Nature Reviews Gastroenterology & Hepatology - Table of Contents alert Volume 10 Issue 11

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TABLE OF CONTENTS
November 2013 Volume 10 Number 11
Impact Factor 10.426*	In this issue Editorial Research Highlights News and Views Reviews Perspectives Also this month  Focus: Focus on NAFLD
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EDITORIAL		Top
NAFLD—the next global epidemic Katrina Ray Published online: 04 November 2013 p621 | doi:10.1038/nrgastro.2013.197 Full Text | PDF
RESEARCH HIGHLIGHTS Top Small intestine: Mucus—is it time to change your gut reaction? Published online: 15 October 2013 p622 | doi:10.1038/nrgastro.2013.200 PDF Obesity: Fatty liver and the metabolic syndrome—fructose at fault? Published online: 17 September 2013 p623 | doi:10.1038/nrgastro.2013.184 PDF Paediatric gastroenterology: New algorithm successfully identifies infants at risk of progressive necrotising enterocolitis Published online: 08 October 2013 p623 | doi:10.1038/nrgastro.2013.196 PDF Gastroenterology & Hepatology JOBS of the week Staff Position in Gastroenterology Scripps Clinic Director of Gastroenterology and Staff Gastroenterologist North Shore-LIJ Department of Medicine Gastroenterologist Dartmouth-Hitchcock Medical Center Interventional Endoscopist University of Colorado Denver Gastroenterologist NorthShore University HealthSystem More Science jobs from Gastroenterology & Hepatology EVENT Asia-Pacific Gastroenterology Cancer Summit 2013 06.12.13 Singapore More science events from
NEWS AND VIEWS		Top
Gastrointestinal surgery: Real-time tissue identification during surgery Benjamin Crawshaw & Conor P. Delaney Published online: 10 September 2013 p624 | doi:10.1038/nrgastro.2013.176 A new 'intelligent knife' provides near-real-time intraoperative tissue analysis and enables accurate differentiation between malignant and benign tissue. This ability to 'smell' cancer could be applicable to a variety of oncological operations in gastroenterology, but some questions and limitations remain as this interesting new technology is explored. Full Text | PDF
IBD: Role of the pathologist in the diagnosis and management of IBD Robert D. Odze Published online: 15 October 2013 p625 | doi:10.1038/nrgastro.2013.198 Much understanding of IBD pathology is based on personal experience, anecdotal observations and small case studies. A paper on the histopathology of IBD provides an exhaustive literature review, and attempts to delineate guidelines for pathologists to use by providing evidence for consensus statements developed by a European contingent of gastrointestinal pathologists and clinicians. Full Text | PDF
Focus on: NAFLD REVIEWS Top From NAFLD to NASH to cirrhosis—new insights into disease mechanisms Alexander Wree et al. Published online: 20 August 2013 p627 | doi:10.1038/nrgastro.2013.149 Here, the authors summarize new insights into the pathogenesis of NAFLD and NASH, in particular the mechanisms responsible for liver injury and fibrosis. They highlight how a complex interplay between the environment (especially diet), host genetics and the gut microflora is crucial for the development and progression of NAFLD. Abstract | Full Text | PDF | Supplementary information The Gordian Knot of dysbiosis, obesity and NAFLD Wajahat Z. Mehal Published online: 20 August 2013 p637 | doi:10.1038/nrgastro.2013.146 The development of obesity and NAFLD is known to be determined by host genetics, diet and lack of exercise. In addition, the gut microbiota has been shown to influence the development of both of these conditions. In this Review, current understanding of the relationship between the intestinal microbiota, obesity and NAFLD is discussed, with an emphasis on causal relationships, latest advances and therapeutic opportunities. Abstract | Full Text | PDF The genetics of NAFLD Quentin M. Anstee & Christopher P. Day Published online: 24 September 2013 p645 | doi:10.1038/nrgastro.2013.182 NAFLD is a complex disease. Considerable variability exists in the severity and risk of morbidity and mortality among individuals with NAFLD, which could be influenced by genetic and environmental factors. Here, the authors discuss the latest knowledge on the genetics of NAFLD and how this genetic variation might determine disease phenotype and progression. Abstract | Full Text | PDF | Supplementary information NAFLD, NASH and liver cancer Gregory A. Michelotti, Mariana V. Machado & Anna Mae Diehl Published online: 01 October 2013 p656 | doi:10.1038/nrgastro.2013.183 The incidence of NAFLD, which increases the risk of liver cancer, is increasing to epidemic proportions. This Review outlines the correlations between liver cancer and NAFLD-related cirrhosis, and the role of the metabolic syndrome in the development of liver cancer. Advances in understanding the progression of NAFLD to hepatocellular carcinoma from preclinical models will also be discussed. Abstract | Full Text | PDF Noninvasive evaluation of NAFLD Laurent Castera, Valerie Vilgrain & Paul Angulo Published online: 24 September 2013 p666 | doi:10.1038/nrgastro.2013.175 Accurate diagnosis and staging of NAFLD is of utmost prognostic importance. The gold standard for diagnosis is histological examination, but growing interest exists in novel noninvasive methods to evaluate NAFLD. This Review describes the advantages and limitations of noninvasive methods for the diagnosis and quantification of steatosis, diagnosis of NASH and staging of hepatic fibrosis in NAFLD. Abstract | Full Text | PDF | Supplementary information Pharmacological agents for NASH Vlad Ratziu Published online: 15 October 2013 p676 | doi:10.1038/nrgastro.2013.193 Optimal management of NASH is required because the condition can progress to cirrhosis and end-stage liver failure. Once first-line therapy with diet and lifestyle changes has failed, pharmacological intervention is indicated. This Review discusses the available evidence from clinical trials on pharmacological agents for NASH. Abstract | Full Text | PDF
Focus on: NAFLD PERSPECTIVES Top SCIENCE AND SOCIETY The global NAFLD epidemic Rohit Loomba & Arun J. Sanyal Published online: 17 September 2013 p686 | doi:10.1038/nrgastro.2013.171 Global differences in the prevalence and presentation of NAFLD are presented in this Perspectives article. The authors also convey how scientific advances in our understanding and management of NAFLD now need to be translated to improve awareness at the level of society, influence global health policy and research priorities and ensure a better future for our coming generations. Abstract | Full Text | PDF
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*Journal Citation Reports, Thomson, 2012. Nature Reviews Gastroenterology & Hepatology was previously published as Nature Clinical Practice Gastroenterology & Hepatology.

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