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| | | Systems biology technologies series |  | New technologies are pushing the limits of biological measurements in terms of scale, resolution and accuracy, which is enabling the engineering of living organisms in unprecedented ways. Increasingly sophisticated computational methods are used to analyze and integrate quantitative and large-scale biological data. This series features Reviews on the technological platforms and methodologies that are driving the fields of systems and synthetic biology forward to reach new frontiers in biology.
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| |  | Biomedically relevant circuit-design strategies in mammalian synthetic biology |
| This review covers the burgeoning field of mammalian synthetic biology. New designs for potential clinical applications are discussed with examples of circuits that directly interface with endogenous cellular activities, enable intercellular communication or function as prothetic networks. William Bacchus, Dominique Aubel & Martin Fussenegger Molecular Systems Biology 9:691; doi:10.1038/msb.2013.48; published 24 September 2013 Full Text | PDF | | Featured Article | |  | Dissection of a Krox20 positive feedback loop driving cell fate choices in hindbrain patterning |
| A positive autoregulatory loop required for the expression of the transcription factor Krox20 was dissected using in vivo quantitative data and biophysical modelling to demonstrate how Krox20 controls cell fate decision and rhombomere size in the hindbrain. Yassine X Bouchoucha, Jürgen Reingruber, Charlotte Labalette, Michel A Wassef, Elodie Thierion, Carole Desmarquet-Trin Dinh, David Holcman, Pascale Gilardi-Hebenstreit & Patrick Charnay Molecular Systems Biology 9:690; doi:10.1038/msb.2013.46; published 24 September 2013 Full Text | PDF | Supp. Inf. | Review Process | | Research Articles | |  | Human disease locus discovery and mapping to molecular pathways through phylogenetic profiling |
| By analyzing the conservation of human proteins across 87 species, we sorted proteins into clusters of coevolution. Some clusters are enriched for genes assigned to particular human diseases or molecular pathways; the other genes in the same cluster may function in related pathways and diseases. Yuval Tabach, Tamar Golan, Abrahan Hernández-Hernández, Arielle R Messer, Tomoyuki Fukuda, Anna Kouznetsova, Jian-Guo Liu, Ingrid Lilienthal, Carmit Levy & Gary Ruvkun Molecular Systems Biology 9:692; doi:10.1038/msb.2013.50; published 1 October 2013 Full Text | PDF | Supp. Inf. | Review Process | | |  | Genome-scale models of metabolism and gene expression extend and refine growth phenotype prediction |
| A constraint-based approach for integrative modeling of metabolism and gene expression is developed. New constraints on molecular catalysis increase both the accuracy and scope of computable phenotypes corresponding to optimal microbial growth. Edward J O’Brien, Joshua A Lerman, Roger L Chang, Daniel R Hyduke & Bernhard Ø Palsson Molecular Systems Biology 9:693; doi:10.1038/msb.2013.52; published 1 October 2013 Full Text | PDF | Supp. Inf. | Review Process | |
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