The EMBO Journal - Table of Contents alert Volume 32 Issue 19

Advertisement Circulation: Cardiovascular Genetics is the #1 journal dedicated to cardiovascular genetics, genomics, and systems biology.  Join an esteemed roster of your peers - submit your manuscript for publication in Circulation: Cardiovascular Genetics today. Visit the journal's Information for Authors to learn about preferred article types and how to submit. TABLE OF CONTENTS 02 October 2013 | Volume 32, Issue 19 Have you seen? Review Articles Also new AOP Sign up for e-alerts Recommend to your library Web feed Subscribe Advertisement Editor's Choice - Pluripotency  Embryonic stem cell self-renewal pathways converge on the transcription factor Tfcp2l1 Shoudong Ye, Ping Li, Chang Tong and Qi-Long Ying   Identification of the missing pluripotency mediator downstream of leukaemia inhibitory Graziano Martello, Paul Bertone and Austin Smith  Have you seen? Top A liaison between intrinsic and extrinsic regulators of pluripotency Two complementary studies in The EMBO Journal establish Tfcp2l1 as intrinsic pluripotency regulator and crucial convergence point for the precise regulation of self-renewal versus differentiation. Kenjiro Adachi and Hitoshi Niwa The EMBO Journal (2013), 32, 2531 - 2532; 10.1038/emboj.2013.196 Abstract | Full text | PDF | Related article | Related article Published online: 27 August 2013 The Yin and Yang of enhancer-like RNAs The transcription factor YY1 inhibits myogenesis by inducing the long intergenic noncoding RNA Yam-1, which in turn activates miRNA-715 expression in cis, a finding that expands the regulatory potential of lincRNAs. Ramin Shiekhattar The EMBO Journal (2013), 32, 2533 - 2534; 10.1038/emboj.2013.185 Abstract | Full text | PDF | Related article Published online: 13 August 2013 Review Top Haematopoietic stem cell niches: new insights inspire new questions This review summarizes the most recent advances on the structural, cellular, and molecular control of HSC-niche interactions. Fernando Ugarte and E Camilla Forsberg The EMBO Journal (2013), 32, 2535 - 2547; 10.1038/emboj.2013.201 Abstract | Full text | PDF Published online: 10 September 2013 Articles Top Embryonic stem cell self-renewal pathways converge on the transcription factor Tfcp2l1 Upregulation under LIF/2i conditions in ESCs identifies Tfcp2I1 as a convergence point of various pluripotency pathways. As direct regulator of Nanog expression, Tfcp2I1 is ultimately linked to core self-renewing circuits. Shoudong Ye, Ping Li, Chang Tong and Qi-Long Ying The EMBO Journal (2013), 32, 2548 - 2560; 10.1038/emboj.2013.175 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 13 August 2013 Identification of the missing pluripotency mediator downstream of leukaemia inhibitory factor  EMBO Open A genome-wide approach to identify critical effectors of Lif/Stat3 signalling in ESCs reveals Tfcp2I1 as sufficient to sustain self-renewal and direct EpiSCs to naïve pluripotency. Graziano Martello, Paul Bertone and Austin Smith The EMBO Journal (2013), 32, 2561 - 2574; 10.1038/emboj.2013.177 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 13 August 2013 Genome-wide survey by ChIP-seq reveals YY1 regulation of lincRNAs in skeletal myogenesis In addition to its role in gene silencing, the transcription factor YY1 can act as a positive regulator of numerous intergenic long non-coding RNAs in myoblasts. One of these lncRNAs, Yam-1, inhibits myogenesis by reducing miR-715 levels in cis. Leina Lu, Kun Sun, Xiaona Chen, Yu Zhao, Lijun Wang, Liang Zhou, Hao Sun and Huating Wang The EMBO Journal (2013), 32, 2575 - 2588; 10.1038/emboj.2013.182 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 13 August 2013 FoxO3 coordinates metabolic pathways to maintain redox balance in neural stem cells Detailed metabolic measurements in neural progenitor cells (NPCs) establish FoxO3 as a central regulator of cellular metabolism and redox homeostasis. These results may have a direct impact on the proliferative capacity of stem and progenitor populations in general. Hyeonju Yeo, Costas A Lyssiotis, Yuqing Zhang, Haoqiang Ying, John M Asara, Lewis C Cantley and Ji-Hye Paik The EMBO Journal (2013), 32, 2589 - 2602; 10.1038/emboj.2013.186 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 06 September 2013 The NAD-dependent deacetylase sirtuin 2 is a suppressor of microglial activation and brain inflammation SIRT2 controls microglial activation and the inflammatory response in the brain by deacetylating NF-κB to regulate the expression of pro-inflammatory genes. Teresa Faria Pais, Éva M Szegő, Oldriska Marques, Leonor Miller-Fleming, Pedro Antas, Patrícia Guerreiro, Rita Machado de Oliveira, Burcu Kasapoglu and Tiago Fleming Outeiro The EMBO Journal (2013), 32, 2603 - 2616; 10.1038/emboj.2013.200 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 06 September 2013 IQGAP1 is a novel phosphatidylinositol 4,5 bisphosphate effector in regulation of directional cell migration IQGAP1 regulates cytoskeletal dynamics, adherens junctions, proliferation and trafficking. The phosphatidylinositol 4,5-bisphosphate (PIP2)-generating kinase PIPKIγ recruits IQGAP1 to the leading edge upon integrin or growth factor stimulation, leading to PIP2-mediated release of IQGAP1 autoinhibition, actin polymerization and cell migration. Suyong Choi, Narendra Thapa, Andrew C Hedman, Zhigang Li, David B Sacks and Richard A Anderson The EMBO Journal (2013), 32, 2617 - 2630; 10.1038/emboj.2013.191 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 27 August 2013 High-resolution analysis of DNA synthesis start sites and nucleosome architecture at efficient mammalian replication origins Strong mammalian replication origins initiate DNA synthesis at positions of high-nucleosome occupancy, in surprising contrast to the increased nucleosome dynamics and chromatin accessibility of ORC binding sites. Rodrigo Lombraña, Ricardo Almeida, Isabel Revuelta, Sofia Madeira, Gonzalo Herranz, Néstor Saiz, Ugo Bastolla and María Gómez The EMBO Journal (2013), 32, 2631 - 2644; 10.1038/emboj.2013.195 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 30 August 2013 Gene promoters dictate histone occupancy within genes Global analysis of nucleosome occupancy upon depletion of histone chaperone and elongation factor Spt6 reveals a novel function for promoters in dictating the histone dynamics in genes through transcriptional activity. Roberto Perales, Benjamin Erickson, Lian Zhang, Hyunmin Kim, Elan Valiquett and David Bentley The EMBO Journal (2013), 32, 2645 - 2656; 10.1038/emboj.2013.194 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 06 September 2013 Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to The EMBO Journal. In order to do so, please purchase a subscription. 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