Clinical Pharmacology and Therapeutics - Table of Contents alert Volume 94 Issue 2

TABLE OF CONTENTS Volume 94, Issue 2 (August 2013) In this issue In This Issue Editorial News & Views Perspectives Translation Development Regulation & Use State of the Art Research Also new AOP Sign up for CPT: Pharmacometrics & Systems Pharmacology e-alerts Sign up for e-alerts Recommend to your library Web feed Subscribe Advertisement New content available each week!  Original Research - Reviews & Perspectives - Tutorials CPT: PSP publishes critical content covering the latest advances in quantitative methods as applied in pharmacology, physiology, and therapeutics in humans with a common focus on the application of these two areas on drug development. CPT: PSP is an online open access journal.    In This Issue Top In This Issue Clin Pharmacol Ther 2013 94: 167; 10.1038/clpt.2013.124 Full Text Editorial Top Genomic Medicine, Precision Medicine, Personalized Medicine: What’s in a Name? D M Roden and R F Tyndale Clin Pharmacol Ther 2013 94: 169-172; 10.1038/clpt.2013.101 Abstract | Full Text News & Views Top Highlights Clin Pharmacol Ther 2013 94: 174-175; 10.1038/clpt.2013.123 Full Text ASCPT News Clin Pharmacol Ther 2013 94: 176-180; 10.1038/clpt.2013.113 Full Text MACROSCOPY The Opportunities and Challenges of Implementing Genomics-Informed Personalized Medicine R L Chisholm Clin Pharmacol Ther 2013 94: 181-182; 10.1038/clpt.2013.71 Full Text Perspectives Top POINT/COUNTERPOINT CYP2D6 Genotype Should Not Be Used to Determine Endocrine Therapy in Postmenopausal Breast Cancer Patients J M Rae Clin Pharmacol Ther 2013 94: 183-185; 10.1038/clpt.2013.102 Full Text CYP2D6 Genotype and Tamoxifen Activity: Understanding Interstudy Variability in Methodological Quality M J Ratain, Y Nakamura and N J Cox Clin Pharmacol Ther 2013 94: 185-187; 10.1038/clpt.2013.66 Full Text COMMENTARIES Genomic Medicine: Too Great Expectations? P P O’Rourke Clin Pharmacol Ther 2013 94: 188-190; 10.1038/clpt.2013.44 Abstract | Full Text Genomic Testing: The Clinical Laboratory Perspective H Faruki Clin Pharmacol Ther 2013 94: 190-192; 10.1038/clpt.2013.61 Abstract | Full Text Educational Challenges in Implementing Genomic Medicine E Passamani Clin Pharmacol Ther 2013 94: 192-195; 10.1038/clpt.2013.38 Abstract | Full Text Regulatory Challenges in the Review of Data from Global Clinical Trials: The PMDA Perspective K Asano, A Tanaka, T Sato and Y Uyama Clin Pharmacol Ther 2013 94: 195-198; 10.1038/clpt.2013.106 Abstract | Full Text Genetics of Cisplatin Ototoxicity: Confirming the Unexplained? A V Boddy Clin Pharmacol Ther 2013 94: 198-200; 10.1038/clpt.2013.116 Abstract | Full Text LETTERS TO THE EDITOR CYP3A5 Genotype, but Not CYP3A4*1b, CYP3A4*22, or Hematocrit, Predicts Tacrolimus Dose Requirements in Brazilian Renal Transplant Patients A B Santoro, C J Struchiner, C R Felipe, H Tedesco-Silva, J O Medina-Pestana and G Suarez-Kurtz Clin Pharmacol Ther 2013 94: 201-202; advance online publication, April 2, 2013; 10.1038/clpt.2013.68 Full Text Response to “CYP3A5 Genotype, but Not CYP3A4*1b, CYP3A4*22, or Hematocrit, Predicts Tacrolimus Dose Requirements in Brazilian Renal Transplant Patients” H de Jonge and D R Kuypers Clin Pharmacol Ther 2013 94: 202-203; advance online publication, May 9, 2013; 10.1038/clpt.2013.94 Full Text Translation Top Challenges in Implementing Genomic Medicine: The Mayo Clinic Center for Individualized Medicine G Farrugia and R M Weinshilboum Clin Pharmacol Ther 2013 94: 204-206; advance online publication, March 11, 2013; 10.1038/clpt.2013.52 Full Text The Pharmacogenomics Research Network Translational Pharmacogenetics