing Genomics-Informed Personalized Medicine

R L Chisholm

Clin Pharmacol Ther 2013 94: 181-182; 10.1038/clpt.2013.71

Full Text

Perspectives

Top

POINT/COUNTERPOINT

CYP2D6 Genotype Should Not Be Used to Determine Endocrine Therapy in Postmenopausal Breast Cancer Patients

J M Rae

Clin Pharmacol Ther 2013 94: 183-185; 10.1038/clpt.2013.102

Full Text

CYP2D6 Genotype and Tamoxifen Activity: Understanding Interstudy Variability in Methodological Quality

M J Ratain, Y Nakamura and N J Cox

Clin Pharmacol Ther 2013 94: 185-187; 10.1038/clpt.2013.66

Full Text

COMMENTARIES

Genomic Medicine: Too Great Expectations?

P P O’Rourke

Clin Pharmacol Ther 2013 94: 188-190; 10.1038/clpt.2013.44

Abstract | Full Text

Genomic Testing: The Clinical Laboratory Perspective

H Faruki

Clin Pharmacol Ther 2013 94: 190-192; 10.1038/clpt.2013.61

Abstract | Full Text

Educational Challenges in Implementing Genomic Medicine

E Passamani

Clin Pharmacol Ther 2013 94: 192-195; 10.1038/clpt.2013.38

Abstract | Full Text

Regulatory Challenges in the Review of Data from Global Clinical Trials: The PMDA Perspective

K Asano, A Tanaka, T Sato and Y Uyama

Clin Pharmacol Ther 2013 94: 195-198; 10.1038/clpt.2013.106

Abstract | Full Text

Genetics of Cisplatin Ototoxicity: Confirming the Unexplained?

A V Boddy

Clin Pharmacol Ther 2013 94: 198-200; 10.1038/clpt.2013.116

Abstract | Full Text

LETTERS TO THE EDITOR

CYP3A5 Genotype, but Not CYP3A4*1b, CYP3A4*22, or Hematocrit, Predicts Tacrolimus Dose Requirements in Brazilian Renal Transplant Patients

A B Santoro, C J Struchiner, C R Felipe, H Tedesco-Silva, J O Medina-Pestana and G Suarez-Kurtz

Clin Pharmacol Ther 2013 94: 201-202; advance online publication, April 2, 2013; 10.1038/clpt.2013.68

Full Text

Response to “CYP3A5 Genotype, but Not CYP3A4*1b, CYP3A4*22, or Hematocrit, Predicts Tacrolimus Dose Requirements in Brazilian Renal Transplant Patients”

H de Jonge and D R Kuypers

Clin Pharmacol Ther 2013 94: 202-203; advance online publication, May 9, 2013; 10.1038/clpt.2013.94

Full Text

Translation

Top

Challenges in Implementing Genomic Medicine: The Mayo Clinic Center for Individualized Medicine

G Farrugia and R M Weinshilboum

Clin Pharmacol Ther 2013 94: 204-206; advance online publication, March 11, 2013; 10.1038/clpt.2013.52

Full Text

The Pharmacogenomics Research Network Translational Pharmacogenetics Program: Overcoming Challenges of Real-World Implementation

A R Shuldiner, M V Relling, J F Peterson, K Hicks, R R Freimuth, W Sadee, N L Pereira, D M Roden, J A Johnson and T E Klein ; for the Pharmacogenomics Research Network Translational Pharmacogenetics Program Group

Clin Pharmacol Ther 2013 94: 207-210; advance online publication, March 19, 2013; 10.1038/clpt.2013.59

Full Text

Development

Top

Challenges in the Pharmacogenomic Annotation of Whole Genomes

R B Altman, M Whirl-Carrillo and T E Klein

Clin Pharmacol Ther 2013 94: 211-213; advance online publication, May 24, 2013; 10.1038/clpt.2013.111

Full Text

Regulation & Use

Top

PRACTICE

The CLIPMERGE PGx Program: Clinical Implementation of Personalized Medicine Through Electronic Health Records and Genomics–Pharmacogenomics

O Gottesman, S A Scott, S B Ellis, C L Overby, A Ludtke, J-S Hulot, J Hall, K Chatani, K Myers, J L Kannry and E P Bottinger

Clin Pharmacol Ther 2013 94: 214-217; advance online publication, April 3, 2013; 10.1038/clpt.2013.72

Full Text

State of the Art

Top

A Systematic Approach to the Development of Novel Therapeutics for Lung Cancer Using Genomic Analyses

Y Daigo, A Takano, K Teramoto, S Chung and Y Nakamura

Clin Pharmacol Ther 2013 94: 218-223; advance online publication, May 8, 2013; 10.1038/clpt.2013.90

Abstract | Full Text

A Health-Care System Perspective on Implementing Genomic Medicine: Pediatric Acute Lymphoblastic Leukemia as a Paradigm

W E Evans, K R Crews and C-H Pui

Clin Pharmacol Ther 2013 94: 224-229; advance online publication, January 17, 2013; 10.1038/clpt.2013.9

Abstract | Full Text

Regulatory and Scientific Issues Regarding Use of Foreign Data in Support of New Drug Applications in the United States: An FDA Perspective

N A Khin, P Yang, H M J Hung, K Maung-U, Y-F Chen, A Meeker-O’Connell, P Okwesili, S U Yasuda, L K Ball, S-M Huang, R T O’Neill and R Temple

Clin Pharmacol Ther 2013 94: 230-242; advance online publication, April 3, 2013; 10.1038/clpt.2013.70

Abstract | Full Text

Research

Top

ARTICLES

Replication of TPMT and ABCC3 Genetic Variants Highly Associated With Cisplatin-Induced Hearing Loss in Children

K Pussegoda, C J Ross, H Visscher, M Yazdanpanah, B Brooks, S R Rassekh, Y F Zada, M-P Dubé, B C Carleton and M R Hayden the CPNDS Consortium

Clin Pharmacol Ther 2013 94: 243-251; advance online publication, April 10, 2013; 10.1038/clpt.2013.80

Abstract | Full Text

The Role of Inherited TPMT and COMT Genetic Variation in Cisplatin-Induced Ototoxicity in Children With Cancer

J J Yang, J Y S Lim, J Huang, J Bass, J Wu, C Wang, J Fang, E Stewart, E H Harstead, S E, G W Robinson, W E Evans, A Pappo, J Zuo, M V Relling, A Onar-Thomas, A Gajjar and C F Stewart

Clin Pharmacol Ther 2013 94: 252-259; advance online publication, June 11, 2013; 10.1038/clpt.2013.121

Abstract | Full Text

A Physiologically Based Pharmacokinetic Modeling Approach to Predict Disease–Drug Interactions: Suppression of CYP3A by IL-6

K K Machavaram, L M Almond, A Rostami-Hodjegan, I Gardner, M Jamei, S Tay, S Wong, A Joshi and J R Kenny

Clin Pharmacol Ther 2013 94: 260-268; advance online publication, April 10, 2013; 10.1038/clpt.2013.79

Abstract | Full Text

Comparative Effectiveness of Dabigatran, Rivaroxaban, Apixaban, and Warfarin in the Management of Patients With Nonvalvular Atrial Fibrillation

J Pink, M Pirmohamed and D A Hughes

Clin Pharmacol Ther 2013 94: 269-276; advance online publication, April 25, 2013; 10.1038/clpt.2013.83

Abstract | Full Text

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