Program: Overcoming Challenges of Real-World Implementation A R Shuldiner, M V Relling, J F Peterson, K Hicks, R R Freimuth, W Sadee, N L Pereira, D M Roden, J A Johnson and T E Klein ; for the Pharmacogenomics Research Network Translational Pharmacogenetics Program Group Clin Pharmacol Ther 2013 94: 207-210; advance online publication, March 19, 2013; 10.1038/clpt.2013.59 Full Text Development Top Challenges in the Pharmacogenomic Annotation of Whole Genomes R B Altman, M Whirl-Carrillo and T E Klein Clin Pharmacol Ther 2013 94: 211-213; advance online publication, May 24, 2013; 10.1038/clpt.2013.111 Full Text Regulation & Use Top PRACTICE The CLIPMERGE PGx Program: Clinical Implementation of Personalized Medicine Through Electronic Health Records and Genomics–Pharmacogenomics O Gottesman, S A Scott, S B Ellis, C L Overby, A Ludtke, J-S Hulot, J Hall, K Chatani, K Myers, J L Kannry and E P Bottinger Clin Pharmacol Ther 2013 94: 214-217; advance online publication, April 3, 2013; 10.1038/clpt.2013.72 Full Text State of the Art Top A Systematic Approach to the Development of Novel Therapeutics for Lung Cancer Using Genomic Analyses Y Daigo, A Takano, K Teramoto, S Chung and Y Nakamura Clin Pharmacol Ther 2013 94: 218-223; advance online publication, May 8, 2013; 10.1038/clpt.2013.90 Abstract | Full Text A Health-Care System Perspective on Implementing Genomic Medicine: Pediatric Acute Lymphoblastic Leukemia as a Paradigm W E Evans, K R Crews and C-H Pui Clin Pharmacol Ther 2013 94: 224-229; advance online publication, January 17, 2013; 10.1038/clpt.2013.9 Abstract | Full Text Regulatory and Scientific Issues Regarding Use of Foreign Data in Support of New Drug Applications in the United States: An FDA Perspective N A Khin, P Yang, H M J Hung, K Maung-U, Y-F Chen, A Meeker-O’Connell, P Okwesili, S U Yasuda, L K Ball, S-M Huang, R T O’Neill and R Temple Clin Pharmacol Ther 2013 94: 230-242; advance online publication, April 3, 2013; 10.1038/clpt.2013.70 Abstract | Full Text Research Top ARTICLES Replication of TPMT and ABCC3 Genetic Variants Highly Associated With Cisplatin-Induced Hearing Loss in Children K Pussegoda, C J Ross, H Visscher, M Yazdanpanah, B Brooks, S R Rassekh, Y F Zada, M-P Dubé, B C Carleton and M R Hayden the CPNDS Consortium Clin Pharmacol Ther 2013 94: 243-251; advance online publication, April 10, 2013; 10.1038/clpt.2013.80 Abstract | Full Text The Role of Inherited TPMT and COMT Genetic Variation in Cisplatin-Induced Ototoxicity in Children With Cancer J J Yang, J Y S Lim, J Huang, J Bass, J Wu, C Wang, J Fang, E Stewart, E H Harstead, S E, G W Robinson, W E Evans, A Pappo, J Zuo, M V Relling, A Onar-Thomas, A Gajjar and C F Stewart Clin Pharmacol Ther 2013 94: 252-259; advance online publication, June 11, 2013; 10.1038/clpt.2013.121 Abstract | Full Text A Physiologically Based Pharmacokinetic Modeling Approach to Predict Disease–Drug Interactions: Suppression of CYP3A by IL-6 K K Machavaram, L M Almond, A Rostami-Hodjegan, I Gardner, M Jamei, S Tay, S Wong, A Joshi and J R Kenny Clin Pharmacol Ther 2013 94: 260-268; advance online publication, April 10, 2013; 10.1038/clpt.2013.79 Abstract | Full Text Comparative Effectiveness of Dabigatran, Rivaroxaban, Apixaban, and Warfarin in the Management of Patients With Nonvalvular Atrial Fibrillation J Pink, M Pirmohamed and D A Hughes Clin Pharmacol Ther 2013 94: 269-276; advance online publication, April 25, 2013; 10.1038/clpt.2013.83 Abstract | Full Text Please note that you need to be a subscriber or site-license holder to enjoy full-text access to Clinical Pharmacology & Therapeutics. 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